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Article: Autoimmune Enteropathy: A Rare Cause of Chronic Diarrhea in an Adult Patient.

Carvalho, Ana C / Pinho, Juliana / Cancela, Eugénia / Silva, Américo

2023 Volume 10, Issue 3, Page(s) e01009

Abstract: Autoimmune enteropathy is a rare cause of malabsorption usually associated with circulating autoantibodies and predisposition to autoimmune disorders. The diagnosis is based on the following criteria: chronic diarrhea (>6 months), malabsorption, specific ...

Abstract	Autoimmune enteropathy is a rare cause of malabsorption usually associated with circulating autoantibodies and predisposition to autoimmune disorders. The diagnosis is based on the following criteria: chronic diarrhea (>6 months), malabsorption, specific histological findings, anti-enterocyte and anti-goblet cell antibodies, and exclusion of similar disorders. We report a case of a 73-year-old woman presenting with severe chronic diarrhea, weight loss, and electrolyte abnormalities. Endoscopy revealed duodenal villous atrophy extending to proximal jejunum, and duodenal biopsies revealed villous blunting, cryptitis with apoptosis, and scattered intraepithelial lymphocytes. Therapeutic management included immunosuppressive treatment with corticosteroids, achieving clinical remission.
Language	English
Publishing date	2023-03-13
Publishing country	United States
Document type	Case Reports
ZDB-ID	2814825-3
ISSN	2326-3253
ISSN	2326-3253
DOI	10.14309/crj.0000000000001009
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Article ; Online: The Characterization and Cytotoxic Evaluation of

Rocha, Miguel S / Marques, Catarina F / Carvalho, Ana C / Martins, Eva / Ereskovsky, Alexander / Reis, Rui L / Silva, Tiago H

Marine drugs

2024 Volume 22, Issue 2

Abstract: Chondrosia ... ...

Abstract	Chondrosia reniformis
MeSH term(s)	Animals ; Cell-Derived Microparticles/metabolism ; Biocompatible Materials/pharmacology ; Biocompatible Materials/metabolism ; Porifera/metabolism ; Collagen/chemistry ; Collagen Type I/metabolism ; Mammals/metabolism
Chemical Substances	Biocompatible Materials ; Collagen (9007-34-5) ; Collagen Type I
Language	English
Publishing date	2024-01-24
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2175190-0
ISSN	1660-3397 ; 1660-3397
ISSN (online)	1660-3397
ISSN	1660-3397
DOI	10.3390/md22020055
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Article ; Online: Potential of Atlantic Codfish (

Rodrigues, Cristina V / Sousa, Rita O / Carvalho, Ana C / Alves, Ana L / Marques, Catarina F / Cerqueira, Mariana T / Reis, Rui L / Silva, Tiago H

Molecules (Basel, Switzerland)

2023 Volume 28, Issue 8

Abstract: Collagen is the major structural protein in extracellular matrix present in connective tissues, including skin, being considered a promising material for skin regeneration. Marine organisms have been attracting interest amongst the industry as an ... ...

Abstract	Collagen is the major structural protein in extracellular matrix present in connective tissues, including skin, being considered a promising material for skin regeneration. Marine organisms have been attracting interest amongst the industry as an alternative collagen source. In the present work, Atlantic codfish skin collagen was analyzed, to evaluate its potential for skincare. The collagen was extracted from two different skin batches (food industry by-product) using acetic acid (ASColl), confirming the method reproducibility since no significant yield differences were observed. The extracts characterization confirmed a profile compatible with type I collagen, without significant differences between batches or with bovine skin collagen (a reference material in biomedicine). Thermal analyses suggested ASColl's native structure loss at 25 °C, and an inferior thermal stability to bovine skin collagen. No cytotoxicity was found for ASColl up to 10 mg/mL in keratinocytes (HaCaT cells). ASColl was used to develop membranes, which revealed smooth surfaces without significative morphological or biodegradability differences between batches. Their water absorption capacity and water contact angle indicated a hydrophilic feature. The metabolic activity and proliferation of HaCaT were improved by the membranes. Hence, ASColl membranes exhibited attractive characteristics to be applied in the biomedical and cosmeceutical field envisaging skincare.
MeSH term(s)	Animals ; Cattle ; Biocompatible Materials/pharmacology ; Biocompatible Materials/analysis ; Gadus morhua/metabolism ; Reproducibility of Results ; Skin/metabolism ; Collagen/chemistry ; Gadiformes/metabolism
Chemical Substances	Biocompatible Materials ; Collagen (9007-34-5)
Language	English
Publishing date	2023-04-12
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	1413402-0
ISSN	1420-3049 ; 1431-5165 ; 1420-3049
ISSN (online)	1420-3049
ISSN	1431-5165 ; 1420-3049
DOI	10.3390/molecules28083394
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Article: Phytotoxicity of

Marques, Maria E M / de Carvalho, Ana C / Yendo, Anna C A / Magedans, Yve V S / Zachert, Eliane / Fett-Neto, Arthur G

Plants (Basel, Switzerland)

2023 Volume 12, Issue 3

Abstract: Weeds are major threats to the integrity of agricultural and natural environments due to their invasive and competing potential. Bioherbicides are substances based on natural compounds that are biodegradable and often have low residual effects. Plant ... ...

Abstract	Weeds are major threats to the integrity of agricultural and natural environments due to their invasive and competing potential. Bioherbicides are substances based on natural compounds that are biodegradable and often have low residual effects. Plant species able to produce and release phytotoxic compounds may represent effective bioherbicide sources. Leaves of
Language	English
Publishing date	2023-02-02
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2704341-1
ISSN	2223-7747
ISSN	2223-7747
DOI	10.3390/plants12030663
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Article ; Online: Zein and hydroxypropyl methylcellulose acetate succinate microfibers combined with metronidazole benzoate and/or metronidazole-incorporated cellulose nanofibrils for potential periodontal treatment.

Ferreira, João O / Zambuzi, Giovana C / Camargos, Camilla H M / Carvalho, Ana C W / Ferreira, Maíra P / Rezende, Camila A / de Freitas, Osvaldo / Francisco, Kelly R

International journal of biological macromolecules

2024 Volume 261, Issue Pt 1, Page(s) 129701

Abstract: The development of flexible and porous materials to control antibacterial delivery is a pivotal endeavor in medical science. In this study, we aimed to produce long and defect-free fibers made of zein and hydroxypropyl methylcellulose acetate succinate ( ... ...

Abstract	The development of flexible and porous materials to control antibacterial delivery is a pivotal endeavor in medical science. In this study, we aimed to produce long and defect-free fibers made of zein and hydroxypropyl methylcellulose acetate succinate (HPMCAS) to be used as a platform for the release of metronidazole (MDZ) and metronidazole benzoate (BMDZ) to be potentially used in periodontal treatment. Microfibers prepared via electrospinning under a 2:3 (w/w) zein to HPMCAS ratio, containing 0.5 % (w/w) poly(ethylene oxide) (PEO) and 1 % (w/w) cellulose nanofibril (CNF) were loaded with 40 % (w/w) MDZ, 40 % (w/w) BMDZ, or a combination of 20 % (w/w) of each drug. The addition of CNF improved the electrospinning process, resulting in long fibers with reduced MDZ and BMDZ surface crystallization. MDZ- and BMDZ-incorporated fibers were semicrystalline and displayed commendable compatibility among drugs, nanocellulose and polymeric chains. Release tests showed that zein/HPMCAS/PEO fibers without CNF and with 20 % (w/w) MDZ/ 20 % (w/w) BMDZ released the drug at a slower and more sustained rate compared to other samples over extended periods (up to 5 days), which is a favorable aspect concerning periodontitis treatment.
MeSH term(s)	Metronidazole/pharmacology ; Cellulose ; Zein ; Methylcellulose/analogs & derivatives ; Benzoates
Chemical Substances	Metronidazole (140QMO216E) ; Cellulose (9004-34-6) ; hydroxypropylmethylcellulose acetate succinate (71138-97-1) ; Zein (9010-66-6) ; Methylcellulose (9004-67-5) ; Benzoates
Language	English
Publishing date	2024-01-25
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	282732-3
ISSN	1879-0003 ; 0141-8130
ISSN (online)	1879-0003
ISSN	0141-8130
DOI	10.1016/j.ijbiomac.2024.129701
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Article: Salmonella

Cota, João B / Carvalho, Ana C / Dias, Inês / Reisinho, Ana / Bernardo, Fernando / Oliveira, Manuela

Antibiotics (Basel, Switzerland)

2021 Volume 10, Issue 3

Abstract: A fraction of ... ...

Abstract	A fraction of human
Language	English
Publishing date	2021-03-19
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2681345-2
ISSN	2079-6382
ISSN	2079-6382
DOI	10.3390/antibiotics10030324
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Article: Ohmic Heating Extract of Vine Pruning Residue Has Anti-Colorectal Cancer Activity and Increases Sensitivity to the Chemotherapeutic Drug 5-FU

Jesus, Meirielly S / Carvalho, Ana C / Teixeira, José A / Domingues, Lucília / Pereira-Wilson, Cristina

Foods. 2020 Aug. 12, v. 9, no. 8

2020

Abstract: Vine pruning residues are by-products of the wine industry that have not received much attention in the past, in spite of being rich in bioactive compounds. In this study, we aimed to test whether an ohmic extract of vine pruning residue (VPE) has anti- ... ...

Abstract	Vine pruning residues are by-products of the wine industry that have not received much attention in the past, in spite of being rich in bioactive compounds. In this study, we aimed to test whether an ohmic extract of vine pruning residue (VPE) has anti-colorectal cancer (CRC) properties, and whether responses differ according with cell’s mutation profile. VPE decreased human CRC cell proliferation, accompanied by DNA effects and cell cycle modulation. VPE also increased cell sensitivity to the chemotherapeutic drug 5-FU. Our results suggest that tumors harboring BRAF mutations may be more responsive to VPE than KRAS mutated tumors. These effects of the extract were not completely reproduced by the most abundant constituents tested individually at the concentrations present in the effective dose of VPE. Globally, our results indicate that VPE, a polyphenol enriched extract produced by ohmic heating of vine pruning residue, has anti-colorectal cancer potential, including sensitizing to a chemotherapeutical drug, and its use in functional foods or nutraceuticals could be exploited in personalized anti colorectal cancer dietary strategies. Valorization of this lignocellulosic residue should encourage bio-waste recycling, adding value to this agricultural by-product and promoting the sustainable use of natural resources.
Keywords	DNA ; agroindustrial byproducts ; bioactive compounds ; cell cycle ; cell proliferation ; colorectal neoplasms ; dietary supplements ; dosage ; drug therapy ; fluorouracil ; functional foods ; humans ; lignocellulose ; mutation ; natural resources ; ohmic heating ; polyphenols ; recycling ; vines ; wastes ; wine industry
Language	English
Dates of publication	2020-0812
Publishing place	Multidisciplinary Digital Publishing Institute
Document type	Article
Note	NAL-light
ZDB-ID	2704223-6
ISSN	2304-8158
ISSN	2304-8158
DOI	10.3390/foods9081102
Database	NAL-Catalogue (AGRICOLA)

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Article: Cell-Laden Marine Gelatin Methacryloyl Hydrogels Enriched with Ascorbic Acid for Corneal Stroma Regeneration.

Alves, Ana L / Carvalho, Ana C / Machado, Inês / Diogo, Gabriela S / Fernandes, Emanuel M / Castro, Vânia I B / Pires, Ricardo A / Vázquez, José A / Pérez-Martín, Ricardo I / Alaminos, Miguel / Reis, Rui L / Silva, Tiago H

Bioengineering (Basel, Switzerland)

2023 Volume 10, Issue 1

Abstract: Corneal pathologies from infectious or noninfectious origin have a significant impact on the daily lives of millions of people worldwide. Despite the risk of organ rejection or infection, corneal transplantation is currently the only effective treatment. ...

Abstract	Corneal pathologies from infectious or noninfectious origin have a significant impact on the daily lives of millions of people worldwide. Despite the risk of organ rejection or infection, corneal transplantation is currently the only effective treatment. Finding safe and innovative strategies is the main goal of tissue-engineering-based approaches. In this study, the potential of gelatin methacryloyl (GelMA) hydrogels produced from marine-derived gelatin and loaded with ascorbic acid (as an enhancer of the biological activity of cells) was evaluated for corneal stromal applications. Marine GelMA was synthesized with a methacrylation degree of 75%, enabling effective photocrosslinking, and hydrogels with or without ascorbic acid were produced, encompassing human keratocytes. All the produced formulations exhibited excellent optical and swelling properties with easy handling as well as structural stability and adequate degradation rates that may allow proper extracellular matrix remodeling by corneal stromal cells. Formulations loaded with 0.5 mg/mL of ascorbic acid enhanced the biological performance of keratocytes and induced collagen production. These results suggest that, in addition to marine-derived gelatin being suitable for the synthesis of GelMA, the hydrogels produced are promising biomaterials for corneal regeneration applications.
Language	English
Publishing date	2023-01-04
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2746191-9
ISSN	2306-5354
ISSN	2306-5354
DOI	10.3390/bioengineering10010062
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Article: Ohmic Heating Extract of Vine Pruning Residue Has Anti-Colorectal Cancer Activity and Increases Sensitivity to the Chemotherapeutic Drug 5-FU.

Jesus, Meirielly S / Carvalho, Ana C / Teixeira, José A / Domingues, Lucília / Pereira-Wilson, Cristina

Foods (Basel, Switzerland)

2020 Volume 9, Issue 8

Abstract	Vine pruning residues are by-products of the wine industry that have not received much attention in the past, in spite of being rich in bioactive compounds. In this study, we aimed to test whether an ohmic extract of vine pruning residue (VPE) has anti-colorectal cancer (CRC) properties, and whether responses differ according with cell's mutation profile. VPE decreased human CRC cell proliferation, accompanied by DNA effects and cell cycle modulation. VPE also increased cell sensitivity to the chemotherapeutic drug 5-FU. Our results suggest that tumors harboring BRAF mutations may be more responsive to VPE than KRAS mutated tumors. These effects of the extract were not completely reproduced by the most abundant constituents tested individually at the concentrations present in the effective dose of VPE. Globally, our results indicate that VPE, a polyphenol enriched extract produced by ohmic heating of vine pruning residue, has anti-colorectal cancer potential, including sensitizing to a chemotherapeutical drug, and its use in functional foods or nutraceuticals could be exploited in personalized anti colorectal cancer dietary strategies. Valorization of this lignocellulosic residue should encourage bio-waste recycling, adding value to this agricultural by-product and promoting the sustainable use of natural resources.
Language	English
Publishing date	2020-08-12
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2704223-6
ISSN	2304-8158
ISSN	2304-8158
DOI	10.3390/foods9081102
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Article ; Online: Correlation of p16 immunohistochemistry with clinical and epidemiological features in oropharyngeal squamous-cell carcinoma.

de C Ferreira, Chrystiano / Dufloth, Rozany / de Carvalho, Ana C / Reis, Rui M / Santana, Iara / Carvalho, Raiany S / Gama, Ricardo R

PloS one

2021 Volume 16, Issue 6, Page(s) e0253418

Abstract: Background: Oropharyngeal cancer is an important public health problem. The aim of our study was to correlatep16 immunohistochemistry in oropharynx squamous cell carcinomas(OPSCC) with clinical and epidemiological features.: Material and methods: We ... ...

Abstract	Background: Oropharyngeal cancer is an important public health problem. The aim of our study was to correlatep16 immunohistochemistry in oropharynx squamous cell carcinomas(OPSCC) with clinical and epidemiological features. Material and methods: We conducted across-sectional study on patients with OPSCC treated at a single institution from 2014 to 2019. Epidemiological and clinical-pathological data were collected from medical records and a questionnaire was applied to determine alcohol consumption, smoking, and sexual behavior. The HPV status was determined by p16 immunohistochemistry. Results: A total of 252 patients participated in the study, of these 221 (87.7%) were male. There were 81 (32.14%) p16 positive cases and 171 (67.85%) p16 negative cases. The p16positive group was significantly associated with younger patients (50-59 years), higher education level, lower clinical stage and patients who never drank or smoked. Through univariate logistic regression, we observed that female sex (OR, 3.47; 95% CI, 1.60-7.51) and higher education level (OR, 9.39; 95% CI, 2, 81-31,38) were significantly more likely to be p16 positive. Early clinical stage (AJCC8ed) was more associated with p16 positivity both in univariate (OR, 0.14; 95% CI, 0.07-0.26, p<0.001) and multivariate analysis (OR, 0.18; 95% CI, 0.06-0.49, p = 0.001). Conclusion: This study showed that drinkers and current smokers were less likely to be p16+. Female sex, higher education level and younger age at diagnosis were associated with a higher probability of being p16+. Additionally, there was a higher proportion of patients with early clinical stage (I or II) in the p16 positive group when compared to the p16 negative group.
MeSH term(s)	Adult ; Age Factors ; Aged ; Aged, 80 and over ; Alcohol Drinking ; Cross-Sectional Studies ; Cyclin-Dependent Kinase Inhibitor p16/metabolism ; Female ; Humans ; Immunohistochemistry ; Male ; Middle Aged ; Neoplasm Staging ; Oropharyngeal Neoplasms/epidemiology ; Oropharyngeal Neoplasms/metabolism ; Oropharyngeal Neoplasms/pathology ; Oropharynx/metabolism ; Oropharynx/pathology ; Risk Factors ; Sex Factors ; Sexual Behavior ; Smoking ; Squamous Cell Carcinoma of Head and Neck/epidemiology ; Squamous Cell Carcinoma of Head and Neck/metabolism ; Squamous Cell Carcinoma of Head and Neck/pathology ; Young Adult
Chemical Substances	CDKN2A protein, human ; Cyclin-Dependent Kinase Inhibitor p16
Language	English
Publishing date	2021-06-17
Publishing country	United States
Document type	Journal Article
ZDB-ID	2267670-3
ISSN	1932-6203 ; 1932-6203
ISSN (online)	1932-6203
ISSN	1932-6203
DOI	10.1371/journal.pone.0253418
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