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  1. Article ; Online: The pharmacotherapeutic management of allergic rhinitis in people with asthma.

    Klimek, Ludger / Werminghaus, Pascal / Casper, Ingrid / Cuevas, Mandy

    Expert opinion on pharmacotherapy

    2024  Volume 25, Issue 1, Page(s) 101–111

    Abstract: Introduction: Up to 90% of asthmatic patients have comorbid allergic rhinitis (AR). Although appropriate therapy of AR can improve asthma symptoms and management, AR is often underdiagnosed and under-treated in asthmatics.A non-systematic literature ... ...

    Abstract Introduction: Up to 90% of asthmatic patients have comorbid allergic rhinitis (AR). Although appropriate therapy of AR can improve asthma symptoms and management, AR is often underdiagnosed and under-treated in asthmatics.A non-systematic literature research was conducted on AR as a comorbidity and risk factor of asthma. Latest international publications in medical databases, international guidelines, and the Internet were reviewed.
    Areas covered: Based on the conducted literature research there is proved evidence of the necessity of diagnosis and treatment of AR in patients with asthma because it affects health care utilization. Therefore, it is recommended in national and global guidelines.
    Expert opinion: AR increases the risk of asthma development and contributes to the severity of an existing asthma. Early treatment of AR with drugs as intranasal steroids, antihistamines, leukotriene receptor antagonists, and especially allergen-specific immunotherapy can reduce the risk of asthma development and the concomitant medication use in addition to severity of symptoms in AR and asthma.
    MeSH term(s) Humans ; Rhinitis, Allergic/drug therapy ; Asthma/drug therapy ; Histamine Antagonists/therapeutic use ; Comorbidity ; Steroids/therapeutic use
    Chemical Substances Histamine Antagonists ; Steroids
    Language English
    Publishing date 2024-02-01
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2001535-5
    ISSN 1744-7666 ; 1465-6566
    ISSN (online) 1744-7666
    ISSN 1465-6566
    DOI 10.1080/14656566.2024.2307476
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  2. Article: [No title information]

    Dramburg, Stephanie / Matricardi, Paolo / Casper, Ingrid / Klimek, Ludger

    Allergo Journal : interdisziplinare Zeitschrift fur Allergologie und Umweltmedizin : Organ der Deutschen Gesellschaft fur Allergie- und Immunitatsforschung

    2021  Volume 30, Issue 6, Page(s) 49–53

    Title translation Nutzung telemedizinischer Anwendungen durch niedergelassene Allergologen vor und während der SARS-CoV-2-Pandemie: Eine Umfrage unter Mitgliedern des Ärzteverbandes Deutscher Allergologen (AeDA).
    Language German
    Publishing date 2021-09-24
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 1136943-7
    ISSN 0941-8849
    ISSN 0941-8849
    DOI 10.1007/s15007-021-4866-x
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  3. Article ; Online: Eosinophil granulocytes in chronic inflammatory respiratory diseases and CRSwNP: Function, immunological basis, and clinical significance.

    Klimek, Felix / Bergmann, Christoph / Hagemann, Jan / Cuevas, Mandy / Becker, Sven / Pfaar, Oliver / Casper, Ingrid / Klimek, Ludger

    Allergologie select

    2024  Volume 8, Page(s) 40–50

    Abstract: Introduction: Eosinophils play an important regulatory and immunomodulatory role in airway mucosa and have antiparasitic and antiviral properties as well as pro-inflammatory effects that may also cause persistence of inflammation with tissue remodeling. ...

    Abstract Introduction: Eosinophils play an important regulatory and immunomodulatory role in airway mucosa and have antiparasitic and antiviral properties as well as pro-inflammatory effects that may also cause persistence of inflammation with tissue remodeling. The number of eosinophils and the detection of specific mediators in biological samples from, e.g., blood, nasal secretions, and bronchial fluid can serve as biomarkers that reflect the underlying pathophysiology of certain diseases, predict treatment success, and detect therapy effects.
    Materials and methods: A literature search was conducted to determine the immunologic basis, mode of action, clinical significance, and available evidence for therapeutic approaches using eosinophil-targeted monoclonal antibodies by searching Medline, Pubmed, and the national and international trial database (ClinicalTrials.gov) and guideline registries as well as the Cochrane Library. Human studies published on the topic in the period up to and including 10/2023 were considered.
    Results: Based on the international literature and previous experience, the results are summarized, and recommendations are given.
    Conclusion: The important role of eosinophils in immunological processes in the airway mucosa is comprehensively analyzed and can serve as a basis for current and future treatment approaches.
    Language English
    Publishing date 2024-03-21
    Publishing country Germany
    Document type Journal Article ; Review
    ZDB-ID 2893503-2
    ISSN 2512-8957 ; 2512-8957
    ISSN (online) 2512-8957
    ISSN 2512-8957
    DOI 10.5414/ALX02469E
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: EGPA: Eosinophilic granulomatosis with polyangiitis (Churg-Strauss syndrome) as a special presentation of chronic rhinosinusitis with nasal polyps (CRSwNP).

    Hagemann, Jan / Laudien, Martin / Becker, Sven / Cuevas, Mandy / Klimek, Felix / Kianfar, Roya / Casper, Ingrid / Klimek, Ludger

    Allergologie select

    2024  Volume 8, Page(s) 18–25

    Abstract: Introduction: Eosinophilic granulomatosis with polyangiitis (EGPA) was formerly known as Churg-Strauss syndrome. The condition is characterized by disseminated necrotizing vasculitis with extravascular granulomas associated with hypereosinophilia. The ... ...

    Abstract Introduction: Eosinophilic granulomatosis with polyangiitis (EGPA) was formerly known as Churg-Strauss syndrome. The condition is characterized by disseminated necrotizing vasculitis with extravascular granulomas associated with hypereosinophilia. The vasculitides affect small vessels and are associated with antineutrophil cytoplasmic antibodies (ANCAs) detectable in the blood. Distinguishing between type 2-mediated chronic airway inflammation such as chronic rhinosinusitis with nasal polyps (CRSwNP) without vasculitis can be clinically challenging and should be considered.
    Materials and methods: Immunological background, diagnosis, and therapy of EGPA were identified through literature searches in Medline, PubMed, as well as national and international studies (ClinicalTrials.gov) and the Cochrane Library. Human studies published up to and including 10/2023 on the topic were considered.
    Results: In cases of deteriorating general health with previously known eosinophilic inflammation of the upper and lower airways, EGPA and its interdisciplinary investigation should be considered. Various types of eosinophilic inflammation and syndromes must be considered differentially.
    Conclusion: Characterization of mucosal airway inflammation through biomarker determination is meaningful and occasionally makes the difference for targeted therapy.
    Language English
    Publishing date 2024-03-21
    Publishing country Germany
    Document type Journal Article ; Review
    ZDB-ID 2893503-2
    ISSN 2512-8957 ; 2512-8957
    ISSN (online) 2512-8957
    ISSN 2512-8957
    DOI 10.5414/ALX02475E
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  5. Article: Use of telemedicine by practising allergists before and during the SARS-CoV-2 pandemic: A survey among members of the Association of German Allergists (AeDA).

    Dramburg, Stephanie / Matricardi, Paolo Maria / Casper, Ingrid / Klimek, Ludger

    Allergo journal international

    2021  Volume 30, Issue 6, Page(s) 193–197

    Abstract: Background: The severe acute respiratory syndrome coronavirus type 2 (SARS-CoV-2) pandemic presented unprecedented challenges to both inpatient and outpatient care. In order to maintain good care under necessary contact restrictions, especially in the ... ...

    Abstract Background: The severe acute respiratory syndrome coronavirus type 2 (SARS-CoV-2) pandemic presented unprecedented challenges to both inpatient and outpatient care. In order to maintain good care under necessary contact restrictions, especially in the outpatient sector, the use of telemedical applications was demanded and promoted. The exploratory survey among members of the Association of German Allergists (AeDA) was intended to show how these were received among allergists in private practice.
    Methods: The survey was restricted to actively practising members of the AeDA who had previously given their consent to receive such surveys (
    Results: In all, 76 specialists with additional qualification in allergology took part in the survey. Of these, 71 completed the full questionnaire. Before the start of the pandemic-related contact restrictions, 46.5% (33/71) stated that they had used telemedicine in their clinical practice. This number increased to 73.2% (52/71) after 31 January 2020. The largest increase (4.3% vs. 15.6%) was seen in the area of video consultations. Furthermore, 43/76 participants can imagine integrating telemedicine services into their daily clinical routine in the future.
    Conclusion: The use of telemedical services, especially video consultations, increased significantly during the SARS-CoV‑2 pandemic in Germany. The majority of respondents perceive the implementation as positive and can imagine continuing to use telemedical methods after the end of the pandemic.
    Language English
    Publishing date 2021-06-11
    Publishing country Germany
    Document type Journal Article
    ISSN 2197-0378
    ISSN 2197-0378
    DOI 10.1007/s40629-021-00175-5
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  6. Book ; Online ; Thesis: Analysen zur Expression proinflammatorischer Mediatoren in humanen Zellkulturmodellen und murinen Tiermodellen chronisch-inflammatorischer Erkrankungen

    Casper, Ingrid [Verfasser]

    2013  

    Author's details Ingrid Casper
    Keywords Biowissenschaften, Biologie ; Life Science, Biology
    Subject code sg570
    Language German
    Publisher Universitätsbibliothek Mainz
    Publishing place Mainz
    Document type Book ; Online ; Thesis
    Database Digital theses on the web

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  7. Article ; Online: Allergietherapie und Allergie-Immuntherapie im Kindesalter.

    Klimek, Ludger / Chaker, Adam M / Casper, Ingrid / Sperl, Annette / Strieth, Sebastian / Mösges, Ralph

    Laryngo- rhino- otologie

    2020  Volume 99, Issue 1, Page(s) 56–66

    Abstract: Adequate diagnostical workup for respiratory allergies and consequent therapy in children determine the individual course of disease. Therapy consists first of symptomatic treatment and includes in the next step the important option of allergy ... ...

    Title translation Therapy of Allergies and Allergy Immunotherapy in Children.
    Abstract Adequate diagnostical workup for respiratory allergies and consequent therapy in children determine the individual course of disease. Therapy consists first of symptomatic treatment and includes in the next step the important option of allergy immunotherapy (AIT) as a causative treatment of disease. Children are an important target group for AIT, since AIT offers a proven longterm effect including secondary preventive properties with not only transiently reduced symptoms but moreover longstanding and beneficial disease modification.New strategies with AIT as primary and secondary preventive interventions are being evaluated with the aim to reduce clinical appearance and the amount and extent of sensitizations to allergens in high-risk children. Until implementation of such potentially preventive strategies the currently more attractive early intervention is the early adoption of AIT within the first 12 to 24 months of onset of symptoms as a first-line treatment of allergic rhinitis.Simplified treatment protocols can improve the willingness to perform an AIT and the adherence and compliance of children and their parents. The overall goal is to make AIT as the most important treatment modality available to more affected children.
    MeSH term(s) Allergens ; Child ; Desensitization, Immunologic ; Humans ; Immunologic Factors ; Immunotherapy ; Rhinitis, Allergic ; Secondary Prevention
    Chemical Substances Allergens ; Immunologic Factors
    Language German
    Publishing date 2020-01-14
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 96005-6
    ISSN 1438-8685 ; 0340-1588 ; 0935-8943
    ISSN (online) 1438-8685
    ISSN 0340-1588 ; 0935-8943
    DOI 10.1055/a-0899-1202
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    Ul II Zs.95: Show issues Location:
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  8. Book ; Online: Allergen immunotherapy in house dust mite-associated allergic rhinitis

    Klimek, Ludger / Brehler, Randolf B.S. / Casper, Ingrid / Klimek, Felix / Hagemann, Jan Hendrik / Cuevas, Mandy / Bergmann, Karl-Christian

    efficacy of the 300 IR mite tablet

    2023  

    Abstract: 10 ... 17 ... Background: A perennial house dust mite-associated allergic rhinitis has a major impact on the quality of life of patients and is associated with a high socioeconomic burden. The most common symptoms of allergic rhinitis include a runny nose ... ...

    Abstract 10

    17

    Background: A perennial house dust mite-associated allergic rhinitis has a major impact on the quality of life of patients and is associated with a high socioeconomic burden. The most common symptoms of allergic rhinitis include a runny nose and nasal congestion, sneezing, itching of nose, mouth and/or throat, and/or ocular symptoms. Affected patients often develop allergic bronchial asthma. Therapy options for allergic rhinitis include allergen avoidance, symptomatic treatment, and allergen immunotherapy. Allergen immunotherapy is the only disease-modifying treatment that can permanently alleviate the symptoms of allergic rhinitis. In July 2021, a new sublingual mite tablet was approved in Germany. Methods: This review summarizes clinical studies on the 300 IR (index of reactivity) mite tablet in adolescents and adults with house dust mite-associated allergic rhinitis and presents the results. Results: In the phase II and phase III studies considered here, different dosages of the mite tablet were investigated. The 300 IR mite tablet showed the best benefit–risk profile and has been approved in Europe, Japan, South Korea, Australia, and New Zealand for the treatment of house dust mite-associated allergic rhinitis. Conclusion: Allergen immunotherapy with the 300 IR mite tablet is an effective treatment that relieves allergic symptoms, reduces the need for symptomatic medication, and improves the quality of life in both adults and adolescents with house dust mite-associated allergic rhinitis. At the same time, treatment with the 300 IR mite tablet is well tolerated. Mild to moderate reactions at the application site subside after a few days.

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    Keywords Allergen immunotherapy ; Allergic asthma ; Allergic rhinitis ; House mites ; Mite tablet
    Subject code 610
    Language English
    Publishing country de
    Document type Book ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  9. Article: Telemedicine in allergology: practical aspects: A position paper of the Association of German Allergists (AeDA).

    Dramburg, Stephanie / Walter, Uso / Becker, Sven / Casper, Ingrid / Röseler, Stefani / Schareina, Astrid / Wrede, Holger / Klimek, Ludger

    Allergo journal international

    2021  Volume 30, Issue 4, Page(s) 119–129

    Abstract: Since spring 2020, the wide-ranging contact restriction measures in the context of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic have also led to a reduction in physician-patient contacts in the ambulatory care setting. ... ...

    Abstract Since spring 2020, the wide-ranging contact restriction measures in the context of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic have also led to a reduction in physician-patient contacts in the ambulatory care setting. Telemedicine applications will increasingly provide a way to efficiently deliver patient care under infection control measures. In allergology, telemedical as well as digital applications can also significantly facilitate everyday clinical practice. However, the technical and legal hurdles associated with the implementation of digital strategies must be overcome for this to happen. The aim of this article is to provide an intuitive overview of the aspects to be considered in the implementation of telemedicine consultations and to highlight the current state of the framework as well as optimization possibilities and perspectives in allergology. If a structured use is guaranteed, digital and telemedical applications can improve patient care-also in allergology. There is potential to be exploited in many areas, from the remote collection of clinical history, and video consultations, to the discussion of diagnostic findings, disease monitoring, and therapy support. The use of telemedical applications, especially video consultations, has experienced a remarkable acceleration in the context of the coronavirus disease 2019 (COVID-19) pandemic. The present overview of the legal, technical and professional framework is intended to support the anchoring of digital and telemedical technologies in everyday allergology. However, in order to consolidate these in the future, an agreement is needed regarding professional standards of action as well as a remuneration structure that is permanently defined beyond the current pandemic.
    Language English
    Publishing date 2021-02-22
    Publishing country Germany
    Document type Journal Article
    ISSN 2197-0378
    ISSN 2197-0378
    DOI 10.1007/s40629-021-00167-5
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  10. Article: [No title information]

    Dramburg, Stephanie / Walter, Uso / Becker, Sven / Casper, Ingrid / Röseler, Stefani / Schareina, Astrid / Wrede, Holger / Klimek, Ludger

    Allergo Journal : interdisziplinare Zeitschrift fur Allergologie und Umweltmedizin : Organ der Deutschen Gesellschaft fur Allergie- und Immunitatsforschung

    2021  Volume 30, Issue 4, Page(s) 24–38

    Title translation Praktischer Leitfaden zum Einsatz telemedizinischer Anwendungen bei der Betreuung von Allergiepatienten: Ein Positionspapier des Ärzteverbands Deutscher Allergologen (AeDA).
    Language German
    Publishing date 2021-06-25
    Publishing country Germany
    Document type Journal Article ; Review
    ZDB-ID 1136943-7
    ISSN 0941-8849
    ISSN 0941-8849
    DOI 10.1007/s15007-021-4823-8
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