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  1. Article: Assay Techniques and Test Development for COVID-19 Diagnosis.

    Carter, Linda J / Garner, Linda V / Smoot, Jeffrey W / Li, Yingzhu / Zhou, Qiongqiong / Saveson, Catherine J / Sasso, Janet M / Gregg, Anne C / Soares, Divya J / Beskid, Tiffany R / Jervey, Susan R / Liu, Cynthia

    ACS central science

    2020  Volume 6, Issue 5, Page(s) 591–605

    Keywords covid19
    Language English
    Publishing date 2020-04-30
    Publishing country United States
    Document type News
    ISSN 2374-7943
    ISSN 2374-7943
    DOI 10.1021/acscentsci.0c00501
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Research and Development on Therapeutic Agents and Vaccines for COVID-19 and Related Human Coronavirus Diseases.

    Liu, Cynthia / Zhou, Qiongqiong / Li, Yingzhu / Garner, Linda V / Watkins, Steve P / Carter, Linda J / Smoot, Jeffrey / Gregg, Anne C / Daniels, Angela D / Jervey, Susan / Albaiu, Dana

    ACS central science

    2020  Volume 6, Issue 3, Page(s) 315–331

    Keywords covid19
    Language English
    Publishing date 2020-03-12
    Publishing country United States
    Document type News
    ISSN 2374-7943
    ISSN 2374-7943
    DOI 10.1021/acscentsci.0c00272
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Assay Techniques and Test Development for COVID-19 Diagnosis

    Carter, Linda J. / Garner, Linda V. / Smoot, Jeffrey W. / Li, Yingzhu / Zhou, Qiongqiong / Saveson, Catherine J. / Sasso, Janet M. / Gregg, Anne C. / Soares, Divya J. / Beskid, Tiffany R. / Jervey, Susan R. / Liu, Cynthia

    ACS Cent. Sci.

    Abstract: An ongoing theme of the COVID-19 pandemic is the need for widespread availability of accurate and efficient diagnostic testing for detection of SARS-CoV-2 and antiviral antibodies in infected individuals. This report describes various assay techniques and ... ...

    Abstract An ongoing theme of the COVID-19 pandemic is the need for widespread availability of accurate and efficient diagnostic testing for detection of SARS-CoV-2 and antiviral antibodies in infected individuals. This report describes various assay techniques and tests for COVID-19 diagnosis. Most tests for early detection of SARS-CoV-2 RNA rely on the reverse transcription-polymerase chain reaction, but isothermal nucleic acid amplification assays, including transcription-mediated amplification and CRISPR-based methodologies, are promising alternatives. Identification of individuals who have developed antibodies to the SARS-CoV-2 virus requires serological tests, including enzyme-linked immunosorbent assay (ELISA) and lateral flow immunoassay. This report also provides an overview of current development in COVID-19 diagnostic techniques and products to facilitate future improvement and innovation.
    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #142071
    Database COVID19

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    Inter-library loan at ZB MED

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  4. Article: Research and Development on Therapeutic Agents and Vaccines for COVID-19 and Related Human Coronavirus Diseases

    Liu, Cynthia / Zhou, Qiongqiong / Li, Yingzhu / Garner, Linda V. / Watkins, Steve P. / Carter, Linda J. / Smoot, Jeffrey / Gregg, Anne C. / Daniels, Angela D. / Jervey, Susan / Albaiu, Dana

    ACS Cent. Sci.

    Abstract: Since the outbreak of the novel coronavirus disease COVID-19, caused by the SARS-CoV-2 virus, this disease has spread rapidly around the globe. Considering the potential threat of a pandemic, scientists and physicians have been racing to understand this ... ...

    Abstract Since the outbreak of the novel coronavirus disease COVID-19, caused by the SARS-CoV-2 virus, this disease has spread rapidly around the globe. Considering the potential threat of a pandemic, scientists and physicians have been racing to understand this new virus and the pathophysiology of this disease to uncover possible treatment regimens and discover effective therapeutic agents and vaccines. To support the current research and development, CAS has produced a special report to provide an overview of published scientific information with an emphasis on patents in the CAS content collection. It highlights antiviral strategies involving small molecules and biologics targeting complex molecular interactions involved in coronavirus infection and replication. The drug-repurposing effort documented herein focuses primarily on agents known to be effective against other RNA viruses including SARS-CoV and MERS-CoV. The patent analysis of coronavirusrelated biologics includes therapeutic antibodies, cytokines, and nucleic acid-based therapies targeting virus gene expression as well as various types of vaccines. More than 500 patents disclose methodologies of these four biologics with the potential for treating and preventing coronavirus infections, which may be applicable to COVID-19. The information included in this report provides a strong intellectual groundwork for the ongoing development of therapeutic agents and vaccines.
    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #8271
    Database COVID19

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    Inter-library loan at ZB MED

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  5. Article ; Online: Assay Techniques and Test Development for COVID-19 Diagnosis

    Carter, Linda J. / Garner, Linda V. / Smoot, Jeffrey W. / Li, Yingzhu / Zhou, Qiongqiong / Saveson, Catherine J. / Sasso, Janet M. / Gregg, Anne C. / Soares, Divya J. / Beskid, Tiffany R. / Jervey, Susan R. / Liu, Cynthia

    ACS Central Science

    2020  Volume 6, Issue 5, Page(s) 591–605

    Keywords covid19
    Language English
    Publisher American Chemical Society (ACS)
    Publishing country us
    Document type Article ; Online
    ISSN 2374-7943
    DOI 10.1021/acscentsci.0c00501
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

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    Order via subito

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    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  6. Article ; Online: Research and Development on Therapeutic Agents and Vaccines for COVID-19 and Related Human Coronavirus Diseases

    Liu, Cynthia / Zhou, Qiongqiong / Li, Yingzhu / Garner, Linda V. / Watkins, Steve P. / Carter, Linda J. / Smoot, Jeffrey / Gregg, Anne C. / Daniels, Angela D. / Jervey, Susan / Albaiu, Dana

    ACS Central Science

    2020  Volume 6, Issue 3, Page(s) 315–331

    Keywords covid19
    Language English
    Publisher American Chemical Society (ACS)
    Publishing country us
    Document type Article ; Online
    ISSN 2374-7943
    DOI 10.1021/acscentsci.0c00272
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

    Inter-library loan at ZB MED

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  7. Article: The impact of an ICU liaison nurse service on patient outcomes.

    Eliott, Suzanne J / Ernest, David / Doric, Andrea G / Page, Karen N / Worrall-Carter, Linda J / Thalib, Lukman / Chaboyer, Wendy

    Critical care and resuscitation : journal of the Australasian Academy of Critical Care Medicine

    2008  Volume 10, Issue 4, Page(s) 296–300

    Abstract: Objective: To determine the effect an intensive care unit liaison nurse service had on ICU patient discharges, readmissions and outcomes.: Methods: We evaluated the impact of our ICU liaison nurse service in a 36-month before-and-after study on ICU ... ...

    Abstract Objective: To determine the effect an intensive care unit liaison nurse service had on ICU patient discharges, readmissions and outcomes.
    Methods: We evaluated the impact of our ICU liaison nurse service in a 36-month before-and-after study on ICU and hospital length of stay (LOS) and mortality, and ICU step-down days (time spent in ICU in a 1 : 2 nurse to patient ratio).
    Results: There was a 13% increase in patient throughput after the introduction of the ICU liaison nurse service (835 ICU admissions in the 18 months before v 943 in the 18 months after). Despite trends to an improvement, there was no significant change in median ICU LOS (2.2 days before v 2.1 days after) or median hospital LOS (12.0 days before v 11.5 days after), or in ICU or hospital mortality (ICU, 15% before v 14% after; hospital, 23% before v 22% after). ICU step-down days were significantly decreased by 48% (71 +/- 14.2 days v 37 +/- 15.5 days; P < 0.001). In the patient group readmitted to the ICU (49 patients before v 55 patients after), there was a 25% (1 day) decrease in median ICU LOS (4.0 v 3.0 days), and a trend to decreased mortality in both the ICU (18% before v 16% after) and hospital (35% before v 26% after).
    Conclusions: The introduction of our ICU liaison nurse service was associated with a trend towards more efficient ICU discharges (increased throughput, decreased ICU step-down days and ICU readmission LOS) and improved survival for ICU patients requiring readmission, but overall ICU and hospital LOS and mortality, and ICU readmission rates were unchanged.
    MeSH term(s) Aged ; Aged, 80 and over ; Critical Care/organization & administration ; Hospital Mortality ; Humans ; Middle Aged ; Nursing Service, Hospital/organization & administration ; Patient Care Team/organization & administration ; Patient Discharge ; Patient Readmission ; Program Evaluation ; Referral and Consultation ; Treatment Outcome ; Victoria
    Language English
    Publishing date 2008-12
    Publishing country Australia
    Document type Evaluation Studies ; Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2401976-8
    ISSN 1441-2772
    ISSN 1441-2772
    Database MEDical Literature Analysis and Retrieval System OnLINE

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