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Article ; Online: Acute renal transplant rejection following nivolumab therapy for metastatic melanoma.

Tan, Brandon / Baxter, Mark / Casasola, Richard

BMJ case reports

2021 Volume 14, Issue 2

Abstract: Cancers can develop the ability to evade immune recognition and destruction. Immune checkpoint inhibitors (ICIs) are drugs targeting these immune evasion mechanisms. ICIs have significantly improved outcomes in several cancers including metastatic ... ...

Abstract	Cancers can develop the ability to evade immune recognition and destruction. Immune checkpoint inhibitors (ICIs) are drugs targeting these immune evasion mechanisms. ICIs have significantly improved outcomes in several cancers including metastatic melanoma. However, data on toxicities associated with allograft transplant recipients receiving ICI is limited. We describe a case of a 71-year-old woman who was diagnosed with metastatic melanoma 13 years after renal transplantation. She was commenced on the ICI nivolumab. She developed acute renal transplant rejection 15 days after administration of the first dose. She continues on haemodialysis but has demonstrated complete oncological response. This case demonstrates the risk of acute renal transplant rejection versus improved oncological outcomes. Patients and clinicians must consider this balance when initiating ICI therapy in allograft transplant recipients. Patients should be fully consented of the potential consequences of acute renal transplant rejection including lifelong dialysis.
MeSH term(s)	Aged ; Antineoplastic Agents, Immunological/adverse effects ; Female ; Graft Rejection/chemically induced ; Humans ; Immune Checkpoint Inhibitors/adverse effects ; Kidney Failure, Chronic/surgery ; Kidney Transplantation ; Lung Neoplasms/drug therapy ; Lung Neoplasms/secondary ; Lymphatic Metastasis ; Melanoma/drug therapy ; Melanoma/pathology ; Nivolumab/adverse effects ; Scalp/pathology ; Skin Neoplasms/drug therapy ; Skin Neoplasms/pathology ; Time Factors ; Transplantation, Homologous
Chemical Substances	Antineoplastic Agents, Immunological ; Immune Checkpoint Inhibitors ; Nivolumab (31YO63LBSN)
Language	English
Publishing date	2021-02-08
Publishing country	England
Document type	Case Reports ; Journal Article
ISSN	1757-790X
ISSN (online)	1757-790X
DOI	10.1136/bcr-2020-238037
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Article ; Online: Hydrometallurgical recycling of EV lithium-ion batteries: Effects of incineration on the leaching efficiency of metals using sulfuric acid.

Vieceli, Nathália / Casasola, Raquel / Lombardo, Gabriele / Ebin, Burçak / Petranikova, Martina

Waste management (New York, N.Y.)

2021 Volume 125, Page(s) 192–203

Abstract: The growing demand for lithium-ion batteries will result in an increasing flow of spent batteries, which must be recycled to prevent environmental and health problems, while helping to mitigate the raw materials dependence and risks of shortage and ... ...

Abstract	The growing demand for lithium-ion batteries will result in an increasing flow of spent batteries, which must be recycled to prevent environmental and health problems, while helping to mitigate the raw materials dependence and risks of shortage and promoting a circular economy. Combining pyrometallurgical and hydrometallurgical recycling approaches has been the focus of recent studies, since it can bring many advantages. In this work, the effects of incineration on the leaching efficiency of metals from EV LIBs were evaluated. The thermal process was applied as a pre-treatment for the electrode material, aiming for carbothermic reduction of the valuable metals by the graphite contained in the waste. Leaching efficiencies above 70% were obtained for Li, Mn, Ni and Co after 60 min of leaching even when using 0.5 M sulfuric acid, which can be linked to the formation of more easily leachable compounds during the incineration process. When the incineration temperature was increased (600-700 °C), the intensity of graphite signals decreased and other oxides were identified, possibly due to the increase in oxidative conditions. Higher leaching efficiencies of Mn, Ni, Co, and Li were reached at lower temperatures of incineration (400-500 °C) and at higher leaching times, which could be related to the partial carbothermic reduction of the metals.
MeSH term(s)	Electric Power Supplies ; Incineration ; Lithium ; Recycling ; Sulfuric Acids
Chemical Substances	Sulfuric Acids ; Lithium (9FN79X2M3F) ; sulfuric acid (O40UQP6WCF)
Language	English
Publishing date	2021-03-08
Publishing country	United States
Document type	Journal Article
ZDB-ID	2001471-5
ISSN	1879-2456 ; 0956-053X
ISSN (online)	1879-2456
ISSN	0956-053X
DOI	10.1016/j.wasman.2021.02.039
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Article ; Online: Influencia de la hiperfrecuentación en las reconsultas en urgencias.

Cortés-Rodríguez, B / Alférez-Reyes, M / Castro, P / Casasola, R / Sánchez, F / Lozano, A

Journal of healthcare quality research

2019 Volume 34, Issue 3, Page(s) 157–158

Title translation	Influence of frequent users of the emergency departments on unscheduled revisits.
MeSH term(s)	Emergency Service, Hospital/statistics & numerical data ; Facilities and Services Utilization/statistics & numerical data ; Humans ; Patient Acceptance of Health Care/statistics & numerical data ; Retrospective Studies
Language	Spanish
Publishing date	2019-03-13
Publishing country	Spain
Document type	Letter
ISSN	2603-6479
ISSN (online)	2603-6479
DOI	10.1016/j.jhqr.2019.01.002
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Article: Devitrification behavior and preferred crystallization mechanism of glasses based on fluorrichterite (Na2CaMg5Si8O22F2) composition

Casasola, R / J.M. Pérez / M. Romero

Thermochimica acta. 2015 Nov. 10, v. 619

2015

Abstract: This paper reports on the effect of different contents of fluorine on the thermal stability of glasses in the SiO2–MgO–CaO–Na2O–F system. Four glass compositions, with experimental fluorine contents varying from 2.12 to 4.39wt.%, were studied using ... ...

Abstract	This paper reports on the effect of different contents of fluorine on the thermal stability of glasses in the SiO2–MgO–CaO–Na2O–F system. Four glass compositions, with experimental fluorine contents varying from 2.12 to 4.39wt.%, were studied using differential scanning calorimetry (DSC). The devitrification behavior was assessed through the evaluation of both the glass stability (GS) and glass-forming ability (GFA) using different parameters calculated from the characteristic temperatures in non-isothermal DSC curves. The predominant crystallization mechanism was determined by the difference in the crystallization temperature (ΔTp) between fine and coarse glass samples. The results indicate that the studied melts exhibit a low tendency to devitrify during cooling, although this trend is increased with the fluorine content. The glass thermal stability is affected by the particle size, with it being easier to crystallize a glass powder sample than a coarse glass sample. The surface crystallization mechanism is predominant at the beginning of the devitrification process; however, the volume crystallization acquires importance with an increase in the fluorine content.
Keywords	cooling ; crystallization ; differential scanning calorimetry ; fluorine ; glass ; melting ; particle size ; temperature ; thermal stability
Language	English
Dates of publication	2015-1110
Size	p. 32-40.
Publishing place	Elsevier B.V.
Document type	Article
ZDB-ID	1500974-9
ISSN	0040-6031
ISSN	0040-6031
DOI	10.1016/j.tca.2015.09.014
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Article: Hypophysitis induced by immune checkpoint inhibitors in a Scottish melanoma population.

Wei, Khor Zhong / Baxter, Mark / Casasola, Richard

Melanoma management

2019 Volume 6, Issue 1, Page(s) MMT13

Abstract: Aim: This study aims to determine the incidence of all immune-mediated adverse events (IMAEs) with a focus on hypophysitis in patients with metastatic melanoma receiving immune checkpoint inhibitors (ICI).: Methods: 51 patients with metastatic ... ...

Abstract	Aim: This study aims to determine the incidence of all immune-mediated adverse events (IMAEs) with a focus on hypophysitis in patients with metastatic melanoma receiving immune checkpoint inhibitors (ICI). Methods: 51 patients with metastatic melanoma who received immune checkpoint inhibitors (ipilimumab, pembrolizumab and nivolumab) in Ninewells Hospital, Dundee between 2014 and 2018 were identified. Patient demographic data and outcomes were recorded retrospectively. Results: A total of 6 patients (11.7%) developed hypophysitis, while 15 patients (29.4%) developed IMAEs. A significant improvement in overall survival (p = 0.03) and progression-free survival (p = 0.041) was seen in patients who developed IMAEs compared with those who did not. Conclusion: This study demonstrates a high rate of hypophysitis in melanoma patients receiving ipilimumab. Careful monitoring of symptoms is crucial to detect and appropriately manage IMAEs.
Language	English
Publishing date	2019-04-15
Publishing country	England
Document type	Journal Article
ISSN	2045-0885
ISSN	2045-0885
DOI	10.2217/mmt-2018-0009
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Article ; Online: Head and neck cancer.

Casasola, R J

The journal of the Royal College of Physicians of Edinburgh

2010 Volume 40, Issue 4, Page(s) 343–5; quiz 345

Abstract: Head and neck cancer is traditionally thought of as being a disease associated with alcohol and tobacco abuse and deprivation. It was the fourth most common cancer in males in Scotland in 2000 and just over 1,000 cases were diagnosed in 2007. As smoking ... ...

Abstract	Head and neck cancer is traditionally thought of as being a disease associated with alcohol and tobacco abuse and deprivation. It was the fourth most common cancer in males in Scotland in 2000 and just over 1,000 cases were diagnosed in 2007. As smoking becomes less prevalent, a fall in the incidence of head and neck cancer could be anticipated; however, increasing evidence of other aetiological factors contributing to the diagnosis of head and neck cancer, particularly oropharyngeal cancer in non-smoking, little-drinking populations, is impacting on that perception. This review will aim to look at current aetiological factors for head and neck cancer, along with current therapeutic modalities in treatment of this disease.
MeSH term(s)	Female ; Head and Neck Neoplasms/therapy ; Head and Neck Neoplasms/virology ; Humans ; Male ; Oropharyngeal Neoplasms/virology ; Papillomavirus Infections/complications ; Treatment Outcome ; Tumor Virus Infections/complications
Language	English
Publishing date	2010-12
Publishing country	Scotland
Document type	Journal Article ; Review
ZDB-ID	2866363-9
ISSN	2042-8189 ; 0953-0932
ISSN (online)	2042-8189
ISSN	0953-0932
DOI	10.4997/JRCPE.2010.423
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Article: Electrospinning of poly(lactic acid): Theoretical approach for the solvent selection to produce defectâfree nanofibers

Casasola, Raffaella / Noreen L. Thomas / Stella Georgiadou

Journal of polymer science. 2016 Aug. 1, v. 54, no. 15

2016

Abstract: In this study an integrated methodology was proposed for the selection of solvent systems to produce electrospinnable solutions that form defectâfree poly(lactic acid) (PLA) fibers with narrow diameter distributions. The solvent systems were chosen ... ...

Abstract	In this study an integrated methodology was proposed for the selection of solvent systems to produce electrospinnable solutions that form defectâfree poly(lactic acid) (PLA) fibers with narrow diameter distributions. The solvent systems were chosen using a thermodynamic approach, combined with electrical and rheological property criteria. More specifically, the three step methodology includes (1) initial choice of solvent by solubility evaluation to meet thermodynamic criteria, (2) electrical properties, that is, conductivity and dielectric constant adjustment by using solvent mixtures to meet electrical property criteria, and (3) critical entanglement concentration (Câ) determination by viscosity measurements, supported by elastic and plastic moduli measurements, followed by concentration adjustment to meet rheological criteria. All three criteria need to be met to ensure defectâfree nanofiber morphology. The methodology was demonstrated using PLA solutions that were characterized in terms of thermodynamic properties, conductivity, surface tension, and viscosity measurements. These data were analyzed and related to the nanofiber morphology and diameter as determined from scanning electron microscopy (SEM). Measurements of the elastic (Gâ²) and the plastic (Gâ³) moduli of PLA solutions showed a sharp increase of Gâ² at the chain entanglement concentration. Â© 2016 Wiley Periodicals, Inc. J. Polym. Sci., Part B: Polym. Phys. 2016, 54, 1483â1498
Keywords	electrical properties ; nanofibers ; polylactic acid ; scanning electron microscopy ; solubility ; solvents ; surface tension ; thermodynamics ; viscosity
Language	English
Dates of publication	2016-0801
Size	p. 1483-1498.
Publishing place	John Wiley & Sons, Ltd
Document type	Article
Note	JOURNAL ARTICLE
ZDB-ID	1473448-5
ISSN	1099-0488 ; 0887-6266
ISSN (online)	1099-0488
ISSN	0887-6266
DOI	10.1002/polb.24042
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Article ; Online: Complete response in a melanoma patient treated with imatinib.

Brown, M C / Casasola, R J

The Journal of laryngology and otology

2012 Volume 126, Issue 6, Page(s) 638–640

Abstract: Background: Imatinib therapy has been successful in gastrointestinal stromal tumours containing mutation of the KIT gene. However, there are few reported cases of successful imatinib therapy in patients with melanoma containing KIT gene mutation or c- ... ...

Abstract	Background: Imatinib therapy has been successful in gastrointestinal stromal tumours containing mutation of the KIT gene. However, there are few reported cases of successful imatinib therapy in patients with melanoma containing KIT gene mutation or c-kit protein expression. Methods and results: A 52-year-old man developed metastatic melanoma from a primary melanoma in the left side of the nasopharynx. The tumour was positive for c-kit protein, and there was a KIT mutation in exon 11. He was treated with imatinib. A follow-up scan one year later showed a complete response. Treatment targeting the biological characteristics of melanoma proved successful in this patient.
MeSH term(s)	Antineoplastic Agents/administration & dosage ; Antineoplastic Agents/therapeutic use ; Benzamides ; Exons/genetics ; Gene Expression ; Humans ; Imatinib Mesylate ; Male ; Melanoma/drug therapy ; Melanoma/genetics ; Melanoma/secondary ; Middle Aged ; Mutation/genetics ; Nasopharyngeal Neoplasms/genetics ; Nasopharyngeal Neoplasms/pathology ; Nasopharyngeal Neoplasms/radiotherapy ; Neoplasm Staging ; Piperazines/administration & dosage ; Piperazines/therapeutic use ; Proto-Oncogene Proteins c-kit/genetics ; Pyrimidines/administration & dosage ; Pyrimidines/therapeutic use ; Remission Induction ; Treatment Outcome
Chemical Substances	Antineoplastic Agents ; Benzamides ; Piperazines ; Pyrimidines ; Imatinib Mesylate (8A1O1M485B) ; Proto-Oncogene Proteins c-kit (EC 2.7.10.1)
Language	English
Publishing date	2012-06
Publishing country	England
Document type	Case Reports ; Journal Article
ZDB-ID	218299-3
ISSN	1748-5460 ; 0022-2151
ISSN (online)	1748-5460
ISSN	0022-2151
DOI	10.1017/S0022215112000527
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Article ; Online: Biological therapy of salivary duct carcinoma.

Nashed, M / Casasola, R J

The Journal of laryngology and otology

2009 Volume 123, Issue 2, Page(s) 250–252

Abstract: Background: The incidence of human epidermal growth factor receptor 2 positivity in salivary duct carcinoma ranges from 25 to 100 per cent and is associated with a poor outcome. Salivary duct carcinoma has significant pathological similarities to ductal ...

Abstract	Background: The incidence of human epidermal growth factor receptor 2 positivity in salivary duct carcinoma ranges from 25 to 100 per cent and is associated with a poor outcome. Salivary duct carcinoma has significant pathological similarities to ductal carcinoma of the breast. Methods and results: A 49-year-old man developed lung and liver metastasis a few months after surgery and adjuvant radiotherapy for salivary duct carcinoma of the parotid gland. There was no response to palliative chemotherapy with doxorubicin. We followed the biological model of breast cancer, whereby two-thirds of human epidermal growth factor receptor 2 positive patients respond to a combination of docetaxel and human epidermal growth factor receptor 2 blocker (trastuzumab). A durable, complete response was achieved with this combination. A rationalised treatment approach targeting the biological characteristics of salivary duct carcinoma had proven successful.
MeSH term(s)	Antibodies, Monoclonal/administration & dosage ; Antibodies, Monoclonal, Humanized ; Antineoplastic Combined Chemotherapy Protocols/therapeutic use ; Carcinoma, Ductal/drug therapy ; Carcinoma, Ductal/radiotherapy ; Combined Modality Therapy/methods ; Humans ; Liver Neoplasms/drug therapy ; Liver Neoplasms/secondary ; Lung Neoplasms/drug therapy ; Lung Neoplasms/secondary ; Lymphatic Metastasis/diagnosis ; Lymphatic Metastasis/radiotherapy ; Male ; Middle Aged ; Neoplasm Recurrence, Local ; Parotid Neoplasms/drug therapy ; Parotid Neoplasms/radiotherapy ; Taxoids/administration & dosage ; Trastuzumab ; Treatment Outcome
Chemical Substances	Antibodies, Monoclonal ; Antibodies, Monoclonal, Humanized ; Taxoids ; docetaxel (15H5577CQD) ; Trastuzumab (P188ANX8CK)
Language	English
Publishing date	2009-02
Publishing country	England
Document type	Case Reports ; Journal Article
ZDB-ID	218299-3
ISSN	1748-5460 ; 0022-2151
ISSN (online)	1748-5460
ISSN	0022-2151
DOI	10.1017/S0022215108002314
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Article: Study on the adsorption of chromium (VI) by hydrolyzed keratin/polyamide 6 blend nanofibres.

Aluigi, Annalisa / Tonetti, Cinzia / Vineis, Claudia / Varesano, Alessio / Tonin, Claudio / Casasola, Raffaella

Journal of nanoscience and nanotechnology

2012 Volume 12, Issue 9, Page(s) 7250–7259

Abstract: In this study, nanofibre mats for chemical adsorption of heavy metals were prepared by electrospinning blends of hydrolyzed keratin (HK) and polyamide 6 (PA6) in formic acid. Viscosity measurements of the spinning solutions and morphological analyses of ... ...

Abstract	In this study, nanofibre mats for chemical adsorption of heavy metals were prepared by electrospinning blends of hydrolyzed keratin (HK) and polyamide 6 (PA6) in formic acid. Viscosity measurements of the spinning solutions and morphological analyses of the fracture sections of the same polymer blends cast into films, suggested intermolecular interactions and good compatibility between HK and PA6. The mats made of continuous randomly oriented blend nanofilaments of HK/PA6 50/50 wt, with a mean diameter of about 200 nm, were tested as chromium (VI) ion adsorbents. The parameters investigated included initial chromium ion concentration, pH, contact time and adsorbent dosage. The maximum adsorption capacity occurred at acidic pH. The pseudo-first order, the pseudo-second order and the intraparticle diffusion models were used to describe the kinetics of adsorption process. It was found that kinetic data fit the pseudo-second order model and follow the intraparticle diffusion model, although diffusion is not the only rate control step. Adsorption data fit well the Freundlich isotherm model and the maximum adsorption capacity was found 55.9 mg/g. Moreover, the mean free energy (E) of adsorption ranges between 8 and 16 kJ/mol, so that the adsorption mechanism for HK-based nanofibres was explained as an ion-exchange process.
Language	English
Publishing date	2012-08-10
Publishing country	United States
Document type	Journal Article
ISSN	1533-4880
ISSN	1533-4880
DOI	10.1166/jnn.2012.6491
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