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Article ; Online: Summary and considerations in genitourinary cancer patient care during the COVID-19 Pandemic.

Rodríguez-Covarrubias, Francisco / Castillejos-Molina, Ricardo A / Autrán-Gómez, Ana María

International braz j urol : official journal of the Brazilian Society of Urology

2020 Volume 46, Issue suppl.1, Page(s) 98–103

Abstract: Purpose: To provide a summary and recommendations for the set-up of strategies for cancer patients care in genitourinary oncology clinics during the pandemic and in the recovery period.: Material and methods: A non-systematic review of available ... ...

Abstract	Purpose: To provide a summary and recommendations for the set-up of strategies for cancer patients care in genitourinary oncology clinics during the pandemic and in the recovery period. Material and methods: A non-systematic review of available literature on the management of urological malignancies during the COVID-19 pandemic was performed to summarize recommendations to improve the diagnosis and treatment of urological cancers during and after the contingence, including clinical and research aspects. Results: Urological cancer diagnosis and management should be tailored according to the severity of the COVID-19 crisis in each region and the aggressiveness of each tumor. Clinicians should adhere to strict protocols in order to prioritize the attention of patients with high-risk malignancies while optimizing resources to avoid the saturation of critical care services. Conclusions: During the COVID-19 pandemic urological cancer care has been severely impaired. For proper patient management, multidisciplinary approach is encouraged tailoring therapy according to COVID-19 regional behavior and local institutional resources. Patients with high-risk malignancies should be prioritized.
MeSH term(s)	Betacoronavirus ; COVID-19 ; Coronavirus Infections/epidemiology ; Humans ; Medical Oncology/methods ; Pandemics ; Patient Care ; Pneumonia, Viral/epidemiology ; SARS-CoV-2 ; Urogenital Neoplasms/therapy
Keywords	covid19
Language	English
Publishing date	2020-06-12
Publishing country	Brazil
Document type	Journal Article ; Review
ZDB-ID	2206649-4
ISSN	1677-6119 ; 1677-5538
ISSN (online)	1677-6119
ISSN	1677-5538
DOI	10.1590/S1677-5538.IBJU.2020.S115
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Article ; Online: Prostate cancer.

Castillejos-Molina, Ricardo Alonso / Gabilondo-Navarro, Fernando Bernardo

Salud publica de Mexico

2016 Volume 58, Issue 2, Page(s) 279–284

Abstract: Prostate cancer is the most frequent tumor found in men worldwide and in Mexico in particular. Age and family history are the main risk factors. The diagnosis is made by prostate biopsy in patients with abnormalities detected in their prostate-specific ... ...

Abstract	Prostate cancer is the most frequent tumor found in men worldwide and in Mexico in particular. Age and family history are the main risk factors. The diagnosis is made by prostate biopsy in patients with abnormalities detected in their prostate-specific antigen (PSA) levels or digital rectal exam (DRE). This article reviews screening and diagnostic methods as well as treatment options for patients diagnosed with prostate cancer.
MeSH term(s)	Antineoplastic Agents, Hormonal/therapeutic use ; Early Detection of Cancer ; Humans ; Male ; Neoplasm Metastasis ; Prostate-Specific Antigen/blood ; Prostatectomy ; Prostatic Neoplasms/diagnosis ; Prostatic Neoplasms/epidemiology ; Prostatic Neoplasms/prevention & control ; Prostatic Neoplasms/therapy ; Radiotherapy, Conformal ; Risk Factors
Chemical Substances	Antineoplastic Agents, Hormonal ; Prostate-Specific Antigen (EC 3.4.21.77)
Language	English
Publishing date	2016-07-05
Publishing country	Mexico
Document type	Journal Article ; Review
ZDB-ID	954220-6
ISSN	1606-7916 ; 0036-3634
ISSN (online)	1606-7916
ISSN	0036-3634
DOI	10.21149/spm.v58i2.7797
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Article: Summary and considerations in genitourinary cancer patient care during the COVID-19 Pandemic

Rodríguez-Covarrubias, Francisco / Castillejos-Molina, Ricardo A. / Autrán-Gómez, Ana María

International braz j urol : official journal of the Brazilian Society of Urology

Abstract: PURPOSE: To provide a summary and recommendations for the set-up of strategies for cancer patients care in genitourinary oncology clinics during the pandemic and in the recovery period MATERIAL AND METHODS: A non-systematic review of available literature ...

Abstract	PURPOSE: To provide a summary and recommendations for the set-up of strategies for cancer patients care in genitourinary oncology clinics during the pandemic and in the recovery period MATERIAL AND METHODS: A non-systematic review of available literature on the management of urological malignancies during the COVID-19 pandemic was performed to summarize recommendations to improve the diagnosis and treatment of urological cancers during and after the contingence, including clinical and research aspects RESULTS: Urological cancer diagnosis and management should be tailored according to the severity of the COVID-19 crisis in each region and the aggressiveness of each tumor Clinicians should adhere to strict protocols in order to prioritize the attention of patients with high-risk malignancies while optimizing resources to avoid the saturation of critical care services CONCLUSIONS: During the COVID-19 pandemic urological cancer care has been severely impaired For proper patient management, multidisciplinary approach is encouraged tailoring therapy according to COVID-19 regional behavior and local institutional resources Patients with high-risk malignancies should be prioritized
Keywords	covid19
Publisher	WHO
Document type	Article
Note	WHO #Covidence: #600943
Database	COVID19

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Article: Routine systematic prostate biopsies not replaced by magnetic resonance imaging-targeted biopsy.

Gómez-Ortiz, David / Garza-Gangemi, Adrián M / Oropeza-Aguilar, Mariano / Rangel-Suárez, Sergio / Espinosa-Cruz, Verónica / Villegas-Hernández, Antonio C / Martínez-Martínez, Ricardo / Castillejos-Molina, Ricardo A

Revista de investigacion clinica; organo del Hospital de Enfermedades de la Nutricion

2022 Volume 74, Issue 4, Page(s) 212–218

Abstract: Background: Multiparametric magnetic resonance imaging improves the performance of prostate cancer (PCa) diagnostics through a better selection of patients.: Objectives: The aim of the study was to study the detection rate (DR) of systematic and ... ...

Abstract	Background: Multiparametric magnetic resonance imaging improves the performance of prostate cancer (PCa) diagnostics through a better selection of patients. Objectives: The aim of the study was to study the detection rate (DR) of systematic and targeted cognitive biopsies in a cohort with the previous negative systematic biopsies. A secondary objective was to describe the value of prostate-specific antigen density (PSAd) in the detection of clinically significant PCa (CSPCa). Methods: We designed a prospective, single-center, and comparative study to determine the DR of systematic and targeted cognitive biopsies. The clinical and pathological characteristics of each patient were described. Results: A total of 111 patients with Prostate Imaging Reporting and Data System lesions > 3 were included in the study. PCa was detected in 41.4% (46 of 111 patients); 42 (91.3%) were detected by systematic biopsy and 30 (65.2%) by targeted biopsy. CSPCa was detected in 26 (23.4%), 23 (88.5%) by systematic biopsy, and 21 (76.9%) by targeted biopsy. PSAd > 0.15 was directly associated with CSPCa. Conclusion: The detection of PCa by systematic biopsy in this series was higher than 80%; hence, its routine use should not be replaced by targeted biopsy, since it continues to be the cornerstone of the diagnosis in patients with prior negative biopsies.
MeSH term(s)	Biopsy ; Humans ; Image-Guided Biopsy/methods ; Magnetic Resonance Imaging/methods ; Male ; Prospective Studies ; Prostate/diagnostic imaging ; Prostate/pathology ; Prostatic Neoplasms/diagnostic imaging ; Prostatic Neoplasms/pathology
Language	English
Publishing date	2022-07-01
Publishing country	Mexico
Document type	Journal Article
ZDB-ID	138348-6
ISSN	0034-8376
ISSN	0034-8376
DOI	10.24875/RIC.22000084
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Article ; Online: Muscle wasting assessment tools for prostate cancer.

Espinosa-Marrón, Alan / Rubio-Blancas, Aquiles / Quiñones-Capistran, Christian Aníbal / Camacho-Zamora, Anais / Salcedo-Grajales, Itzel / Bravo-García, Ana Paula / Bourlon, Maria T / Castillejos-Molina, Ricardo A / Dias, Julie-Alexia / Del Pilar Milke-García, María

Scientific reports

2022 Volume 12, Issue 1, Page(s) 4662

Abstract: Prostate cancer and its treatment may induce muscle wasting. Body composition and muscle functionality are rarely assessed in patients with prostate cancer from developing countries due to the limited availability of high-quality equipment for routine ... ...

Abstract	Prostate cancer and its treatment may induce muscle wasting. Body composition and muscle functionality are rarely assessed in patients with prostate cancer from developing countries due to the limited availability of high-quality equipment for routine diagnosis. This cross-sectional study evaluated the association between several simplistic techniques for assessing muscle mass and function with a more complex standard of reference for muscle wasting among Mexican men with prostate cancer. Muscle wasting was highly prevalent, yet it was presumably associated with aging rather than cancer and its treatment itself. The restricted availability of specific equipment in clinical settings with technological limitations supports using unsophisticated techniques as surrogate measurements for muscle wasting. The left-arm handgrip dynamometry displayed the highest correlation with the standard of reference and exhibited an acceptable predicted probability for muscle estimation. Combining several simplistic techniques may be preferable. We also developed and internally validated a manageable model that helps to identify elderly patients with prostate cancer at risk of muscle depletion and impairment. These findings promote the early recognition and treatment of muscle wasting alterations occurring among older adults with prostate cancer.
MeSH term(s)	Aged ; Cross-Sectional Studies ; Hand Strength/physiology ; Humans ; Male ; Muscle, Skeletal ; Muscles ; Muscular Atrophy ; Prostatic Neoplasms/complications
Language	English
Publishing date	2022-03-18
Publishing country	England
Document type	Journal Article
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-022-08501-9
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Article ; Online: Urological Cancers and Kidney Transplantation: a Literature Review.

Hernández-Gaytán, Cristian Axel / Rodríguez-Covarrubias, Francisco / Castillejos-Molina, Ricardo A / Hernández-Porras, Andrés / Tobia, Ignacio / Dubin, Justin M / Autrán-Gómez, Ana María

Current urology reports

2021 Volume 22, Issue 12, Page(s) 62

Abstract: Purpose of review: The aim of this review is to provide an overview of epidemiology, risk factors, and treatment of urological malignancies in renal transplant recipients (RTR).: Recent findings: Although optimal immunosuppressive therapy and cancer ... ...

Abstract	Purpose of review: The aim of this review is to provide an overview of epidemiology, risk factors, and treatment of urological malignancies in renal transplant recipients (RTR). Recent findings: Although optimal immunosuppressive therapy and cancer management in these patients remain controversial, adherence to general guidelines is recommended. Kidney transplantation is recognized as the standard of care for the treatment of end-stage renal disease (ESRD) as it offers prolonged survival and better quality of life. In the last decades, survival of RTRs has increased as a result of improved immunosuppressive therapy; nonetheless, the risk of developing cancer is higher among RTRs compared to the general population. Urological malignancies are the second most common after hematological cancer and often have more aggressive behavior and poor prognosis.
MeSH term(s)	Humans ; Kidney Failure, Chronic/epidemiology ; Kidney Failure, Chronic/etiology ; Kidney Failure, Chronic/surgery ; Kidney Transplantation/adverse effects ; Quality of Life ; Transplant Recipients ; Urologic Neoplasms/epidemiology ; Urologic Neoplasms/therapy
Language	English
Publishing date	2021-12-16
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	2057354-6
ISSN	1534-6285 ; 1527-2737
ISSN (online)	1534-6285
ISSN	1527-2737
DOI	10.1007/s11934-021-01078-2
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Article ; Online: Incidence and treatment of malignant tumors of the genitourinary tract in renal transplant recipients.

Ochoa-López, Juan Manuel / Gabilondo-Pliego, Bernardo / Collura-Merlier, Sylvain / Herrera-Cáceres, Jaime O / de Zavaleta, Mariano Sotomayor / Rodríguez-Covarrubias, Francisco Tomás / Feria-Bernal, Guillermo / Gabilondo-Navarro, Fernando / Castillejos-Molina, Ricardo Alonso

International braz j urol : official journal of the Brazilian Society of Urology

2018 Volume 44, Issue 5, Page(s) 874–881

Abstract: Purpose: To provide data of the incidence and management of common urological malignancies in renal transplant recipients.: Materials and methods: We conducted a retrospective analysis of a prospective database from August 1967 to August 2015. A ... ...

Abstract	Purpose: To provide data of the incidence and management of common urological malignancies in renal transplant recipients. Materials and methods: We conducted a retrospective analysis of a prospective database from August 1967 to August 2015. A descriptive analysis of the sample was performed. Results: Among 1256 consecutive RTR a total of 88 patients developed malignancies (7%). There were 18 genitourinary tumors in the 16 patients (20.45% of all malignant neoplasms), incidence of 1.27%. The most common neoplasm encounter was renal cancer (38.8%), followed by urothelial carcinoma (33.3%). Median follow up of transplantation was 197 months (R, 36-336). Mean time from RT to cancer diagnosis 89±70 months (R, 12-276). CsA and AZA was the most common immunosuppression regimen in 68.75%. Mean follow-up after diagnosis was 103±72 months (R 10-215). Recurrence free survival rate of 100%. Overall survival of 89.5% of the sample; there were two non-related cancer deaths during follow up. Conclusions: The incidence of neoplasms in RTR was lower than in other series, with favorable functional and oncologic results after treatment. This suggests that actions to reduce the risk of these malignancies as well as a strict follow-up are mandatory for an early detection and treatment.
MeSH term(s)	Adolescent ; Adult ; Aged ; Female ; Humans ; Incidence ; Kidney Transplantation/adverse effects ; Kidney Transplantation/statistics & numerical data ; Male ; Mexico/epidemiology ; Middle Aged ; Prospective Studies ; Retrospective Studies ; Urogenital Neoplasms/epidemiology ; Urogenital Neoplasms/therapy ; Young Adult
Language	English
Publishing date	2018-05-14
Publishing country	Brazil
Document type	Journal Article
ZDB-ID	2206649-4
ISSN	1677-6119 ; 1677-5538
ISSN (online)	1677-6119
ISSN	1677-5538
DOI	10.1590/S1677-5538.IBJU.2017.0471
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Article: Volumetric assessment of lymph node metastases in patients with non-seminomatous germ cell tumours treated with chemotherapy.

Basilio-de-Leo, Carlos I / Villeda-Sandoval, Christian I / Culebro-García, Carolina / Rodríguez-Covarrubias, Francisco / Castillejos-Molina, Ricardo A

Canadian Urological Association journal = Journal de l'Association des urologues du Canada

2015 Volume 9, Issue 5-6, Page(s) E247–51

Abstract: Introduction: We evaluate volumetry and RECIST (Response Evaluation Criteria In Solid Tumors) as methodologies for response after chemotherapy for non-seminomatous germ cell tumour with retroperitoneal lymph node metastases.: Methods: We performed a ... ...

Abstract	Introduction: We evaluate volumetry and RECIST (Response Evaluation Criteria In Solid Tumors) as methodologies for response after chemotherapy for non-seminomatous germ cell tumour with retroperitoneal lymph node metastases. Methods: We performed a retrospective analysis of non-seminomatous testicular tumours and concurrent retroperitoneal lymph node metastases, which received chemotherapy and had computed tomography scans before and after treatment. Volumetric analysis and RECIST criteria were used to calculate response rates. We included a new category (favourable response) for patients with response rates between <100% and >70%. We calculated the correlation between volumetric and RECIST criteria with histological and clinical variables. Results: In total, 18 patients met the inclusion criteria. Histopathologic analysis of orchiectomy showed teratoma in 55.5% of patients, and those without teratoma had predominantly embryonal carcinoma. The mean baseline volume of retroperitoneal metastases was 447 cc, the mean post-chemotherapy volume was 33.6 cc, and the response rate was 62.6%. According to RECIST criteria, the mean baseline diameter was 4.93 cm, the mean post-chemotherapy diameter was 2.39 cm, and the response rate was 42.4%. Large post-chemotherapy residual masses correlated in both classifications with teratoma. The response rate was associated with the need for surgical treatment and the volumetric classification correlated with the need for lymphadenectomy. Conclusions: This study evaluated volumetry as a way to measure clinical response in lymph node metastases of non-seminomatous germ cell tumours. Volumetric analysis is the next step in the evaluation of response rate; its accuracy remains to be determined. Teratoma had greater residual masses and our classification correlated with the need for lymphadenectomy.
Language	English
Publishing date	2015-05-13
Publishing country	Canada
Document type	Journal Article
ZDB-ID	2431403-1
ISSN	1911-6470
ISSN	1911-6470
DOI	10.5489/cuaj.2152
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Article ; Online: Surgical treatment of renal-cell carcinoma in elderly people.

Rodríguez-Covarrubias, F / Rivera-Ramirez, J A / Gabilondo-Pliego, B / Castillejos-Molina, R A / Sotomayor, M / Feria-Bernal, G / Gabilondo-Navarro, F

Actas urologicas espanolas

2016 Volume 40, Issue 6, Page(s) 395–399

Abstract: Objective: To describe the oncological characteristics and evolution of patients 65 years or older who underwent surgery for renal-cell carcinoma (RCC).: Methods: We reviewed our prospectively maintained database of patients with RCC treated ... ...

Title translation	Tratamiento quirúrgico del carcinoma de células renales en personas de edad avanzada.
Abstract	Objective: To describe the oncological characteristics and evolution of patients 65 years or older who underwent surgery for renal-cell carcinoma (RCC). Methods: We reviewed our prospectively maintained database of patients with RCC treated surgically. Those ≥ 65 years old were selected. We analyzed clinical and pathological characteristics as well as oncological and functional outcomes. Overall survival (OS) was estimated with the Kaplan-Meier method. Multivariate Cox-proportional hazards model was used to determine predictors of OS. Results: A total of 156 elderly patients with mean age 72.0±5.5 years (range 65-92) and median follow-up of 33 months were included. Surgical approach was open radical nephrectomy in 114 (73.5%), laparoscopic radical nephrectomy in 13 (8.4%), open partial nephrectomy in 23 (14.2%) and laparoscopic partial nephrectomy in 6 (3.9%). Pathological stage was: Stage I, 71 (45.5%); Stage II, 27 (17.3%); Stage III, 48 (30.8%); and Stage IV, 10 (6.4%). Lastly, 51 (32.6%) patients died, 22 (43.1%) from cancer. The 5-year OS according to pathological stage was 77.6%, 71.9%, 45.1% and 11.7% for stage I, II, III and IV, respectively (P<.001). On multivariate analysis, pathological stage independently predicted OS (HR 1.96, 95% CI [1.36-2.84], P=.0003). Conclusions: The surgical management of RCC appears to be safe in properly selected patients 65 years or older. Pathological stage predicts survival in this population.
MeSH term(s)	Aged ; Aged, 80 and over ; Carcinoma, Renal Cell/mortality ; Carcinoma, Renal Cell/pathology ; Carcinoma, Renal Cell/surgery ; Female ; Humans ; Kidney Neoplasms/mortality ; Kidney Neoplasms/pathology ; Kidney Neoplasms/surgery ; Male ; Nephrectomy/methods ; Proportional Hazards Models ; Retrospective Studies
Language	Spanish
Publishing date	2016-07
Publishing country	Spain
Document type	Journal Article
ZDB-ID	604530-3
ISSN	1699-7980 ; 0210-4806
ISSN (online)	1699-7980
ISSN	0210-4806
DOI	10.1016/j.acuro.2016.01.009
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Article: The role of radical prostatectomy in the management of patients with high-grade prostate cancer and/or locally advanced disease.

Rodríguez-Covarrubias, Francisco / Castillejos-Molina, Ricardo A / Sotomayor, Mariano / Gabilondo, Fernando / Feria-Bernal, Guillermo

Revista de investigacion clinica; organo del Hospital de Enfermedades de la Nutricion

2009 Volume 61, Issue 6, Page(s) 456–460

Abstract: Objective: To analyze the outcome of patients with clinically localized prostate cancer (PCa) treated with radical prostatectomy (RP) in whom high-grade (HGPCa) and/or locally advanced disease (LAPCa) was found at RP specimen and to evaluate the ... ...

Abstract	Objective: To analyze the outcome of patients with clinically localized prostate cancer (PCa) treated with radical prostatectomy (RP) in whom high-grade (HGPCa) and/or locally advanced disease (LAPCa) was found at RP specimen and to evaluate the prognostic value of well-known factors in this subset of patients. Material and methods: Biochemical progression-free (bPFS) was determined with the Kaplan-Meier method. The effect of PSA, biopsy Gleason, clinical stage and number of adverse pathological factors was assessed with univariate and multivariate analyses. Results: After RP, 87 men had HGPCa (20.7%) or LAPCa (56.3%), with 20 (23%) having both criteria. Mean PSA was 15.5 +/- 14.0 ng/mL and mean follow-up 50.5 +/- 42.6 months. The 5-year bPFS for men with PSA < 10 ng/mL and > or = 10 ng/mL was 54.7% and 35.7%, respectively (p = 0.03). Regarding biopsy Gleason, the 5-year bPFS was 49% and 26% for patients with a score < or = 7 and > 7, respectively (p = 0.002). In the multivariate model, the biopsy Gleason score remained independently associated with biochemical progression. Conclusions: HGPCa and/or LAPCa confer poor prognosis; however, RP appears to offer acceptable control, particularly when initial PSA is < 10 ng/mL and biopsy Gleason is 7 or less.
MeSH term(s)	Aged ; Humans ; Male ; Middle Aged ; Neoplasm Staging ; Prostatectomy ; Prostatic Neoplasms/pathology ; Prostatic Neoplasms/surgery
Language	English
Publishing date	2009-11
Publishing country	Mexico
Document type	Journal Article
ZDB-ID	138348-6
ISSN	0034-8376
ISSN	0034-8376
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