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Article ; Online: Relationship between male aging and semen quality: a retrospective study on over 2500 men.

Castellini, Chiara / Cordeschi, Giuliana / Tienforti, Daniele / Barbonetti, Arcangelo

2024

Abstract: Purpose: We aimed to evaluate whether and to what extent an association exists between male aging and worsening of semen parameters and to determine whether a threshold age can be identified above which the decline in semen quality becomes statistically ...

Abstract	Purpose: We aimed to evaluate whether and to what extent an association exists between male aging and worsening of semen parameters and to determine whether a threshold age can be identified above which the decline in semen quality becomes statistically significant. Methods: 2612 men (age: 16-56 years) attending an andrology outpatient clinic for semen analysis and clinical evaluation were studied. Semen analyses were performed according to the ongoing WHO-recommended procedures. Total motile count (TMC) and total progressive motile count (TPMC) were calculated by multiplying total sperm number by total motility and progressive motility, respectively. Results: Significant negative correlations were found between age and total motility (r = - 0.131, p < 0.0001), progressive motility (r = - 0.112, p < 0.0001), TPMC (r = - 0.042, p = 0.037), and normal sperm morphology (r = - 0.053, p = 0.007). All these associations persisted in multivariate regression models adjusted for abstinence time, smoking, history of male accessory gland infections, varicocele and the year in which semen analysis was performed. When comparisons were performed among quartiles of increasing age, the fourth quartile, corresponding to the age group > 40 years, was associated with a significant decrease in total and progressive motility. An earlier decline in the TPMC and percentage of normal forms was also observed. Conclusion: Advancing male age exhibits an independent association with a decrease in the percentage of motile and morphologically normal spermatozoa, with greater evidence from the age of > 40 years. Further studies are warranted to elucidate the mechanisms and clinical reflections of these associations.
Language	English
Publishing date	2024-03-29
Publishing country	Germany
Document type	Journal Article
ZDB-ID	896455-5
ISSN	1432-0711 ; 0932-0067
ISSN (online)	1432-0711
ISSN	0932-0067
DOI	10.1007/s00404-024-07448-8
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Article ; Online: Is marijuana a foe of male sexuality? Data from a large cohort of men with sexual dysfunction.

Barbonetti, Arcangelo / Rastrelli, Giulia / Sparano, Clotilde / Castellini, Chiara / Vignozzi, Linda / Maggi, Mario / Corona, Giovanni

Andrology

2023 Volume 12, Issue 1, Page(s) 9–19

Abstract: Background: Although it has been assumed that chronic cannabis use may have an unfavorable impact on male sexual function and its metabolic correlates, evidence from clinical studies remains inconclusive.: Objective: To investigate the relationship ... ...

Abstract	Background: Although it has been assumed that chronic cannabis use may have an unfavorable impact on male sexual function and its metabolic correlates, evidence from clinical studies remains inconclusive. Objective: To investigate the relationship between cannabis use and sexual behavior, anthropometrics and metabolic/vascular profiles in a large series of men evaluated for sexual dysfunction. Methods: A total of 4800 men (mean age 50.8 years) attending an andrology outpatient clinic for sexual dysfunction were studied. Sexual symptoms, hormonal, metabolic, and instrumental (penile color Doppler ultrasound, PCDU) parameters were evaluated according to the reported habitual use of recreational substances (no use, 1-2 joints/week, >2 joints/week, and use of illicit drugs other than cannabis). Results: When compared with non-users, cannabis users were younger and exhibited a lower prevalence of comorbidities as well as better PCDU parameters, despite reporting higher alcohol and tobacco consumption. After adjustment for confounders, cannabis use was associated with a greater instability in the couple's relationship and a higher frequency of masturbation. In addition, the group smoking >2 joints/week showed a significantly lower body mass index than both controls and users of substances other than cannabis. Men who reported using recreational drugs (either cannabis or other) exhibited significantly lower levels of both total and low-density lipoprotein cholesterol than non-users. At the PCDU, smoking 1-2 joints/week was associated with significantly higher dynamic peak systolic velocity than both non-drug use and use of >2 joints/week. Prolactin levels were significantly higher in individuals smoking 1-2 joints/week and in those who used substances other than cannabis when compared with controls, whereas no difference in total testosterone levels was observed. Discussion: In men with sexual dysfunction, mild cannabis consumption may be associated with a more favorable anthropometric and lipid profile and with a better penile arterial vascular response to intracavernous prostaglandin injection.
MeSH term(s)	Humans ; Male ; Middle Aged ; Cannabis ; Erectile Dysfunction ; Sexual Dysfunction, Physiological ; Penis/blood supply ; Sexuality
Language	English
Publishing date	2023-01-20
Publishing country	England
Document type	Journal Article
ZDB-ID	2696108-8
ISSN	2047-2927 ; 2047-2919
ISSN (online)	2047-2927
ISSN	2047-2919
DOI	10.1111/andr.13382
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Article ; Online: Iodine Intake and Testosterone.

Barbonetti, Arcangelo / Castellini, Chiara / Di Giulio, Francesca / Antolini, Federica / Tienforti, Daniele / Muselli, Mario / Baroni, Marco Giorgio

JAMA network open

2023 Volume 6, Issue 12, Page(s) e2348573

MeSH term(s)	Humans ; Testosterone ; Testosterone Congeners ; Nutritional Status ; Iodine
Chemical Substances	Testosterone (3XMK78S47O) ; Testosterone Congeners ; Iodine (9679TC07X4)
Language	English
Publishing date	2023-12-01
Publishing country	United States
Document type	Journal Article
ISSN	2574-3805
ISSN (online)	2574-3805
DOI	10.1001/jamanetworkopen.2023.48573
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Article ; Online: ACE2 Receptor and Its Isoform Short-ACE2 Are Expressed on Human Spermatozoa.

Ramal-Sanchez, Marina / Castellini, Chiara / Cimini, Costanza / Taraschi, Angela / Valbonetti, Luca / Barbonetti, Arcangelo / Bernabò, Nicola / Barboni, Barbara

International journal of molecular sciences

2022 Volume 23, Issue 7

Abstract: Angiotensin-converting enzyme 2 (ACE2) is a protein widely expressed in numerous cell types, with different biological roles mainly related to the renin-angiotensin system. Recently, ACE2 has been in the spotlight due to its involvement in the SARS-CoV-2 ...

Abstract	Angiotensin-converting enzyme 2 (ACE2) is a protein widely expressed in numerous cell types, with different biological roles mainly related to the renin-angiotensin system. Recently, ACE2 has been in the spotlight due to its involvement in the SARS-CoV-2 entry into cells. There are no data available regarding the expression of ACE2 and its short-ACE2 isoform at the protein level on human spermatozoa. Here, protein expression was demonstrated by western blot and the percentage of sperm displaying surface ACE2 was assessed by flow cytometry. Immunocytochemistry assays showed that full-length ACE2 was mainly expressed in sperm midpiece, while short ACE2 was preferentially distributed on the equatorial and post-acrosomal region of the sperm head. To our knowledge, this is the first study demonstrating the expression of protein ACE2 on spermatozoa. Further studies are warranted to determine the role of ACE2 isoforms in male reproduction.
MeSH term(s)	Angiotensin-Converting Enzyme 2 ; COVID-19 ; Humans ; Male ; Protein Isoforms/genetics ; Protein Isoforms/metabolism ; SARS-CoV-2 ; Spermatozoa/metabolism
Chemical Substances	Protein Isoforms ; ACE2 protein, human (EC 3.4.17.23) ; Angiotensin-Converting Enzyme 2 (EC 3.4.17.23)
Language	English
Publishing date	2022-03-28
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2019364-6
ISSN	1422-0067 ; 1422-0067 ; 1661-6596
ISSN (online)	1422-0067
ISSN	1422-0067 ; 1661-6596
DOI	10.3390/ijms23073694
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Article ; Online: Systematic review and meta-analysis: the advantage of endoscopic Mayo score 0 over 1 in patients with ulcerative colitis.

Viscido, Angelo / Valvano, Marco / Stefanelli, Gianpiero / Capannolo, Annalisa / Castellini, Chiara / Onori, Eugenia / Ciccone, Antonio / Vernia, Filippo / Latella, Giovanni

BMC gastroenterology

2022 Volume 22, Issue 1, Page(s) 92

Abstract: Background: Mucosal healing (MH) evaluated by endoscopy is a novel target of therapy in UC as it is associated with improved long-term outcomes. It is defined based on the Mayo endoscopic score (MES), but it is still to define whether a value of MES 0 ... ...

Abstract	Background: Mucosal healing (MH) evaluated by endoscopy is a novel target of therapy in UC as it is associated with improved long-term outcomes. It is defined based on the Mayo endoscopic score (MES), but it is still to define whether a value of MES 0 or 1 should be the target. The purpose of this paper is to present the results of a systematic review with meta-analysis which compares long-term outcomes of patients in steroid-free clinical remission with MES 0 with those with MES 1. Methods: A systematic electronic search of the literature was performed using Medline, Scopus, and CENTRAL through December 2020 (PROSPERO n:CRD42020179333). The studies concerned UC patients, in steroid-free clinical remission, with MES of 0 or 1, and with at least 12-months of follow-up. Results: Out of 4611 citations, 15 eligible studies were identified. Increases in clinical relapse among patients with MES 1 were observed in all the studies included in this review, suggesting that MES of 1 have a higher risk of relapse than a score of 0. MES 0 patients displayed a lower risk of clinical relapse (OR 0.33; 95% CI 0.26-0.43; I Conclusions: MES 0 is associated with a lower rate of clinical relapse than is MES 1. For this reason, MES 0, rather than MES 0-1, should be considered the therapeutic target for patients with UC.
MeSH term(s)	Colectomy ; Colitis, Ulcerative/drug therapy ; Colonoscopy/methods ; Humans ; Intestinal Mucosa ; Severity of Illness Index ; Wound Healing
Language	English
Publishing date	2022-03-03
Publishing country	England
Document type	Journal Article ; Meta-Analysis ; Systematic Review
ZDB-ID	2041351-8
ISSN	1471-230X ; 1471-230X
ISSN (online)	1471-230X
ISSN	1471-230X
DOI	10.1186/s12876-022-02157-5
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Article ; Online: Non-steroidal anti-inflammatory drugs and acetylsalicylic acid increase the risk of complications of diverticular disease: a meta-analysis of case-control and cohort studies.

Longo, Salvatore / Altobelli, Emma / Castellini, Chiara / Vernia, Filippo / Valvano, Marco / Magistroni, Marco / Mancusi, Antonio / Viscido, Angelo / Ashktorab, Hassan / Latella, Giovanni

International journal of colorectal disease

2022 Volume 37, Issue 3, Page(s) 521–529

Abstract: Background: The role of non-steroidal anti-inflammatory drugs (NSAIDs) and acetylsalicylic acid in the occurrence of diverticular bleeding (DB), complicated diverticulitis (CD), and acute diverticulitis (AD) is not yet defined.: Aim: Update a ... ...

Abstract	Background: The role of non-steroidal anti-inflammatory drugs (NSAIDs) and acetylsalicylic acid in the occurrence of diverticular bleeding (DB), complicated diverticulitis (CD), and acute diverticulitis (AD) is not yet defined. Aim: Update a systematic review and meta-analyses of case-control and cohort studies to evaluate the association between NSAIDs or acetylsalicylic acid with DB, CD, or AD. Methods: The study included were identified through MEDLINE, Scopus, Web of Science, and Cochrane Library databases. Sizes were pooled across studies to obtain the overall effect size. A random-effects model was used to account for different sources of variation among studies. Odds ratio (OR) with 95% confidence interval (CI) was used as a measure of effect size. Results: Thirteen studies were included in the systematic review and meta-analysis. NSAIDs and acetylsalicylic acid use were associated with an increased risk of DB (OR: 6.90, 95% CI 3.86 to 12.35, P ˂ 0.00001, and OR 2.84, 95% CI 2.19 to 3.67, P < 0.00001, respectively). NSAIDs and acetylsalicylic acid use were also associated with increased risk of CD occurrence (OR 3.13, 95% CI 1.73 to 5.68, P = 0.0002, and OR 1.49, 95% CI 1.02 to 2.17, P = 0.04, respectively). The only study found about AD occurrence showed that NSAIDs use was not associated with AD and acetylsalicylic acid use had a low risk of AD. Conclusion: NSAIDs and acetylsalicylic acid significantly increase the risk of DB and CD. Further studies are needed to clarify the role of NSAIDs and acetylsalicylic acid in AD. However, increasing evidence suggests caution in the use of such medications in patients with colonic diverticula.
MeSH term(s)	Anti-Inflammatory Agents, Non-Steroidal/adverse effects ; Aspirin/adverse effects ; Case-Control Studies ; Cohort Studies ; Diverticulum, Colon ; Humans ; Pharmaceutical Preparations
Chemical Substances	Anti-Inflammatory Agents, Non-Steroidal ; Pharmaceutical Preparations ; Aspirin (R16CO5Y76E)
Language	English
Publishing date	2022-01-30
Publishing country	Germany
Document type	Journal Article ; Meta-Analysis ; Review ; Systematic Review
ZDB-ID	84975-3
ISSN	1432-1262 ; 0179-1958
ISSN (online)	1432-1262
ISSN	0179-1958
DOI	10.1007/s00384-021-04088-1
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Article ; Online: Infection rate of penile prosthesis implants in men with spinal cord injury: a meta-analysis of available evidence.

Tienforti, Daniele / Totaro, Maria / Spagnolo, Luca / Di Giulio, Francesca / Castellini, Chiara / Felzani, Giorgio / Baroni, Marco Giorgio / Francavilla, Sandro / Barbonetti, Arcangelo

International journal of impotence research

2022 Volume 36, Issue 3, Page(s) 206–213

Abstract: The risk of penile prosthesis implants (PPIs) infection in men with spinal cord injury (SCI), empirically theorized to be high, is widely variable among the studies. We performed a meta-analysis to define the pooled PPI infection rate and its possible ... ...

Abstract	The risk of penile prosthesis implants (PPIs) infection in men with spinal cord injury (SCI), empirically theorized to be high, is widely variable among the studies. We performed a meta-analysis to define the pooled PPI infection rate and its possible risk factors in men with SCI. A thorough search of PubMed, Scopus and Web of Science was performed. The eighteen included studies provided information on 1079 implantation procedures, determining a pooled PPI infection rate of 8.0% (95% CI: 5.0-11.0%), with significant heterogeneity (I² = 67.0%). Trim-and-fill adjustment for publication bias had a small effect on the pooled estimate (adjusted odds ratio: 6.3%, 95% CI: 2.5-10.0%) with a substantial reduction in heterogeneity (I
Language	English
Publishing date	2022-10-18
Publishing country	England
Document type	Journal Article
ZDB-ID	1034295-3
ISSN	1476-5489 ; 0955-9930
ISSN (online)	1476-5489
ISSN	0955-9930
DOI	10.1038/s41443-022-00632-x
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Article ; Online: Effect of antioxidants on semen parameters in men with oligo-astheno-teratozoospermia: a network meta-analysis.

Barbonetti, Arcangelo / Tienforti, Daniele / Castellini, Chiara / Giulio, Francesca Di / Muselli, Mario / Pizzocaro, Alessandro / Vena, Walter / Baroni, Marco Giorgio / Pivonello, Rosario / Isidori, Andrea M / Maggi, Mario / Corona, Giovanni

Andrology

2023 Volume 12, Issue 3, Page(s) 538–552

Abstract: Background: Although antioxidants are largely used in subfertile men with oligo-astheno-teratozoospermia (OAT), the choice among different molecules is challenged by the lack of comparative head-to-head studies. The network meta-analysis (NMA) can ... ...

Abstract	Background: Although antioxidants are largely used in subfertile men with oligo-astheno-teratozoospermia (OAT), the choice among different molecules is challenged by the lack of comparative head-to-head studies. The network meta-analysis (NMA) can overcome limitations of pairwise meta-analyses, since it incorporates direct and indirect evidence into a single model generating an effectiveness hierarchy. Objective: To assess with a NMA the effects of antioxidants in improving seminal parameters in idiopathic OAT. Materials and methods: PubMed, Scopus, Cinahl, and Cochrane Library databases were searched for randomized controlled trials (RCTs) comparing any antioxidant treatment to each other or placebo in men with at least one idiopathic seminal abnormality. Data were included in a random-effects NMA, where efficacy of treatments was ranked by surface under the cumulative ranking curve (SUCRA). Results: 29 RCTs provided information on 2045 men (mean age: 33.5 years) with idiopathic OAT and 19 antioxidant preparations. Compared to placebo, l-carnitine, especially in combination with l-acetyl-carnitine (LAC), had the highest SUCRA for sperm concentration, progressive motility, and morphology. Folate was the only other compound effective on sperm concentration. Vitamin E+selenium or zinc had the highest SUCRA for total motility. A contribution on progressive motility was revealed for pentoxifylline and vitamin E+CoQ10.
MeSH term(s)	Male ; Humans ; Adult ; Antioxidants/therapeutic use ; Antioxidants/pharmacology ; Semen ; Network Meta-Analysis ; Spermatozoa ; Asthenozoospermia/drug therapy ; Vitamin E/pharmacology ; Vitamin E/therapeutic use ; Sperm Motility
Chemical Substances	Antioxidants ; Vitamin E (1406-18-4)
Language	English
Publishing date	2023-07-26
Publishing country	England
Document type	Meta-Analysis ; Journal Article
ZDB-ID	2696108-8
ISSN	2047-2927 ; 2047-2919
ISSN (online)	2047-2927
ISSN	2047-2919
DOI	10.1111/andr.13498
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Article ; Online: Selective modulation of estrogen receptor in obese men with androgen deficiency: A systematic review and meta-analysis.

Tienforti, Daniele / Castellini, Chiara / Di Giulio, Francesca / Totaro, Maria / Dalmazio, Gilda / Spagnolo, Luca / Muselli, Mario / Corona, Giovanni / Baroni, Marco Giorgio / Barbonetti, Arcangelo

Andrology

2023 Volume 11, Issue 6, Page(s) 1067–1076

Abstract: Background: Although selective estrogen receptor modulators have been proposed as a treatment for men with central functional hypogonadism, only a few data have been produced in men with obesity-related functional androgen deficiency.: Objective: To ... ...

Abstract	Background: Although selective estrogen receptor modulators have been proposed as a treatment for men with central functional hypogonadism, only a few data have been produced in men with obesity-related functional androgen deficiency. Objective: To determine whether and to what extent selective estrogen receptor modulators are an effective and safe therapy in men with obesity-related functional androgen deficiency. Materials and methods: A thorough search of PubMed, Web of Science, Scopus, and Cochrane Library databases was performed to identify studies comparing testosterone levels before and after treatment. Mean differences with 95% coefficient intervals were combined using random effects models. Funnel plot, Egger's test, and trim-and-fill analysis were used to assess publication bias. Results: Seven studies met the inclusion criteria providing information on 292 men with obesity-related functional androgen deficiency treated with clomiphene citrate (12.5-50 mg daily) or enclomiphene citrate (12.5-25 mg daily) for 1.5-4 months. The pooled estimates indicated a significant increase in testosterone levels both with clomiphene (mean difference: 11.56 nmol/L; 95% coefficient interval: 9.68, 13.43; I Discussion and conclusion: Treatment with clomiphene citrate and enclomiphene citrate may be an effective and safe alternative to testosterone replacement therapy in men with obesity-related functional androgen deficiency. Further long-term studies are warranted to define clinical reflections of the selective estrogen receptor modulators-induced increase in testosterone levels and to better clarify the safety profile.
MeSH term(s)	Humans ; Male ; Androgens/therapeutic use ; Clomiphene/therapeutic use ; Enclomiphene/therapeutic use ; Eunuchism/drug therapy ; Hypogonadism/complications ; Hypogonadism/drug therapy ; Obesity/complications ; Obesity/drug therapy ; Receptors, Estrogen ; Selective Estrogen Receptor Modulators/therapeutic use ; Testosterone/therapeutic use
Chemical Substances	Androgens ; Clomiphene (1HRS458QU2) ; Enclomiphene (R6D2UI4FLS) ; Receptors, Estrogen ; Selective Estrogen Receptor Modulators ; Testosterone (3XMK78S47O) ; ESR1 protein, human
Language	English
Publishing date	2023-01-18
Publishing country	England
Document type	Meta-Analysis ; Systematic Review ; Journal Article
ZDB-ID	2696108-8
ISSN	2047-2927 ; 2047-2919
ISSN (online)	2047-2927
ISSN	2047-2919
DOI	10.1111/andr.13373
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Article: Pathophysiology of Mitochondrial Dysfunction in Human Spermatozoa: Focus on Energetic Metabolism, Oxidative Stress and Apoptosis.

Castellini, Chiara / D'Andrea, Settimio / Cordeschi, Giuliana / Totaro, Maria / Parisi, Antonio / Di Emidio, Giovanna / Tatone, Carla / Francavilla, Sandro / Barbonetti, Arcangelo

Antioxidants (Basel, Switzerland)

2021 Volume 10, Issue 5

Abstract: The dogma of mitochondria as the major source of energy in supporting sperm motility should be critically reconsidered in the light of several experimental data pointing to a major role of glycolysis in mammalian spermatozoa. In this light, the reported ... ...

Abstract	The dogma of mitochondria as the major source of energy in supporting sperm motility should be critically reconsidered in the light of several experimental data pointing to a major role of glycolysis in mammalian spermatozoa. In this light, the reported positive correlation between the mitochondrial membrane potential (ΔΨm) and motility of ejaculated spermatozoa cannot be explained convincingly by an impaired mitochondrial ATP generation only. Evidence has been produced suggesting that, in human sperm, dysfunctional mitochondria represent the main site of generation of reactive oxygen species (ROS). Furthermore, in these organelles, a complex bidirectional relationship could exist between ROS generation and apoptosis-like events that synergize with oxidative stress in impairing sperm biological integrity and functions. Despite the activity of enzymatic and non-enzymatic antioxidant factors, human spermatozoa are particularly vulnerable to oxidative stress, which plays a major role in male factor infertility. The purpose of this article is to provide an overview of metabolic, oxidative and apoptosis-like inter-linkages of mitochondrial dysfunction and their reflections on human sperm biology.
Language	English
Publishing date	2021-04-28
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2704216-9
ISSN	2076-3921
ISSN	2076-3921
DOI	10.3390/antiox10050695
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