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  1. Book ; Online ; E-Book: Celiac disease

    Castellanos-Rubio, Ainara / Galluzzi, Lorenzo

    2023  

    Author's details Ainara Castellanos-Rubio and Lorenzo Galluzzi
    Keywords Celiac disease
    Subject code 616.399
    Language English
    Size 1 online resource (230 pages)
    Edition 1st ed.
    Publisher Academic Press
    Publishing place Cambridge, MA
    Document type Book ; Online ; E-Book
    Remark Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
    ISBN 0-443-19203-0 ; 0-443-19202-2 ; 978-0-443-19203-6 ; 978-0-443-19202-9
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  2. Book: Immunopathology of celiac disease

    Castellanos-Rubio, Ainara

    (International review of cell and molecular biology ; volume 358)

    2021  

    Author's details edited by Ainara Castellanos-Rubio, Lorenzo Galluzzi
    Series title International review of cell and molecular biology ; volume 358
    Collection
    Language English
    Size xi, 264 Seiten, Illustrationen
    Edition First edition
    Publisher Elsevier Academic Press
    Publishing place Cambridge, MA
    Publishing country United States
    Document type Book
    HBZ-ID HT020876751
    ISBN 978-0-323-85311-8 ; 0-323-85311-0
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    Uc I Zs 317 -358- verfügbar in Königswinter Königswinter

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  3. Article: Functional Implications of Intergenic GWAS SNPs in Immune-Related LncRNAs.

    Castellanos-Rubio, Ainara / Ghosh, Sankar

    Advances in experimental medicine and biology

    2022  Volume 1363, Page(s) 147–160

    Abstract: Genome wide association studies (GWAS) have identified many loci contributing to genetic variation of complex traits. Immune mediated disorders are complex diseases for which hundreds of risk alleles have been identified by GWAS. However, the intergenic ... ...

    Abstract Genome wide association studies (GWAS) have identified many loci contributing to genetic variation of complex traits. Immune mediated disorders are complex diseases for which hundreds of risk alleles have been identified by GWAS. However, the intergenic location of most of the signals has make it difficult to decipher their implication in disease pathogenesis. A significant number of immune disease-associated SNPs are located within long noncoding RNAs (lncRNAs). LncRNAs have gained importance due to their involvement in the regulation of a wide range of biological processes, including immune responses. GWAS SNPs located within lncRNAs can affect their regulatory capacity by modifying their secondary structure, altering their expression levels or regulating the transcription of different isoforms. In this review we discuss the functional implications of immune-related lncRNAs harboring disease associated SNPs on various disease conditions.
    MeSH term(s) Alleles ; Genetic Predisposition to Disease ; Genome-Wide Association Study ; Humans ; Polymorphism, Single Nucleotide ; RNA, Long Noncoding/genetics ; RNA, Long Noncoding/metabolism
    Chemical Substances RNA, Long Noncoding
    Language English
    Publishing date 2022-02-26
    Publishing country United States
    Document type Journal Article ; Review
    ISSN 2214-8019 ; 0065-2598
    ISSN (online) 2214-8019
    ISSN 0065-2598
    DOI 10.1007/978-3-030-92034-0_8
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: In vivo sensitization to gliadin by oral administration.

    Romero, M Mar / Serra, Dolors / Castellanos-Rubio, Ainara / Herrero, Laura

    Methods in cell biology

    2023  Volume 179, Page(s) 51–57

    Abstract: Celiac disease is a highly prevalent immune-mediated enteropathy that develops in genetically susceptible individuals expressing HLA-DQ2 or HLA-DQ8 after ingestion of gluten and results in decreased quality of life and increased morbidity. This pathology ...

    Abstract Celiac disease is a highly prevalent immune-mediated enteropathy that develops in genetically susceptible individuals expressing HLA-DQ2 or HLA-DQ8 after ingestion of gluten and results in decreased quality of life and increased morbidity. This pathology is triggered by immunogenic peptides generated from gliadins present in gluten, which act on the intestinal mucosa in a context of high intestinal permeability, activating the innate and adaptive response of the immune system. Several in vivo rodent models attempt to reproduce some phases of the intestinal inflammatory process that occurs in celiac disease. Allergic sensitization to gluten simulates, or enhances in some animal models, the loss of tolerance to gliadin peptides and the initial events that lead to celiac disease in a specific genetic or environmental context. Here we describe a simple method for performing gliadin sensitization in an in vivo animal model.
    MeSH term(s) Animals ; Gliadin ; Celiac Disease/genetics ; Quality of Life ; Glutens ; Administration, Oral
    Chemical Substances Gliadin (9007-90-3) ; Glutens (8002-80-0)
    Language English
    Publishing date 2023-07-13
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ISSN 0091-679X
    ISSN 0091-679X
    DOI 10.1016/bs.mcb.2022.09.019
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: A fast, cheap, and easy protocol for celiac disease HLA haplotype typing using buccal swabs.

    Sebastian-delaCruz, Maialen / Castellanos-Rubio, Ainara

    Methods in cell biology

    2022  Volume 179, Page(s) 203–212

    Abstract: Celiac disease (CeD) is a complex autoimmune disorder characterized by intestinal immune-derived injury that develops in response to dietary gluten consumption. Human Leucocyte Antigen (HLA) complex haplotype typing is one of the main tests for CeD ... ...

    Abstract Celiac disease (CeD) is a complex autoimmune disorder characterized by intestinal immune-derived injury that develops in response to dietary gluten consumption. Human Leucocyte Antigen (HLA) complex haplotype typing is one of the main tests for CeD diagnosis, together with anti-endomysium and anti-transglutaminase autoantibody detection in blood and inflammation observation in the intestine, being the former mainly used for the initial discarding of the pathogenesis. Among the many types of HLA proteins, HLA-DQ2.5 and HLA-DQ8 are considered essential for CeD development. These receptors are only expressed when specific alleles are present, which can be accurately predicted by the presence of the tagging SNPs rs2187668 and rs7454108, respectively. Taking advantage of this premise, we present here an easy workflow to assess HLA genotyping in saliva by a quick and cheap isopropanol-ethanol precipitation-based DNA extraction method followed by the genotyping of two tagging SNPs for the most frequent CeD risk-associated HLA haplotypes. All the actual diagnostic methods for CeD are performed after acquisition of intestine biopsies or blood samples by invasive techniques. Therefore, the development of non-invasive methods would be of a great improvement and advantage for patients, especially children, as an alternative method for initial CeD screening.
    MeSH term(s) Child ; Humans ; Celiac Disease/diagnosis ; Celiac Disease/genetics ; Haplotypes/genetics ; 2-Propanol ; Alleles ; Biopsy
    Chemical Substances 2-Propanol (ND2M416302)
    Language English
    Publishing date 2022-10-31
    Publishing country United States
    Document type Journal Article
    ISSN 0091-679X
    ISSN 0091-679X
    DOI 10.1016/bs.mcb.2022.09.021
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Disease-Associated SNPs in Inflammation-Related lncRNAs.

    Castellanos-Rubio, Ainara / Ghosh, Sankar

    Frontiers in immunology

    2019  Volume 10, Page(s) 420

    Abstract: Immune-mediated diseases, such as celiac disease, type 1 diabetes or multiple sclerosis, are a clinically heterogeneous group of diseases that share many key genetic triggers. Although the pathogenic mechanisms responsible for the development of immune ... ...

    Abstract Immune-mediated diseases, such as celiac disease, type 1 diabetes or multiple sclerosis, are a clinically heterogeneous group of diseases that share many key genetic triggers. Although the pathogenic mechanisms responsible for the development of immune mediated disorders is not totally understood, high-throughput genomic studies, such as GWAS and Immunochip, performed in the past few years have provided intriguing hints about underlying mechanisms and pathways that lead to disease. More than a hundred gene variants associated with disease susceptibility have been identified through such studies, but the progress toward understanding the underlying mechanisms has been slow. The majority of the identified risk variants are located in non-coding regions of the genome making it difficult to assign a molecular function to the SNPs. However, recent studies have revealed that many of the non-coding regions bearing disease-associated SNPs generate long non-coding RNAs (lncRNAs). LncRNAs have been implicated in several inflammatory diseases, and many of them have been shown to function as regulators of gene expression. Many of the disease associated SNPs located in lncRNAs modify their secondary structure, or influence expression levels, thereby affecting their regulatory function, hence contributing to the development of disease.
    MeSH term(s) Gene Expression Regulation/immunology ; Genome-Wide Association Study ; Humans ; Immune System Diseases/genetics ; Immune System Diseases/immunology ; Immune System Diseases/pathology ; Inflammation/genetics ; Inflammation/immunology ; Inflammation/pathology ; Polymorphism, Single Nucleotide ; RNA, Long Noncoding/genetics ; RNA, Long Noncoding/immunology
    Chemical Substances RNA, Long Noncoding
    Language English
    Publishing date 2019-03-08
    Publishing country Switzerland
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Review
    ZDB-ID 2606827-8
    ISSN 1664-3224 ; 1664-3224
    ISSN (online) 1664-3224
    ISSN 1664-3224
    DOI 10.3389/fimmu.2019.00420
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Functional evolutionary convergence of long noncoding RNAs involved in embryonic development.

    Olazagoitia-Garmendia, Ane / Senovilla-Ganzo, Rodrigo / García-Moreno, Fernando / Castellanos-Rubio, Ainara

    Communications biology

    2023  Volume 6, Issue 1, Page(s) 908

    Abstract: Long noncoding RNAs have been identified in most vertebrates, but the functional characterization of these molecules is challenging, mainly due to the lack of linear sequence homology between species. In this work, we aimed to find functional ... ...

    Abstract Long noncoding RNAs have been identified in most vertebrates, but the functional characterization of these molecules is challenging, mainly due to the lack of linear sequence homology between species. In this work, we aimed to find functional evolutionary convergent lncRNAs involved in development by screening of k-mer content (nonlinear similarity) and secondary structure-based approaches combining in silico, in vitro and in vivo validation analysis. From the Madagascar gecko genes, we have found a non-orthologous lncRNA with a similar k-mer content and structurally concordant with the human lncRNA EVX1AS. Analysis of function-related characteristics together with locus-specific targeting of human EVX1AS and gecko EVX1AS-like (i.e., CRISPR Display) in human neuroepithelial cells and chicken mesencephalon have confirmed that gecko EVX1AS-like lncRNA mimics human EVX1AS function and induces EVX1 expression independently of the target species. Our data shows functional convergence of non-homologous lncRNAs and presents a useful approach for the definition and manipulation of lncRNA function within different model organisms.
    MeSH term(s) Animals ; Female ; Humans ; Biological Evolution ; Embryonic Development ; Lizards/genetics ; RNA, Long Noncoding
    Chemical Substances RNA, Long Noncoding
    Language English
    Publishing date 2023-09-05
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ISSN 2399-3642
    ISSN (online) 2399-3642
    DOI 10.1038/s42003-023-05278-z
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Relative Quantification of Residue-Specific m

    Olazagoitia-Garmendia, Ane / Castellanos-Rubio, Ainara

    Methods in molecular biology (Clifton, N.J.)

    2021  Volume 2298, Page(s) 185–195

    Abstract: Technological advances in high-throughput sequencing in combination with antibody enrichment and/or induced nucleotide-specific chemical modifications have accelerated the mapping of epitranscriptomic modifications. However, site-specific detection and ... ...

    Abstract Technological advances in high-throughput sequencing in combination with antibody enrichment and/or induced nucleotide-specific chemical modifications have accelerated the mapping of epitranscriptomic modifications. However, site-specific detection and quantification of m
    MeSH term(s) Cell Line ; Cell Line, Tumor ; HCT116 Cells ; HEK293 Cells ; High-Throughput Nucleotide Sequencing/methods ; Humans ; Methylation ; RNA/genetics ; RNA Processing, Post-Transcriptional/genetics ; Reverse Transcriptase Polymerase Chain Reaction/methods ; Transcriptome/genetics
    Chemical Substances RNA (63231-63-0)
    Language English
    Publishing date 2021-06-03
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ISSN 1940-6029
    ISSN (online) 1940-6029
    DOI 10.1007/978-1-0716-1374-0_12
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: A Novel, Noninvasive Method to Diagnose Active Eosinophilic Esophagitis, Combining Clinical Data and Oral Cavity RNA Levels.

    Sebastian-Delacruz, Maialen / Garcia-Etxebarria, Koldo / Bilbao, Jose Ramón / Lucendo, Alfredo J / Bujanda, Luis / Castellanos-Rubio, Ainara

    Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association

    2023  Volume 22, Issue 3, Page(s) 656–658.e3

    MeSH term(s) Humans ; Eosinophilic Esophagitis/diagnosis ; RNA ; Mouth ; Enteritis ; Eosinophilia ; Gastritis
    Chemical Substances RNA (63231-63-0)
    Language English
    Publishing date 2023-08-04
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2119789-1
    ISSN 1542-7714 ; 1542-3565
    ISSN (online) 1542-7714
    ISSN 1542-3565
    DOI 10.1016/j.cgh.2023.07.023
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5836: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  10. Article ; Online: m

    Olazagoitia-Garmendia, Ane / Rojas-Márquez, Henar / Sebastian-delaCruz, Maialen / Agirre-Lizaso, Aloña / Ochoa, Anne / Mendoza-Gomez, Luis Manuel / Perugorria, Maria J / Bujanda, Luis / Madrigal, Alain Huerta / Santin, Izortze / Castellanos-Rubio, Ainara

    Advanced science (Weinheim, Baden-Wurttemberg, Germany)

    2024  Volume 11, Issue 13, Page(s) e2307928

    Abstract: Cytokine mediated sustained inflammation increases the risk to develop different complex chronic inflammatory diseases, but the implicated mechanisms remain unclear. Increasing evidence shows that long noncoding RNAs (lncRNAs) play key roles in the ... ...

    Abstract Cytokine mediated sustained inflammation increases the risk to develop different complex chronic inflammatory diseases, but the implicated mechanisms remain unclear. Increasing evidence shows that long noncoding RNAs (lncRNAs) play key roles in the pathogenesis of inflammatory disorders, while inflammation associated variants are described to affect their function or essential RNA modifications as N
    MeSH term(s) Humans ; RNA, Long Noncoding/genetics ; RNA, Long Noncoding/metabolism ; Inflammation/genetics ; Inflammation/metabolism ; Cytokines ; Intestines ; Inflammatory Bowel Diseases
    Chemical Substances RNA, Long Noncoding ; Cytokines
    Language English
    Publishing date 2024-01-25
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 2808093-2
    ISSN 2198-3844 ; 2198-3844
    ISSN (online) 2198-3844
    ISSN 2198-3844
    DOI 10.1002/advs.202307928
    Database MEDical Literature Analysis and Retrieval System OnLINE

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