Article: Prolactin does not seem to mediate the improvement on insulin resistance markers and blood glucose levels related to breastfeeding.
2023 Volume 14, Page(s) 1219119
Abstract: Introduction: The prevalence of type 2 diabetes mellitus (T2DM) is increasing worldwide. Strategies to decrease this risk should be strongly encouraged. Lactation has been associated, for the mother, with reduction in future T2DM risk in several studies. ...
| Abstract | Introduction: The prevalence of type 2 diabetes mellitus (T2DM) is increasing worldwide. Strategies to decrease this risk should be strongly encouraged. Lactation has been associated, for the mother, with reduction in future T2DM risk in several studies. The mechanisms behind this phenomenon, however, are poorly understood. The aims of this study were, first, to compare blood glucose levels and markers of insulin resistance (MIR) in early postpartum women with overweight/obesity according to their breastfeeding status and, second, to evaluate whether prolactin (PRL) levels could mediate improvements in these parameters. Methods: The prospective study followed 95 women older than 18 years from early pregnancy for up to 60 to 180 days postpartum. All participants had a BMI > 25 kg/m Results: Breastfeeding women ( Conclusion: Breastfeeding was associated with improvement in glucose metabolism and MIR 60 to 180 days after birth in overweight and obese women, even when adjusted for confounders. PRL levels were not found to mediate the association between breastfeeding and improvement in MIR. |
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| MeSH term(s) | Pregnancy ; Humans ; Female ; Prolactin ; Blood Glucose ; Diabetes Mellitus, Type 2/epidemiology ; Insulin Resistance ; Overweight ; Prospective Studies |
| Chemical Substances | Prolactin (9002-62-4) ; Blood Glucose |
| Language | English |
| Publishing date | 2023-08-30 |
| Publishing country | Switzerland |
| Document type | Journal Article ; Research Support, Non-U.S. Gov't |
| ZDB-ID | 2592084-4 |
| ISSN | 1664-2392 |
| ISSN | 1664-2392 |
| DOI | 10.3389/fendo.2023.1219119 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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