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  1. Article ; Online: Notch, RORC and IL-23 signals cooperate to promote multi-lineage human innate lymphoid cell differentiation

    Carys A. Croft / Anna Thaller / Solenne Marie / Jean-Marc Doisne / Laura Surace / Rui Yang / Anne Puel / Jacinta Bustamante / Jean-Laurent Casanova / James P. Di Santo

    Nature Communications, Vol 13, Iss 1, Pp 1-

    2022  Volume 14

    Abstract: Innate lymphoid cells (ILC) are effector cells that rapidly respond to immune evading stimuli, and despite their functional diversity arise from common precursors. Authors here show how the Notch signalling pathway orchestrates ILC development from ... ...

    Abstract Innate lymphoid cells (ILC) are effector cells that rapidly respond to immune evading stimuli, and despite their functional diversity arise from common precursors. Authors here show how the Notch signalling pathway orchestrates ILC development from circulating human ILC precursors via RORC and its target IL-23R.
    Keywords Science ; Q
    Language English
    Publishing date 2022-07-01T00:00:00Z
    Publisher Nature Portfolio
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  2. Article ; Online: STING Gain-of-Function Disrupts Lymph Node Organogenesis and Innate Lymphoid Cell Development in Mice

    Brock G. Bennion / Carys A. Croft / Teresa L. Ai / Wei Qian / Amber M. Menos / Cathrine A. Miner / Marie-Louis Frémond / Jean-Marc Doisne / Prabhakar S. Andhey / Derek J. Platt / Jennifer K. Bando / Erin R. Wang / Hella Luksch / Thierry J. Molina / Elisha D.O. Roberson / Maxim N. Artyomov / Angela Rösen-Wolff / Marco Colonna / Frédéric Rieux-Laucat /
    James P. Di Santo / Bénédicte Neven / Jonathan J. Miner

    Cell Reports, Vol 31, Iss 11, Pp 107771- (2020)

    2020  

    Abstract: Summary: STING gain-of-function causes autoimmunity and immunodeficiency in mice and STING-associated vasculopathy with onset in infancy (SAVI) in humans. Here, we report that STING gain-of-function in mice prevents development of lymph nodes and Peyer’s ...

    Abstract Summary: STING gain-of-function causes autoimmunity and immunodeficiency in mice and STING-associated vasculopathy with onset in infancy (SAVI) in humans. Here, we report that STING gain-of-function in mice prevents development of lymph nodes and Peyer’s patches. We show that the absence of secondary lymphoid organs is associated with diminished numbers of innate lymphoid cells (ILCs), including lymphoid tissue inducer (LTi) cells. Although wild-type (WT) α4β7+ progenitors differentiate efficiently into LTi cells, STING gain-of-function progenitors do not. Furthermore, STING gain-of-function impairs development of all types of ILCs. Patients with STING gain-of-function mutations have fewer ILCs, although they still have lymph nodes. In mice, expression of the STING mutant in RORγT-positive lineages prevents development of lymph nodes and reduces numbers of LTi cells. RORγT lineage-specific expression of STING gain-of-function also causes lung disease. Since RORγT is expressed exclusively in LTi cells during fetal development, our findings suggest that STING gain-of-function prevents lymph node organogenesis by reducing LTi cell numbers in mice.
    Keywords STING ; ILC ; lymphoid tissue organogenesis ; lymphopoiesis ; SAVI ; LTi cell ; Biology (General) ; QH301-705.5
    Language English
    Publishing date 2020-06-01T00:00:00Z
    Publisher Elsevier
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

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    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

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