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  1. Article ; Online: Acute hypernatremia and hypocalcemia after oral sodium phosphate administration to a dog.

    VanDerslice, Julia / Carroll, Maureen

    Journal of veterinary internal medicine

    2024  Volume 38, Issue 2, Page(s) 1157–1159

    Abstract: A 15-year-old male neutered mixed breed dog weighing 28 kg presented to a referral center after developing severe tremors and altered mentation. There was hypocalcemia and hypernatremia after oral administration of sodium phosphate as a bowel cleansing ... ...

    Abstract A 15-year-old male neutered mixed breed dog weighing 28 kg presented to a referral center after developing severe tremors and altered mentation. There was hypocalcemia and hypernatremia after oral administration of sodium phosphate as a bowel cleansing agent in preparation for colonoscopy. The dog was treated intravenously with low sodium fluids and calcium gluconate. Neurologic status and electrolyte derangements normalized over the next 12 hours. Oral administration of sodium phosphate appeared to cause clinical electrolyte derangements in this dog.
    MeSH term(s) Male ; Dogs ; Animals ; Hypocalcemia/chemically induced ; Hypocalcemia/veterinary ; Hypernatremia/chemically induced ; Hypernatremia/veterinary ; Phosphates/adverse effects ; Administration, Oral ; Dog Diseases/chemically induced ; Dog Diseases/drug therapy
    Chemical Substances sodium phosphate (SE337SVY37) ; Phosphates
    Language English
    Publishing date 2024-01-11
    Publishing country United States
    Document type Case Reports
    ZDB-ID 92798-3
    ISSN 1939-1676 ; 0891-6640
    ISSN (online) 1939-1676
    ISSN 0891-6640
    DOI 10.1111/jvim.16989
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    Zs.A 4095: Show issues Location:
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  2. Article ; Online: Advanced Cystic Fibrosis Lung Disease and Lung Transplantation in the Era of Cystic Fibrosis Transmembrane Conductance Regulator Modulators.

    O'Carroll, Mark

    Seminars in respiratory and critical care medicine

    2023  Volume 44, Issue 2, Page(s) 260–268

    Abstract: Cystic fibrosis transmembrane conductance regulator (CFTR) modulators have changed the clinical landscape of cystic fibrosis (CF) by improving clinically significant outcome measures and quality of life of people with CF (pwCF). There are now long-term ... ...

    Abstract Cystic fibrosis transmembrane conductance regulator (CFTR) modulators have changed the clinical landscape of cystic fibrosis (CF) by improving clinically significant outcome measures and quality of life of people with CF (pwCF). There are now long-term data showing improved 5-year survival with the use of ivacaftor, and the field continues to evolve at a rapid pace with the continued development of highly effective CFTR modulators. While the randomized controlled trials of CFTR modulators excluded patients with severe lung disease (forced expiratory volume in 1 second <40% predicted), observational data based on case reports and registry data show similar benefits in those with advanced lung disease. This has altered clinical practice particularly as it pertains to the role of lung transplantation in CF. This article describes the impact of highly effective modulator therapy (HEMT) on the natural history of CF and the influence on the timing of referral and consideration of listing for lung transplantation. CF clinicians play a pivotal role to ensure that the impetus of the CF foundation consensus guidelines to facilitate timely referral for lung transplantation is not lost among the excitement of anticipated sustained benefit from HEMT. While the widespread availability of elexacaftor/tezacaftor/ivacaftor over the past 2 years has been associated with a sharp drop in the number of people referred for consideration for lung transplantation and the number of people wait-listed for lung transplantation, it is difficult to accurately determine the true impact due to the confounding effect of the coronavirus disease 2019 pandemic. It is expected that lung transplantation will remain an important treatment for a smaller number of pwCF. Lung transplantation offers survival benefits in CF, and there remains an imperative to ensure timely consideration of lung transplantation in patients with advanced disease to further reduce the number of pwCF dying without consideration of lung transplant.
    MeSH term(s) Humans ; Cystic Fibrosis/drug therapy ; Cystic Fibrosis/surgery ; Cystic Fibrosis Transmembrane Conductance Regulator/genetics ; Quality of Life ; COVID-19 ; Lung Transplantation ; Mutation
    Chemical Substances Cystic Fibrosis Transmembrane Conductance Regulator (126880-72-6) ; ivacaftor (1Y740ILL1Z)
    Language English
    Publishing date 2023-03-09
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1183617-9
    ISSN 1098-9048 ; 1069-3424
    ISSN (online) 1098-9048
    ISSN 1069-3424
    DOI 10.1055/s-0042-1758731
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    Zs.A 1555: Show issues Location:
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  3. Article ; Online: Understanding how retinoic acid derivatives induce differentiation in non-M3 acute myelogeneous leukemia.

    Carroll, Martin

    Haematologica

    2021  Volume 106, Issue 4, Page(s) 927–928

    MeSH term(s) Cell Differentiation ; Humans ; Leukemia, Myelomonocytic, Chronic ; Leukemia, Promyelocytic, Acute/drug therapy ; Retinoids ; Tretinoin
    Chemical Substances Retinoids ; Tretinoin (5688UTC01R)
    Language English
    Publishing date 2021-04-01
    Publishing country Italy
    Document type Editorial ; Comment
    ZDB-ID 2333-4
    ISSN 1592-8721 ; 0017-6567 ; 0390-6078
    ISSN (online) 1592-8721
    ISSN 0017-6567 ; 0390-6078
    DOI 10.3324/haematol.2020.275412
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  4. Article ; Online: Direct enhancement of viral neutralising antibody potency by the complement system: a largely forgotten phenomenon.

    Mellors, Jack / Carroll, Miles

    Cellular and molecular life sciences : CMLS

    2024  Volume 81, Issue 1, Page(s) 22

    Abstract: Neutralisation assays are commonly used to assess vaccine-induced and naturally acquired immune responses; identify correlates of protection; and inform important decisions on the screening, development, and use of therapeutic antibodies. Neutralisation ... ...

    Abstract Neutralisation assays are commonly used to assess vaccine-induced and naturally acquired immune responses; identify correlates of protection; and inform important decisions on the screening, development, and use of therapeutic antibodies. Neutralisation assays are useful tools that provide the gold standard for measuring the potency of neutralising antibodies, but they are not without limitations. Common methods such as the heat-inactivation of plasma samples prior to neutralisation assays, or the use of anticoagulants such as EDTA for blood collection, can inactivate the complement system. Even in non-heat-inactivated samples, the levels of complement activity can vary between samples. This can significantly impact the conclusions regarding neutralising antibody potency. Restoration of the complement system in these samples can be achieved using an exogenous source of plasma with preserved complement activity or with purified complement proteins. This can significantly enhance the neutralisation titres for some antibodies depending on characteristics such as antibody isotype and the epitope they bind, enable neutralisation with otherwise non-neutralising antibodies, and demonstrate a better relationship between in vitro and in vivo findings. In this review, we discuss the evidence for complement-mediated enhancement of antibody neutralisation against a range of viruses, explore the potential mechanisms which underpin this enhancement, highlight current gaps in the literature, and provide a brief summary of considerations for adopting this approach in future research applications.
    MeSH term(s) Humans ; Antibodies, Neutralizing ; Biological Assay ; Complement System Proteins ; Epitopes ; Memory Disorders
    Chemical Substances Antibodies, Neutralizing ; Complement System Proteins (9007-36-7) ; Epitopes
    Language English
    Publishing date 2024-01-11
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 1358415-7
    ISSN 1420-9071 ; 1420-682X
    ISSN (online) 1420-9071
    ISSN 1420-682X
    DOI 10.1007/s00018-023-05074-2
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    Zs.A 195: Show issues Location:
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  5. Article ; Online: The Multifaceted Effects of Osteocytic TGFβ Signaling on the Skeletal and Extraskeletal Functions of Bone.

    Carroll, M / Alliston, T / Dole, N

    Current osteoporosis reports

    2023  Volume 21, Issue 4, Page(s) 414–425

    Abstract: Purpose of review: To summarize the fundamental role of transforming growth factor beta (TGFβ) signaling in osteocytes and highlight the physiological and pathophysiological conditions stemming from the deregulation of this pathway in osteocytes.: ... ...

    Abstract Purpose of review: To summarize the fundamental role of transforming growth factor beta (TGFβ) signaling in osteocytes and highlight the physiological and pathophysiological conditions stemming from the deregulation of this pathway in osteocytes.
    Recent findings: Osteocytes perform a myriad of skeletal and extraskeletal functions, including mechanosensing, coordinating bone remodeling, local bone matrix turnover, and maintaining systemic mineral homeostasis and global energy balance. Transforming growth factor-beta (TGFβ) signaling, which is crucial for embryonic and postnatal bone development and maintenance, has been found to be essential for several osteocyte functions. There is some evidence that TGFβ might be accomplishing these functions through crosstalk with the Wnt, PTH, and YAP/TAZ pathways in osteocytes, and a better understanding of this complex molecular network can help identify the pivotal convergence points responsible for distinct osteocyte functions. This review provides recent updates on the interwoven signaling cascades coordinated by TGFβ signaling within osteocytes to support their skeletal and extraskeletal functions and highlights physiological and pathophysiological conditions implicating the role of TGFβ signaling in osteocytes.
    Language English
    Publishing date 2023-07-03
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2186581-4
    ISSN 1544-2241 ; 1544-1873
    ISSN (online) 1544-2241
    ISSN 1544-1873
    DOI 10.1007/s11914-023-00802-w
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    Zs.A 6146: Show issues Location:
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  6. Article ; Online: A common protein target for an uncommon subtype of AML.

    Carroll, Martin

    Blood

    2020  Volume 136, Issue 4, Page(s) 377–378

    MeSH term(s) Cyclin-Dependent Kinase 6 ; Humans ; Leukemia, Myeloid, Acute/drug therapy ; Nuclear Pore Complex Proteins
    Chemical Substances Nuclear Pore Complex Proteins ; Nup98 protein, human ; nuclear pore complex protein 98 ; CDK6 protein, human (EC 2.7.11.22) ; Cyclin-Dependent Kinase 6 (EC 2.7.11.22)
    Language English
    Publishing date 2020-08-24
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 80069-7
    ISSN 1528-0020 ; 0006-4971
    ISSN (online) 1528-0020
    ISSN 0006-4971
    DOI 10.1182/blood.2020006487
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    Uh III Zs.140: Show issues Location:
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    Zs.MO 364: Show issues

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  7. Article ; Online: The vulnerability and resilience of older people in rural/regional areas in times of climate, environmental and global health challenges.

    Carroll, Matthew

    Australasian journal on ageing

    2020  Volume 39, Issue 4, Page(s) 325–327

    MeSH term(s) Aged ; Climate Change ; Global Health ; Humans ; Rural Population
    Language English
    Publishing date 2020-12-30
    Publishing country Australia
    Document type Editorial
    ZDB-ID 1457406-8
    ISSN 1741-6612 ; 0726-4240 ; 1440-6381
    ISSN (online) 1741-6612
    ISSN 0726-4240 ; 1440-6381
    DOI 10.1111/ajag.12865
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    Zs.A 5001: Show issues Location:
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  8. Article ; Online: Inequities in hypertension management.

    Carroll, Maurice / O'Cinnéide, Emma

    The British journal of general practice : the journal of the Royal College of General Practitioners

    2023  Volume 74, Issue 738, Page(s) 12–13

    MeSH term(s) Humans ; Cross-Sectional Studies ; Electronic Health Records ; London ; Hypertension/diagnosis ; Hypertension/drug therapy ; Health Status Disparities
    Language English
    Publishing date 2023-12-28
    Publishing country England
    Document type Letter ; Comment
    ZDB-ID 1043148-2
    ISSN 1478-5242 ; 0035-8797 ; 0960-1643
    ISSN (online) 1478-5242
    ISSN 0035-8797 ; 0960-1643
    DOI 10.3399/bjgp24X735933
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    Zs.B 576: Show issues Location:
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  9. Article ; Online: Impostor phenomenon and ambiguity tolerance in practicing physical therapists: an exploratory correlational study.

    Carroll, Melissa / Griech, Sean

    International journal of medical education

    2023  Volume 14, Page(s) 168–177

    Abstract: Objectives: Investigate the prevalence and contextualize the relationship of impostor phenomenon (IP) and ambiguity tolerance (AT) in practicing physical therapists (PTs).: Methods: Online survey including demographic questions, Clance Impostor ... ...

    Abstract Objectives: Investigate the prevalence and contextualize the relationship of impostor phenomenon (IP) and ambiguity tolerance (AT) in practicing physical therapists (PTs).
    Methods: Online survey including demographic questions, Clance Impostor Phenomenon Scale (CIPS), and Tolerance of Ambiguity Scale (TAS).  Descriptive analyses assessed (N = 422) demographic data, CIPS, and TAS scores. Chi-square tests determined distribution across demographic variables.  Kruskal-Wallis tests assessed differences between CIPS and TAS.  Age was a proxy for career stage in Pearson product-moment correlations to assess relationships between CIPS and TAS.
    Results: In practicing PTs (M age = 42.12, SD = 12.34), moderate (48.6%; n = 205) to frequent (26.8%; n = 113) IP feelings were prevalent, but only 31.5% (n = 133) were true impostors.  Significant differences exist in clinical experience for CIPS, H(7, n = 422) = 67.82, p <.001 and TAS, H(7, n = 422) = 21.79, p= .003. Most PTs tolerate ambiguity (M = 54.93, SD = 8.19).  A moderate negative correlation between age and CIPS, r = -.36, p <.001 and a small negative correlation between age and TAS, r=-.19, p <.001 exists. Age accounts for 13% of the variance per IP and 3.6% variance per TAS score.  A small positive relationship exists between CIPS and TAS, r = .10, p <.05.
    Conclusions: Practicing PTs experience moderate to frequent IP and are ambiguity tolerant.  Clinical experience is inversely related to IP and AT.  Almost half of early-career PTs feel like impostors, which can lead to decreased job satisfaction, burnout, psychological distress, feelings of self-doubt, and depression.
    MeSH term(s) Humans ; Adult ; Physical Therapists ; Self Concept ; Anxiety Disorders ; Surveys and Questionnaires
    Language English
    Publishing date 2023-11-10
    Publishing country England
    Document type Journal Article
    ISSN 2042-6372
    ISSN (online) 2042-6372
    DOI 10.5116/ijme.6532.4c20
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  10. Article ; Online: Eculizumab in severe Shiga toxin-mediated haemolytic uraemic syndrome.

    Carroll, Mitchell / Blake, Louise / Sharma, Susheel

    BMJ case reports

    2024  Volume 17, Issue 1

    Abstract: Shiga toxin (Stx)- ... ...

    Abstract Shiga toxin (Stx)-producing
    MeSH term(s) Humans ; Child ; Female ; Shiga Toxin/therapeutic use ; Hemolytic-Uremic Syndrome/drug therapy ; Shiga-Toxigenic Escherichia coli ; Escherichia coli Infections/complications ; Escherichia coli Infections/drug therapy ; Acute Kidney Injury/drug therapy ; Acute Kidney Injury/etiology ; Antibodies, Monoclonal, Humanized
    Chemical Substances eculizumab (A3ULP0F556) ; Shiga Toxin (75757-64-1) ; Antibodies, Monoclonal, Humanized
    Language English
    Publishing date 2024-01-18
    Publishing country England
    Document type Case Reports ; Journal Article
    ISSN 1757-790X
    ISSN (online) 1757-790X
    DOI 10.1136/bcr-2023-256524
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