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Article: Editorial: Microfluidics and mass spectrometry in drug discovery and development: from synthesis to evaluation.

Caruso, Giuseppe

2023 Volume 14, Page(s) 1201926

Language	English
Publishing date	2023-05-19
Publishing country	Switzerland
Document type	Editorial
ZDB-ID	2587355-6
ISSN	1663-9812
ISSN	1663-9812
DOI	10.3389/fphar.2023.1201926
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Book ; Online ; E-Book: The Botany of Beer

Caruso, Giuseppe / Fontefrancesco, Michele F. / Josephson, Marika / Kosmos SRL, / Lido, Catanzaro / Musso, Teo / Pieroni, Andrea

An Illustrated Guide to More Than 500 Plants Used in Brewing

(Arts and Traditions of the Table: Perspectives on Culinary History)

2022

Abstract: From mass-produced lagers to craft-brewery IPAs, from beers made in Trappist monasteries according to traditional techniques to those created by innovative local brewers seeking to capture regional terroir, the world of beer boasts endless varieties. The ...

Author's details	Giuseppe Caruso
Series title	Arts and Traditions of the Table: Perspectives on Culinary History
Abstract	From mass-produced lagers to craft-brewery IPAs, from beers made in Trappist monasteries according to traditional techniques to those created by innovative local brewers seeking to capture regional terroir, the world of beer boasts endless varieties. The diversity of beer does not only reflect the differences among the people and cultures who brew this beverage. It also testifies to the vast range of plants that help give different styles of beer their distinguishing flavor profiles.This book is a comprehensive and beautifully illustrated compendium of the characteristics and properties of the plants used in making beer around the world. The botanical expert Giuseppe Caruso presents scientifically rigorous descriptions, accompanied by his own hand-drawn ink images, of more than 500 species. For each one, he gives the scientific classification, common names, and information about morphology, geographical distribution and habitat, and cultivation range. Caruso provides detailed information about each plant’s applications in beer making, including which of its parts are employed, as well as its chemical composition, potential toxicity, and examples of beers and styles in which it is typically used. The book also considers historical uses, aiding brewers who seek to rediscover ancient and early modern concoctions.This book will appeal to a wide audience, from beer aficionados to botany enthusiasts, providing valuable information for homebrewers and professional beer makers alike. It reveals how botanical knowledge can open new possibilities for today’s and tomorrow’s brewers.
Keywords	Beer ; Botany ; Brewing ; SOCIAL SCIENCE / Agriculture & Food (see also POLITICAL SCIENCE / Public Policy / Agriculture & Food Policy)
Subject code	663/.42
Language	English
Dates of publication	2022-2022
Size	1 online resource
Publisher	Columbia University Press
Publishing place	New York, NY
Publishing country	nyu ; US-NY
Document type	Book ; Online ; E-Book
Note	In English.
Remark	Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
ISBN	0-231-55417-6 ; 978-0-231-55417-6
DOI	10.7312/caru20158
Database	ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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Article ; Online: Unveiling the Hidden Therapeutic Potential of Carnosine, a Molecule with a Multimodal Mechanism of Action: A Position Paper.

Caruso, Giuseppe

Molecules (Basel, Switzerland)

2022 Volume 27, Issue 10

Abstract: Carnosine (β-alanyl-L-histidine) is a naturally occurring endogenous dipeptide and an over-the-counter food supplement with a well-demonstrated multimodal mechanism of action that includes the detoxification of reactive oxygen and nitrogen species, the ... ...

Abstract	Carnosine (β-alanyl-L-histidine) is a naturally occurring endogenous dipeptide and an over-the-counter food supplement with a well-demonstrated multimodal mechanism of action that includes the detoxification of reactive oxygen and nitrogen species, the down-regulation of the production of pro-inflammatory mediators, the inhibition of aberrant protein formation, and the modulation of cells in the peripheral (macrophages) and brain (microglia) immune systems. Since its discovery more than 100 years ago, a plethora of in vivo preclinical studies have been carried out; however, there is still substantial heterogeneity regarding the route of administration, the dosage, the duration of the treatment, and the animal model selected, underlining the urgent need for "coordinated/aligned" preclinical studies laying the foundations for well-defined future clinical trials. The main aim of the present position paper is to critically and concisely consider these key points and open a discussion on the possible "alignment" for future studies, with the goal of validating the full therapeutic potential of this intriguing molecule.
MeSH term(s)	Animals ; Brain ; Carnosine/pharmacology ; Dietary Supplements ; Disease Models, Animal
Chemical Substances	Carnosine (8HO6PVN24W)
Language	English
Publishing date	2022-05-20
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	1413402-0
ISSN	1420-3049 ; 1431-5165 ; 1420-3049
ISSN (online)	1420-3049
ISSN	1431-5165 ; 1420-3049
DOI	10.3390/molecules27103303
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Article ; Online: Assessment of the Blue Light Ocular Hazard by Solar Measurements and the Impact of Selected Sunglasses Based upon the Limits of the International Commission on Non-Ionizing Radiation Protection Guideline.

Krejci, Martin / Caruso, Giuseppe

Health physics

2023 Volume 125, Issue 5, Page(s) 338–351

Abstract: Abstract: A quantitative assessment of the blue light hazard for the human eye related to direct solar irradiation is presented. For six radiation situations, missing eye protection was compared to protection by nine different commercial sunglasses with ...

Abstract	Abstract: A quantitative assessment of the blue light hazard for the human eye related to direct solar irradiation is presented. For six radiation situations, missing eye protection was compared to protection by nine different commercial sunglasses with and without an optimized blue light filter. Measurements of the solar irradiance were performed on Earth's surface as well as at an elevation of 12 km in the cockpit of an airliner. An irradiation time limit was calculated from the measurement data, within which the maximum blue light dose of 100 J m -2 , recommended by the International Commission on Non-Ionizing Radiation Protection and mandatory for the safe operation of lamps according to the norm ICE 62471, is reached. The results suggest that the blue light dose limit is violated within less than 3 s when looking without eye protection directly into the sun. For Category 3 sunglasses without the optimized blue light filter, time limits of 10 to 25 s on Earth's surface and 7 to 8 s at 12 km altitude were observed. The investigated Category 3 sunglasses with optimized blue light protection and suited for traffic use allow a time limit of more than 40 s on Earth's surface and 18 to 95 s in the airliner's cockpit. The outcome of the study is that the eye protection against blue light hazard related to solar radiation can be quantified using existing limits and that the choice of sunglasses is relevant: Traffic-worthy sunglasses optimized for protection against blue light hazard offer a better protection than non-optimized sunglasses.
MeSH term(s)	Humans ; Ultraviolet Rays ; Light ; Sunlight/adverse effects ; Eye/radiation effects ; Eye Protective Devices
Language	German
Publishing date	2023-08-15
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2406-5
ISSN	1538-5159 ; 0017-9078
ISSN (online)	1538-5159
ISSN	0017-9078
DOI	10.1097/HP.0000000000001723
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Zs.MO 253: Show issues

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Book: The botany of beer

Caruso, Giuseppe / Josephson, Marika

an illustrated guide to more than 500 plants used in brewing

(Arts and traditions of the table)

2022

Abstract: With beautiful India ink illustrations by the author, this book describes every known plant species around the world (roughly 500) that in one way or another is used in the process of brewing, or making beer. The book is as much for homebrewers and ... ...

Title translation	Botanica della birra.
Title variant	Illustrated guide to more than five hundred plants used in brewing
Institution	Kosmos (Firm : Reggio Emilia, Italy),
Author's details	Giuseppe Caruso ; foreword by Marika Josephson ; translated by Kosmos, Reggio Emilia, Italy
Series title	Arts and traditions of the table
Abstract	"With beautiful India ink illustrations by the author, this book describes every known plant species around the world (roughly 500) that in one way or another is used in the process of brewing, or making beer. The book is as much for homebrewers and professional beer makers as it is for beer aficionados, botany enthusiasts, and collectors of illustrated food books. The volume contains detailed information that is scientifically verified and precise and offers new stimuli for rediscovering and replicating ancient and early modern uses of these plants. The work contains botanical and beer-making fact sheets for the individual species, botanical illustrations, and information boxes on the plant's use throughout history as well as in current beer production. Each section provides the particular plant's scientific name and classification, morphology and geographical distribution, and detailed information about which of its parts are used in beer making, potential toxicity, chemical composition, and the brewing styles in which it's most commonly used. The volume concludes with a useful glossary to permit non-botanists to make sense of the more technical terminology"--
MeSH term(s)	Beer
Keywords	Beer. ; Botany. ; Brewing. ; SCIENCE / Chemistry / Industrial & Technical.
Language	English
Size	xv, 621 pages :, illustrations ;, 29 cm.
Publisher	Columbia University Press
Publishing place	New York
Document type	Book
Note	Translated from the Italian.
ISBN	9780231201582 ; 0231201583 ; 9780231554176 ; 0231554176 ; 0231201583 ; 9780231201582 ; 0231554176 ; 9780231554176
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Gap Junctions and Connexins in Microglia-Related Oxidative Stress and Neuroinflammation: Perspectives for Drug Discovery.

Caruso, Giuseppe / Di Pietro, Lucia / Caraci, Filippo

Biomolecules

2023 Volume 13, Issue 3

Abstract: Microglia represent the immune system of the brain. Their role is central in two phenomena, neuroinflammation and oxidative stress, which are at the roots of different pathologies related to the central nervous system (CNS). In order to maintain the ... ...

Abstract	Microglia represent the immune system of the brain. Their role is central in two phenomena, neuroinflammation and oxidative stress, which are at the roots of different pathologies related to the central nervous system (CNS). In order to maintain the homeostasis of the brain and re-establish the equilibrium after a threatening imbalance, microglia communicate with each other and other cells within the CNS by receiving specific signals through membrane-bound receptors and then releasing neurotrophic factors into either the extracellular
MeSH term(s)	Humans ; Connexins/metabolism ; Microglia/metabolism ; Neuroinflammatory Diseases ; Gap Junctions/metabolism ; Neurodegenerative Diseases/metabolism ; Oxidative Stress ; Drug Discovery
Chemical Substances	Connexins
Language	English
Publishing date	2023-03-09
Publishing country	Switzerland
Document type	Journal Article ; Review ; Research Support, Non-U.S. Gov't
ZDB-ID	2701262-1
ISSN	2218-273X ; 2218-273X
ISSN (online)	2218-273X
ISSN	2218-273X
DOI	10.3390/biom13030505
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Book: Electromyography in the diagnosis and management of peripheral nerve injuries

Caruso, Giuseppe

1983

Keywords	ELECTROMYOGRAPHY ; PERIPHERAL NERVES / INJURIES ; Elektromyographie ; Periphere Nervenverletzung
Subject	EMG ; Elektromyografie
Size	130 S.
Publisher	Huber
Publishing place	Bern
Document type	Book
HBZ-ID	HT002549769
ISBN	3-456-81289-2 ; 978-3-456-81289-2
Database	Catalogue ZB MED Medicine, Health

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1984 B 1113	order for loan	Magazin

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Article ; Online: Vaginal health and quality of sexual life of postmenopausal women on hyaluronic acid and Biosaccharide Gum-1 vaginal gel.

Caruso, Salvatore / Bruno, Maria Teresa / Boemi, Sara / Palermo, Gaia / Mazza, Gabriele / Caruso, Giuseppe

Taiwanese journal of obstetrics & gynecology

2023 Volume 62, Issue 5, Page(s) 702–708

Abstract: Objective: To evaluate the efficacy of daily vaginal gel containing hyaluronic acid (HA) and Biosaccharide Gum-1 (BG-1) on vulvovaginal atrophy (VVA) and on sexual function and quality of life (QoL).: Materials and methods: One hundred-four ... ...

Abstract	Objective: To evaluate the efficacy of daily vaginal gel containing hyaluronic acid (HA) and Biosaccharide Gum-1 (BG-1) on vulvovaginal atrophy (VVA) and on sexual function and quality of life (QoL). Materials and methods: One hundred-four postmenopausal women with VVA were enrolled in the nonrandomized comparison cohort study. Of them, 50 women on HA/BG-1 participated in the study group and 54 women on lubricants/moisturizers on-demand as a control group. The primary endpoint was the efficacy of the vaginal gel on VVA evaluated by the Vaginal Health Index (VHI) score. Secondary endpoints included sexual behavior by the self-administered female sexual function index (FSFI) questionnaire, and quality of life (QoL), by the Short Form-36 questionnaire (SF-36). Results: All symptoms of AVV improved after 12 weeks of treatment in women on HA/BG-1. The VMI, although improved at the 12-week follow-up compared to baseline, it connoted a low estrogenic stimulation value. Sexual function improved significantly in women on HA/BG-1. Moreover, women reported a significant improvement in the somatic aspects of QoL. No benefits were obtained by the women in the control group. Conclusions: Treatment with HA/BG-1 could have used in postmenopausal women who complain of vaginal dryness. The amelioration of VVA-related signs could improve sexual function and QoL.
MeSH term(s)	Humans ; Female ; Cohort Studies ; Hyaluronic Acid ; Postmenopause ; Quality of Life ; Vaginal Creams, Foams, and Jellies ; Sexual Behavior
Chemical Substances	Hyaluronic Acid (9004-61-9) ; Vaginal Creams, Foams, and Jellies
Language	English
Publishing date	2023-03-16
Publishing country	China (Republic : 1949- )
Document type	Journal Article
ZDB-ID	2202946-1
ISSN	1875-6263 ; 1875-6263
ISSN (online)	1875-6263
ISSN	1875-6263
DOI	10.1016/j.tjog.2023.07.011
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Article ; Online: The therapeutic potential of carnosine: Focus on cellular and molecular mechanisms.

Caruso, Giuseppe / Di Pietro, Lucia / Cardaci, Vincenzo / Maugeri, Salvatore / Caraci, Filippo

Current research in pharmacology and drug discovery

2023 Volume 4, Page(s) 100153

Abstract: Carnosine is a naturally occurring endogenous dipeptide composed by the ligation of β-alanine and L-histidine performed particularly by tissues with an increased oxidative metabolism such as muscles and brain. In the last 50 years different studies have ... ...

Abstract	Carnosine is a naturally occurring endogenous dipeptide composed by the ligation of β-alanine and L-histidine performed particularly by tissues with an increased oxidative metabolism such as muscles and brain. In the last 50 years different studies have assessed the role and function of carnosine through numerous
Language	English
Publishing date	2023-03-07
Publishing country	Netherlands
Document type	Journal Article ; Review
ISSN	2590-2571
ISSN (online)	2590-2571
DOI	10.1016/j.crphar.2023.100153
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Article ; Online: Myeloid neoplasms post PARP inhibitors for ovarian cancer.

Caruso, Giuseppe / Gigli, Federica / Parma, Gabriella / Lapresa, Mariateresa / Derio, Silvia / Palaia, Innocenza / Colombo, Nicoletta

International journal of gynecological cancer : official journal of the International Gynecological Cancer Society

2023 Volume 33, Issue 4, Page(s) 598–606

Abstract: The incidence of myeloid neoplasms following treatment with poly (ADP-ribose) polymerase inhibitors (PARPi) in patients with ovarian cancer has been gradually increasing over the last few years. The cumulative exposure to PARPi and the improved overall ... ...

Abstract	The incidence of myeloid neoplasms following treatment with poly (ADP-ribose) polymerase inhibitors (PARPi) in patients with ovarian cancer has been gradually increasing over the last few years. The cumulative exposure to PARPi and the improved overall survival of patients with ovarian cancer may represent key underlying explanations behind such trend. Fortunately, the earlier introduction of PARPi in the frontline setting reduces the risk of developing secondary myeloid neoplasms. The etiopathogenesis is still unclear but is likely to be multifactorial. The first 2 years of PARPi exposure seem to be the critical window for the onset of myeloid neoplasms post PARPi, with persistent cytopenia recognized as an early warning sign. Despite intensive treatment strategies, the outcome remains poor. There is an unmet clinical need to learn how to minimize risk, make an early diagnosis, and manage myeloid neoplasms post PARPi. First, decision making regarding the optimal maintenance treatment should avoid a 'PARPi-for-all' strategy. PARPi should be used cautiously in cases of high baseline risk for myeloid neoplasms and/or patients who are less likely to have a benefit. Active surveillance, accurate differential diagnosis, and prompt hematological referral are key management pillars. This review discusses what is known on this emerging issue as well as unresolved questions.
MeSH term(s)	Humans ; Female ; Poly(ADP-ribose) Polymerase Inhibitors/therapeutic use ; Poly(ADP-ribose) Polymerase Inhibitors/pharmacology ; Ovarian Neoplasms/drug therapy ; Ovarian Neoplasms/pathology
Chemical Substances	Poly(ADP-ribose) Polymerase Inhibitors
Language	English
Publishing date	2023-04-03
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	1070385-8
ISSN	1525-1438 ; 1048-891X
ISSN (online)	1525-1438
ISSN	1048-891X
DOI	10.1136/ijgc-2022-004190
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