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  1. Article ; Online: Massive myocardial calcification as an aetiology of heart failure.

    Bernardo, Marta Catarina / Carvalho, Sofia Silva / Moreira, Ilídio

    European heart journal

    2024  Volume 45, Issue 12, Page(s) 1086

    MeSH term(s) Humans ; Cardiomyopathies/complications ; Cardiomyopathies/diagnostic imaging ; Myocardium ; Heart Failure/complications ; Heart Defects, Congenital/complications
    Language English
    Publishing date 2024-01-23
    Publishing country England
    Document type Journal Article
    ZDB-ID 603098-1
    ISSN 1522-9645 ; 0195-668X
    ISSN (online) 1522-9645
    ISSN 0195-668X
    DOI 10.1093/eurheartj/ehae009
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    Zs.A 1563: Show issues Location:
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  2. Article ; Online: Ocular Complications of COVID-19 Patients Admitted to Intensive Care in Portugal.

    Carvalho, Sofia / Lima-Fontes, Mário / Falcão, Manuel / Artur Paiva, José / Pinheiro-Costa, João

    Acta medica portuguesa

    2023  Volume 36, Issue 12, Page(s) 776–778

    MeSH term(s) Humans ; COVID-19/complications ; Portugal/epidemiology ; Critical Care ; SARS-CoV-2 ; Hospitalization ; Intensive Care Units
    Language English
    Publishing date 2023-12-04
    Publishing country Portugal
    Document type Journal Article
    ZDB-ID 603078-6
    ISSN 1646-0758 ; 0870-399X
    ISSN (online) 1646-0758
    ISSN 0870-399X
    DOI 10.20344/amp.20083
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.B 2343: Show issues Location:
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  3. Article: Influence of Light on Plant-Phyllosphere Interaction.

    Carvalho, Sofia D / Castillo, José A

    Frontiers in plant science

    2018  Volume 9, Page(s) 1482

    Abstract: Plant-phyllosphere interactions depend on microbial diversity, the plant host and environmental factors. Light is perceived by plants and by microorganisms and is used as a cue for their interaction. Photoreceptors respond to narrow-bandwidth wavelengths ...

    Abstract Plant-phyllosphere interactions depend on microbial diversity, the plant host and environmental factors. Light is perceived by plants and by microorganisms and is used as a cue for their interaction. Photoreceptors respond to narrow-bandwidth wavelengths and activate specific internal responses. Light-induced plant responses include changes in hormonal levels, production of secondary metabolites, and release of volatile compounds, which ultimately influence plant-phyllosphere interactions. On the other hand, microorganisms contribute making some essential elements (N, P, and Fe) biologically available for plants and producing growth regulators that promote plant growth and fitness. Therefore, light directly or indirectly influences plant-microbe interactions. The usage of light-emitting diodes in plant growth facilities is helping increasing knowledge in the field. This progress will help define light recipes to optimize outputs on plant-phyllosphere communications. This review describes research advancements on light-regulated plant-phyllosphere interactions. The effects of full light spectra and narrow bandwidth-wavelengths from UV to far-red light are discussed.
    Language English
    Publishing date 2018-10-12
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2613694-6
    ISSN 1664-462X
    ISSN 1664-462X
    DOI 10.3389/fpls.2018.01482
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  4. Article ; Online: GAWA during COVID-19 pandemic: a setback?

    Carvalho, Sofia Almeida / Ferraz, Inês Fernandes / Duarte, Filipa Pires / Ghira, Miguel

    Brazilian journal of anesthesiology (Elsevier)

    2021  Volume 71, Issue 2, Page(s) 198–200

    MeSH term(s) Airway Management/methods ; Anesthesia, General/methods ; COVID-19 ; Child ; Female ; Humans ; Middle Aged
    Language English
    Publishing date 2021-02-19
    Publishing country Brazil
    Document type Case Reports ; Letter
    ZDB-ID 1142792-9
    ISSN 0104-0014 ; 0104-0014
    ISSN (online) 0104-0014
    ISSN 0104-0014
    DOI 10.1016/j.bjane.2020.12.021
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    Zs.A 3612: Show issues Location:
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  5. Article: Postpartum Eosinophilic Ascites: A Case Report.

    Gonçalves, Inês / Pinho, Ana Filipa S / Antunes, Ana / Carvalho, Sofia / Pinto, Luisa

    Cureus

    2022  Volume 14, Issue 3, Page(s) e23301

    Abstract: Eosinophilic gastrointestinal diseases (EGID) are a group of conditions characterized by histopathologic eosinophilic infiltrates in one or more segments of the gastrointestinal (GI) tract. It occurs in the absence of known causes for eosinophilia. It ... ...

    Abstract Eosinophilic gastrointestinal diseases (EGID) are a group of conditions characterized by histopathologic eosinophilic infiltrates in one or more segments of the gastrointestinal (GI) tract. It occurs in the absence of known causes for eosinophilia. It can affect every part of the gastrointestinal tract, but eosinophilic ascites (EA) is uncommon. There is a clinical overlap between EGID and GI involvement of hypereosinophilic syndrome (HES), so distinguishing them may not be easy. We report a case of eosinophilic gastroenteritis in a 26-year-old-woman with the uncommon presentation of eosinophilic ascites after delivery. It is vital to maintain a high grade of suspicion to diagnose these disorders and exclude the secondary causes since treatment varies. In addition, the occurrence of this postpartum syndrome has been described, so it is essential to recognize this entity in this period.
    Language English
    Publishing date 2022-03-18
    Publishing country United States
    Document type Case Reports
    ZDB-ID 2747273-5
    ISSN 2168-8184
    ISSN 2168-8184
    DOI 10.7759/cureus.23301
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  6. Article ; Online: Gestational exposure to erenumab-The outcome of three pregnancies.

    Bonifácio, Gonçalo V / de Carvalho, Sofia Cupertino / Oliveira, Renato / Gil-Gouveia, Raquel

    Headache

    2022  Volume 62, Issue 9, Page(s) 1218–1221

    Abstract: Erenumab is a monoclonal antibody (mAb) approved for the preventive treatment of migraine. While preclinical studies on calcitonin gene-related peptide mAbs did not identify any reproductive toxicity, pregnant and breastfeeding women were excluded from ... ...

    Abstract Erenumab is a monoclonal antibody (mAb) approved for the preventive treatment of migraine. While preclinical studies on calcitonin gene-related peptide mAbs did not identify any reproductive toxicity, pregnant and breastfeeding women were excluded from the pivotal human studies, and therefore the safety of calcitonin gene-related peptide medications in this population must be studied. So far, postmarketing data of accidental exposures have not brought to light any specific toxicities. Three women treated with erenumab in our series conceived while exposed to the drug. All had previous successful pregnancies, were on erenumab for more than 6 months, and had ≥80% reduction in headache frequency. The one who stopped erenumab only 1 month before conceiving had a spontaneous abortion during the first trimester due to a gestational trophoblastic neoplasia and has since conceived with an uneventful gestation. The other two women stopped treatment during the first trimester, and both pregnancies went to term with no complications. All babies have shown normal development. No plausible explanation relates the mechanism of action of erenumab and the serious complication that occurred in one patient. Continuous follow-up and reporting of all exposures are encouraged to gather safety data on pregnant and nursing women and on the development of the newborns. So far, immediately stopping the drug is advised and may contribute to decreasing the potential risks.
    MeSH term(s) Female ; Humans ; Infant, Newborn ; Pregnancy ; Antibodies, Monoclonal/therapeutic use ; Antibodies, Monoclonal, Humanized/adverse effects ; Calcitonin Gene-Related Peptide ; Calcitonin Gene-Related Peptide Receptor Antagonists/therapeutic use ; Treatment Outcome
    Chemical Substances Antibodies, Monoclonal ; Antibodies, Monoclonal, Humanized ; Calcitonin Gene-Related Peptide (JHB2QIZ69Z) ; Calcitonin Gene-Related Peptide Receptor Antagonists ; erenumab (I5I8VB78VT)
    Language English
    Publishing date 2022-09-23
    Publishing country United States
    Document type Case Reports ; Journal Article
    ZDB-ID 410130-3
    ISSN 1526-4610 ; 0017-8748
    ISSN (online) 1526-4610
    ISSN 0017-8748
    DOI 10.1111/head.14393
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    Zs.B 539: Show issues Location:
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  7. Article: Neurological Disease Modeling Using Pluripotent and Multipotent Stem Cells: A Key Step towards Understanding and Treating Mucopolysaccharidoses.

    Carvalho, Sofia / Santos, Juliana Inês / Moreira, Luciana / Gonçalves, Mariana / David, Hugo / Matos, Liliana / Encarnação, Marisa / Alves, Sandra / Coutinho, Maria Francisca

    Biomedicines

    2023  Volume 11, Issue 4

    Abstract: Despite extensive research, the links between the accumulation of glycosaminoglycans (GAGs) and the clinical features seen in patients suffering from various forms of mucopolysaccharidoses (MPSs) have yet to be further elucidated. This is particularly ... ...

    Abstract Despite extensive research, the links between the accumulation of glycosaminoglycans (GAGs) and the clinical features seen in patients suffering from various forms of mucopolysaccharidoses (MPSs) have yet to be further elucidated. This is particularly true for the neuropathology of these disorders; the neurological symptoms are currently incurable, even in the cases where a disease-specific therapeutic approach does exist. One of the best ways to get insights on the molecular mechanisms driving that pathogenesis is the analysis of patient-derived cells. Yet, not every patient-derived cell recapitulates relevant disease features. For the neuronopathic forms of MPSs, for example, this is particularly evident because of the obvious inability to access live neurons. This scenario changed significantly with the advent of induced pluripotent stem cell (iPSC) technologies. From then on, a series of differentiation protocols to generate neurons from iPSC was developed and extensively used for disease modeling. Currently, human iPSC and iPSC-derived cell models have been generated for several MPSs and numerous lessons were learnt from their analysis. Here we review most of those studies, not only listing the currently available MPS iPSC lines and their derived models, but also summarizing how they were generated and the major information different groups have gathered from their analyses. Finally, and taking into account that iPSC generation is a laborious/expensive protocol that holds significant limitations, we also hypothesize on a tempting alternative to establish MPS patient-derived neuronal cells in a much more expedite way, by taking advantage of the existence of a population of multipotent stem cells in human dental pulp to establish mixed neuronal and glial cultures.
    Language English
    Publishing date 2023-04-21
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2720867-9
    ISSN 2227-9059
    ISSN 2227-9059
    DOI 10.3390/biomedicines11041234
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  8. Article ; Online: Towards a scalable bioprocess for rAAV production using a HeLa stable cell line.

    Escandell, José / Moura, Filipa / Carvalho, Sofia B / Silva, Ricardo J S / Correia, Ricardo / Roldão, Antonio / Gomes-Alves, Patrícia / Alves, Paula M

    Biotechnology and bioengineering

    2023  Volume 120, Issue 9, Page(s) 2578–2587

    Abstract: The majority of recombinant adeno-associated viruses (rAAV) approved for clinical use or in clinical trials areproduced by transient transfection using the HEK293 cell line. However, this platform has several manufacturing bottlenecks at commercial ... ...

    Abstract The majority of recombinant adeno-associated viruses (rAAV) approved for clinical use or in clinical trials areproduced by transient transfection using the HEK293 cell line. However, this platform has several manufacturing bottlenecks at commercial scales namely, low product quality (full to empty capsid ratio <20% in most rAAV serotypes), lower productivities obtained after scale-up and the high cost of raw materials, in particular of Good Manufacturing Practice grade plasmid DNA required for transfection. The HeLa-based stable cell line rAAV production system provides a robust and scalable alternative to transient transfection systems. Nevertheless, the time required to generate the producer cell lines combined with the complexity of rAAV production and purification processes still pose several barriers to the use of this platform as a suitable alternative to the HEK293 transient transfection. In this work we streamlined the cell line development and bioprocessing for the HeLaS3-based production of rAAV. By exploring this optimized approach, producer cell lines were generated in 3-4 months, and presented rAAV2 volumetric production (bulk) > 3 × 10
    MeSH term(s) Humans ; Dependovirus/genetics ; Genetic Vectors ; HEK293 Cells ; HeLa Cells ; Transfection
    Language English
    Publishing date 2023-04-07
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 280318-5
    ISSN 1097-0290 ; 0006-3592
    ISSN (online) 1097-0290
    ISSN 0006-3592
    DOI 10.1002/bit.28394
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  9. Article: Leveraging rAAV bioprocess understanding and next generation bioanalytics development

    Escandell, Jose M / Pais, Daniel AM / Carvalho, Sofia B / Vincent, Karen / Gomes-Alves, Patrícia / Alves, Paula M

    Current opinion in biotechnology. 2022 Apr., v. 74

    2022  

    Abstract: Recombinant adeno-associated (rAAV) vector-based gene therapy has been the focus of intense research driven by the safety profile and several recent clinical breakthroughs. As of April 2021, there are two rAAV-based gene therapies approved and more than ... ...

    Abstract Recombinant adeno-associated (rAAV) vector-based gene therapy has been the focus of intense research driven by the safety profile and several recent clinical breakthroughs. As of April 2021, there are two rAAV-based gene therapies approved and more than two-hundred active clinical trials (approximately thirty in Phase III). However, the expected increase in demand for rAAV vectors still poses several challenges. Discussed herein are key aspects related to R&D needs and Chemistry, Manufacturing and Control (CMC) efforts required to attend this growing demand. Authors provide their perspective on strategic topics for rAAV-based therapies success: scalability and productivity; improved safety; increased process understanding combined with development of orthogonal bioanalytics that are able to identify, monitor and control Critical Quality Attributes (CQAs) during bioprocessing.
    Keywords bioprocessing ; biotechnology ; chemistry ; gene therapy ; genes
    Language English
    Dates of publication 2022-04
    Size p. 271-277.
    Publishing place Elsevier Ltd
    Document type Article
    ZDB-ID 1052045-4
    ISSN 1879-0429 ; 0958-1669
    ISSN (online) 1879-0429
    ISSN 0958-1669
    DOI 10.1016/j.copbio.2021.12.009
    Database NAL-Catalogue (AGRICOLA)

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  10. Article ; Online: Leser-Trélat sign in metastatic melanoma to pleura.

    Pereira, Raquel / Carvalho, Sofia Daniela / Cruz, João Filipe

    BMJ case reports

    2019  Volume 12, Issue 4

    MeSH term(s) Aged ; Diagnosis, Differential ; Fatal Outcome ; Female ; Humans ; Keratosis, Seborrheic/etiology ; Melanoma/pathology ; Pleural Neoplasms/pathology ; Pleural Neoplasms/secondary ; Sentinel Lymph Node Biopsy
    Language English
    Publishing date 2019-04-03
    Publishing country England
    Document type Case Reports ; Journal Article
    ISSN 1757-790X
    ISSN (online) 1757-790X
    DOI 10.1136/bcr-2018-228834
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