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  1. AU="Cascorbi, Ingolf"
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  1. Book ; Online ; E-Book: Precision medicine

    Cascorbi, Ingolf / Schwab, Matthias

    (Handbook of experimental pharmacology ; 280)

    2023  

    Author's details Ingolf Cascorbi, Matthias Schwab editors
    Series title Handbook of experimental pharmacology ; 280
    Collection
    Keywords Pharmacology ; Internal medicine ; Cancer
    Language English
    Size 1 Online-Ressource (x, 283 Seiten), Illustrationen, Diagramme
    Publisher Springer
    Publishing place Cham
    Publishing country Switzerland
    Document type Book ; Online ; E-Book
    Remark Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
    HBZ-ID HT030370305
    ISBN 978-3-031-40047-6 ; 9783031400469 ; 3-031-40047-X ; 3031400461
    DOI 10.1007/978-3-031-40047-6
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

    Full text online

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  2. Book ; Online ; E-Book: Medikamenten-Pocket Schmerztherapie

    Cascorbi, Ingolf / Sorge, Jürgen / Strumpf, Michael

    2018  

    Author's details Ingolf Cascorbi, Jürgen Sorge, Michael Strumpf
    Keywords Pain Medicine ; Family medicine
    Subject code 616.0472
    Language German
    Size 1 Online-Ressource (VI, 120 Seiten)
    Edition 2. überarbeitete Auflage
    Publisher Springer
    Publishing place Berlin
    Publishing country Germany
    Document type Book ; Online ; E-Book
    Remark Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
    HBZ-ID HT019851360
    ISBN 978-3-662-57844-5 ; 9783662578438 ; 3-662-57844-1 ; 3662578433
    DOI 10.1007/978-3-662-57844-5
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  3. Article ; Online: Clinical Pharmacology of Cannabinoid Therapeutics: Drug Interactions and Side Effects.

    Cascorbi, Ingolf

    Clinical pharmacology and therapeutics

    2023  Volume 114, Issue 5, Page(s) 943–946

    MeSH term(s) Humans ; Cannabinoids/adverse effects ; Drug-Related Side Effects and Adverse Reactions ; Drug Interactions ; Iatrogenic Disease ; Pharmacology ; Pharmacology, Clinical
    Chemical Substances Cannabinoids
    Language English
    Publishing date 2023-10-13
    Publishing country United States
    Document type Editorial
    ZDB-ID 123793-7
    ISSN 1532-6535 ; 0009-9236
    ISSN (online) 1532-6535
    ISSN 0009-9236
    DOI 10.1002/cpt.3037
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 20: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  4. Article ; Online: Why is There Still Debate About Recommending DPYD-Testing Before Fluoropyrimidine Treatment?

    Cascorbi, Ingolf

    Clinical pharmacology and therapeutics

    2023  Volume 114, Issue 4, Page(s) 733–737

    Language English
    Publishing date 2023-09-29
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 123793-7
    ISSN 1532-6535 ; 0009-9236
    ISSN (online) 1532-6535
    ISSN 0009-9236
    DOI 10.1002/cpt.3016
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Jg. 1995 - 2021: Lesesall (1.OG)
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  5. Article ; Online: The Uncertainties of Metamizole Use.

    Cascorbi, Ingolf

    Clinical pharmacology and therapeutics

    2021  Volume 109, Issue 6, Page(s) 1373–1375

    MeSH term(s) Anti-Inflammatory Agents, Non-Steroidal/adverse effects ; Dipyrone/adverse effects ; Humans ; Uncertainty
    Chemical Substances Anti-Inflammatory Agents, Non-Steroidal ; Dipyrone (6429L0L52Y)
    Language English
    Publishing date 2021-05-26
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 123793-7
    ISSN 1532-6535 ; 0009-9236
    ISSN (online) 1532-6535
    ISSN 0009-9236
    DOI 10.1002/cpt.2258
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 20: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  6. Article: Polypharmazie – Interaktionen bei älteren Menschen

    Cascorbi, Ingolf

    Aktuelle Kardiologie

    2022  Volume 11, Issue 06, Page(s) 532–536

    Abstract: Thrombozytenaggregationshemmer und Antikoagulanzien sind wichtige Standardmedikationen in der Prophylaxe und Therapie kardiovaskulärer Erkrankungen. Die oft multiple Medikation und durch zusätzliche Begleiterkrankungen notwendige weitere ... ...

    Abstract Thrombozytenaggregationshemmer und Antikoagulanzien sind wichtige Standardmedikationen in der Prophylaxe und Therapie kardiovaskulärer Erkrankungen. Die oft multiple Medikation und durch zusätzliche Begleiterkrankungen notwendige weitere Medikation birgt besonders bei älteren Patienten ein hohes Risiko von Arzneimittelwechselwirkungen. Diese können das Blutungsrisiko oder im Fall des Wirkungsverlusts das Risiko thromboembolischer Ereignisse erhöhen. In diesem Artikel werden klinisch relevante Interaktionen von COX-Hemmern (COX: Cyclooxygenase) und Adenosinrezeptorantagonisten sowie von Vitamin-K-Antagonisten und direkten oralen Antikoagulanzien (DOAK) wie auch Strategien zur Vermeidung unerwünschter Wirkungen diskutiert.
    Keywords P-Glycoprotein ; Blutungsereignis ; Thromboembolie ; Interaktionen ; Arzneistoffmetabolismus ; drug metabolism ; P-glycoprotein ; bleeding events ; thromboembolism ; interactions
    Language German
    Publishing date 2022-12-01
    Publisher Georg Thieme Verlag KG
    Publishing place Stuttgart ; New York
    Document type Article
    ZDB-ID 2654127-0
    ISSN 2193-5211 ; 2193-5203
    ISSN (online) 2193-5211
    ISSN 2193-5203
    DOI 10.1055/a-1911-8015
    Database Thieme publisher's database

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    Zs.A 6986: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    ab Jg. 2022: Lesesaal (EG)

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  7. Article: Molecular Mechanisms of Tyrosine Kinase Inhibitor Resistance in Chronic Myeloid Leukemia.

    Kaehler, Meike / Cascorbi, Ingolf

    Handbook of experimental pharmacology

    2023  Volume 280, Page(s) 65–83

    Abstract: The hematopoietic neoplasm chronic myeloid leukemia (CML) is a rare disease caused by chromosomal reciprocal translocation t(9;22)(q34:q11) with subsequent formation of the BCR-ABL1 fusion gene. This fusion gene encodes a constitutively active tyrosine ... ...

    Abstract The hematopoietic neoplasm chronic myeloid leukemia (CML) is a rare disease caused by chromosomal reciprocal translocation t(9;22)(q34:q11) with subsequent formation of the BCR-ABL1 fusion gene. This fusion gene encodes a constitutively active tyrosine kinase, which results in malignant transformation of the cells. Since 2001, CML can be effectively treated using tyrosine kinase inhibitors (TKIs) such as imatinib, which prevent phosphorylation of downstream targets by blockade of the BCR-ABL kinase. Due to its tremendous success, this treatment became the role model of targeted therapy in precision oncology. Here, we review the mechanisms of TKI resistance focusing on BCR-ABL1-dependent and -independent mechanisms. These include the genomics of the BCR-ABL1, TKI metabolism and transport and alternative signaling pathways.
    MeSH term(s) Humans ; Tyrosine Kinase Inhibitors ; Fusion Proteins, bcr-abl/genetics ; Fusion Proteins, bcr-abl/metabolism ; Drug Resistance, Neoplasm/genetics ; Precision Medicine ; Protein Kinase Inhibitors/pharmacology ; Protein Kinase Inhibitors/therapeutic use ; Leukemia, Myelogenous, Chronic, BCR-ABL Positive/drug therapy ; Leukemia, Myelogenous, Chronic, BCR-ABL Positive/genetics
    Chemical Substances Tyrosine Kinase Inhibitors ; Fusion Proteins, bcr-abl (EC 2.7.10.2) ; Protein Kinase Inhibitors
    Language English
    Publishing date 2023-03-07
    Publishing country Germany
    Document type Review ; Journal Article
    ISSN 0171-2004
    ISSN 0171-2004
    DOI 10.1007/164_2023_639
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Sign. bis Bd. 125 (1997): 1982 A 2146: Show issues
     danach: Sign. bei den Einzelbänden: Show issues

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  8. Article ; Online: Drug Interactions of Tetrahydrocannabinol and Cannabidiol in Cannabinoid Drugs.

    Herdegen, Thomas / Cascorbi, Ingolf

    Deutsches Arzteblatt international

    2023  Volume 120, Issue 49, Page(s) 833–840

    Abstract: Background: Cannabinoid drugs containing tetrahydrocannabinol (THC), or its structural analogues, as monotherapeutic agents or as extracts or botanical preparations with or without cannabidiol (CBD) are often prescribed to multimorbid patients who are ... ...

    Abstract Background: Cannabinoid drugs containing tetrahydrocannabinol (THC), or its structural analogues, as monotherapeutic agents or as extracts or botanical preparations with or without cannabidiol (CBD) are often prescribed to multimorbid patients who are taking multiple drugs. This raises the question of the risk of drug interactions.
    Methods: This review of the pharmacokinetics and pharmacodynamics of interactions with cannabinoid drugs and their potential effects is based on pertinent publications retrieved by a selective literature search.
    Results: As THC and CBD are largely metabolized in the liver, their bioavailability after oral or oral-mucosal administration is low (6-8% and 11-13%, respectively). The plasma concentrations of THC and its active metabolite 11-OH-THC can be increased by strong CYP3A4 inhibitors (verapamil, clarithromycin) and decreased by strong CYP3A4 inductors (rifampicin, carbamazepine). The clinical significance of these effects is unclear because of the variable plasma level and therapeutic spectrum of THC. The metabolism of CBD is less dependent on cytochrome P450 enzymes than that of THC. THC and CBD inhibit CYP2C and CYP3A4; the corresponding clinically relevant drug interactions probably are likely to arise only with THC doses above 30 mg/day and CBD doses above 300 mg/day.
    Conclusion: Potential drug interactions with THC and CBD are probably of little importance at low or moderate doses. Strong CYP inhibitors or inductors can intensify or weaken their effect. Slowly ramping up the dose of oral cannabinoid drugs can lessen their pharmacodynamic interactions, which can generally be well controlled. Administration by inhalation can worsen the interactions.
    MeSH term(s) Humans ; Cannabinoids ; Cannabidiol/pharmacokinetics ; Dronabinol/pharmacology ; Pharmaceutical Preparations ; Cytochrome P-450 CYP3A ; Drug Interactions
    Chemical Substances Cannabinoids ; Cannabidiol (19GBJ60SN5) ; Dronabinol (7J8897W37S) ; Pharmaceutical Preparations ; Cytochrome P-450 CYP3A (EC 1.14.14.1)
    Language English
    Publishing date 2023-10-24
    Publishing country Germany
    Document type Journal Article ; Review
    ZDB-ID 2406159-1
    ISSN 1866-0452 ; 1866-0452
    ISSN (online) 1866-0452
    ISSN 1866-0452
    DOI 10.3238/arztebl.m2023.0223
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Challenges in Neuropharmacology.

    Cascorbi, Ingolf

    Clinical pharmacology and therapeutics

    2019  Volume 105, Issue 5, Page(s) 1050–1053

    MeSH term(s) Drug Discovery/trends ; Humans ; Inventions ; Mental Disorders/drug therapy ; Mental Disorders/metabolism ; Molecular Biology/trends ; Nervous System Diseases/drug therapy ; Nervous System Diseases/metabolism ; Neuropharmacology/methods ; Neuropharmacology/trends ; Neuropsychiatry/trends ; Signal Transduction/drug effects
    Language English
    Publishing date 2019-04-15
    Publishing country United States
    Document type Editorial ; Introductory Journal Article
    ZDB-ID 123793-7
    ISSN 1532-6535 ; 0009-9236
    ISSN (online) 1532-6535
    ISSN 0009-9236
    DOI 10.1002/cpt.1407
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 20: Show issues Location:
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  10. Book ; Thesis: Genetische Polymorphismen Fremdstoff-metabolisierender Enzyme und ihre Assoziation zu Karzinomen des Respirationstraktes

    Cascorbi, Ingolf

    1999  

    Author's details von Ingolf Cascorbi
    Language German
    Size 62 Bl., graph. Darst., 30 cm
    Publishing country Germany
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Berlin, Humboldt-Univ., Habil.-Schr., 1999
    HBZ-ID HT013172942
    Database Catalogue ZB MED Medicine, Health

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    Shelf markLoan statusLocation
    2001 MB 2903 order for loan Magazin

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