Article ; Online: Excessive generalized and visceral adiposity is associated with a higher prevalence of diabetic retinopathy in Caucasian patients with type 2 diabetes.
Nutrition, metabolism, and cardiovascular diseases : NMCD
2023 Volume 34, Issue 3, Page(s) 763–770
Abstract: Background and aims: Type 2 Diabetes Mellitus (T2D) has heterogeneous clinical phenotypes related to different risk of developing diabetes complications. We investigated the correlation between generalized and abdominal adiposity and the prevalence of ... ...
| Abstract | Background and aims: Type 2 Diabetes Mellitus (T2D) has heterogeneous clinical phenotypes related to different risk of developing diabetes complications. We investigated the correlation between generalized and abdominal adiposity and the prevalence of both micro- and macrovascular complications in Caucasian patients with T2D. Methods and results: We evaluated 769 individuals with T2D consecutively referred to our diabetes center. Body mass index (BMI), waist circumference (WC), waist to hip (W/H) ratio, glycated hemoglobin (HbA1c), systolic and diastolic blood pressure, lipid profile, smoking habit, diabetes therapy, and micro- and macrovascular complications were recorded. Patients were divided into three groups based on BMI and WC: non-obese with normal WC (nWC, n = 220), non-obese with excess of abdominal fat (AF, n = 260) and obese (Ob, n = 289). We found that nWC, compared with AF and Ob individuals, were predominantly males (p<0.01), had lower HbA1c (p<0.01), diastolic blood pressure (p<0.01), triglycerides (p<0.01), and showed a significantly lower prevalence of diabetic retinopathy (DR) (p = 0.01). The rate of proliferative DR was significantly higher in Ob (13.2 %) compared to the other groups (p = 0.03). Multivariate analyses showed a significantly decreased prevalence of DR in nWC compared to both AF (OR 0.58, 95 CI 0.34-0.96; p = 0.03) and Ob (OR 0.57, 95 CI 0.33-0.98; p = 0.04) individuals. Conversely, DR was associated, mainly in women, to higher WC and W/H ratio. The prevalence of the other diabetes-related complications was similar among the studied groups. Conclusions: In our population, nWC subjects showed a lower prevalence of DR. An increased generalized and abdominal adiposity was associated to a higher prevalence of DR, especially among females. |
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| MeSH term(s) | Male ; Humans ; Female ; Diabetes Mellitus, Type 2/diagnosis ; Diabetes Mellitus, Type 2/epidemiology ; Diabetes Mellitus, Type 2/complications ; Diabetic Retinopathy/diagnosis ; Diabetic Retinopathy/epidemiology ; Adiposity ; Glycated Hemoglobin ; Prevalence ; Obesity, Abdominal/diagnosis ; Obesity, Abdominal/epidemiology ; Obesity, Abdominal/complications |
| Chemical Substances | Glycated Hemoglobin |
| Language | English |
| Publishing date | 2023-10-29 |
| Publishing country | Netherlands |
| Document type | Journal Article |
| ZDB-ID | 1067704-5 |
| ISSN | 1590-3729 ; 0939-4753 |
| ISSN (online) | 1590-3729 |
| ISSN | 0939-4753 |
| DOI | 10.1016/j.numecd.2023.10.031 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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