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  1. Article ; Online: Detection of Rat Hepatitis E Virus in Pigs, Spain, 2023.

    Rios-Muñoz, Lucia / Gonzálvez, Moisés / Caballero-Gomez, Javier / Castro-Scholten, Sabrina / Casares-Jimenez, María / Agulló-Ros, Irene / Corona-Mata, Diana / García-Bocanegra, Ignacio / Lopez-Lopez, Pedro / Fajardo, Tomás / Mesquita, João R / Risalde, María A / Rivero-Juarez, Antonio / Rivero, Antonio

    Emerging infectious diseases

    2024  Volume 30, Issue 4, Page(s) 823–826

    Abstract: We identified rat hepatitis E virus (HEV) RNA in farmed pigs from Spain. Our results indicate that pigs might be susceptible to rat HEV and could serve as viral intermediaries between rodents and humans. Europe should evaluate the prevalence of rat HEV ... ...

    Abstract We identified rat hepatitis E virus (HEV) RNA in farmed pigs from Spain. Our results indicate that pigs might be susceptible to rat HEV and could serve as viral intermediaries between rodents and humans. Europe should evaluate the prevalence of rat HEV in farmed pigs to assess the risk to public health.
    MeSH term(s) Humans ; Rats ; Animals ; Swine ; Spain/epidemiology ; Hepatitis E virus/genetics ; Europe ; Farms ; Public Health ; RNA
    Chemical Substances RNA (63231-63-0)
    Language English
    Publishing date 2024-03-01
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1380686-5
    ISSN 1080-6059 ; 1080-6040
    ISSN (online) 1080-6059
    ISSN 1080-6040
    DOI 10.3201/eid3004.231629
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4778: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  2. Article: Butchering activity is the main risk factor for hepatitis E virus (

    Oluremi, Adeolu S / Casares-Jimenez, Maria / Opaleye, Oluyinka O / Caballero-Gomez, Javier / Ogbolu, David Olusoga / Lopez-Lopez, Pedro / Corona-Mata, Diana / Rivero-Juarez, Antonio / Rivero, Antonio

    Frontiers in microbiology

    2023  Volume 14, Page(s) 1247467

    Abstract: Introduction: Paslahepevirus balayani: Methods: A prospective cross-sectional study was carried out on a total of 752 subjects from southwestern Nigeria. In all individuals, anti-HEV IgG and anti-HEV IgM antibodies were evaluated by using ELISA ( ... ...

    Abstract Introduction: Paslahepevirus balayani
    Methods: A prospective cross-sectional study was carried out on a total of 752 subjects from southwestern Nigeria. In all individuals, anti-HEV IgG and anti-HEV IgM antibodies were evaluated by using ELISA (confirming positive results via immunoblotting), and serum viral RNA was evaluated by using two RT-PCR assays.
    Results: The overall seroprevalence of HEV IgG and HEV IgM was 14.9% (95% CI: 12.5-17.6%) and 1.3% (95% CI: 0.7-2.5%), respectively. We observed the highest seroprevalence among animal contact individuals, with butchers being the population with the highest HEV IgG seroprevalence (31.1%). Similarly, HEV IgM was higher in the animal contact group (2.2%) than in the non-animal contact cohort (0%).
    Discussions: Viral RNA was not detected in any of the samples. Butchering was significantly associated with higher HEV prevalence. Although all efforts to prevent HEV in Africa have focused on the chlorination of water, our study suggests that most new infections could currently be linked to animal manipulation. Therefore, education and guidelines must be provided in southwest Nigeria to ensure that animal handling and processing methods are safe.
    Language English
    Publishing date 2023-09-26
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2587354-4
    ISSN 1664-302X
    ISSN 1664-302X
    DOI 10.3389/fmicb.2023.1247467
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Lack of associations of microRNAs with severe NAFLD in people living with HIV: discovery case-control study.

    Frías, Mario / Corona-Mata, Diana / Moyano, Jose M / Camacho-Espejo, Angela / López-López, Pedro / Caballero-Gómez, Javier / Ruiz-Cáceres, Inmaculada / Casares-Jiménez, María / Pérez-Valero, Ignacio / Rivero-Juárez, Antonio / Rivero, Antonio

    Frontiers in endocrinology

    2023  Volume 14, Page(s) 1230046

    Abstract: Background & objective: Nonalcoholic fatty liver disease (NAFLD) is highly prevalent in people living with HIV (PLWH) and the expression of some microRNAs could be useful as biomarkers for the diagnosis of NAFLD. The aim of this study was to identify ... ...

    Abstract Background & objective: Nonalcoholic fatty liver disease (NAFLD) is highly prevalent in people living with HIV (PLWH) and the expression of some microRNAs could be useful as biomarkers for the diagnosis of NAFLD. The aim of this study was to identify patterns of differential expression of microRNAs in PLWH and assess their diagnostic value for NALFD.
    Methods: A discovery case-control study with PLWH was carried out. The expression of miRNAs was determined using HTG EdgeSeq technology. Cases were defined as patients with severe NAFLD and controls as patients without NAFLD, characterized using the controlled attenuation parameter (CAP). Cases and controls were matched 1:1 for age, sex, BMI, CD4+ lymphocyte count, active HCV infection, and ART regimen.
    Results: Serum 2,083 simultaneous microRNA transcripts were analyzed using HTG technology and compared between cases and controls. Forty-five patients, 23 cases, and 22 controls were included in the study. In the analysis of the expression pattern of the 2,083 microRNAs, no differential expression patterns were found between both groups of patients included in the study.
    Conclusion: Analysis of the microRNA transcriptome profile of nonobese PLWH with severe NAFLD did not appear to differ from that of patients without NAFLD. Thus, microRNA might not serve as a proper biomarker for predicting severe NALFD in this population.
    MeSH term(s) Humans ; Non-alcoholic Fatty Liver Disease/complications ; Non-alcoholic Fatty Liver Disease/genetics ; Non-alcoholic Fatty Liver Disease/diagnosis ; MicroRNAs/genetics ; HIV ; Case-Control Studies ; HIV Infections/complications ; HIV Infections/genetics ; Biomarkers
    Chemical Substances MicroRNAs ; Biomarkers
    Language English
    Publishing date 2023-09-22
    Publishing country Switzerland
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2592084-4
    ISSN 1664-2392
    ISSN 1664-2392
    DOI 10.3389/fendo.2023.1230046
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Rat hepatitis E virus (

    Casares-Jimenez, María / Rivero-Juarez, Antonio / Lopez-Lopez, Pedro / Montes, María Luisa / Navarro-Soler, Roser / Peraire, Joaquín / Espinosa, Nuria / Alemán-Valls, María Remedios / Garcia-Garcia, Tránsito / Caballero-Gomez, Javier / Corona-Mata, Diana / Perez-Valero, Ignacio / Ulrich, Rainer G / Rivero, Antonio

    Emerging microbes & infections

    2023  Volume 13, Issue 1, Page(s) 2295389

    Abstract: Rat hepatitis E virus (ratHEV; ... ...

    Abstract Rat hepatitis E virus (ratHEV; species
    MeSH term(s) Male ; Humans ; Animals ; Rats ; Hepatitis E virus/genetics ; Hepatitis E/epidemiology ; Hepatitis Antibodies ; RNA, Viral ; Immunoglobulin G ; HIV Infections/complications
    Chemical Substances Hepatitis Antibodies ; RNA, Viral ; Immunoglobulin G
    Language English
    Publishing date 2023-12-30
    Publishing country United States
    Document type Multicenter Study ; Journal Article
    ZDB-ID 2681359-2
    ISSN 2222-1751 ; 2222-1751
    ISSN (online) 2222-1751
    ISSN 2222-1751
    DOI 10.1080/22221751.2023.2295389
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Correlation of hepatitis E and rat hepatitis E viruses urban wastewater monitoring and clinical cases.

    Casares-Jimenez, Maria / Garcia-Garcia, Transito / Suárez-Cárdenas, José M / Perez-Jimenez, Ana B / Martín, María A / Caballero-Gómez, Javier / Michán, Carmen / Corona-Mata, Diana / Risalde, María A / Perez-Valero, Ignacio / Guerra, Rafael / Garcia-Bocanegra, Ignacio / Rivero, Antonio / Rivero-Juarez, Antonio / Garrido, Juan J

    The Science of the total environment

    2023  Volume 908, Page(s) 168203

    Abstract: Background: Wastewater pathogen monitoring is useful for surveillance of enteric pathogens. Information about the presence of Paslahepevirus balayani (HEV) and emergent Rocahepevirus ratti (RHEV) in untreated water and their correlation with clinical ... ...

    Abstract Background: Wastewater pathogen monitoring is useful for surveillance of enteric pathogens. Information about the presence of Paslahepevirus balayani (HEV) and emergent Rocahepevirus ratti (RHEV) in untreated water and their correlation with clinical cases is scarce. Aim To longitudinally monitor HEV and RHEV in wastewater and to evaluate their possible correlation with human cases.
    Methods: This study was carried out in the city of Cordoba (southern Spain) from March 2021 to March 2023. HEV and RHEV occurrence were evaluated by PCR in three sample types: i) sera from patients with acute hepatitis attended at the reference hospital, ii) liver and faeces from urban rodents, and iii) grab sewage samples collected weekly from the municipal wastewater treatment plant.
    Results: We analysed 106 untreated wastewater samples, 304 individuals with acute hepatitis, and 20 rodents. HEV and RHEV were detected in only one (0.9 %) and almost all samples (94.3 %) of wastewater samples, respectively. A total of 22 cases of acute HEV infection (7.2 %) and two cases of RHEV (0.7 %) were detected from all acute hepatitis cases observed. Only RHEV was found in rodents, with a positive frequency of 55 %. The presence of HEV in wastewater coincided with the detection of one case in which the same HEV genotype was isolated. A concentration of HEV clinical cases between June and July of 2022 was observed but not detected in water. Both RHEV clinical cases were detected in summer 2022, but no correlation was found with wastewater detection.
    Conclusions: Our study shows that there is no correlation between clinical cases and wastewater detection of HEV or RHEV.
    MeSH term(s) Humans ; Animals ; Rats ; Hepatitis E/epidemiology ; Hepatitis E virus ; Wastewater ; Water
    Chemical Substances Wastewater ; Water (059QF0KO0R)
    Language English
    Publishing date 2023-10-31
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 121506-1
    ISSN 1879-1026 ; 0048-9697
    ISSN (online) 1879-1026
    ISSN 0048-9697
    DOI 10.1016/j.scitotenv.2023.168203
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 949: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  6. Article: Global molecular diversity of Hepatitis E virus in wild boar and domestic pig

    Casares-Jimenez, Maria / Lopez-Lopez, Pedro / Caballero-Gomez, Javier / Frias, Mario / Perez-Hernando, Belen / Oluremi, Adeolu Sunday / Risalde, Maria A. / Ruiz-Caceres, Inmaculada / Opaleye, Oluyinka Oladele / Garcia-Bocanegra, Ignacio / Rivero-Juarez, Antonio / Rivero, Antonio

    One health. 2021 Dec., v. 13

    2021  

    Abstract: Our study aim was to describe and characterize the global Hepatitis E virus (HEV) molecular and genotype geographical distribution in domestic pig and wild boar, which could facilitate the traceability of human cases. We performed a systematic sequence ... ...

    Abstract Our study aim was to describe and characterize the global Hepatitis E virus (HEV) molecular and genotype geographical distribution in domestic pig and wild boar, which could facilitate the traceability of human cases. We performed a systematic sequence search for HEVs identified in domestic pig and wild boar from the available data in GenBank. Only sequences with lengths greater than 300 nt were included. For all sequences, the sequence length, host (i.e., domestic pig or wild boar), country of origin, and HEV genotype/subtype were recorded. Genotypes were assigned by the HEVnet typing tool. The genotype distributions were described by country and host. In countries with sequences available for both species, the genotype coincidences between both animal populations were analyzed. A total of 1404 viral sequences were included: 32.6% from wild boar and 67.4% from domestic pig. Most sequences were consistent with HEV genotype 3 (n = 1165). Genotype 4 was represented by 193 sequences, while genotypes 5 and 6 were represented by only 6 sequences. Sequences were identified in 39 countries, which included all continents except Antarctica. The genotypes with a wide distribution were 3a and 3f. Twenty-five countries had sequences that were found only in domestic pig, three countries only in wild boar, and 11 countries had sequences in both populations. In all countries with available sequences in both populations, the same viral genotype was identified. Our study shows that the number of swine HEV sequences is small, which limits direct comparisons with the sequences identified in humans. The global distribution of genotype 3, together with the wide distribution of genotype 4 in Asia, strongly limits the interpretation of the molecular analysis in the absence of an epidemiological survey of the cases. Increased HEV sequencing in swine should be a priority.
    Keywords Orthohepevirus A ; epidemiological studies ; genotype ; geographical distribution ; humans ; swine ; traceability ; wild boars ; Asia
    Language English
    Dates of publication 2021-12
    Publishing place Elsevier B.V.
    Document type Article
    ZDB-ID 2834831-X
    ISSN 2352-7714
    ISSN 2352-7714
    DOI 10.1016/j.onehlt.2021.100304
    Database NAL-Catalogue (AGRICOLA)

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  7. Article ; Online: Rat Hepatitis E virus ( Rocahepevirus ratti ) in people living with HIV

    Rivero-Juarez, Antonio / Casares-Jimenez, María / Lopez-Lopez, Pedro / Montes, María Luisa / Navarro-Soler, Roser / Peraire, Joaquín / Espinosa, Nuria / Alemán-Valls, María Remedios / Garcia-Garcia, Tránsito / Caballero-Gomez, Javier / Corona-Mata, Diana / Perez-Valero, Ignacio / Ulrich, Rainer G. / Rivero, Antonio

    2023  

    Abstract: Rat hepatitis E virus (ratHEV; species Rocahepevirus ratti) is considered a newly emerging cause of acute hepatitis of zoonotic origin. ratHEV infection of people living with HIV (PLWH) might portend a worse, as with hepatitis E virus (HEV; species ... ...

    Abstract Rat hepatitis E virus (ratHEV; species Rocahepevirus ratti) is considered a newly emerging cause of acute hepatitis of zoonotic origin. ratHEV infection of people living with HIV (PLWH) might portend a worse, as with hepatitis E virus (HEV; species Paslahepevirus balayani), and consequently this group may constitute a high-risk population. We aimed to evaluate the prevalence of ratHEV by measuring viral RNA and specific IgG antibodies in a large Spanish cohort of PLWH. Multicenter study conducted in Spain evaluating PLWHIV included in the Spanish AIDS Research Network (CoRIS). Patients were evaluated for ratHEV infection using PCR at baseline and anti-ratHEV IgG by dot blot analysis to evaluate exposure to ratHEV strains. Patients with detectable ratHEV RNA were followed-up to evaluate persistence of viremia and IgG seroconversion. Eight-hundred and forty-two individuals were tested. A total of 9 individuals showed specific IgG antibodies against ratHEV, supposing a prevalence of 1.1 (95% CI; 0.5%-2.1%). Of these, only one was reactive to HEV IgG antibodies by ELISA. One sample was positive for ratHEV RNA (prevalence of infection: 0.1%; 95% CI: 0.08%-0.7%). The case was a man who had sex with men exhibiting a slightly increased alanine transaminase level (49 IU/L) as only biochemical alteration. In the follow-up, the patients showed undetectable ratHEV RNA and seroconversion to specific ratHEV IgG antibodies. Our study shows that ratHEV is geographical broadly distributed in Spain, representing a potential zoonotic threat.
    Keywords article ; Text ; ddc:570 ; Hepatitis E -- rat Hepatitis E virus -- acute hepatitis -- HIV -- zoonoses -- public health
    Language English
    Publishing date 2023-12-30
    Publisher Informa UK Limited
    Publishing country de
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  8. Article: Global molecular diversity of Hepatitis E virus in wild boar and domestic pig.

    Casares-Jimenez, Maria / Lopez-Lopez, Pedro / Caballero-Gomez, Javier / Frias, Mario / Perez-Hernando, Belen / Oluremi, Adeolu Sunday / Risalde, Maria A / Ruiz-Caceres, Inmaculada / Opaleye, Oluyinka Oladele / Garcia-Bocanegra, Ignacio / Rivero-Juarez, Antonio / Rivero, Antonio

    One health (Amsterdam, Netherlands)

    2021  Volume 13, Page(s) 100304

    Abstract: Our study aim was to describe and characterize the global Hepatitis E virus (HEV) molecular and genotype geographical distribution in domestic pig and wild boar, which could facilitate the traceability of human cases. We performed a systematic sequence ... ...

    Abstract Our study aim was to describe and characterize the global Hepatitis E virus (HEV) molecular and genotype geographical distribution in domestic pig and wild boar, which could facilitate the traceability of human cases. We performed a systematic sequence search for HEVs identified in domestic pig and wild boar from the available data in GenBank. Only sequences with lengths greater than 300 nt were included. For all sequences, the sequence length, host (i.e., domestic pig or wild boar), country of origin, and HEV genotype/subtype were recorded. Genotypes were assigned by the HEVnet typing tool. The genotype distributions were described by country and host. In countries with sequences available for both species, the genotype coincidences between both animal populations were analyzed. A total of 1404 viral sequences were included: 32.6% from wild boar and 67.4% from domestic pig. Most sequences were consistent with HEV genotype 3 (
    Language English
    Publishing date 2021-08-09
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 2834831-X
    ISSN 2352-7714
    ISSN 2352-7714
    DOI 10.1016/j.onehlt.2021.100304
    Database MEDical Literature Analysis and Retrieval System OnLINE

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