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  1. Article ; Online: Sudden unexpected death in a middle-aged woman.

    Casimero, Faye Victoria C / Patalas, Eva D / Stone, James R

    Journal of clinical pathology

    2024  Volume 77, Issue 5, Page(s) 297–300

    MeSH term(s) Middle Aged ; Female ; Humans ; Death, Sudden/etiology ; Risk Factors ; Cause of Death
    Language English
    Publishing date 2024-04-18
    Publishing country England
    Document type Journal Article
    ZDB-ID 80261-x
    ISSN 1472-4146 ; 0021-9746
    ISSN (online) 1472-4146
    ISSN 0021-9746
    DOI 10.1136/jcp-2022-208691
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Duration of SARS-CoV-2 mRNA vaccine persistence and factors associated with cardiac involvement in recently vaccinated patients.

    Krauson, Aram J / Casimero, Faye Victoria C / Siddiquee, Zakir / Stone, James R

    NPJ vaccines

    2023  Volume 8, Issue 1, Page(s) 141

    Abstract: At the start of the COVID-19 pandemic, the BNT162b2 (BioNTech-Pfizer) and mRNA-1273 (Moderna) mRNA vaccines were expediently designed and mass produced. Both vaccines produce the full-length SARS-CoV-2 spike protein for gain of immunity and have greatly ... ...

    Abstract At the start of the COVID-19 pandemic, the BNT162b2 (BioNTech-Pfizer) and mRNA-1273 (Moderna) mRNA vaccines were expediently designed and mass produced. Both vaccines produce the full-length SARS-CoV-2 spike protein for gain of immunity and have greatly reduced mortality and morbidity from SARS-CoV-2 infection. The distribution and duration of SARS-CoV-2 mRNA vaccine persistence in human tissues is unclear. Here, we developed specific RT-qPCR-based assays to detect each mRNA vaccine and screened lymph nodes, liver, spleen, and myocardium from recently vaccinated deceased patients. Vaccine was detected in the axillary lymph nodes in the majority of patients dying within 30 days of vaccination, but not in patients dying more than 30 days from vaccination. Vaccine was not detected in the mediastinal lymph nodes, spleen, or liver. Vaccine was detected in the myocardium in a subset of patients vaccinated within 30 days of death. Cardiac ventricles in which vaccine was detected had healing myocardial injury at the time of vaccination and had more myocardial macrophages than the cardiac ventricles in which vaccine was not detected. These results suggest that SARS-CoV-2 mRNA vaccines routinely persist up to 30 days from vaccination and can be detected in the heart.
    Language English
    Publishing date 2023-09-27
    Publishing country England
    Document type Journal Article
    ISSN 2059-0105
    ISSN (online) 2059-0105
    DOI 10.1038/s41541-023-00742-7
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  3. Article ; Online: Wild-type Transthyretin Amyloid Deposition in an Ascending Aortic Aneurysm.

    Hoteit, Abbas / Casimero, Faye Victoria C / Stone, James R / Cameron, Duke / Isselbacher, Eric M / Seyedsadjadi, Reza / Gaggin, Hanna K

    JACC. Case reports

    2024  Volume 29, Issue 9, Page(s) 102311

    Abstract: Amyloid deposition in aortic tissue is associated with increased stiffness. We report a patient with ascending aortic aneurysm and chronic abdominal aortic dissection who had significant wild-type transthyretin amyloid deposition on surgical pathology. ... ...

    Abstract Amyloid deposition in aortic tissue is associated with increased stiffness. We report a patient with ascending aortic aneurysm and chronic abdominal aortic dissection who had significant wild-type transthyretin amyloid deposition on surgical pathology. The patient did not have cardiac involvement on further workup.
    Language English
    Publishing date 2024-03-28
    Publishing country Netherlands
    Document type Journal Article
    ISSN 2666-0849
    ISSN (online) 2666-0849
    DOI 10.1016/j.jaccas.2024.102311
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Researching COVID to enhance recovery (RECOVER) tissue pathology study protocol: Rationale, objectives, and design.

    Troxel, Andrea B / Bind, Marie-Abele C / Flotte, Thomas J / Cordon-Cardo, Carlos / Decker, Lauren A / Finn, Aloke V / Padera, Robert F / Reichard, R Ross / Stone, James R / Adolphi, Natalie L / Casimero, Faye Victoria C / Crary, John F / Elifritz, Jamie / Faustin, Arline / Ghosh, Saikat Kumar B / Krausert, Amanda / Martinez-Lage, Maria / Melamed, Jonathan / Mitchell, Roger A /
    Sampson, Barbara A / Seifert, Alan C / Simsir, Aylin / Adams, Cheryle / Haasnoot, Stephanie / Hafner, Stephanie / Siciliano, Michelle A / Vallejos, Brittany B / Del Boccio, Phoebe / Lamendola-Essel, Michelle F / Young, Chloe E / Kewlani, Deepshikha / Akinbo, Precious A / Parent, Brendan / Chung, Alicia / Cato, Teresa C / Mudumbi, Praveen C / Esquenazi-Karonika, Shari / Wood, Marion J / Chan, James / Monteiro, Jonathan / Shinnick, Daniel J / Thaweethai, Tanayott / Nguyen, Amber N / Fitzgerald, Megan L / Perlowski, Alice A / Stiles, Lauren E / Paskett, Moira L / Katz, Stuart D / Foulkes, Andrea S

    PloS one

    2024  Volume 19, Issue 1, Page(s) e0285645

    Abstract: Importance: SARS-CoV-2 infection can result in ongoing, relapsing, or new symptoms or organ dysfunction after the acute phase of infection, termed Post-Acute Sequelae of SARS-CoV-2 (PASC), or long COVID. The characteristics, prevalence, trajectory and ... ...

    Abstract Importance: SARS-CoV-2 infection can result in ongoing, relapsing, or new symptoms or organ dysfunction after the acute phase of infection, termed Post-Acute Sequelae of SARS-CoV-2 (PASC), or long COVID. The characteristics, prevalence, trajectory and mechanisms of PASC are poorly understood. The objectives of the Researching COVID to Enhance Recovery (RECOVER) tissue pathology study (RECOVER-Pathology) are to: (1) characterize prevalence and types of organ injury/disease and pathology occurring with PASC; (2) characterize the association of pathologic findings with clinical and other characteristics; (3) define the pathophysiology and mechanisms of PASC, and possible mediation via viral persistence; and (4) establish a post-mortem tissue biobank and post-mortem brain imaging biorepository.
    Methods: RECOVER-Pathology is a cross-sectional study of decedents dying at least 15 days following initial SARS-CoV-2 infection. Eligible decedents must meet WHO criteria for suspected, probable, or confirmed infection and must be aged 18 years or more at the time of death. Enrollment occurs at 7 sites in four U.S. states and Washington, DC. Comprehensive autopsies are conducted according to a standardized protocol within 24 hours of death; tissue samples are sent to the PASC Biorepository for later analyses. Data on clinical history are collected from the medical records and/or next of kin. The primary study outcomes include an array of pathologic features organized by organ system. Causal inference methods will be employed to investigate associations between risk factors and pathologic outcomes.
    Discussion: RECOVER-Pathology is the largest autopsy study addressing PASC among US adults. Results of this study are intended to elucidate mechanisms of organ injury and disease and enhance our understanding of the pathophysiology of PASC.
    MeSH term(s) Adult ; Humans ; COVID-19 ; SARS-CoV-2 ; Cross-Sectional Studies ; Post-Acute COVID-19 Syndrome ; Disease Progression ; Risk Factors
    Language English
    Publishing date 2024-01-10
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2267670-3
    ISSN 1932-6203 ; 1932-6203
    ISSN (online) 1932-6203
    ISSN 1932-6203
    DOI 10.1371/journal.pone.0285645
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Researching COVID to enhance recovery (RECOVER) autopsy tissue pathology study protocol: Rationale, objectives, and design

    Troxel, Andrea B. / Bind, Marie-Abele C. / Flotte, Thomas J. / Cordon-Cardo, Carlos / Decker, Lauren A. / Finn, Aloke V. / Padera, Robert F. / Reichard, R. Ross / Stone, James R. / Adolphi, Natalie L. / Casimero, Faye Victoria C. / Crary, John F. / Elifritz, Jamie / Faustin, Arline / Ghosh, Saikat Kumar B. / Krausert, Amanda / Martinez-Lage, Maria / Melamed, Jonathan / Mitchell, Roger A. /
    Sampson, Barbara A. / Seifert, Alan C. / Simsir, Aylin / Adams, Cheryle / Haasnoot, Stephanie / Hafner, Stephanie / Siciliano, Michelle A. / Vallejos, Brittany B. / Boccio, Phoebe Del / Lamendola-Essel, Michelle F. / Young, Chloe E. / Kewlani, Deepshikha / Akinbo, Precious A. / Parent, Brendan / Chung, Alicia / Cato, Teresa C. / Mudumbi, Praveen C. / Esquenazi-Karonika, Shari / Wood, Marion J. / Chan, James / Monteiro, Jonathan / Shinnick, Daniel J. / Thaweethai, Tanayott / Nguyen, Amber N. / Fitzgerald, Megan L. / Perlowski, Alice A. / Stiles, Lauren E. / Paskett, Moira L. / Katz, Stuart D. / Foulkes, Andrea S.

    medRxiv

    Abstract: Importance: SARS-CoV-2 infection can result in ongoing, relapsing, or new symptoms or organ dysfunction after the acute phase of infection, termed Post-Acute Sequelae of SARS-CoV-2 (PASC), or long COVID. The characteristics, prevalence, trajectory and ... ...

    Abstract Importance: SARS-CoV-2 infection can result in ongoing, relapsing, or new symptoms or organ dysfunction after the acute phase of infection, termed Post-Acute Sequelae of SARS-CoV-2 (PASC), or long COVID. The characteristics, prevalence, trajectory and mechanisms of PASC are poorly understood. The objectives of the Researching COVID to Enhance Recovery (RECOVER) Tissue Pathology Study (RECOVER-Pathology) are to: (1) characterize prevalence and types of organ injury/disease and pathology occurring with PASC; (2) characterize the association of pathologic findings with clinical and other characteristics; (3) define the pathophysiology and mechanisms of PASC, and possible mediation via viral persistence; and (4) establish a post-mortem tissue biobank and post-mortem brain imaging biorepository. Methods: RECOVER-Pathology is a cross-sectional study of decedents dying at least 15 days following initial SARS-CoV-2 infection. Eligible decedents must meet WHO criteria for suspected, probable, or confirmed infection and must be aged 18 years or more at the time of death. Enrollment occurs at 7 sites in four U.S. states and Washington, DC. Comprehensive autopsies are conducted according to a standardized protocol within 24 hours of death; tissue samples are sent to the PASC Biorepository for later analyses. Data on clinical history are collected from the medical records and/or next of kin. The primary study outcomes include an array of pathologic features organized by organ system.  Casual inference methods will be employed to investigate associations between risk factors and pathologic outcomes. Discussion: RECOVER-Pathology is the largest autopsy study addressing PASC among US adults. Results of this study are intended to elucidate mechanisms of organ injury and disease and enhance our understanding of the pathophysiology of PASC.
    Keywords covid19
    Language English
    Publishing date 2023-05-04
    Publisher Cold Spring Harbor Laboratory Press
    Document type Article ; Online
    DOI 10.1101/2023.04.27.23289234
    Database COVID19

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  6. Article ; Online: Researching COVID to enhance recovery (RECOVER) autopsy study protocol: Rationale, objectives, and design

    Troxel, Andrea B. / Bind, Marie-Abele C. / Flotte, Thomas J. / Cordon-Cardo, Carlos / Decker, Lauren A. / Finn, Aloke V. / Padera, Robert F. / Reichard, R. Ross / Stone, James R. / Adolphi, Natalie L. / Casimero, Faye Victoria C. / Crary, John F. / Elifritz, Jamie / Faustin, Arline / Ghosh, Saikat Kumar B. / Krausert, Amanda / Martinez-Lage, Maria / Melamed, Jonathan / Mitchell, Roger A. /
    Sampson, Barbara A. / Seifert, Alan C. / Simsir, Aylin / Adams, Cheryle / Haasnoot, Stephanie / Hafner, Stephanie / Siciliano, Michelle A. / Vallejos, Brittany / Del Boccio, Phoebe / Lamendola-Essel, Michelle F. / Young, Chloe E. / Kewlani, Deepshikha / Akinbo, Precious A. / Parent, Brendan / Chung, Alicia / Cato, Teresa C. / Mudumbi, Praveen C. / Esquenazi-Karonika, Shari / Wood, Marion J. / Chan, James / Monteiro, Jonathan / Shinnick, Daniel J. / Thaweethai, Tanayott / Nguyen, Amber N. / Fitzgerald, Megan L. / Perlowski, Alice A. / Stiles, Lauren E. / Paskett, Moira L. / Katz, Stuart D. / Foulkes, Andrea S. / RECOVER Initiative

    medRxiv

    Abstract: Importance: SARS-CoV-2 infection can result in ongoing, relapsing, or new symptoms or organ dysfunction after the acute phase of infection, termed Post-Acute Sequelae of SARS-CoV-2 (PASC), or long COVID. The characteristics, prevalence, trajectory and ... ...

    Abstract Importance: SARS-CoV-2 infection can result in ongoing, relapsing, or new symptoms or organ dysfunction after the acute phase of infection, termed Post-Acute Sequelae of SARS-CoV-2 (PASC), or long COVID. The characteristics, prevalence, trajectory and mechanisms of PASC are poorly understood. The objectives of the Researching COVID to Enhance Recovery (RECOVER) Tissue Pathology Study (RECOVER-Pathology) are to: (1) characterize prevalence and types of organ injury/disease and pathology occurring with PASC; (2) characterize the association of pathologic findings with clinical and other characteristics; (3) define the pathophysiology and mechanisms of PASC, and possible mediation via viral persistence; and (4) establish a post-mortem tissue biobank and post-mortem brain imaging biorepository. Methods: RECOVER-Pathology is a cross-sectional study of decedents dying at least 15 days following initial SARS-CoV-2 infection. Eligible decedents must meet WHO criteria for suspected, probable, or confirmed infection and must be aged 18 years or more at the time of death. Enrollment occurs at 7 sites in four U.S. states and Washington, DC. Comprehensive autopsies are conducted according to a standardized protocol within 24 hours of death; tissue samples are sent to the PASC Biorepository for later analyses. Data on clinical history are collected from the medical records and/or next of kin. The primary study outcomes include an array of pathologic features organized by organ system.  Casual inference methods will be employed to investigate associations between risk factors and pathologic outcomes. Discussion: RECOVER-Pathology is the largest autopsy study addressing PASC among US adults. Results of this study are intended to elucidate mechanisms of organ injury and disease and enhance our understanding of the pathophysiology of PASC.
    Keywords covid19
    Language English
    Publishing date 2023-05-04
    Publisher Cold Spring Harbor Laboratory Press
    Document type Article ; Online
    DOI 10.1101/2023.04.27.23289234
    Database COVID19

    Full text online

    Kategorien

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