LIVIVO - The Search Portal for Life Sciences

zur deutschen Oberfläche wechseln
Advanced search

Search results

Result 1 - 10 of total 93

Search options

  1. Article ; Online: Application of indocyanine green (ICG)-guided surgery in clinical practice: lesson to learn from other organs-an overview on clinical applications and future perspectives.

    Cassinotti, E / Boni, L / Baldari, L

    Updates in surgery

    2022  Volume 75, Issue 2, Page(s) 357–365

    Abstract: Indocyanine green (ICG) fluorescence-guided surgery is a modality of intra-operative navigation that might support the surgeon with enhanced visualization of anatomical structures in real time. Over the last years, it has emerged as one of the most ... ...

    Abstract Indocyanine green (ICG) fluorescence-guided surgery is a modality of intra-operative navigation that might support the surgeon with enhanced visualization of anatomical structures in real time. Over the last years, it has emerged as one of the most promising and rapidly developing technical innovations in surgery. The most popular current clinical applications include fluorescence cholangiography, bowel anastomotic perfusion assessment, fluorescence-guided lymphography for sentinel lymph-node identification and guided lymphadenectomy and the possible use in oncological surgery for the identification and localization of tumors and the diagnosis and treatment of peritoneal carcinosis. This paper provides an overview of the multiple fields of applications of ICG fluorescence-guided surgery in visceral and oncological surgery, discussing indications summarizing most recent and significative available literature and giving technical notes of use.
    MeSH term(s) Humans ; Indocyanine Green ; Lymphatic Metastasis ; Sentinel Lymph Node ; Lymph Node Excision ; Surgery, Computer-Assisted ; Sentinel Lymph Node Biopsy
    Chemical Substances Indocyanine Green (IX6J1063HV)
    Language English
    Publishing date 2022-10-06
    Publishing country Italy
    Document type Journal Article ; Review
    ZDB-ID 2572692-4
    ISSN 2038-3312 ; 2038-131X
    ISSN (online) 2038-3312
    ISSN 2038-131X
    DOI 10.1007/s13304-022-01361-y
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  2. Article ; Online: Porto-spleno-mesenteric venous thrombosis after elective splenectomy: a retrospective cohort study.

    Baldari, Ludovica / Boni, Luigi / Giuliani, Beatrice / Cassinotti, Elisa

    Frontiers in immunology

    2023  Volume 14, Page(s) 1216283

    Abstract: Background: Elective splenectomy is the main treatment for a wide range of haematological diseases. Porto-spleno-mesenteric venous thrombosis represents one of the most severe complications of this procedure. The aim of this study was to evaluate risk ... ...

    Abstract Background: Elective splenectomy is the main treatment for a wide range of haematological diseases. Porto-spleno-mesenteric venous thrombosis represents one of the most severe complications of this procedure. The aim of this study was to evaluate risk factors associated with development of porto-spleno-mesenteric venous thrombosis after elective splenectomy.
    Methods: All cases of elective splenectomy carried out from April 1
    Results: Twenty-two patients (10 women, 12 men) underwent splenectomy during the study period. Indications were: immune thrombocytopenia (n: 6), myeloproliferative disorder (n: 6), hereditary spherocytosis (n: 4), thalassemia (n: 1), lymphoma (n: 1), leukaemia (n: 1), other malignancies (n: 3). Six patients developed porto-spleno-mesenteric venous thrombosis and only 2 of them were symptomatic. Patients were treated with anticoagulation therapy with complete resolution. Analysis identified three main factors associated with thrombosis: spleen diameter (p = 0.03), myeloproliferative disorder (p = 0.02), intraoperative platelet transfusion (p = 0.002) and intraoperative red blood cells transfusion (p = 0.009).
    Conclusion: Standardized postoperative screening allows prompt diagnosis and treatment of porto-spleno-mesenteric venous thrombosis even in asymptomatic cases. Patient with splenomegaly and affected by myeloproliferative disorder have a greater risk to develop this complication.
    MeSH term(s) Male ; Humans ; Female ; Spleen ; Splenectomy/adverse effects ; Splenectomy/methods ; Retrospective Studies ; Venous Thrombosis/diagnostic imaging ; Venous Thrombosis/epidemiology ; Venous Thrombosis/etiology ; Thrombosis/etiology ; Myeloproliferative Disorders/etiology
    Language English
    Publishing date 2023-10-20
    Publishing country Switzerland
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2606827-8
    ISSN 1664-3224 ; 1664-3224
    ISSN (online) 1664-3224
    ISSN 1664-3224
    DOI 10.3389/fimmu.2023.1216283
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  3. Article ; Online: Lymph node mapping with ICG near-infrared fluorescence imaging: technique and results.

    Baldari, Ludovica / Boni, Luigi / Cassinotti, Elisa

    Minimally invasive therapy & allied technologies : MITAT : official journal of the Society for Minimally Invasive Therapy

    2023  Volume 32, Issue 5, Page(s) 213–221

    Abstract: Purpose: Lymphadenectomy represents a fundamental step during gastrointestinal cancer resection, as the removal of an adequate number of lymph nodes is crucial to define the stage of the disease and prognosis. Lymphadenectomy during gastric and ... ...

    Abstract Purpose: Lymphadenectomy represents a fundamental step during gastrointestinal cancer resection, as the removal of an adequate number of lymph nodes is crucial to define the stage of the disease and prognosis. Lymphadenectomy during gastric and colorectal resection and adrenalectomy for cancer are technically demanding and can be associated with risk of bleeding. To date, lymphadenectomy is often performed without any visual aid. Indocyanine green fluorescence for lymph node mapping can provide better intraoperative visualization. The purpose of this review is to report the current evidence on this topic.
    Materials and methods: A systematic research of the electronic databases Medline, Embase and Google Scholar was conducted from the inception to December 2022.
    Results: This review summarizes the current evidence of techniques and results of fluorescence guided lymphatic mapping during gastrointestinal and adrenal surgery.
    Conclusion: According to this review, ICG guided lymphadenectomy for gastrointestinal tumours and adrenocortical carcinoma is feasible and safe. In gastrointestinal tumours it allows higher number of harvested lymph nodes.
    MeSH term(s) Humans ; Fluorescence ; Lymph Nodes/surgery ; Lymph Nodes/pathology ; Lymph Node Excision/methods ; Lymphatic Metastasis/pathology ; Indocyanine Green ; Stomach Neoplasms/surgery ; Sentinel Lymph Node Biopsy/methods ; Optical Imaging/methods
    Chemical Substances Indocyanine Green (IX6J1063HV)
    Language English
    Publishing date 2023-06-01
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 1317160-4
    ISSN 1365-2931 ; 1364-5706
    ISSN (online) 1365-2931
    ISSN 1364-5706
    DOI 10.1080/13645706.2023.2217916
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  4. Article ; Online: Identification of the ideal weight-based indocyanine green dose for fluorescent cholangiography.

    Baldari, Ludovica / Boni, Luigi / Kurihara, Hayato / Cassinotti, Elisa

    Surgical endoscopy

    2023  Volume 37, Issue 10, Page(s) 7616–7624

    Abstract: Background: Ideal visualization of fluorescent cholangiography during laparoscopic cholecystectomy is when maximum fluorescence into biliary ducts and absent signal into liver parenchyma, defined as "signal to background ratio" (SBR), is obtained. Such ... ...

    Abstract Background: Ideal visualization of fluorescent cholangiography during laparoscopic cholecystectomy is when maximum fluorescence into biliary ducts and absent signal into liver parenchyma, defined as "signal to background ratio" (SBR), is obtained. Such condition is mainly dependent by indocyanine green (ICG) dose and timing. The aim of this study was to identify the ideal ICG dose to obtain the best possible intraoperative visualization of the extra-hepatic biliary tree.
    Methods: The first part of the study was used to define a range of small weight-based ICG dosages using the mathematical function bisection method. During the second part of the study, the midpoint dose of the identified range, was tested in 50 consecutive cholecystectomies using a laser-based fluorescence laparoscopic camera (Synergy
    Results: Fourteen patients were included in the first part of the study and ICG dose between 0.01191406 and 0.0119873 mg/kg was identified. The second part confirmed previous results after testing the dosage equal to 0.0119 mg/kg (midpoint of the defined range) in 50 consecutive cholecystectomies. Cystic duct was identified in 66 and 100% of cases before and after dissection of Calot's triangle respectively. On the other hand, common bile duct was identified in 82 and 92% before and after dissection respectively. Subjective and objective SBRs confirmed the benefit of the identified ICG dose.
    Conclusion: ICG dose calculated by 0.0119 mg/kg administered one hour before surgery allows an ideal intraoperative visualization of the extra-hepatic biliary tree.
    Registration number: ISRCTN10190039.
    MeSH term(s) Humans ; Indocyanine Green ; Cholangiography/methods ; Coloring Agents ; Biliary Tract ; Bile Ducts/diagnostic imaging ; Bile Ducts/surgery ; Cholecystectomy, Laparoscopic/methods
    Chemical Substances Indocyanine Green (IX6J1063HV) ; Coloring Agents
    Language English
    Publishing date 2023-07-20
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 639039-0
    ISSN 1432-2218 ; 0930-2794
    ISSN (online) 1432-2218
    ISSN 0930-2794
    DOI 10.1007/s00464-023-10280-x
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  5. Article: Right Hemicolectomy with Complete Mesocolic Excision Using the Versius Surgical System: A Step-by-Step Guide.

    Baldari, Ludovica / Boni, Luigi / Cassinotti, Elisa / Crippa, Jacopo / Mari, Giulio

    Chirurgia (Bucharest, Romania : 1990)

    2023  Volume 118, Issue 1, Page(s) 54–62

    Abstract: The application of new robotic platforms in colorectal surgery has increased greatly in the last 10 years. New systems have been released and entered the surgical panorama, broadening the technological offer. Robotic surgery applied to colorectal ... ...

    Abstract The application of new robotic platforms in colorectal surgery has increased greatly in the last 10 years. New systems have been released and entered the surgical panorama, broadening the technological offer. Robotic surgery applied to colorectal oncological surgery has been widely described. Hybrid robotic surgery in right sided colonic cancer has been previously reported. According to the site and local extension of a right-sided colon cancer, a different lymphadenectomy could be required. For more distant and locally advanced tumors a complete mesocolic excision (CME) is indicated. CME for right colon cancer is a complex operation compared to standard right hemicolectomy. Therefore a hybrid robotic system may be effectively applied to CME during a minimally-invasive right hemicolectomy to improve the dissection accuracy. Here we report a step-by-step hybrid laparoscopic/robotic right hemicolectomy with CME performed with the Versius Surgical System, a tele-operated surgical robotic system intended for the use of robotic assisted surgery.
    MeSH term(s) Humans ; Robotic Surgical Procedures ; Treatment Outcome ; Laparoscopy ; Lymph Node Excision ; Colonic Neoplasms/surgery ; Colonic Neoplasms/pathology ; Colectomy
    Language English
    Publishing date 2023-03-13
    Publishing country Romania
    Document type Journal Article
    ZDB-ID 419244-8
    ISSN 1842-368X ; 1221-9118 ; 0009-4730 ; 0377-5003
    ISSN (online) 1842-368X
    ISSN 1221-9118 ; 0009-4730 ; 0377-5003
    DOI 10.21614/chirurgia.2828
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  6. Article ; Online: Laparoscopic en bloc resection of T4b splenic flexure cancer with infiltration of the stomach and tail of the pancreas - a video vignette.

    Ballabio, M / Boni, L / Baldari, L / Cassinotti, E

    Colorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland

    2019  Volume 22, Issue 2, Page(s) 225–226

    MeSH term(s) Adenocarcinoma/pathology ; Adenocarcinoma/surgery ; Aged ; Colectomy/methods ; Colon, Transverse/pathology ; Colon, Transverse/surgery ; Colonic Neoplasms/pathology ; Colonic Neoplasms/surgery ; Humans ; Laparoscopy/methods ; Male ; Neoplasm Invasiveness ; Pancreas/pathology ; Pancreas/surgery ; Stomach/pathology ; Stomach/surgery
    Language English
    Publishing date 2019-10-15
    Publishing country England
    Document type Case Reports ; Letter ; Video-Audio Media
    ZDB-ID 1440017-0
    ISSN 1463-1318 ; 1462-8910
    ISSN (online) 1463-1318
    ISSN 1462-8910
    DOI 10.1111/codi.14861
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  7. Article ; Online: Laparoscopic 'ultra' minimally access left colectomy for cancer using 2.9 mm percutaneous instruments and transvaginal specimen extraction--a video vignette.

    Boni, L / Cassinotti, E / Colombo, E M

    Colorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland

    2016  Volume 18, Issue 4, Page(s) 422

    MeSH term(s) Biopsy/methods ; Colectomy/instrumentation ; Colectomy/methods ; Colonic Neoplasms/pathology ; Colonic Neoplasms/surgery ; Female ; Humans ; Laparoscopy/instrumentation ; Laparoscopy/methods ; Vagina/surgery
    Language English
    Publishing date 2016-04
    Publishing country England
    Document type Case Reports ; Letter ; Video-Audio Media
    ZDB-ID 1440017-0
    ISSN 1463-1318 ; 1462-8910
    ISSN (online) 1463-1318
    ISSN 1462-8910
    DOI 10.1111/codi.13283
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  8. Article: Laparoscopic vs Open Treatment for Gastric and Non-Gastric Gastrointestinal Stromal Tumors: a Two-Center Experience.

    Pappalardo, Vincenzo / Lianos, Georgios D / Morabito, Marika / Gianazza, Simone / Cassinotti, Elisa / Frattini, Francesco / Pino, Antonella / Rausei, Stefano / Carcano, Giulio

    Surgical technology international

    2023  Volume 42

    Abstract: We retrospectively reviewed the medical records of 109 patients who underwent curative laparoscopic or open resection for different types of gastrointestinal stromal tumors (GIST). Only primary GIST patients who did not receive preoperative chemotherapy ... ...

    Abstract We retrospectively reviewed the medical records of 109 patients who underwent curative laparoscopic or open resection for different types of gastrointestinal stromal tumors (GIST). Only primary GIST patients who did not receive preoperative chemotherapy or oral imatinib treatment were included in the analysis. We divided the patients into 2 groups according to the surgical approach:a laparoscopic group (LAP) and a laparotomic group (OPEN). Our aim was to confirm the feasibility and safety of laparoscopic surgery for GISTs that differed in size and location, and to assess its long-term oncologic outcome in terms of overall survival (OS) and disease-free survival (DFS). Furthermore, we performed a surgical short-term outcome analysis. The two groups did not differ with respect to age at operation, gender, BMI or comorbidities. Even the NIH and AFIP risk classifications were not significantly different between the two groups. Furthermore, in our analysis, there was no significant difference in mean tumor size or location between the two groups. Wedge resection was the most frequently performed procedure. The conversion rate was 7.8%. The operative time was 194.75 (60- 350) min for the open group and 181.70 (57-480) min for the laparoscopic group. Our data clearly indicated that the long-term oncologic outcome and DFS of laparoscopic resection were not inferior to those of traditional open operations and laparoscopic resection was still feasible in cases with large tumors: the median size of the tumor was 4.5 cm (3-25) and the tumor was larger than 4.5 cm in 47.7% of the cases in the LAP group. With regard to short-term outcomes, our study demonstrated that the LAP group had fewer complications, faster gastrointestinal recovery, reduced use of analgesic drugs and shorter postoperative hospital stay (each p<0.05). In conclusion, our experience confirms that GISTs are very uncommon cancers for which the prognosis is closely related to size, localization and class of risk. In light of our clinical data, laparoscopic resection for gastric and non-gastric GISTs is a safe, feasible and oncologically correct procedure. The most important advantage of this technique is that it ensures a better postoperative outcome compared with open surgery, without worsening the prognosis.
    Language English
    Publishing date 2023-06-15
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1225512-9
    ISSN 1090-3941
    ISSN 1090-3941
    DOI 10.52198/23.STI.42.GS1699
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  9. Article ; Online: Near-infrared fluorescence cholangiography assisted laparoscopic cholecystectomy (FALCON): an international multicentre randomized controlled trial.

    van den Bos, J / Schols, R M / Boni, L / Cassinotti, E / Carus, T / Luyer, M D / Vahrmeijer, A L / Mieog, J S D / Warnaar, N / Berrevoet, F / van de Graaf, F / Lange, J F / Van Kuijk, S M J / Bouvy, N D / Stassen, L P S

    Surgical endoscopy

    2023  Volume 37, Issue 6, Page(s) 4574–4584

    Abstract: Aim: To assess the added value of Near InfraRed Fluorescence (NIRF) imaging during laparoscopic cholecystectomy.: Methods: This international multicentre randomized controlled trial included participants with an indication for elective laparoscopic ... ...

    Abstract Aim: To assess the added value of Near InfraRed Fluorescence (NIRF) imaging during laparoscopic cholecystectomy.
    Methods: This international multicentre randomized controlled trial included participants with an indication for elective laparoscopic cholecystectomy. Participants were randomised into a NIRF imaging assisted laparoscopic cholecystectomy (NIRF-LC) group and a conventional laparoscopic cholecystectomy (CLC) group. Primary end point was time to 'Critical View of Safety' (CVS). The follow-up period of this study was 90 postoperative days. An expert panel analysed the video recordings after surgery to confirm designated surgical time points.
    Results: A total of 294 patients were included, of which 143 were randomized in the NIRF-LC and 151 in the CLC group. Baseline characteristics were equally distributed. Time to CVS was on average 19 min and 14 s for the NIRF-LC group and 23 min and 9 s for the CLC group (p 0.032). Time to identification of the CD was 6 min and 47 s and 13 min for NIRF-LC and CLC respectively (p < 0.001). Transition of the CD in the gallbladder was identified after an average of 9 min and 39 s with NIRF-LC, compared to 18 min and 7 s with CLC (p < 0.001). No difference in postoperative length of hospital stay nor occurrence of postoperative complications was found. ICG related complications were limited to one patient who developed a rash after injection of ICG.
    Conclusion: Use of NIRF imaging in laparoscopic cholecystectomy provides earlier identification of relevant extrahepatic biliary anatomy: earlier achievement of CVS, cystic duct visualisation and visualisation of both cystic duct and cystic artery transition into the gallbladder.
    MeSH term(s) Humans ; Cholecystectomy, Laparoscopic/methods ; Indocyanine Green ; Cholangiography/methods ; Biliary Tract ; Cystic Duct/surgery
    Chemical Substances Indocyanine Green (IX6J1063HV)
    Language English
    Publishing date 2023-02-27
    Publishing country Germany
    Document type Randomized Controlled Trial ; Multicenter Study ; Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 639039-0
    ISSN 1432-2218 ; 0930-2794
    ISSN (online) 1432-2218
    ISSN 0930-2794
    DOI 10.1007/s00464-023-09935-6
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  10. Article: Laparoscopic Cholecystectomy in the Cirrhotic: Review of Literature on Indications and Technique.

    Cassinotti, Elisa / Baldari, Ludovica / Boni, Luigi / Uranues, Selman / Fingerhut, Abe

    Chirurgia (Bucharest, Romania : 1990)

    2020  Volume 115, Issue 2, Page(s) 208–212

    Abstract: Cholelithiasis is twice more common in patients suffering from liver cirrhosis compared to overall population and in those patients, acute cholecystitis occurs significantly more often. Our goal was to review the literature and to overview the ... ...

    Abstract Cholelithiasis is twice more common in patients suffering from liver cirrhosis compared to overall population and in those patients, acute cholecystitis occurs significantly more often. Our goal was to review the literature and to overview the indications, contra-indications, and alternatives in the cirrhotic with biliary stones. We conducted a systematic review of the literature using the key words "Cirrhosis", "cholecystectomy", "laparoscopy"and "indications". Selected articles were reviewed for information specific to indications, contra-indications, and alternatives to laparoscopic cholecystectomy in cirrhotics. Results showed that laparoscopic cholecystectomy might offer several advantages in cirrhotic population, however cholecystectomy can be challenging: specific indications and alternatives to surgery must be discussed case by case. Laparoscopic cholecystectomy can be performed safely in selected patients with cirrhosis; special precautions are warranted regarding pneumoperitoneum pressure, trocar placement and increased safety with Indocyanine-green (ICG) fluorescence cholangiography. Nevertheless, in high-risk cirrhotic patients (Child C) and/or in common bile duct lithiasis endoscopic and non-surgical conservative treatments are preferable.
    MeSH term(s) Cholangiography ; Cholecystectomy, Laparoscopic/methods ; Cholecystitis, Acute/etiology ; Cholecystitis, Acute/surgery ; Cholelithiasis/etiology ; Cholelithiasis/surgery ; Humans ; Liver Cirrhosis/complications
    Language English
    Publishing date 2020-05-05
    Publishing country Romania
    Document type Journal Article ; Review
    ZDB-ID 419244-8
    ISSN 1842-368X ; 1221-9118 ; 0009-4730 ; 0377-5003
    ISSN (online) 1842-368X
    ISSN 1221-9118 ; 0009-4730 ; 0377-5003
    DOI 10.21614/chirurgia.115.2.208
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

To top