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Book ; Online ; E-Book: Histone modifications in therapy

Castelo-Branco, Pedro / Jerónimo, Carmen

(Translational epigenetics series ; volume 20)

2020

Author's details	edited by Pedro Castelo-Branco, Carmen Jerónimo
Series title	Translational epigenetics series ; volume 20
Collection
Keywords	Electronic books
Language	English
Size	1 Online-Ressource (xviii, 472 Seiten)
Publisher	Elsevier Academic Press
Publishing place	London
Publishing country	Great Britain
Document type	Book ; Online ; E-Book
Remark	Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
HBZ-ID	HT020580625
ISBN	978-0-12-816740-3 ; 9780128164228 ; 0-12-816740-8 ; 0128164220
Database	ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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Article ; Online: Marine Natural Products as a Promising Source of Therapeutic Compounds to Target Cancer Stem Cells.

Vizetto-Duarte, Catarina / Castelo-Branco, Pedro / Custódio, Luísa

Current medicinal chemistry

2020 Volume 28, Issue 22, Page(s) 4343–4355

Abstract: Cancer is the world's leading cause of death after heart diseases and involves abnormal cell growth at a primary site and the potential to spread to other parts of the body. Tumors are highly heterogeneous and consist of subgroups of cells with distinct ... ...

Abstract	Cancer is the world's leading cause of death after heart diseases and involves abnormal cell growth at a primary site and the potential to spread to other parts of the body. Tumors are highly heterogeneous and consist of subgroups of cells with distinct characteristics. Of these, the cancer stem cells (CSC) niche plays a crucial role in driving the spread of the tumor and are thought to provide treatment resistance. CSC is a rare special population of cancer cells exhibiting high tumorigenic properties together with self-renewal and differentiation capability. CSC is not only linked with high tumor-initiating activity, but is also implicated in chemotherapeutic resistance, metastasis, epithelial to mesenchymal transition, and recurrence. Thereafter, novel therapeutic strategies targeting CSC are in need to improve long-term clinical outcomes. The literature supports the evidence that marine natural compounds can exhibit antioxidant, antimitotic, anti-inflammatory, antibiotic as well as anticancer activity. In this review, we will provide an insight into the relevance of selected marine natural products as a source of bioactive compounds with anti-cancer properties to target CSC, which may benefit the development of novel anti-cancer therapeutic strategies.
MeSH term(s)	Biological Products/pharmacology ; Biological Products/therapeutic use ; Cell Differentiation ; Epithelial-Mesenchymal Transition ; Humans ; Neoplasm Recurrence, Local ; Neoplastic Stem Cells
Chemical Substances	Biological Products
Language	English
Publishing date	2020-03-13
Publishing country	United Arab Emirates
Document type	Journal Article ; Review
ZDB-ID	1319315-6
ISSN	1875-533X ; 0929-8673
ISSN (online)	1875-533X
ISSN	0929-8673
DOI	10.2174/0929867327666200320155053
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Article: Halophyte Plants as Potential Sources of Anticancer Agents: A Comprehensive Review.

Custodio, Luísa / Garcia-Caparros, Pedro / Pereira, Catarina Guerreiro / Castelo-Branco, Pedro

Pharmaceutics

2022 Volume 14, Issue 11

Abstract: Salt-tolerant plants (halophytes) are widely distributed worldwide in several environments such as coastal salt marshes, sand dunes, and inland deserts. To cope with the harsh conditions that characterize those habitats, which include high salinity and ... ...

Abstract	Salt-tolerant plants (halophytes) are widely distributed worldwide in several environments such as coastal salt marshes, sand dunes, and inland deserts. To cope with the harsh conditions that characterize those habitats, which include high salinity and radiation levels, such plants have developed morphological and physiological traits, the latter including the synthesis and accumulation of important secondary metabolites such as alkaloids and polyphenols. While essential in maintaining plant homeostasis, these compounds are highly valued in the medical field for the treatment of several human diseases, including cancer. Cancer is one of the most life-threatening disorders worldwide, which accentuates the need to improve current cancer therapies and minimize potential adverse secondary side-effects. In this context, the pharmacological evaluation of natural compounds has attracted growing interest since nature has already provided some important anti-cancer drugs. This review compiles, for the first time, research regarding the anticancer activity of halophytes from different families, including, whenever possible, the bioactive molecules involved in such therapeutical properties along with possible mechanisms of action. The introduction section provides some pertinent information regarding cancer and a summary of the most important characteristics of halophytes. The next section gives information regarding the in vitro and in vivo cytotoxic properties of several halophyte species, grouped by families, including contents in bioactive metabolites and proposed modes of action, if possible. Lastly, the conclusion presents the most relevant metabolites and/or promising species and extracts that could be further explored in anticancer drug research.
Language	English
Publishing date	2022-11-08
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2527217-2
ISSN	1999-4923
ISSN	1999-4923
DOI	10.3390/pharmaceutics14112406
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Article ; Online: How can we modulate aging through nutrition and physical exercise? An epigenetic approach.

Rajado, Ana Teresa / Silva, Nádia / Esteves, Filipa / Brito, David / Binnie, Alexandra / Araújo, Inês M / Nóbrega, Clévio / Bragança, José / Castelo-Branco, Pedro

Aging

2023 Volume 15, Issue 8, Page(s) 3191–3217

Abstract: The World Health Organization predicts that by 2050, 2.1 billion people worldwide will be over 60 years old, a drastic increase from only 1 billion in 2019. Considering these numbers, strategies to ensure an extended "healthspan" or healthy longevity are ...

Abstract	The World Health Organization predicts that by 2050, 2.1 billion people worldwide will be over 60 years old, a drastic increase from only 1 billion in 2019. Considering these numbers, strategies to ensure an extended "healthspan" or healthy longevity are urgently needed. The present study approaches the promotion of healthspan from an epigenetic perspective. Epigenetic phenomena are modifiable in response to an individual's environmental exposures, and therefore link an individual's environment to their gene expression pattern. Epigenetic studies demonstrate that aging is associated with decondensation of the chromatin, leading to an altered heterochromatin structure, which promotes the accumulation of errors. In this review, we describe how aging impacts epigenetics and how nutrition and physical exercise can positively impact the aging process, from an epigenetic point of view. Canonical histones are replaced by histone variants, concomitant with an increase in histone post-translational modifications. A slight increase in DNA methylation at promoters has been observed, which represses transcription of previously active genes, in parallel with global genome hypomethylation. Aging is also associated with deregulation of gene expression - usually provided by non-coding RNAs - leading to both the repression of previously transcribed genes and to the transcription of previously repressed genes. Age-associated epigenetic events are less common in individuals with a healthy lifestyle, including balanced nutrition, caloric restriction and physical exercise. Healthy aging is associated with more tightly condensed chromatin, fewer PTMs and greater regulation by ncRNAs.
MeSH term(s)	Humans ; Histones/metabolism ; Aging/genetics ; Epigenesis, Genetic ; Chromatin ; DNA Methylation ; RNA, Untranslated/metabolism ; Exercise
Chemical Substances	Histones ; Chromatin ; RNA, Untranslated
Language	English
Publishing date	2023-04-20
Publishing country	United States
Document type	Review ; Journal Article ; Research Support, Non-U.S. Gov't
ISSN	1945-4589
ISSN (online)	1945-4589
DOI	10.18632/aging.204668
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: CRISPR-based strategies in infectious disease diagnosis and therapy.

Binnie, Alexandra / Fernandes, Emanuel / Almeida-Lousada, Helder / de Mello, Ramon Andrade / Castelo-Branco, Pedro

Infection

2021 Volume 49, Issue 3, Page(s) 377–385

Abstract: Purpose: CRISPR gene-editing technology has the potential to transform the diagnosis and treatment of infectious diseases, but most clinicians are unaware of its broad applicability. Derived from an ancient microbial defence system, these so-called " ... ...

Abstract	Purpose: CRISPR gene-editing technology has the potential to transform the diagnosis and treatment of infectious diseases, but most clinicians are unaware of its broad applicability. Derived from an ancient microbial defence system, these so-called "molecular scissors" enable precise gene editing with a low error rate. However, CRISPR systems can also be targeted against pathogenic DNA or RNA sequences. This potential is being combined with innovative delivery systems to develop new therapeutic approaches to infectious diseases. Methods: We searched Pubmed and Google Scholar for CRISPR-based strategies in the diagnosis and treatment of infectious diseases. Reference lists were reviewed and synthesized for narrative review. Results: CRISPR-based strategies represent a novel approach to many challenging infectious diseases. CRISPR technologies can be harnessed to create rapid, low-cost diagnostic systems, as well as to identify drug-resistance genes. Therapeutic strategies, such as CRISPR systems that cleave integrated viral genomes or that target resistant bacteria, are in development. CRISPR-based therapies for emerging viruses, such as SARS-CoV-2, have also been proposed. Finally, CRISPR systems can be used to reprogram human B cells to produce neutralizing antibodies. The risks of CRISPR-based therapies include off-target and on-target modifications. Strategies to control these risks are being developed and a phase 1 clinical trials of CRISPR-based therapies for cancer and monogenic diseases are already underway. Conclusions: CRISPR systems have broad applicability in the field of infectious diseases and may offer solutions to many of the most challenging human infections.
MeSH term(s)	Animals ; Bacteria/genetics ; Bacteria/isolation & purification ; Bacteria/pathogenicity ; CRISPR-Cas Systems ; Communicable Diseases/diagnosis ; Communicable Diseases/therapy ; Gene Editing ; Humans ; Molecular Diagnostic Techniques ; Molecular Targeted Therapy ; Viruses/genetics ; Viruses/isolation & purification ; Viruses/pathogenicity
Language	English
Publishing date	2021-01-03
Publishing country	Germany
Document type	Journal Article ; Review
ZDB-ID	185104-4
ISSN	1439-0973 ; 0300-8126 ; 0173-2129
ISSN (online)	1439-0973
ISSN	0300-8126 ; 0173-2129
DOI	10.1007/s15010-020-01554-w
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Zs.A 881: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
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Article ; Online: Besieged sovereignty

Gouvêa, Carina Barbosa / Castelo Branco, Pedro Hermílio Villas Bôas

HAPSc Policy Briefs Series; Vol 1, No; 171-176 ; 2732-6586 ; 2732-6578

The pandemic and the triple relation between state, international organizations and integral society

2020 Volume 1, Issue :

Abstract: The theory of sovereignty has been challenged by the limits established by the international field and tensions, a likely subordination of the internal right to the global community that is governed by rules and principles and not simply by the exercise ... ...

Abstract	The theory of sovereignty has been challenged by the limits established by the international field and tensions, a likely subordination of the internal right to the global community that is governed by rules and principles and not simply by the exercise of power. The pandemic from COVID-19 has provided an opening in the theoretical field of fragmentation of the theory regarding state sovereignty. A new way to materialize sovereignty that, when put into practice, can assume the functions of global governance exercised by an international organization. This ability of exercising state sovereignty, named besieged sovereignty in this document, has the initial goal of justifying the use of this new concept that emerged from a state of global exception, in addition to presenting, briefly, the approach to the validity of legal norms. Two hypotheses will be presented for the field of this research: can there be unilateral and/or plurilateral intervention in state sovereignty in case there is a declaration of a state of emergency, of exception, in the global field? Can there be an authorization of the United Nations Charter for direct intervention on behalf of individual or collective self-defense, in the case of an armed attack upon the nation that represents imminent risk of transmission and spread of the pandemic? We will argue that besieged sovereignty represents a serious risk to state sovereignty and that the international community needs to be actively engaged in ensuring that governments observe the standards and quickly return to normal so that there is no “legitimate use of force ”and unilateral or plurilateral interventions, since the sovereign will be the one who is capable, over the abnormality, in order to suspend the legal order in whole or in part and with the purpose of restoring normality.
Keywords	COVID-19 ; pandemic ; coronavirus ; state ; sovereignty ; solidarity ; international organizations ; social cohesion ; international relations ; integral society ; unilateral ; plurilateral ; state of emergency ; covid19
Language	English
Publishing date	2020-06-30
Publisher	Hellenic Association of Political Scientists (HAPSc)
Publishing country	gr
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Correction for: Identification of colorectal cancer associated biomarkers: an integrated analysis of miRNA expression.

Fonseca, André / Ramalhete, Sara Ventura / Mestre, André / Pires das Neves, Ricardo / Marreiros, Ana / Castelo-Branco, Pedro / Roberto, Vânia Palma

Aging

2022 Volume 14, Issue 4, Page(s) 2014–2015

Language	English
Publishing date	2022-02-28
Publishing country	United States
Document type	Journal Article ; Published Erratum
ISSN	1945-4589
ISSN (online)	1945-4589
DOI	10.18632/aging.203866
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Article ; Online: Measuring healthy ageing: current and future tools.

Silva, Nádia / Rajado, Ana Teresa / Esteves, Filipa / Brito, David / Apolónio, Joana / Roberto, Vânia Palma / Binnie, Alexandra / Araújo, Inês / Nóbrega, Clévio / Bragança, José / Castelo-Branco, Pedro

Biogerontology

2023 Volume 24, Issue 6, Page(s) 845–866

Abstract: Human ageing is a complex, multifactorial process characterised by physiological damage, increased risk of age-related diseases and inevitable functional deterioration. As the population of the world grows older, placing significant strain on social and ... ...

Abstract	Human ageing is a complex, multifactorial process characterised by physiological damage, increased risk of age-related diseases and inevitable functional deterioration. As the population of the world grows older, placing significant strain on social and healthcare resources, there is a growing need to identify reliable and easy-to-employ markers of healthy ageing for early detection of ageing trajectories and disease risk. Such markers would allow for the targeted implementation of strategies or treatments that can lessen suffering, disability, and dependence in old age. In this review, we summarise the healthy ageing scores reported in the literature, with a focus on the past 5 years, and compare and contrast the variables employed. The use of approaches to determine biological age, molecular biomarkers, ageing trajectories, and multi-omics ageing scores are reviewed. We conclude that the ideal healthy ageing score is multisystemic and able to encompass all of the potential alterations associated with ageing. It should also be longitudinal and able to accurately predict ageing complications at an early stage in order to maximize the chances of successful early intervention.
MeSH term(s)	Humans ; Healthy Aging ; Aging ; Biomarkers
Chemical Substances	Biomarkers
Language	English
Publishing date	2023-07-13
Publishing country	Netherlands
Document type	Journal Article ; Review ; Research Support, Non-U.S. Gov't
ZDB-ID	2047160-9
ISSN	1573-6768 ; 1389-5729
ISSN (online)	1573-6768
ISSN	1389-5729
DOI	10.1007/s10522-023-10041-2
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Article ; Online: Reprogramming iPSCs to study age-related diseases: Models, therapeutics, and clinical trials.

Esteves, Filipa / Brito, David / Rajado, Ana Teresa / Silva, Nádia / Apolónio, Joana / Roberto, Vânia Palma / Araújo, Inês / Nóbrega, Clévio / Castelo-Branco, Pedro / Bragança, José

Mechanisms of ageing and development

2023 Volume 214, Page(s) 111854

Abstract: The unprecedented rise in life expectancy observed in the last decades is leading to a global increase in the ageing population, and age-associated diseases became an increasing societal, economic, and medical burden. This has boosted major efforts in ... ...

Abstract	The unprecedented rise in life expectancy observed in the last decades is leading to a global increase in the ageing population, and age-associated diseases became an increasing societal, economic, and medical burden. This has boosted major efforts in the scientific and medical research communities to develop and improve therapies to delay ageing and age-associated functional decline and diseases, and to expand health span. The establishment of induced pluripotent stem cells (iPSCs) by reprogramming human somatic cells has revolutionised the modelling and understanding of human diseases. iPSCs have a major advantage relative to other human pluripotent stem cells as their obtention does not require the destruction of embryos like embryonic stem cells do, and do not have a limited proliferation or differentiation potential as adult stem cells. Besides, iPSCs can be generated from somatic cells from healthy individuals or patients, which makes iPSC technology a promising approach to model and decipher the mechanisms underlying the ageing process and age-associated diseases, study drug effects, and develop new therapeutic approaches. This review discusses the advances made in the last decade using iPSC technology to study the most common age-associated diseases, including age-related macular degeneration (AMD), neurodegenerative and cardiovascular diseases, brain stroke, cancer, diabetes, and osteoarthritis.
MeSH term(s)	Humans ; Induced Pluripotent Stem Cells ; Pluripotent Stem Cells ; Cell Differentiation ; Adult Stem Cells ; Aging
Language	English
Publishing date	2023-08-12
Publishing country	Ireland
Document type	Review ; Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	183915-9
ISSN	1872-6216 ; 0047-6374
ISSN (online)	1872-6216
ISSN	0047-6374
DOI	10.1016/j.mad.2023.111854
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Article: DNA Methylation of PI3K/AKT Pathway-Related Genes Predicts Outcome in Patients with Pancreatic Cancer: A Comprehensive Bioinformatics-Based Study.

Faleiro, Inês / Roberto, Vânia Palma / Demirkol Canli, Secil / Fraunhoffer, Nicolas A / Iovanna, Juan / Gure, Ali Osmay / Link, Wolfgang / Castelo-Branco, Pedro

Cancers

2021 Volume 13, Issue 24

Abstract: Pancreatic cancer (PCA) is one of the most lethal malignancies worldwide with a 5-year survival rate of 9%. Despite the advances in the field, the need for an earlier detection and effective therapies is paramount. PCA high heterogeneity suggests that ... ...

Abstract	Pancreatic cancer (PCA) is one of the most lethal malignancies worldwide with a 5-year survival rate of 9%. Despite the advances in the field, the need for an earlier detection and effective therapies is paramount. PCA high heterogeneity suggests that epigenetic alterations play a key role in tumour development. However, only few epigenetic biomarkers or therapeutic targets have been identified so far. Here we explored the potential of distinct DNA methylation signatures as biomarkers for early detection and prognosis of PCA. PI3K/AKT-related genes differentially expressed in PCA were identified using the Pancreatic Expression Database (
Language	English
Publishing date	2021-12-17
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2527080-1
ISSN	2072-6694
ISSN	2072-6694
DOI	10.3390/cancers13246354
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