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Article ; Online: A "Gut Feeling" to Create a 10th Hallmark of Aging.

Carter, Christy S

The journals of gerontology. Series A, Biological sciences and medical sciences

2021 Volume 76, Issue 11, Page(s) 1891–1894

MeSH term(s)	Aging ; Periodicals as Topic
Language	English
Publishing date	2021-07-13
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural
ZDB-ID	1223643-3
ISSN	1758-535X ; 1079-5006
ISSN (online)	1758-535X
ISSN	1079-5006
DOI	10.1093/gerona/glab191
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Article ; Online: Maintaining a scientific community while social distancing.

Lamming, Dudley W / Carter, Christy S

Translational medicine of aging

2020 Volume 4, Page(s) 55–59

Abstract: The "Aging Science Talks: Science for the Community" daily online seminar series was established in reaction to the cancellation of a myriad of regional, national, and international meetings focused on the biology of aging due to the COVID-19 pandemic. ... ...

Abstract	The "Aging Science Talks: Science for the Community" daily online seminar series was established in reaction to the cancellation of a myriad of regional, national, and international meetings focused on the biology of aging due to the COVID-19 pandemic. The inability to attend scientific meetings has far-reaching implications for our field, as we lose the ability to 1) disseminate both published and non-published data through talks and posters; 2) network and establish new collaborations to produce innovative science in the aging field; and 3) continue the career development of early career researchers (ECRs). Through these virtual seminars, we hope to offset the negative effects of these canceled meetings. We established the program rapidly using a "lean" approach, making use of existing technologies broadly available at academic institutions. Here, we provide an initial description of how this program was developed and implemented. We discuss advantages and limitations of this approach, including "real-time" participation and the creation of an on/off-line community of inquiry (CoI). In the future, we hope to formally evaluate the success of this program in building engagement, creating a community, and enhancing the development of ECRs, and to capture metrics associated with the continued progress of science. Our approach to building a CoI may be applied across multiple scientific disciplines during this time of uncertainty, and may offer a valuable example of how to continue to advance science during pandemics or similar events.
Keywords	covid19
Language	English
Publishing date	2020-06-12
Publishing country	Netherlands
Document type	Journal Article
ISSN	2468-5011
ISSN (online)	2468-5011
DOI	10.1016/j.tma.2020.05.002
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Introduction: Special issue on Aging Science Talks: Science for our community during isolation.

Lamming, Dudley W / Carter, Christy S

Translational medicine of aging

2020 Volume 4, Page(s) 149–150

Keywords	covid19
Language	English
Publishing date	2020-09-06
Publishing country	Netherlands
Document type	Editorial
ISSN	2468-5011
ISSN (online)	2468-5011
DOI	10.1016/j.tma.2020.09.001
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Behavioral comparison of the C57BL/6 inbred mouse strain and their CB6F1 siblings

Corder, Katelynn M. / Carter, Christy S. / Hoffman, Jessica M. / Sogorovic, Anamarija / Austad, Steven N.

Behavioural Processes. 2023 Apr., v. 207 p.104836-

2023

Abstract: A large portion of basic biomedical research studies are conducted using genetically defined, inbred mouse strains. The C57BL/6 mouse strain is the most widely used genetic background in current rodent research. The rationale for using inbred strains is ... ...

Abstract	A large portion of basic biomedical research studies are conducted using genetically defined, inbred mouse strains. The C57BL/6 mouse strain is the most widely used genetic background in current rodent research. The rationale for using inbred strains is that all individuals are genetically identical with minimal phenotypic variation, allowing for more statistically powerful analyses. F₁ hybrids between two inbred strains are also genetically identical to one another but are heterozygous at every locus at which the parental strains differ rather than homozygous. Both theoretical and empirical evidence suggests that this heterozygosity in F₁ hybrids allow for potentially greater resilience in response to the inevitable stresses of laboratory environments. The purpose of this study was to characterize the differences in commonly used tests of physical performance (forelimb grip strength and rotarod) and anxiety-like behavior between the F₁ hybrids created from BALB/c females mated to C57BL/6 males (called CB6F1 mice) and one of its parental strains, C57BL/6. We used a natural cross-fostering breeding scheme to minimize maternal care effects and emphasize the effects of genetic differences. We found significant correlations between anxiety-like behavioral measures and physical performance measures which are not traditionally associated with anxiety-like behavior, and which differ between strains. Findings from this study should be taken into consideration when designing behavioral studies and choosing model organisms.
Keywords	biomedical research ; genetic background ; heterozygosity ; homozygosity ; loci ; mice ; muscle strength ; phenotypic variation ; physical activity ; Mouse model ; Anxiety ; Nest building ; Variation ; Grip strength ; F1 hybrid mice
Language	English
Dates of publication	2023-04
Publishing place	Elsevier B.V.
Document type	Article ; Online
ZDB-ID	196999-7
ISSN	1872-8308 ; 0376-6357
ISSN (online)	1872-8308
ISSN	0376-6357
DOI	10.1016/j.beproc.2023.104836
Database	NAL-Catalogue (AGRICOLA)

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Article: Maintaining a scientific community while social distancing

Lamming, Dudley W. / Carter, Christy S.

Transl. Med. Aging

Abstract: The “Aging Science Talks: Science for the Community” daily online seminar series was established in reaction to the cancellation of a myriad of regional, national, and international meetings focused on the biology of aging due to the COVID-19 pandemic. ... ...

Abstract	The “Aging Science Talks: Science for the Community” daily online seminar series was established in reaction to the cancellation of a myriad of regional, national, and international meetings focused on the biology of aging due to the COVID-19 pandemic. The inability to attend scientific meetings has far-reaching implications for our field, as we lose the ability to 1) disseminate both published and non-published data through talks and posters; 2) network and establish new collaborations to produce innovative science in the aging field; and 3) continue the career development of early career researchers (ECRs). Through these virtual seminars, we hope to offset the negative effects of these canceled meetings. We established the program rapidly using a “lean” approach, making use of existing technologies broadly available at academic institutions. Here, we provide an initial description of how this program was developed and implemented. We discuss advantages and limitations of this approach, including “real-time” participation and the creation of an on/off-line community of inquiry (CoI). In the future, we hope to formally evaluate the success of this program in building engagement, creating a community, and enhancing the development of ECRs, and to capture metrics associated with the continued progress of science. Our approach to building a CoI may be applied across multiple scientific disciplines during this time of uncertainty, and may offer a valuable example of how to continue to advance science during pandemics or similar events.
Keywords	covid19
Publisher	WHO
Document type	Article
Note	WHO #Covidence: #597677
Database	COVID19

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Article ; Online: Angiotensin (1-7) Expressing Probiotic as a Potential Treatment for Dementia.

Hernandez, Abbi R / Banerjee, Anisha / Carter, Christy S / Buford, Thomas W

Frontiers in aging

2021 Volume 2

Abstract: Increasing life expectancies are unfortunately accompanied by increased prevalence of Alzheimer's disease (AD). Regrettably, there are no current therapeutic options capable of preventing or treating AD. We review here data indicating that AD is ... ...

Abstract	Increasing life expectancies are unfortunately accompanied by increased prevalence of Alzheimer's disease (AD). Regrettably, there are no current therapeutic options capable of preventing or treating AD. We review here data indicating that AD is accompanied by gut dysbiosis and impaired renin angiotensin system (RAS) function. Therefore, we propose the potential utility of an intervention targeting both the gut microbiome and RAS as both are heavily involved in proper CNS function. One potential approach which our group is currently exploring is the use of genetically-modified probiotics (GMPs) to deliver therapeutic compounds. In this review, we specifically highlight the potential utility of utilizing a GMP to deliver Angiotensin (1-7), a beneficial component of the renin-angiotensin system with relevant functions in circulation as well as locally in the gut and brain.
Language	English
Publishing date	2021-03-30
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	3076785-4
ISSN	2673-6217 ; 2673-6217
ISSN (online)	2673-6217
ISSN	2673-6217
DOI	10.3389/fragi.2021.629164
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Influence of Aging, Macronutrient Composition and Time-Restricted Feeding on the Fischer344 x Brown Norway Rat Gut Microbiota.

Hernandez, Abbi R / Kemp, Keri M / Burke, Sara N / Buford, Thomas W / Carter, Christy S

Nutrients

2022 Volume 14, Issue 9

Abstract: Both ketogenic diets (KD) and time-restricted feeding (TRF) regimens have the ability to influence several parameters of physical health, including gut microbiome composition and circulating cytokine concentration. Moreover, both of these dietary ... ...

Abstract	Both ketogenic diets (KD) and time-restricted feeding (TRF) regimens have the ability to influence several parameters of physical health, including gut microbiome composition and circulating cytokine concentration. Moreover, both of these dietary interventions prevent common impairments associated with the aging process. However, significantly altering macronutrient intake, which is required for a KD, may be unappealing to individuals and decrease compliance to dietary treatments. In contrast to a KD, TRF allows individuals to continue eating the foods they are used to, and only requires a change in the time of day at which they eat. Therefore, we investigated both a KD and a diet with a more Western-like macronutrient profile in the context of TRF, and compared both diets to animals allowed access to standard chow ad libitum in young adult and aged rats. While limited effects on cytokine levels were observed, both methods of microbiome analysis (16S sequencing and metagenomics) indicate that TRF and KDs significantly altered the gut microbiome in aged rats. These changes were largely dependent on changes to feeding paradigm (TRF vs. ad libitum) alone regardless of macronutrient content for many gut microbiota, but there were also macronutrient-specific changes. Specifically, functional analysis indicates significant differences in several pathways, including those involved in the tricarboxylic acid (TCA) cycle, carbohydrate metabolism and neurodegenerative disease. These data indicate that age- and disease-related gut dysbiosis may be ameliorated through the use of TRF with both standard diets and KDs.
MeSH term(s)	Aging ; Animals ; Cytokines ; Gastrointestinal Microbiome ; Neurodegenerative Diseases ; Nutrients ; Rats
Chemical Substances	Cytokines
Language	English
Publishing date	2022-04-22
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2518386-2
ISSN	2072-6643 ; 2072-6643
ISSN (online)	2072-6643
ISSN	2072-6643
DOI	10.3390/nu14091758
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Geriatric Care Boot Camp Series: Interprofessional education for a new training paradigm.

Solberg, Lauren B / Carter, Christy S / Solberg, Laurence M

Geriatric nursing (New York, N.Y.)

2019 Volume 40, Issue 6, Page(s) 579–583

Abstract: Interprofessional education of health care professionals caring for older adults is critical to address the unique needs of geriatric patients. An interprofessional education program - the Geriatric Care Boot Camp Series ("Series") - was designed for ... ...

Abstract	Interprofessional education of health care professionals caring for older adults is critical to address the unique needs of geriatric patients. An interprofessional education program - the Geriatric Care Boot Camp Series ("Series") - was designed for health care professionals to fill this education gap. The program consisted of three half-day, intensive boot camps conducted over a one-year period. A total of 112 learners participated; more than half were nurses. Data analysis revealed statistically significant increases following each boot camp in attendees' reported knowledge about caring for older adults; statistically significant increases in comfort caring for older adults were also seen among participants in two boot camps. Attendees found the interprofessional nature of the program beneficial and said they would attend a similar program again. The Series is easily replicable, appealing to the target audience, and fulfills the need to better educate health care professionals on caring for older adults.
MeSH term(s)	Aged ; Education, Continuing ; Educational Measurement ; Female ; Geriatrics/education ; Health Personnel/education ; Humans ; Interprofessional Relations ; Male
Language	English
Publishing date	2019-05-27
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	632559-2
ISSN	1528-3984 ; 0197-4572
ISSN (online)	1528-3984
ISSN	0197-4572
DOI	10.1016/j.gerinurse.2019.05.010
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Article ; Online: Lipotoxicity, aging, and muscle contractility: does fiber type matter?

Carter, Christy S / Justice, Jamie N / Thompson, LaDora

GeroScience

2019 Volume 41, Issue 3, Page(s) 297–308

Abstract: Sarcopenia is a universal characteristic of the aging process and is often accompanied by increases in whole-body adiposity. These changes in body composition have important clinical implications, given that loss of muscle and gain of fat mass are both ... ...

Abstract	Sarcopenia is a universal characteristic of the aging process and is often accompanied by increases in whole-body adiposity. These changes in body composition have important clinical implications, given that loss of muscle and gain of fat mass are both significantly and independently associated with declining physical performance as well as an increased risk for disability, hospitalizations, and mortality in older individuals. This increased fat mass is not exclusively stored in adipose depots but may become deposited in non-adipose tissues, such as skeletal muscle, when the oxidative capacity of the adipose tissue itself is exceeded. The redistributed adipose tissue is thought to exert detrimental local effects on the muscle environment given the close proximity. Thus, sarcopenia observed with aging may be better defined in the context of loss of muscle quality rather than loss of muscle quantity per se. In this perspective, we briefly review the age-related physiological changes in cellularity, secretory profiles, and inflammatory status of adipose tissue which drive lipotoxicity (spillover) of skeletal muscle and then provide evidence of how this may affect specific fiber type contractility. We focus on biological contributors (cellular machinery) to contractility for which there is some evidence of vulnerability to lipid stress distinguishing between fiber types.
MeSH term(s)	Adipogenesis/physiology ; Adipose Tissue/physiopathology ; Aging/physiology ; Animals ; Humans ; Insulin Resistance/physiology ; Lipids/blood ; Lipids/toxicity ; Muscle Contraction/physiology ; Muscle Fibers, Skeletal/physiology ; Obesity/physiopathology ; Sarcopenia/physiopathology
Chemical Substances	Lipids
Language	English
Publishing date	2019-06-22
Publishing country	Switzerland
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Review
ZDB-ID	2886586-8
ISSN	2509-2723 ; 2509-2715
ISSN (online)	2509-2723
ISSN	2509-2715
DOI	10.1007/s11357-019-00077-z
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Article: Crosstalk Between the Gut Microbiome and Bioactive Lipids: Therapeutic Targets in Cognitive Frailty.

Baptista, Liliana C / Sun, Yi / Carter, Christy S / Buford, Thomas W

Frontiers in nutrition

2020 Volume 7, Page(s) 17

Abstract: Cognitive frailty is a geriatric condition defined by the coexistence of cognitive impairment and physical frailty. This "composite" aging phenotype is associated with a higher risk of several adverse health-related outcomes, including dementia. In the ... ...

Abstract	Cognitive frailty is a geriatric condition defined by the coexistence of cognitive impairment and physical frailty. This "composite" aging phenotype is associated with a higher risk of several adverse health-related outcomes, including dementia. In the last decade, cognitive frailty has gained increased attention from the scientific community that has focused on understanding the clinical impact and the physiological and pathological mechanisms of development and on identifying preventive and/or rehabilitative therapeutic interventions. The emergence of gut microbiome in neural signaling increased the interest in targeting the gut-brain axis as a modulation strategy. Multiple studies on gastroenteric, metabolic, and neurodegenerative diseases support the existence of a wide bidirectional communication network of signaling mediators, e.g., bioactive lipids, that can modulate inflammation, gut permeability, microbiota composition, and the gut-brain axis. This crosstalk between the gut-brain axis, microbiome, and bioactive lipids may emerge as the basis of a promising therapeutic strategy to counteract cognitive frailty. In this review, we summarize the evidence in the literature regarding the link between the gut microbiome, brain, and several families of bioactive lipids. In addition, we also explore the applicability of several bioactive lipid members as a potential routes for therapeutic interventions to combat cognitive frailty.
Language	English
Publishing date	2020-03-11
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2776676-7
ISSN	2296-861X
ISSN	2296-861X
DOI	10.3389/fnut.2020.00017
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