Article: Progenitor with cardiometabolic disorders increases food intake, systemic inflammation and gut microbiota alterations in the second-generation offspring
Food & function. 2022 Aug. 15, v. 13, no. 16
2022
Abstract: This work presents the effects of the high-fat diet (H) consumed by the progenitor (G₀) on cardiometabolic disorders and intestinal microbiota in the second-generation offspring (F₂). The rats submitted to H (G₀H) or control (C) (G₀C) diets, during ... ...
| Abstract | This work presents the effects of the high-fat diet (H) consumed by the progenitor (G₀) on cardiometabolic disorders and intestinal microbiota in the second-generation offspring (F₂). The rats submitted to H (G₀H) or control (C) (G₀C) diets, during mating, gestation and lactation, generated F₂ offspring (F₂-G₀H and F₂-G₀C, respectively), which received only the C diet. Both, G₀H and F₂-G₀H, showed changes in the intestinal microbiota, increased MAP, plasma TAG levels, adiposity index and the inflammatory process in retroperitoneal fat and in the colon shown by increased TNF-α, MCP-1, MyD88 and CAV-1 gene expression. In addition, F₂-G₀H showed increased food intake, leptin resistance, total cholesterol and plasma levels of MCP-1 and reduced adiponectin. Regarding microbial communities, a greater diversity was observed in 5 unique families of bacteria that was correlated with cardiometabolic disorders. Overall, progenitors with cardiometabolic disorders induce an increase in food intake, systemic inflammation and microbiota alterations in the F₂-G₀H offspring. |
|---|---|
| Keywords | adiponectin ; adiposity ; cholesterol ; colon ; food intake ; gene expression ; high fat diet ; inflammation ; intestinal microorganisms ; lactation ; leptin ; pregnancy ; progeny |
| Language | English |
| Dates of publication | 2022-0815 |
| Size | p. 8685-8702. |
| Publishing place | The Royal Society of Chemistry |
| Document type | Article |
| ZDB-ID | 2612033-1 |
| ISSN | 2042-650X ; 2042-6496 |
| ISSN (online) | 2042-650X |
| ISSN | 2042-6496 |
| DOI | 10.1039/d1fo02838c |
| Database | NAL-Catalogue (AGRICOLA) |
More links
Kategorien
In stock of ZB MED Bonn / Germany
| Z 7872: Show issues |
Order via subito
This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.
Inter-library loan at ZB MED
Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.