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  1. Book ; Online: Can the COVID-19 epidemic be controlled on the basis of daily test reports?

    Casella, Francesco

    2020  

    Abstract: This paper studies if and to which extent COVID-19 epidemics can be controlled by authorities taking decisions on public health measures on the basis of daily reports of swab test results, active cases and total cases. A suitably simplified process model ...

    Abstract This paper studies if and to which extent COVID-19 epidemics can be controlled by authorities taking decisions on public health measures on the basis of daily reports of swab test results, active cases and total cases. A suitably simplified process model is derived to support the controllability analysis, highlighting the presence of very significant time delay; the model is validated with data from several outbreaks. The analysis shows that suppression strategies can be effective if strong enough and enacted early on. It also shows how mitigation strategies can fail because of the combination of delay, unstable dynamics, and uncertainty in the feedback loop; approximate conditions based on the theory of limitation of linear control are given for feedback control to be feasible.

    Comment: 6 pages double-column + 1 page of supplementary material. 6-page paper resubmitted to IEEE Control Systems Letters after first peer review
    Keywords Physics - Physics and Society ; Electrical Engineering and Systems Science - Systems and Control ; Quantitative Biology - Populations and Evolution ; covid19
    Publishing date 2020-03-15
    Publishing country us
    Document type Book ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  2. Article ; Online: Can the COVID-19 epidemic be controlled on the basis of daily test reports?

    Casella, Francesco

    Abstract: This paper studies if and to which extent COVID-19 epidemics can be controlled by authorities taking decisions on public health measures on the basis of daily reports of swab test results, active cases and total cases. A suitably simplified process model ...

    Abstract This paper studies if and to which extent COVID-19 epidemics can be controlled by authorities taking decisions on public health measures on the basis of daily reports of swab test results, active cases and total cases. A suitably simplified process model is derived to support the controllability analysis, highlighting the presence of very significant time delay; the model is validated with data from several outbreaks. The analysis shows that suppression strategies can be effective if strong enough and enacted early on. It also shows how mitigation strategies can fail because of the combination of delay, unstable dynamics, and uncertainty in the feedback loop; approximate conditions based on the theory of limitation of linear control are given for feedback control to be feasible.
    Keywords covid19
    Publisher ArXiv
    Document type Article ; Online
    DOI 10.1109/lcsys.2020.3009912
    Database COVID19

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  3. Article ; Online: Can the COVID-19 epidemic be controlled on the basis of daily test reports?

    Casella, Francesco

    2020  

    Keywords covid19
    Language English
    Publishing country it
    Document type Article ; Online
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  4. Article ; Online: I Will Be at Your (Bed)Side - The Role of Bedside Echocardiography for Non-Cardiologists.

    Casella, Francesco / Schiavon, Riccardo / Ceriani, Elisa / Cogliati, Chiara

    Ultraschall in der Medizin (Stuttgart, Germany : 1980)

    2020  Volume 41, Issue 4, Page(s) 362–386

    Abstract: As the availability of portable echocardiographic equipment is becoming more and more widespread, physicians can add a powerful tool to their bedside examination skills, thus helping them to more effectively face the growing complexity of patients ... ...

    Title translation Ich bin an Ihrer (Bett-) Seite. Die Rolle der bettseitigen Echokardiografie für Nicht-Kardiologen.
    Abstract As the availability of portable echocardiographic equipment is becoming more and more widespread, physicians can add a powerful tool to their bedside examination skills, thus helping them to more effectively face the growing complexity of patients admitted to internal medicine departments or the emergency room. Focused cardiac ultrasound (FoCUS) can be defined as a goal-directed, simplified, qualitative examination performed at the bedside using portable echocardiographic devices. FoCUS is not meant to be a substitute for a standard 2D color Doppler echocardiographic examination. Nevertheless, it can provide rapid and reliable information when limited to basic questions, even when performed by non-cardiologists with brief training. Furthermore, a focused cardiac ultrasound examination maximizes its diagnostic role when integrated with an ultrasonographic assessment of the lung, abdomen and deep veins, in a multisystem approach that is particularly dear to internists. In this article, we will focus on the specific targets of a focused cardiac ultrasound examination, as well as the most common pitfalls that can be encountered in ultrasonographic practice. We will also address the application of FoCUS in the management of two typical scenarios in clinical practice, such as dyspnea and non-post-traumatic hypotension.
    MeSH term(s) Echocardiography ; Emergency Service, Hospital ; Humans ; Physicians ; Point-of-Care Systems ; Ultrasonography
    Language English
    Publishing date 2020-08-04
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 801064-x
    ISSN 1438-8782 ; 1439-0914 ; 1431-4894 ; 0172-4614
    ISSN (online) 1438-8782
    ISSN 1439-0914 ; 1431-4894 ; 0172-4614
    DOI 10.1055/a-1198-4980
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: Multifocal Humeral Fractures: Clinical Results, Functional Outcomes and Flowchart of Surgical Treatment.

    Scaglione, Michelangelo / Casella, Francesco / Ipponi, Edoardo / Agretti, Federico / Polloni, Simone / Giuntoli, Michele / Marchetti, Stefano

    Strategies in trauma and limb reconstruction

    2022  Volume 17, Issue 2, Page(s) 81–87

    Abstract: Aim and objective: Multifocal fractures of the humerus are rare. The aim of our study is to evaluate the effectiveness of surgical treatment and propose a modification to the Maresca-Pascarella classification. A flowchart for surgical treatment is ... ...

    Abstract Aim and objective: Multifocal fractures of the humerus are rare. The aim of our study is to evaluate the effectiveness of surgical treatment and propose a modification to the Maresca-Pascarella classification. A flowchart for surgical treatment is provided.
    Materials and methods: Thirty-one patients with multifocal humeral fractures were treated and evaluated. The Maresca-Pascarella classification was used. All were treated using with either plates and screws, external fixation or intramedullary nailing. Functional outcomes were evaluated using the QuickDASH test, the University of California - Los Angeles (UCLA) shoulder score and the Mayo elbow performance score (MEPS).
    Results: There were 12 Type A, 17 Type B, 1 Type C and 1 of combined fractures of the proximal and distal epiphysis. Of the 31 patients, 5 were lost to the follow-up (FU), 1 died of pulmonary embolism (PE) and the remaining 25 had a mean FU of 19.8 (7-35) months. Three patients had radial nerve damage and 1 went to a non-union that required further surgical intervention. The mean QuickDASH score was 15.7, the average UCLA shoulder score was 26.3 and the mean MEPS elbow score resulted to be 83.0.
    Conclusion: Although multifocal fractures are severe injuries, patients are able to recover good functionality if treated judiciously.
    Clinical significance: We proposed a standardised surgical approach based on the fracture characteristics, site and a modified Maresca-Pascarella classification.
    How to cite this article: Scaglione M, Casella F, Ipponi E,
    Language English
    Publishing date 2022-08-17
    Publishing country India
    Document type Journal Article
    ZDB-ID 2387508-2
    ISSN 1828-8928 ; 1828-8936
    ISSN (online) 1828-8928
    ISSN 1828-8936
    DOI 10.5005/jp-journals-10080-1559
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  6. Article ; Online: A Multiple Emergency Ventilator as Backup Solution in Pandemic: A Specifically Designed and Dimensioned Device.

    Baselli, Giuseppe / Fiore, Gianfranco / Casella, Francesco / Cinquemani, Simone / Vigano, Roberto / Pesenti, Antonio / Zanella, Alberto

    IEEE open journal of engineering in medicine and biology

    2022  Volume 3, Page(s) 41–46

    Abstract: Goal: ...

    Abstract Goal:
    Language English
    Publishing date 2022-02-18
    Publishing country United States
    Document type Journal Article
    ISSN 2644-1276
    ISSN (online) 2644-1276
    DOI 10.1109/OJEMB.2022.3152673
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Two-years chest-CT follow-up after severe COVID-19 pneumonia.

    Flor, Nicola / Leidi, Federica / Casella, Francesco / Mariani, Leonardo / Piazza, Mattia / Del Medico, Marta / Cogliati, Chiara Beatrice

    Internal and emergency medicine

    2023  Volume 18, Issue 4, Page(s) 1243–1245

    MeSH term(s) Humans ; COVID-19 ; Follow-Up Studies ; Tomography, X-Ray Computed ; Lung ; Thorax ; Retrospective Studies
    Language English
    Publishing date 2023-03-16
    Publishing country Italy
    Document type Letter ; Comment
    ZDB-ID 2454173-4
    ISSN 1970-9366 ; 1828-0447
    ISSN (online) 1970-9366
    ISSN 1828-0447
    DOI 10.1007/s11739-023-03250-7
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  8. Article ; Online: Integrated short peripheral intravenous cannulas and risk of catheter failure: A systematic review and meta-analysis.

    Gidaro, Antonio / Quici, Massimiliano / Giustivi, Davide / Pinelli, Fulvio / Samartin, Federica / Casella, Francesco / Cogliati, Chiara / Rizzi, Giulia / Salvi, Emanuele / Bartoli, Arianna / Foschi, Antonella / Castelli, Roberto / Calloni, Maria / Gemma, Marco

    The journal of vascular access

    2024  , Page(s) 11297298231218468

    Abstract: Background: Short peripheral catheters (SPCs) are used to provide intravenous therapies in hospitalized patients. Recently, the category of SPC has become more complex, with the introduction in clinical practice of "integrated" SPCs (ISPCs), renewed ... ...

    Abstract Background: Short peripheral catheters (SPCs) are used to provide intravenous therapies in hospitalized patients. Recently, the category of SPC has become more complex, with the introduction in clinical practice of "integrated" SPCs (ISPCs), renewed regarding the material (polyurethane rather than polytetrafluoroethylene) and design (large wing; pre-assembled extension; preassembled needle-free connector (NFC)).
    Methods: This systematic review and meta-analysis aimed to analyze randomized controlled trials (RCTs) and quasi-randomized studies in hospitalized patients, analyzing the risk of overall catheter failure as well as the risk of each type of complication (occlusion, infiltration, thrombophlebitis, and dislodgement) for ISPCs compared to non-integrated SPCs. These systematic review and meta-analysis were registered on PROSPERO (CRD42022322970).
    Data sources: We searched PUBMED
    Results: included studies: The research identified 1260 articles. After the abstract review, 13 studies were included for full manuscript review and, after that, six papers (4727 patients) were included in the meta-analysis.
    Description of the effect: We found a significantly reduced risk of catheter failure (pooling all complications) for ISPCs compared to SPCs (
    Conclusions: ISPCs significantly reduce the risks of catheter failure (overall complications) and occlusion. More RCTs are needed to understand if the preassembled ISPC is better than the composted closed system (non-integrated SPC + extension line + NFC).
    Language English
    Publishing date 2024-01-02
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2252820-9
    ISSN 1724-6032 ; 1129-7298
    ISSN (online) 1724-6032
    ISSN 1129-7298
    DOI 10.1177/11297298231218468
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  9. Book ; Conference proceedings ; Online: Proceedings of the 7th International Modelica Conference, September 20 - 22, 2009, Grand Hotel di Como, Como, Italy

    Casella, Francesco

    (Linköping electronic conference proceedings)

    2009  

    Institution Modelica Association
    Politecnico di Milano
    Event/congress International Modelica Conference (7Como:2009.09.20-22)
    Author's details Francesco Casella, ed., organized by The Modelica Association and Politecnico di Milano
    Series title Linköping electronic conference proceedings
    Language English
    Size Online-Ressource (912 S., 1 PDF)
    Publisher Univ. Electronic Press
    Publishing place Linköping
    Document type Book ; Conference proceedings ; Online
    ISBN 9789173935135 ; 9173935131
    DOI 10.3384/ecp0943
    Database Library catalogue of the German National Library of Science and Technology (TIB), Hannover

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  10. Article ; Online: Lung ultrasound in the follow-up of severe COVID-19 pneumonia: six months evaluation and comparison with CT.

    Russo, Giulia / Flor, Nicola / Casella, Francesco / Ippolito, Sonia / Leidi, Federica / Casazza, Giovanni / Radovanovic, Dejan / Vezzulli, Federico / Santus, Pierachille / Cogliati, Chiara

    Internal and emergency medicine

    2022  Volume 17, Issue 8, Page(s) 2261–2268

    Abstract: While lung ultrasonography (LUS) proved to be a useful diagnostic and prognostic tool in acute phase of COVID 19 pneumonia, its role in detecting long-term pulmonary sequelae has yet to be explored. In our prospective observational study we assessed the ... ...

    Abstract While lung ultrasonography (LUS) proved to be a useful diagnostic and prognostic tool in acute phase of COVID 19 pneumonia, its role in detecting long-term pulmonary sequelae has yet to be explored. In our prospective observational study we assessed the potential of LUS in detecting the presence of computed tomography (CT) fibrotic-like changes after 6 months from COVID-19 pneumonia. Patients who were discharged with a diagnosis of severe COVID-19 pneumonia were enrolled. After 6 months from hospital discharge they underwent LUS, chest CT scan and pulmonary function tests. A logistic regression analysis was performed to assess the association between presence of symptoms, LUS score and diffusing capacity for carbon monoxide (DLCO) at 6-month after hospital discharge and CT scan fibrotic-like changes. A second logistic model was performed to assess the value of some predefined baseline factors (age, sex, worst PaO2/FiO2, ventilator support, worst CRP value, worst D-dimer value and worst LUS score during hospitalization) to predict fibrotic-like changes on 6-month CT scan. Seventy-four patients were enrolled in the study. Twenty-four (32%) showed lung abnormalities suitable for fibrotic-like changes. At multivariate logistic regression analysis LUS score after 6 months from acute disease was significantly associated with fibrotic-like pattern on CT scan. The second logistic model showed that D-dimer value was the only baseline predictive variable of fibrotic-like changes at multivariate analysis. LUS performed after 6 months from severe COVID-19 pneumonia may be a promising tool for detection and follow-up of pulmonary fibrotic sequelae.
    MeSH term(s) Humans ; COVID-19/diagnostic imaging ; Follow-Up Studies ; Lung/diagnostic imaging ; Ultrasonography/methods ; Tomography, X-Ray Computed/methods
    Language English
    Publishing date 2022-09-14
    Publishing country Italy
    Document type Observational Study ; Journal Article
    ZDB-ID 2454173-4
    ISSN 1970-9366 ; 1828-0447
    ISSN (online) 1970-9366
    ISSN 1828-0447
    DOI 10.1007/s11739-022-03084-9
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