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  1. Article ; Online: Transfusion thresholds in cardiac surgery: Commentary on Bracey et al., 1999.

    Carson, Jeffrey L

    Transfusion

    2022  Volume 62, Issue 12, Page(s) 2438–2448

    MeSH term(s) Humans ; Cardiac Surgical Procedures ; Blood Transfusion
    Language English
    Publishing date 2022-12-07
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 208417-x
    ISSN 1537-2995 ; 0041-1132
    ISSN (online) 1537-2995
    ISSN 0041-1132
    DOI 10.1111/trf.17150
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Acute myocardial infarction and blood transfusion: lessons learned from animal models and clinical studies.

    Roubinian, Nareg H / Carson, Jeffrey L

    Blood transfusion = Trasfusione del sangue

    2023  Volume 21, Issue 3, Page(s) 185–188

    MeSH term(s) Animals ; Humans ; Blood Transfusion ; Myocardial Infarction/therapy ; Models, Animal
    Language English
    Publishing date 2023-05-04
    Publishing country Italy
    Document type Editorial ; Comment
    ZDB-ID 2135732-8
    ISSN 2385-2070 ; 0041-1787 ; 1723-2007
    ISSN (online) 2385-2070
    ISSN 0041-1787 ; 1723-2007
    DOI 10.2450/BloodTransfus.427
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  3. Article ; Online: Transfusion Strategy in Myocardial Infarction and Anemia. Reply.

    Carson, Jeffrey L / Brooks, Maria Mori / Hébert, Paul C

    The New England journal of medicine

    2024  Volume 390, Issue 10, Page(s) 961–962

    MeSH term(s) Humans ; Anemia/etiology ; Anemia/therapy ; Myocardial Infarction/complications ; Myocardial Infarction/therapy
    Language English
    Publishing date 2024-03-06
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 207154-x
    ISSN 1533-4406 ; 0028-4793
    ISSN (online) 1533-4406
    ISSN 0028-4793
    DOI 10.1056/NEJMc2400982
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  4. Article ; Online: How I treat anemia with red blood cell transfusion and iron.

    Carson, Jeffrey L / Brittenham, Gary M

    Blood

    2022  Volume 142, Issue 9, Page(s) 777–785

    Abstract: Severe anemia is commonly treated with red blood cell transfusion. Clinical trials have demonstrated that a restrictive transfusion strategy of 7 to 8 g/dL is as safe as a liberal transfusion strategy of 9 to 10 g/dL in many clinical settings. Evidence ... ...

    Abstract Severe anemia is commonly treated with red blood cell transfusion. Clinical trials have demonstrated that a restrictive transfusion strategy of 7 to 8 g/dL is as safe as a liberal transfusion strategy of 9 to 10 g/dL in many clinical settings. Evidence is lacking for subgroups of patients, including those with preexisting coronary artery disease, acute myocardial infarction, congestive heart failure, and myelodysplastic neoplasms. We present 3 clinical vignettes that highlight the clinical challenges in caring for patients with coronary artery disease with gastrointestinal bleeding, congestive heart failure, or myelodysplastic neoplasms. We emphasize that transfusion practice should be guided by patient symptoms and preferences in conjunction with the patient's hemoglobin concentration. Along with the transfusion decision, evaluation and management of the etiology of the anemia is essential. Iron-restricted erythropoiesis is a common cause of anemia severe enough to be considered for red blood cell transfusion but diagnosis and management of absolute iron deficiency anemia, the anemia of inflammation with functional iron deficiency, or their combination may be problematic. Intravenous iron therapy is generally the treatment of choice for absolute iron deficiency in patients with complex medical disorders, with or without coexisting functional iron deficiency.
    MeSH term(s) Humans ; Iron/therapeutic use ; Erythrocyte Transfusion/adverse effects ; Coronary Artery Disease/complications ; Anemia/etiology ; Anemia/therapy ; Anemia, Iron-Deficiency/complications ; Anemia, Iron-Deficiency/therapy ; Myelodysplastic Syndromes/complications ; Heart Failure/therapy ; Heart Failure/complications ; Neoplasms/complications ; Hemoglobins/analysis
    Chemical Substances Iron (E1UOL152H7) ; Hemoglobins
    Language English
    Publishing date 2022-10-26
    Publishing country United States
    Document type Journal Article
    ZDB-ID 80069-7
    ISSN 1528-0020 ; 0006-4971
    ISSN (online) 1528-0020
    ISSN 0006-4971
    DOI 10.1182/blood.2022018521
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  5. Article ; Online: Pain, Analgesic Use, and Patient Satisfaction With Spinal Versus General Anesthesia for Hip Fracture Surgery.

    Neuman, Mark D / Ellenberg, Susan S / Carson, Jeffrey L / Sieber, Frederick E

    Annals of internal medicine

    2023  Volume 176, Issue 1, Page(s) eL220367

    MeSH term(s) Humans ; Patient Satisfaction ; Analgesics ; Hip Fractures/surgery ; Pain ; Anesthesia, General ; Anesthesia, Spinal ; Pain, Postoperative/drug therapy
    Chemical Substances Analgesics
    Language English
    Publishing date 2023-01-16
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 336-0
    ISSN 1539-3704 ; 0003-4819
    ISSN (online) 1539-3704
    ISSN 0003-4819
    DOI 10.7326/L22-0367
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  6. Article ; Online: Web Exclusive. Annals On Call - Intravenous Iron: Rarely a Cause of Anaphylaxis.

    Centor, Robert M / Carson, Jeffrey L / Setoguchi, Soko

    Annals of internal medicine

    2022  Volume 175, Issue 6, Page(s) OC1

    Language English
    Publishing date 2022-06-07
    Publishing country United States
    Document type Journal Article
    ZDB-ID 336-0
    ISSN 1539-3704 ; 0003-4819
    ISSN (online) 1539-3704
    ISSN 0003-4819
    DOI 10.7326/A21-0012
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  7. Article ; Online: Spinal vs. General Anesthesia for Hip-Fracture Surgery. Reply.

    Neuman, Mark D / Carson, Jeffrey L / Ellenberg, Susan S

    The New England journal of medicine

    2022  Volume 386, Issue 8, Page(s) 802–803

    MeSH term(s) Anesthesia, General ; Hip Fractures/surgery ; Humans ; Spine
    Language English
    Publishing date 2022-02-23
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 207154-x
    ISSN 1533-4406 ; 0028-4793
    ISSN (online) 1533-4406
    ISSN 0028-4793
    DOI 10.1056/NEJMc2119756
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  8. Article: The shifting paradigm for transfusion of red blood cells.

    Carson, Jeffrey L

    Clinical advances in hematology & oncology : H&O

    2015  Volume 13, Issue 3, Page(s) 152–154

    MeSH term(s) Anemia/etiology ; Anemia/therapy ; Clinical Decision-Making ; Clinical Trials as Topic ; Erythrocyte Transfusion/adverse effects ; Erythrocyte Transfusion/history ; Erythrocyte Transfusion/standards ; History, 20th Century ; History, 21st Century ; Humans ; Neoplasms/etiology ; Practice Guidelines as Topic ; Risk Factors ; Thrombosis/etiology
    Language English
    Publishing date 2015-03
    Publishing country United States
    Document type Historical Article ; Interview
    ZDB-ID 2271951-9
    ISSN 1543-0790
    ISSN 1543-0790
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Risks for Anaphylaxis With Intravenous Iron Formulations : A Retrospective Cohort Study.

    Dave, Chintan V / Brittenham, Gary M / Carson, Jeffrey L / Setoguchi, Soko

    Annals of internal medicine

    2022  Volume 175, Issue 5, Page(s) 656–664

    Abstract: Background: The risks for anaphylaxis among intravenous (IV) iron products currently in use have not been assessed.: Objective: To compare risks for anaphylaxis among 5 IV iron products that are used frequently.: Design: Retrospective cohort study ...

    Abstract Background: The risks for anaphylaxis among intravenous (IV) iron products currently in use have not been assessed.
    Objective: To compare risks for anaphylaxis among 5 IV iron products that are used frequently.
    Design: Retrospective cohort study using a target trial emulation framework.
    Setting: Medicare fee-for-service data with Part D coverage between July 2013 and December 2018.
    Participants: Older adults receiving their first administration of IV iron.
    Measurements: The primary outcome was the occurrence of anaphylaxis within 1 day of IV iron administration, ascertained using a validated case definition. Analysis was adjusted for 40 baseline covariates using inverse probability of treatment weighting. The adjusted incidence rates (IRs) for anaphylaxis per 10 000 first administrations and odds ratios (ORs) were computed.
    Results: The adjusted IRs for anaphylaxis per 10 000 first administrations were 9.8 cases (95% CI, 6.2 to 15.3 cases) for iron dextran, 4.0 cases (CI, 2.5 to 6.6 cases) for ferumoxytol, 1.5 cases (CI, 0.3 to 6.6 cases) for ferric gluconate, 1.2 cases (CI, 0.6 to 2.5 cases) for iron sucrose, and 0.8 cases (CI, 0.3 to 2.6 cases) for ferric carboxymaltose. Using iron sucrose as the referent category, the adjusted ORs for anaphylaxis were 8.3 (CI, 3.5 to 19.8) for iron dextran and 3.4 (CI, 1.4 to 8.3) for ferumoxytol. When cohort entry was restricted to the period after withdrawal of high-molecular-weight iron dextran from the U.S. market in 2014, the risk for anaphylaxis associated with low-molecular-weight iron dextran (OR, 8.4 [CI, 2.8 to 24.7]) did not change appreciably. Anaphylactic reactions requiring hospitalizations were observed only among patients using iron dextran or ferumoxytol.
    Limitation: Generalizability to non-Medicare populations.
    Conclusion: The rates of anaphylaxis were very low with all IV iron products but were 3- to 8-fold greater for iron dextran and ferumoxytol than for iron sucrose.
    Primary funding source: None.
    MeSH term(s) Aged ; Anaphylaxis/chemically induced ; Anaphylaxis/epidemiology ; Cohort Studies ; Dextrans ; Ferric Oxide, Saccharated/adverse effects ; Ferrosoferric Oxide ; Humans ; Iron/adverse effects ; Iron-Dextran Complex/adverse effects ; Medicare ; Retrospective Studies ; United States/epidemiology
    Chemical Substances Dextrans ; Iron-Dextran Complex (9004-66-4) ; Iron (E1UOL152H7) ; Ferric Oxide, Saccharated (FZ7NYF5N8L) ; Ferrosoferric Oxide (XM0M87F357)
    Language English
    Publishing date 2022-03-29
    Publishing country United States
    Document type Journal Article
    ZDB-ID 336-0
    ISSN 1539-3704 ; 0003-4819
    ISSN (online) 1539-3704
    ISSN 0003-4819
    DOI 10.7326/M21-4009
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  10. Article ; Online: Risks for Anaphylaxis With Intravenous Iron Formulations.

    Dave, Chintan V / Brittenham, Gary M / Carson, Jeffrey L / Setoguchi, Soko

    Annals of internal medicine

    2022  Volume 175, Issue 11, Page(s) W143–W144

    MeSH term(s) Humans ; Anaphylaxis/chemically induced ; Iron/adverse effects ; Drug Hypersensitivity
    Chemical Substances Iron (E1UOL152H7)
    Language English
    Publishing date 2022-10-28
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 336-0
    ISSN 1539-3704 ; 0003-4819
    ISSN (online) 1539-3704
    ISSN 0003-4819
    DOI 10.7326/L22-0283
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