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Article: Effects of glibenclamide on ventricular fibrillation in non-insulin-dependent diabetics with acute myocardial infarction.

Lomuscio, A / Vergani, D / Marano, L / Castagnone, M / Fiorentini, C

1994 Volume 5, Issue 9, Page(s) 767–771

Abstract: Background: Glibenclamide, a hypoglycemic sulfonylurea, has shown antiarrhythmic effects in acutely ischemic myocardium. The aim of the present study was to evaluate the effectiveness of the drug in preventing ventricular fibrillation in diabetic ... ...

Abstract	Background: Glibenclamide, a hypoglycemic sulfonylurea, has shown antiarrhythmic effects in acutely ischemic myocardium. The aim of the present study was to evaluate the effectiveness of the drug in preventing ventricular fibrillation in diabetic patients with acute myocardial infarction. Methods: We studied 232 patients with non-insulin-dependent diabetes mellitus (106 on glibenclamide, group A1; 126 treated with another hypoglycemic drug or with diet only, group A2) and 830 non-diabetic people. All the patients were admitted to our coronary care unit with their first myocardial infarction. Results: Ventricular fibrillation occurred in 1.9% of group A1, 7.9% of group A2, and 9.9% of the non-diabetic (A1 versus A2, P < 0.05; A2 versus the non-diabetic group, NS; A1 versus the non-diabetic group, P < 0.01). Sustained ventricular tachycardia was not significantly different among the groups. Conclusions: The antiarrhythmic effectiveness of glibenclamide might be related to its blocking action on the ATP-dependent potassium channel, with consequent attenuation of the efflux of potassium induced by ischemia. We also observed a higher mortality rate resulting from heart failure in group A2 than in group A1 or the non-diabetic group. Since glibenclamide has never shown significant effects on myocardial contractility, this finding remains to be elucidated. Glibenclamide therefore appears to have an antifibrillatory effect in acute myocardial infarction; with respect to acute coronary events, the drug might be able to prevent ventricular fibrillation, which is most often fatal when it occurs before hospitalization.
MeSH term(s)	Adult ; Aged ; Aged, 80 and over ; Diabetes Mellitus, Type 2/complications ; Female ; Glyburide/therapeutic use ; Humans ; Male ; Middle Aged ; Myocardial Infarction/complications ; Ventricular Fibrillation/etiology ; Ventricular Fibrillation/prevention & control
Chemical Substances	Glyburide (SX6K58TVWC)
Language	English
Publishing date	1994-09
Publishing country	England
Document type	Clinical Trial ; Journal Article
ZDB-ID	1047268-x
ISSN	1473-5830 ; 0954-6928
ISSN (online)	1473-5830
ISSN	0954-6928
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Zs.A 3039: Show issues

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Article: Determination of agreement between cardiopulmonary and standard ECG stress testing in coronary artery disease.

Bigi, R / Bandini, P / Castagnone, M / Pozzoni, L / Occhi, G

European heart journal

1993 Volume 14, Issue 9, Page(s) 1210–1215

Abstract: The agreement between the results of standard ECG (CX) and cardiopulmonary (CPX) exercise stress tests performed in randomized sequence was evaluated in 40 patients with known coronary artery disease but who were not taking cardioactive therapy. Systolic ...

Abstract	The agreement between the results of standard ECG (CX) and cardiopulmonary (CPX) exercise stress tests performed in randomized sequence was evaluated in 40 patients with known coronary artery disease but who were not taking cardioactive therapy. Systolic blood pressure and heart rate were significantly higher during CPX only at low workload (less than 100 W). Exercise time and rate-pressure product at both peak exercise and ischaemic threshold were not significantly different between the two tests, even though their variability exceeded the value of 20%, which is generally accepted as the cut-off point for defining CX parameters as reproducible. However, the metabolic response to exercise, assessed by means of blood lactate kinetics analysis, was highly reproducible between the two tests. We conclude that the provocative role of exercise testing is not altered by the gas exchange analysis technique used in CAD patients. However, the common indexes of myocardial as well as of global physical performance may be influenced, thus requiring caution in comparing data with those derived from CX or from reference values.
MeSH term(s)	Adult ; Aged ; Blood Pressure ; Coronary Disease/diagnosis ; Coronary Disease/physiopathology ; Electrocardiography ; Exercise Test ; Female ; Heart Rate ; Humans ; Lactates/blood ; Male ; Middle Aged ; Prognosis ; Reference Values ; Reproducibility of Results
Chemical Substances	Lactates
Language	English
Publishing date	1993-09
Publishing country	England
Document type	Journal Article
ZDB-ID	603098-1
ISSN	1522-9645 ; 0195-668X
ISSN (online)	1522-9645
ISSN	0195-668X
DOI	10.1093/eurheartj/14.9.1210
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Zs.A 1563: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MO 640: Show issues

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Article: L'elettrocardiogramma nell'ipotermia.

Fogari, R / Zoppi, A / Croce, L / Castagnone, M

Minerva medica

1987 Volume 78, Issue 4, Page(s) 231–241

Abstract: Hypothermia is reflected in the electrocardiogram in the form of alterations that permit early recognition of the condition. In fact the electrocardiogram is a more sensitive indicator of temperature than the standard measurements of body temperature ... ...

Title translation	The electrocardiogram in hypothermia.
Abstract	Hypothermia is reflected in the electrocardiogram in the form of alterations that permit early recognition of the condition. In fact the electrocardiogram is a more sensitive indicator of temperature than the standard measurements of body temperature used in clinical practice. The various aetiological aspects of hypothermia are described as are its electrocardiographic features.
MeSH term(s)	Atrial Fibrillation/etiology ; Echocardiography ; Electrocardiography ; Heart Rate ; Humans ; Hypothermia/complications ; Hypothermia/diagnosis ; Hypothermia/etiology ; Hypothermia/physiopathology ; Pre-Excitation Syndromes/etiology ; Ventricular Fibrillation/etiology
Language	Italian
Publishing date	1987-02-28
Publishing country	Italy
Document type	English Abstract ; Journal Article
ZDB-ID	123586-2
ISSN	1827-1669 ; 0026-4806
ISSN (online)	1827-1669
ISSN	0026-4806
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Ua VI Zs.132: Show issues

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Article: Clinical correlation between diabetic and non diabetic patients with myocardial infarction.

Lomuscio, A / Castagnone, M / Vergani, D / Verzoni, A / Beltrami, A / Ravaglia, R / Pozzoni, L

Acta cardiologica

1991 Volume 46, Issue 5, Page(s) 543–554

Abstract: We have studied 130 patients with diabetes mellitus and 455 patients without. All the patients were consecutively admitted to our Coronary Care Unit with their first myocardial infarction. We have observed a higher incidence of heart failure, in-hospital ...

Abstract	We have studied 130 patients with diabetes mellitus and 455 patients without. All the patients were consecutively admitted to our Coronary Care Unit with their first myocardial infarction. We have observed a higher incidence of heart failure, in-hospital mortality, atrial fibrillation, conduction abnormalities, and post-infarction angina among diabetics. Nevertheless, diabetic patients do not show evidence of larger infarcts than those without diabetes. In our patients the higher mortality among diabetics is related to an increased occurrence of left ventricular failure. Moreover, post-infarction ischemic episodes are more common compared with non diabetics. Since infarcts in diabetics do not seem to be more extensive than in non diabetics, we suggest, in accordance with others, that the poorer outcome among diabetic patients with AMI could be related to an underlying cardiac dysfunction of diabetics in addition to coronary artery diseases.
MeSH term(s)	Adult ; Aged ; Arrhythmias, Cardiac/complications ; Arrhythmias, Cardiac/epidemiology ; Arrhythmias, Cardiac/mortality ; Diabetes Complications ; Diabetes Mellitus/epidemiology ; Diabetes Mellitus/mortality ; Female ; Hospital Mortality ; Hospitalization ; Humans ; Male ; Middle Aged ; Myocardial Infarction/complications ; Myocardial Infarction/epidemiology ; Myocardial Infarction/mortality
Language	English
Publishing date	1991
Publishing country	England
Document type	Comparative Study ; Journal Article
ZDB-ID	390197-x
ISSN	0001-5385
ISSN	0001-5385
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Ui IV Zs.50: Show issues

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Article: L'ecocardiogramma del ventricolo sinistro prima e dopo by pass aorto-coronarico. Studio M-mode in 30 pazienti.

Castagnone, M / Corallo, S / Faletra, F / Mantero, A / Pezzano, A

Giornale italiano di cardiologia

1980 Volume 10, Issue 4, Page(s) 405–413

Abstract: 30 coronary artery disease (CAD) patients (pts) were studied by echocardiography before and after left anterior descending (LAD) coronary bypass graft in order to evaluate left ventricular (LV) behaviour. Echocardiograms were recorded early pre- (48 ... ...

Title translation	Left ventricular behaviour before and after left anterior descending coronary artery bypass graft. M-mode echocardiographic study in 30 patients (author's transl).
Abstract	30 coronary artery disease (CAD) patients (pts) were studied by echocardiography before and after left anterior descending (LAD) coronary bypass graft in order to evaluate left ventricular (LV) behaviour. Echocardiograms were recorded early pre- (48 hours) and post-operatively (mean 12 days) and at a mean distance of 12 months (6 to 15) after operation. The following parameters were considered: left ventricular end diastolic dimension (LVDD), right ventricular diastolic dimension (LVDD), right ventricular diastolic dimension (RVDD), diastolic thickness, systolic thickening and motion of the interventricular septum (IVS) and of the LV posterior wall (LVPW). 21 pts (70%) showed reduced systolic thickening (RST less than or equal to 30%) and 17 (57%) reduced systolic motion (RSM less than or equal to 3 mm) of the septum. Before surgery no patient showed IVS paradoxical movement, left bundle branch block, valvular regurgitation, shunt, LV aneurysm. A previous myocardial infarction was present in the story of 7 pts: anterior location in 4 pts, inferior in 3 pts. Soon after operation (mean 12 days) 4 pts showed normal IVS motion; in 7 pts it was reduced (less than or equal to 3 mm) and in 19 IVS was paradoxical. In 15 pts of this last group LVPW motion resulted remarkably increased after the bypass graft. The other echo parameters didn't show significant variation. Averaging 12 months after operation, IVS systolic thickening resulted normal in 21 of the 30 pts. (70%); in 14 of the last group of 21 there was a RST preoperatively. IVS motion resulted normal in 21 of the 30 pts (70%), reduced in 5 (17%), paradoxical in 4 (13%). LVPW motion returned to the preoperative value in all but 3 pts, in whom it remained elevated. The other echo parameters didn't show any significant variation. We conclude that: 1) IVS paradoxical motion is frequently recorded by echo shortly after coronary bypass graft surgery. 2) In most pts it is accompanied by an increased excursion of LVPW, probably compensatory in origin. Both tend to normalize within few months in most of the subjects.
MeSH term(s)	Angina Pectoris/diagnosis ; Angina Pectoris/surgery ; Coronary Artery Bypass ; Coronary Disease/diagnosis ; Coronary Disease/surgery ; Echocardiography ; Follow-Up Studies ; Heart/physiopathology ; Heart Ventricles/physiopathology ; Humans ; Male ; Middle Aged ; Myocardial Infarction/diagnosis ; Myocardial Infarction/surgery ; Postoperative Period
Language	Italian
Publishing date	1980
Publishing country	Italy
Document type	Comparative Study ; English Abstract ; Journal Article
ZDB-ID	184670-x
ISSN	0046-5968
ISSN	0046-5968
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Zs.A 761: Show issues

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Article: Validita' dell'ecocardiografia nella diagnosi di aneurisma dissecante dell'aorta.

Corallo, S / Pezzano, A / Castagnone, M / Brusoni, B / Cadel, A

Giornale italiano di cardiologia

1977 Volume 7, Issue 12, Page(s) 1200–1206

Abstract: A revision of 1300 echocardiograms of adults showed 14 patients whose echocardiographic diagnosis of aortic root dissecting aneurism (D.A.). Of these, 8 didn't have any anamnestic, clinical or instrumental evidence of D.A. In the other 6, admitted to our ...

Title translation	Value of echocardiography in the diagnosis of dissecting aneurysm of the aorta.
Abstract	A revision of 1300 echocardiograms of adults showed 14 patients whose echocardiographic diagnosis of aortic root dissecting aneurism (D.A.). Of these, 8 didn't have any anamnestic, clinical or instrumental evidence of D.A. In the other 6, admitted to our department with a suspected D.A., echocardiography proved to be useful in confirming such diagnosis in 4, in excluding it in 1, but gave a false positive diagnosis of D.A. in the sixth, affected by a diffuse carcinomatosis with pleuropericardial blood effusion. From the examination of the present experience, the Authors deem echocardiography is a useful diagnostic tool in the screening of D.A. when the following conditions are fulfilled: 1) presence of all the major criteria of Nanda and Gramiak, especially the aortic root anterior wall dilatation beyond 16 mm; 2) an almost suggestive story and clinical evidence of D.A. The usefulness of an echocardiographic pattern recently described as diagnostic of D.A. (loss of continuity between the borders of the anterior aortic wall with interventricular septum, and/or posterior aortic wall with mitral anulus) was confirmed: it was detected in 3 of the 4 D.A. patients but in none of the others. The presence of a false positive and the possibility of technical artifacts nevertheless induce caution in the interpretation of the echocardiographic pattern alone.
MeSH term(s)	Adult ; Aged ; Aortic Aneurysm/complications ; Aortic Aneurysm/diagnosis ; Echocardiography ; Evaluation Studies as Topic ; Humans ; Male ; Middle Aged
Language	Italian
Publishing date	1977
Publishing country	Italy
Document type	English Abstract ; Journal Article
ZDB-ID	184670-x
ISSN	0046-5968
ISSN	0046-5968
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Article: Valore e limiti dell'ecocardiografia M-mode nella malattia coronarica. Studio in 100 pazienti anginosi.

Corallo, S / Pezzano, A / Castagnone, M / Brusoni, B / Augello, M / Morandi, G / Rovelli, F

Giornale italiano di cardiologia

1979 Volume 9, Issue 8, Page(s) 806–816

Title translation	Value and limitations of M-mode echocardiography in coronary disease. Study in 100 patients with angina pectoris.
MeSH term(s)	Adult ; Aged ; Angina Pectoris/diagnosis ; Angina Pectoris/etiology ; Coronary Disease/complications ; Coronary Disease/diagnosis ; Echocardiography ; Electrocardiography ; Female ; Humans ; Male ; Middle Aged ; Myocardial Contraction
Language	Italian
Publishing date	1979
Publishing country	Italy
Document type	English Abstract ; Journal Article
ZDB-ID	184670-x
ISSN	0046-5968
ISSN	0046-5968
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Zs.A 761: Show issues

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Article: Studio correlativo dell'evoluzione dell'infarto miocardico mediante la scintigrafia con 131Cs e l'ecocardiografia

Corallo, S / Belli, C / Banfi, F / Spinelli-Ressi, F / Castagnone, M / Selvini, A

Giornale italiano di cardiologia

1976 Volume 6, Issue 8, Page(s) 1333–1344

Abstract: 21 patients with acute myocardial infarction (A.M.I.) were studied by echocardiography (Echo) and 131CS myocardial scintigraphy (M.S.). Some months after discharge from Hospital (mean value = 10 months), the echocardiograms and myocardial scintigrams ... ...

Title translation	A correlative study of the evolution of myocardial infarction using 131Cs scintigraphy and ecocardiography (author's transl).
Abstract	21 patients with acute myocardial infarction (A.M.I.) were studied by echocardiography (Echo) and 131CS myocardial scintigraphy (M.S.). Some months after discharge from Hospital (mean value = 10 months), the echocardiograms and myocardial scintigrams were taken again. M.S. resulted modified in 13 patients (62%); in 7 of these there was a reduction of the "cold" area due to M.I.; in 6 an extension with scintigraphic pattern of left ventricular aneurysm was shown. Echo showed in the first group of 7, with normal ventricular cavity (L.V.C.), dimension and good movement of the walls affected by A.M.I. In the second group of 6, L.V.C. dilatation (mean value = 5,6 cm) and reduction of L.V. walls movements gave noticeable results. In the patients (8 = 38%) with unchanged M.S., Echo showed an L.V.C. dimensions increase and L.V. wall movement reduction. The most important results of the present study is the sensitivity of the M.S. and Echo to picking up left ventricular aneurysm by means of non-invasive techniques. The Authors emphasize the availability of Echo and M.S. in the follow up of M.I.
MeSH term(s)	Cesium Radioisotopes ; Echocardiography ; Female ; Follow-Up Studies ; Heart/physiopathology ; Heart Aneurysm/diagnosis ; Heart Aneurysm/etiology ; Heart Ventricles/physiopathology ; Humans ; Male ; Middle Aged ; Myocardial Infarction/complications ; Myocardial Infarction/physiopathology ; Radionuclide Imaging
Chemical Substances	Cesium Radioisotopes
Language	Italian
Publishing date	1976
Publishing country	Italy
Document type	English Abstract ; Journal Article
ZDB-ID	184670-x
ISSN	0046-5968
ISSN	0046-5968
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