LIVIVO - Search results -

Search results

Result 1 - 10 of total 244

Search options

Article ; Online: Remaining true to one's identity.

Caruso, Joseph A / Tlsty, Thea D

Nature aging

2023 Volume 1, Issue 9, Page(s) 757–759

MeSH term(s)	Humans ; Female ; Self Concept ; Aging ; Mutation ; BRCA1 Protein ; BRCA2 Protein
Chemical Substances	BRCA1 protein, human ; BRCA1 Protein ; BRCA2 protein, human ; BRCA2 Protein
Language	English
Publishing date	2023-08-01
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Comment
ISSN	2662-8465
ISSN (online)	2662-8465
DOI	10.1038/s43587-021-00113-8
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Book: Vibrational spectroscopy for plant varieties and cultivars characterization

Caruso, Joseph A / Lopes, João / Sousa, Clara

(Comprehensive analytical chemistry ; / advisory board: Joseph A. Caruso ; Volume 80)

2018

Author's details	edited by João Lopes (Research Institute for Medicines (iMed.ULisboa),Faculdade de Farmácia, Universidade de Lisboa, Portugal), Clara Sousa (LAQV, REQUIMTE, Departamento de Ciencias Quimicas, Faculdade de Farmácia, Universidade do Porto, Porto, Portugal)
Series title	Comprehensive analytical chemistry / advisory board: Joseph A. Caruso ; Volume 80
Language	English
Size	xiv, 299 Seiten, Illustrationen, Diagramme, 24 cm
Document type	Book
Note	Literaturangaben
ISBN	9780444640482 ; 0444640487
Database	Federal Institute for Risk Assessment

Order via subito

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Article ; Online: 2009 International Symposium on Metallomics.

Caruso, Joseph A

Metallomics : integrated biometal science

2010 Volume 2, Issue 2, Page(s) 103

MeSH term(s)	Computational Biology ; Metalloproteins/chemistry ; Metalloproteins/metabolism ; Metals/chemistry ; Metals/metabolism
Chemical Substances	Metalloproteins ; Metals
Language	English
Publishing date	2010-02
Publishing country	England
Document type	Editorial
ZDB-ID	2474317-3
ISSN	1756-591X ; 1756-5901
ISSN (online)	1756-591X
ISSN	1756-5901
DOI	10.1039/c001179g
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article ; Online: Neutrophil Elastase Remodels Mammary Tumors to Facilitate Lung Metastasis.

Lulla, Amriti R / Akli, Said / Karakas, Cansu / Caruso, Joseph A / Warma, Lucas D / Fowlkes, Natalie W / Rao, Xiayu / Wang, Jing / Hunt, Kelly K / Watowich, Stephanie S / Keyomarsi, Khandan

Molecular cancer therapeutics

2023 Volume 23, Issue 4, Page(s) 492–506

Abstract: Metastatic disease remains the leading cause of death due to cancer, yet the mechanism(s) of metastasis and its timely detection remain to be elucidated. Neutrophil elastase (NE), a serine protease secreted by neutrophils, is a crucial mediator of ... ...

Abstract	Metastatic disease remains the leading cause of death due to cancer, yet the mechanism(s) of metastasis and its timely detection remain to be elucidated. Neutrophil elastase (NE), a serine protease secreted by neutrophils, is a crucial mediator of chronic inflammation and tumor progression. In this study, we used the PyMT model (NE+/+ and NE-/-) of breast cancer to interrogate the tumor-intrinsic and -extrinsic mechanisms by which NE can promote metastasis. Our results showed that genetic ablation of NE significantly reduced lung metastasis and improved metastasis-free survival. RNA-sequencing analysis of primary tumors indicated differential regulation of tumor-intrinsic actin cytoskeleton signaling pathways by NE. These NE-regulated pathways are critical for cell-to-cell contact and motility and consistent with the delay in metastasis in NE-/- mice. To evaluate whether pharmacologic inhibition of NE inhibited pulmonary metastasis and phenotypically mimicked PyMT NE-/- mice, we utilized AZD9668, a clinically available and specific NE inhibitor. We found AZD9668 treated PyMT-NE+/+ mice showed significantly reduced lung metastases, improved recurrence-free, metastasis-free and overall survival, and their tumors showed similar molecular alterations as those observed in PyMT-NE-/- tumors. Finally, we identified a NE-specific signature that predicts recurrence and metastasis in patients with breast cancer. Collectively, our studies suggest that genetic ablation and pharmacologic inhibition of NE reduces metastasis and extends survival of mouse models of breast cancer, providing rationale to examine NE inhibitors as a treatment strategy for the clinical management of patients with metastatic breast cancer.
MeSH term(s)	Animals ; Female ; Humans ; Mice ; Breast Neoplasms/drug therapy ; Breast Neoplasms/genetics ; Breast Neoplasms/pathology ; Leukocyte Elastase/genetics ; Lung Neoplasms/pathology ; Pyridones ; Sulfones
Chemical Substances	Leukocyte Elastase (EC 3.4.21.37) ; N-((5-(methanesulfonyl)pyridin-2-yl)methyl)-6-methyl-5-(1-methyl-1H-pyrazol-5-yl)-2-oxo-1-(3-(trifluoromethyl)phenyl)-1,2-dihydropyridine-3-carboxamide (6Y5629322X) ; Pyridones ; Sulfones
Language	English
Publishing date	2023-11-23
Publishing country	United States
Document type	Journal Article
ZDB-ID	2063563-1
ISSN	1538-8514 ; 1535-7163
ISSN (online)	1538-8514
ISSN	1535-7163
DOI	10.1158/1535-7163.MCT-23-0414
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 5750: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (2.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Loss of PPARγ activity characterizes early protumorigenic stromal reprogramming and dictates the therapeutic window of opportunity.

Caruso, Joseph A / Wang, Xianhong / Murrow, Lyndsay M / Rodriguez, Carlos Ivan / Chen-Tanyolac, Chira / Vu, Lisa / Chen, Yunn-Yi / Gascard, Philippe / Gartner, Zev J / Kerlikowske, Karla / Tlsty, Thea D

Proceedings of the National Academy of Sciences of the United States of America

2023 Volume 120, Issue 42, Page(s) e2303774120

Abstract: Although robustly expressed in the disease-free (DF) breast stroma, CD36 is consistently absent from the stroma surrounding invasive breast cancers (IBCs). In this study, we primarily observed CD36 expression in adipocytes and intralobular capillaries ... ...

Abstract	Although robustly expressed in the disease-free (DF) breast stroma, CD36 is consistently absent from the stroma surrounding invasive breast cancers (IBCs). In this study, we primarily observed CD36 expression in adipocytes and intralobular capillaries within the DF breast. Larger vessels concentrated in interlobular regions lacked CD36 and were instead marked by the expression of CD31. When evaluated in perilesional capillaries surrounding ductal carcinoma in situ, a nonobligate IBC precursor, CD36 loss was more commonly observed in lesions associated with subsequent IBC. Peroxisome proliferator-activated receptor γ (PPARγ) governs the expression of CD36 and genes involved in differentiation, metabolism, angiogenesis, and inflammation. Coincident with CD36 loss, we observed a dramatic suppression of PPARγ and its target genes in capillary endothelial cells (ECs) and pericytes, which typically surround and support the stability of the capillary endothelium. Factors present in conditioned media from malignant cells repressed PPARγ and its target genes not only in cultured ECs and pericytes but also in adipocytes, which require PPARγ for proper differentiation. In addition, we identified a role for PPARγ in opposing the transition of pericytes toward a tumor-supportive myofibroblast phenotype. In mouse xenograft models, early intervention with rosiglitazone, a PPARγ agonist, demonstrated significant antitumor effects; however, following the development of a palpable tumor, the antitumor effects of rosiglitazone were negated by the repression of PPARγ in the mouse stroma. In summary, PPARγ activity in healthy tissues places several stromal cell types in an antitumorigenic state, directly inhibiting EC proliferation, maintaining adipocyte differentiation, and suppressing the transition of pericytes into tumor-supportive myofibroblasts.
MeSH term(s)	Animals ; Female ; Humans ; Mice ; Adipocytes/metabolism ; Breast Neoplasms/pathology ; Endothelial Cells/metabolism ; PPAR gamma/genetics ; PPAR gamma/metabolism ; Rosiglitazone/pharmacology
Chemical Substances	PPAR gamma ; Rosiglitazone (05V02F2KDG) ; PPARG protein, human
Language	English
Publishing date	2023-10-10
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	209104-5
ISSN	1091-6490 ; 0027-8424
ISSN (online)	1091-6490
ISSN	0027-8424
DOI	10.1073/pnas.2303774120
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 1148: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (1.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Influence of culinary treatment on the concentration and on the bioavailability of cadmium, chromium, copper, and lead in seafood.

Schmidt, Lucas / Novo, Diogo La Rosa / Druzian, Gabriel Toneto / Landero, Julio Alberto / Caruso, Joseph / Mesko, Marcia Foster / Flores, Erico Marlon Moraes

Journal of trace elements in medicine and biology : organ of the Society for Minerals and Trace Elements (GMS)

2021 Volume 65, Page(s) 126717

Abstract: Background: Seafood present important advantages for human nutrition, but it can also accumulate high levels of toxic and potentially toxic elements. Culinary treatments could influence seafood chemical element content and element bioavailability. In ... ...

Abstract	Background: Seafood present important advantages for human nutrition, but it can also accumulate high levels of toxic and potentially toxic elements. Culinary treatments could influence seafood chemical element content and element bioavailability. In this study, the influence of culinary treatments on the total concentration and on the bioavailability of Cd, Cr, Cu and Pb in shark, shrimp, squid, oyster, and scallop was assessed. Methods: Boiling, frying, and sautéing with or without seasonings (salt, lemon juice and garlic) were evaluated. Total concentration and bioavailability of Cd, Cr, Cu and Pb in seafood after all these culinary treatments were compared with those in uncooked samples. Analytes were determined by triple-quadrupole inductively coupled plasma mass spectrometry (ICP-MS/MS). An alternative to express the results avoiding underestimated or overestimated values was proposed. Results: The analytes concentration in seafood without culinary treatment varied from 0.0030 μg g Conclusion: Cadmium concentration was reduced in scallop after some culinary treatments (reduction o 37-53% after boiling, frying, and sautéing), but bioavailability percentage was not influenced. The employed analytical method was adequate for the purpose, presenting import results for food safety assessment about the influence of culinary treatments on metals concentration and bioavailability in seafood.
MeSH term(s)	Biological Availability ; Cadmium/analysis ; Cadmium/pharmacokinetics ; Chromium/analysis ; Chromium/pharmacokinetics ; Cooking ; Copper/analysis ; Copper/pharmacokinetics ; Food Contamination/analysis ; Humans ; Lead/analysis ; Lead/pharmacokinetics ; Seafood/analysis
Chemical Substances	Cadmium (00BH33GNGH) ; Chromium (0R0008Q3JB) ; Lead (2P299V784P) ; Copper (789U1901C5)
Language	English
Publishing date	2021-01-10
Publishing country	Germany
Document type	Journal Article
ZDB-ID	1236267-0
ISSN	1878-3252 ; 1611-602X ; 0946-672X
ISSN (online)	1878-3252 ; 1611-602X
ISSN	0946-672X
DOI	10.1016/j.jtemb.2021.126717
Database	MEDical Literature Analysis and Retrieval System OnLINE

Full text online

Accessible to users with ZB MED library card

In stock of ZB MED Cologne/Königswinter

Zs.A 2279: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (2.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾

Article: Case involving CAD/CAM-generated, screw-retained bridge demonstrates dentistry's scientific progression.

Caruso, Joseph L / Kahng, Luke

Compendium of continuing education in dentistry (Jamesburg, N.J. : 1995)

2012 Volume 33, Issue 8, Page(s) 600–2, 604

Abstract: The patient in the case presented had successfully used a maxillary overdenture for more than three decades. However, the time had come for the prosthetic appliance to be replaced. This case, which involved the use of a titanium understructure that was ... ...

Abstract	The patient in the case presented had successfully used a maxillary overdenture for more than three decades. However, the time had come for the prosthetic appliance to be replaced. This case, which involved the use of a titanium understructure that was designed and fabricated using CAD/CAM technology, illustrates how far dentistry has come since the patient first presented to the clinician some 35 years ago when dental science had not yet included such innovations as bone grafting and CT scans.
MeSH term(s)	Computer-Aided Design ; Dental Implantation, Endosseous ; Dental Prosthesis Design ; Dental Prosthesis Retention ; Dental Prosthesis, Implant-Supported ; Denture, Partial, Fixed ; Female ; Humans ; Maxilla ; Middle Aged
Language	English
Publishing date	2012-09
Publishing country	United States
Document type	Case Reports ; Journal Article
ZDB-ID	632569-5
ISSN	1548-8578 ; 0734-0338
ISSN	1548-8578 ; 0734-0338
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.B 2795: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: A metallomics approach discovers selenium-containing proteins in selenium-enriched soybean.

Chan, Qilin / Caruso, Joseph A

Analytical and bioanalytical chemistry

2012 Volume 403, Issue 5, Page(s) 1311–1321

Abstract: Our previous study found that high-molecular-weight selenium (Se) species make up 82% of the total Se in the bean of Se-enriched soybean plants (Chan et al. 2010, Metallomics, 2(2): p. 147-153). The Se species have been commonly seen in other plants in ... ...

Abstract	Our previous study found that high-molecular-weight selenium (Se) species make up 82% of the total Se in the bean of Se-enriched soybean plants (Chan et al. 2010, Metallomics, 2(2): p. 147-153). The Se species have been commonly seen in other plants in addition to soybean, but their identities remain unresolved. The present study employs a multi-technique metallomics approach to characterize the proteins containing Se in the beans of Se-enriched soybean plants. Two main categories of proteins, maturation proteins and protease inhibitors, were found in Se-containing high-performance liquid chromatography (HPLC) fractions. The proteins were screened by two-dimensional HPLC-inductively coupled plasma mass spectrometry, size-exclusion chromatography, and anion-exchange chromatography, and the Se-containing fractions were then identified by peptide mapping using HPLC-Chip-electrospray ion trap mass spectrometry. Based on the belief that Se goes into proteins through non-specific incorporation, a new method was designed and applied for the Se-containing peptide identification. The Se-containing peptide KSDQSSSYDDDEYSKPCCDLCMCTRS, part of the sequence of protein Bowman-Birk proteinase isoinhibitor (Glycine max), was found in one of the Se-containing fractions. The nutritional value of the Se-containing proteins in Se-enriched soybeans will be an interesting topic for the future studies.
MeSH term(s)	Chromatography, High Pressure Liquid/methods ; Mass Spectrometry/methods ; Molecular Sequence Data ; Plant Proteins/chemistry ; Plant Proteins/metabolism ; Proteomics/methods ; Selenium/analysis ; Selenium/metabolism ; Glycine max/chemistry ; Glycine max/metabolism
Chemical Substances	Plant Proteins ; Selenium (H6241UJ22B)
Language	English
Publishing date	2012-03-30
Publishing country	Germany
Document type	Evaluation Study ; Journal Article
ZDB-ID	201093-8
ISSN	1618-2650 ; 0016-1152 ; 0372-7920
ISSN (online)	1618-2650
ISSN	0016-1152 ; 0372-7920
DOI	10.1007/s00216-012-5948-0
Database	MEDical Literature Analysis and Retrieval System OnLINE

Full text online

Accessible to users with ZB MED library card

In stock of ZB MED Bonn / Germany

Z 4' 69/97: Show issues
Archiv 3: Show issues
Z 9.4: Show issues

Order via subito

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Details ▾

Article ; Online: Low level Hg

Carruthers, Nicholas J / Rosenspire, Allen J / Caruso, Joseph A / Stemmer, Paul M

Journal of proteomics

2017 Volume 173, Page(s) 107–114

Abstract: Exposure of Wehi-231 B-cells to Hg: Significance: Mercury (Hg) is a wide spread environmental toxicant. Epidemiological and laboratory studies suggest that exposure to environmental Hg at current levels, which have been perceived to be non-toxic, may ... ...

Abstract	Exposure of Wehi-231 B-cells to Hg Significance: Mercury (Hg) is a wide spread environmental toxicant. Epidemiological and laboratory studies suggest that exposure to environmental Hg at current levels, which have been perceived to be non-toxic, may contribute to immune system dysfunction and autoimmune disease in humans and animals respectively. While we have previously shown that exposure of B lymphocytes to low levels of mercury interferes with B-cell receptor signaling mediated by post transcriptional phosphorylation events, overall the mechanism that is responsible for increased autoimmunity in mercury exposed human or animal populations is not well understood. The current study evaluated the dose dependent actions of mercury to change phosphorylation in the Wehi-231 cell line, an immature B-cell model in which actions of mercury on development of cell function can be evaluated. The study identified the cytoskeletal proteins as the most sensitive to modulation by mercury with changes in Ser/Thr phosphorylation being observed at the lowest concentrations of mercury. These findings indicate that the actions of mercury on B-cell immune function and development are at least in part likely mediated through changes in cytoskeletal protein phosphorylation.
MeSH term(s)	Animals ; B-Lymphocytes/chemistry ; B-Lymphocytes/ultrastructure ; Cell Line ; Cytoskeleton/chemistry ; Dose-Response Relationship, Drug ; Environmental Exposure ; GTP Phosphohydrolases/metabolism ; Humans ; Mass Spectrometry ; Mercury/pharmacology ; Phosphoproteins/analysis ; Phosphorylation/drug effects ; Proteome/analysis ; Serine/metabolism ; Signal Transduction ; Threonine/metabolism
Chemical Substances	Phosphoproteins ; Proteome ; Threonine (2ZD004190S) ; Serine (452VLY9402) ; GTP Phosphohydrolases (EC 3.6.1.-) ; Mercury (FXS1BY2PGL)
Language	English
Publishing date	2017-12-02
Publishing country	Netherlands
Document type	Journal Article ; Research Support, N.I.H., Extramural
ZDB-ID	2400835-7
ISSN	1876-7737 ; 1874-3919
ISSN (online)	1876-7737
ISSN	1874-3919
DOI	10.1016/j.jprot.2017.11.026
Database	MEDical Literature Analysis and Retrieval System OnLINE

Full text online

Accessible to users with ZB MED library card

Order via subito

Details ▾
- Full text online
- Order with fees

Article: Evaluation of microbial air quality and aerosol distribution in a large dental clinic.

Suprono, Montry S / Savignano, Roberto / Won, John B / Lillard, Stan / Zhong, Zhe / Ahmed, Abu / Roque-Torres, Gina / Zhang, Wu / Oyoyo, Udochukwu B / Richardson, Paul / Caruso, Joseph / Handysides, Robert / Li, Yiming

American journal of dentistry

2022 Volume 35, Issue 5, Page(s) 268–272

Abstract: Purpose: To evaluate the microbial air quality during dental clinical procedures in a large clinical setting with increasing patient capacity.: Methods: This was a single-center, observational study design evaluating the microbial air quality and ... ...

Abstract	Purpose: To evaluate the microbial air quality during dental clinical procedures in a large clinical setting with increasing patient capacity. Methods: This was a single-center, observational study design evaluating the microbial air quality and aerosol distribution during normal clinical sessions at 5% (sessions 1 and 2) and at > 50% (session 3) treatment capacity of dental aerosol generating procedures. Sessions 1 and 2 were evaluated on the same day with a 30-minute fallow time between the sessions. Session 3 was evaluated on a separate day. For each session, passive air-sampling technique was performed for three collection periods: baseline, treatment, and post-treatment. Blood agar plates were collected and incubated at 37°C for 48 hours. Colonies were counted using an automatic colony counter. Mean colony forming units (CFU) per plate were converted to CFU/m²/h. Results: Kruskal Wallis test was performed to compare the mean CFU/m²/h between the clinic sessions. Statistically significant differences were observed between sessions 1 and 2 (P< 0.05), but not between sessions 2 and 3 (P> 0.05). Combining all clinical sessions, the mean CFU/m²/h were 977 (baseline), 873 (treatment), and 1,631 (post-treatment) for the collection periods. A decrease-to-increase CFU/m²/h trend was observed from baseline to treatment, and from treatment to post-treatment that was observed for all clinic sessions and was irrespective to treatment capacity. Higher amounts of CFU/m²/h were found near the air exhaust outlets for all three clinic sessions. Microbial aerosol distribution is most likely due to the positions and power levels of the air inlets and outlets, and to a lesser extent with patient treatment capacity. Clinical significance: Dental clinics should be designed and optimized to minimize the risk of airborne transmissions. The results of this study emphasize the need to evaluate dental clinic ventilation systems.
MeSH term(s)	Humans ; Air Microbiology ; Dental Clinics ; Agar ; Aerosols ; Colony Count, Microbial ; Air Pollution
Chemical Substances	Agar (9002-18-0) ; Aerosols
Language	English
Publishing date	2022-10-19
Publishing country	United States
Document type	Observational Study ; Journal Article
ZDB-ID	645142-1
ISSN	0894-8275
ISSN	0894-8275
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 2516: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (2.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

To top

More links

Kategorien

Order via subito

Inter-library loan at ZB MED

More links

Kategorien

Order via subito

Inter-library loan at ZB MED

More links

Kategorien

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

Full text online

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

Full text online

More links

Kategorien

In stock of ZB MED Bonn / Germany

Order via subito

Inter-library loan at ZB MED

Full text online

More links

Kategorien

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito