Article: Dalbavancin as suppressive antibiotic therapy in patients with prosthetic infections: efficacy and safety.
2023 Volume 14, Page(s) 1185602
Abstract: Suppressive antibiotic therapy (SAT) is a strategy to alleviate symptoms and/or to reduce the progression of an infection when other treatment options cannot be used. Dalbavancin, due to its prolonged half-life, enables (bi) weekly dosing. Here, we ... ...
| Abstract | Suppressive antibiotic therapy (SAT) is a strategy to alleviate symptoms and/or to reduce the progression of an infection when other treatment options cannot be used. Dalbavancin, due to its prolonged half-life, enables (bi) weekly dosing. Here, we report our multicenter real-life clinical experience with dalbavancin used as SAT in patients with prosthetic joint or vascular infections. Medical records of all adult patients with documented vascular or orthopedic chronic prosthetic infections, who received dalbavancin as SAT between 2016 and 2018 from four Spanish hospitals were reviewed for inclusion. Descriptive analysis of demographic characteristics, Charlson Comorbidity index, Barthel index, isolated pathogens and indication, concomitant antibiotic use, adverse events, and clinical outcome of SAT were performed. Eight patients were eligible for inclusion, where six patients had prosthetic vascular infections (aortic valve) and two patients had knee prosthetic joint infections. The most common pathogens were |
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| Language | English |
| Publishing date | 2023-06-28 |
| Publishing country | Switzerland |
| Document type | Journal Article |
| ZDB-ID | 2587355-6 |
| ISSN | 1663-9812 |
| ISSN | 1663-9812 |
| DOI | 10.3389/fphar.2023.1185602 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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