Article ; Online: Serum deprivation initiates adaptation and survival to oxidative stress in prostate cancer cells.
2020 Volume 10, Issue 1, Page(s) 12505
Abstract: Inadequate nutrient intake leads to oxidative stress disrupting homeostasis, activating signaling, and altering metabolism. Oxidative stress serves as a hallmark in developing prostate lesions, and an aggressive cancer phenotype activating mechanisms ... ...
| Abstract | Inadequate nutrient intake leads to oxidative stress disrupting homeostasis, activating signaling, and altering metabolism. Oxidative stress serves as a hallmark in developing prostate lesions, and an aggressive cancer phenotype activating mechanisms allowing cancer cells to adapt and survive. It is unclear how adaptation and survival are facilitated; however, literature across several organisms demonstrates that a reversible cellular growth arrest and the transcription factor, nuclear factor-kappaB (NF-κB), contribute to cancer cell survival and therapeutic resistance under oxidative stress. We examined adaptability and survival to oxidative stress following nutrient deprivation in three prostate cancer models displaying varying degrees of tumorigenicity. We observed that reducing serum (starved) induced reactive oxygen species which provided an early oxidative stress environment and allowed cells to confer adaptability to increased oxidative stress (H |
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| MeSH term(s) | Adaptation, Physiological/drug effects ; Antineoplastic Agents/pharmacology ; Apoptosis/drug effects ; Cell Cycle/drug effects ; Cell Line, Tumor ; Cell Nucleus/drug effects ; Cell Nucleus/metabolism ; Cell Proliferation/drug effects ; Cell Survival/drug effects ; Culture Media, Serum-Free ; Humans ; Male ; NF-kappa B/metabolism ; Oxidative Stress/drug effects ; Phenotype ; Prostatic Neoplasms/pathology ; Protein Transport/drug effects |
| Chemical Substances | Antineoplastic Agents ; Culture Media, Serum-Free ; NF-kappa B |
| Language | English |
| Publishing date | 2020-07-27 |
| Publishing country | England |
| Document type | Journal Article ; Research Support, N.I.H., Extramural |
| ZDB-ID | 2615211-3 |
| ISSN | 2045-2322 ; 2045-2322 |
| ISSN (online) | 2045-2322 |
| ISSN | 2045-2322 |
| DOI | 10.1038/s41598-020-68668-x |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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