Article ; Online: Novel active fixation lead guided by electrical delay can improve response to cardiac resynchronization therapy in heart failure.
2021 Volume 9, Issue 1, Page(s) 146–154
Abstract: Aims: Cardiac resynchronization therapy (CRT) for heart failure (HF) recently has shown optimal results by targeting electrically delayed sites in coronary sinus (CS) branches. However this purpose often cannot be reached because of unstable left ... ...
| Abstract | Aims: Cardiac resynchronization therapy (CRT) for heart failure (HF) recently has shown optimal results by targeting electrically delayed sites in coronary sinus (CS) branches. However this purpose often cannot be reached because of unstable left ventricular (LV) lead position. In current study were assessed the long-term effects of the novel active fixation LV lead in CS, guided by electrical delay (QLV), in patients with HF due to coronary artery disease. Methods: One hundred eighty-five consecutive patients underwent CRT with intraoperative evaluation of QLV in the target position of the LV lead. When the novel active fixation LV lead was available, 98 consecutive patients received it, composing the Fix group. They were compared with 87 patients with a conventional passive fixation lead (No Fix group). The final LV lead position was assessed by fluoroscopy. Clinical response to CRT was assessed within a period of about 3 years: patients experiencing HF rehospitalization and death due to HF were defined as non-responders. Results: There were no significant differences between groups in the final position of LV lead in left anterior oblique view (Pearson χ Conclusions: The novel active fixation LV lead allowed to target sites with greater QLV. Often maximum QLV was documented in basal segments, were stability of conventional passive fixation leads is not enough. Patients receiving it experienced less HF rehospitalizations and less death due to HF. Active fixation lead in CS guided by QLV can improve long-term prognosis in patients with HF due to coronary artery disease undergoing to CRT. |
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| MeSH term(s) | Cardiac Resynchronization Therapy/methods ; Cardiac Resynchronization Therapy Devices ; Heart Failure/therapy ; Heart Ventricles/diagnostic imaging ; Humans ; Treatment Outcome |
| Language | English |
| Publishing date | 2021-12-24 |
| Publishing country | England |
| Document type | Journal Article |
| ZDB-ID | 2814355-3 |
| ISSN | 2055-5822 ; 2055-5822 |
| ISSN (online) | 2055-5822 |
| ISSN | 2055-5822 |
| DOI | 10.1002/ehf2.13727 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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