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Article ; Online: Toxicology of Nanomaterials

Castranova Vince / Borm Paul

Particle and Fibre Toxicology, Vol 6, Iss 1, p

Permanent interactive learning

2009 Volume 28

Abstract: Abstract Particle and Fibre Toxicology wants to play a decisive role in a time where particle research is challenged and driven by the developments and applications of nanomaterials. This aim is not merely quantitative in publishing a given number of ... ...

Abstract	Abstract Particle and Fibre Toxicology wants to play a decisive role in a time where particle research is challenged and driven by the developments and applications of nanomaterials. This aim is not merely quantitative in publishing a given number of papers on nanomaterials, but also qualitatively since the field of nanotoxicology is rapidly emerging and benchmarks for good science are needed. Since then a number of things have happened that merit further analysis. The interactive learning issue is best shown by report and communications on the toxicology of multi-wall carbon nanotubes (CNT). A special workshop on the CNT has now been organized twice in Nagano (Japan) and this editorial contains a summary of the most important outcomes. Finally, we take the opportunity discuss some recent reports from the nanotech literature, and more specifically a Chinese study that claims severe consequences of nanoparticle exposure.
Keywords	Chemistry ; QD1-999 ; Science ; Q ; DOAJ:Chemistry (General) ; DOAJ:Chemistry ; Toxicology. Poisons ; RA1190-1270 ; Public aspects of medicine ; RA1-1270 ; Medicine ; R ; DOAJ:Public Health ; DOAJ:Health Sciences
Subject code	306
Language	English
Publishing date	2009-10-01T00:00:00Z
Publisher	BioMed Central
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Toxicology of Nanomaterials: Permanent interactive learning.

Borm, Paul / Castranova, Vince

Particle and fibre toxicology

2009 Volume 6, Page(s) 28

Abstract: Particle and Fibre Toxicology wants to play a decisive role in a time where particle research is challenged and driven by the developments and applications of nanomaterials. This aim is not merely quantitative in publishing a given number of papers on ... ...

Abstract	Particle and Fibre Toxicology wants to play a decisive role in a time where particle research is challenged and driven by the developments and applications of nanomaterials. This aim is not merely quantitative in publishing a given number of papers on nanomaterials, but also qualitatively since the field of nanotoxicology is rapidly emerging and benchmarks for good science are needed. Since then a number of things have happened that merit further analysis. The interactive learning issue is best shown by report and communications on the toxicology of multi-wall carbon nanotubes (CNT). A special workshop on the CNT has now been organized twice in Nagano (Japan) and this editorial contains a summary of the most important outcomes. Finally, we take the opportunity discuss some recent reports from the nanotech literature, and more specifically a Chinese study that claims severe consequences of nanoparticle exposure.
Language	English
Publishing date	2009-10-28
Publishing country	England
Document type	Journal Article
ZDB-ID	2170936-1
ISSN	1743-8977 ; 1743-8977
ISSN (online)	1743-8977
ISSN	1743-8977
DOI	10.1186/1743-8977-6-28
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Article ; Online: Oxidant-induced epithelial alarmin pathway mediates lung inflammation and functional decline following ultrafine carbon and ozone inhalation co-exposure.

Majumder, Nairrita / Goldsmith, William T / Kodali, Vamsi K / Velayutham, Murugesan / Friend, Sherri A / Khramtsov, Valery V / Nurkiewicz, Timothy R / Erdely, Aaron / Zeidler-Erdely, Patti C / Castranova, Vince / Harkema, Jack R / Kelley, Eric E / Hussain, Salik

Redox biology

2021 Volume 46, Page(s) 102092

Abstract: Environmental inhalation exposures are inherently mixed (gases and particles), yet regulations are still based on single toxicant exposures. While the impacts of individual components of environmental pollution have received substantial attention, the ... ...

Abstract	Environmental inhalation exposures are inherently mixed (gases and particles), yet regulations are still based on single toxicant exposures. While the impacts of individual components of environmental pollution have received substantial attention, the impact of inhalation co-exposures is poorly understood. Here, we mechanistically investigated pulmonary inflammation and lung function decline after inhalation co-exposure and individual exposures to ozone (O
MeSH term(s)	Air Pollutants/toxicity ; Alarmins/pharmacology ; Animals ; Carbon/pharmacology ; Inhalation Exposure ; Lung ; Mice ; Oxidants/pharmacology ; Ozone/toxicity ; Particle Size ; Pneumonia/chemically induced
Chemical Substances	Air Pollutants ; Alarmins ; Oxidants ; Ozone (66H7ZZK23N) ; Carbon (7440-44-0)
Language	English
Publishing date	2021-08-05
Publishing country	Netherlands
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, U.S. Gov't, P.H.S.
ZDB-ID	2701011-9
ISSN	2213-2317 ; 2213-2317
ISSN (online)	2213-2317
ISSN	2213-2317
DOI	10.1016/j.redox.2021.102092
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Article ; Online: Transcriptomics of single dose and repeated carbon black and ozone inhalation co-exposure highlight progressive pulmonary mitochondrial dysfunction.

Hathaway, Quincy A / Majumder, Nairrita / Goldsmith, William T / Kunovac, Amina / Pinti, Mark V / Harkema, Jack R / Castranova, Vince / Hollander, John M / Hussain, Salik

Particle and fibre toxicology

2021 Volume 18, Issue 1, Page(s) 44

Abstract: Background: Air pollution is a complex mixture of particles and gases, yet current regulations are based on single toxicant levels failing to consider potential interactive outcomes of co-exposures. We examined transcriptomic changes after inhalation co- ...

Abstract	Background: Air pollution is a complex mixture of particles and gases, yet current regulations are based on single toxicant levels failing to consider potential interactive outcomes of co-exposures. We examined transcriptomic changes after inhalation co-exposure to a particulate and a gaseous component of air pollution and hypothesized that co-exposure would induce significantly greater impairments to mitochondrial bioenergetics. A whole-body inhalation exposure to ultrafine carbon black (CB), and ozone (O Results: Compared to individual exposure groups, co-exposure induced significantly greater neutrophils and protein levels in broncho-alveolar lavage fluid as well as a significant increase in mRNA expression of oxidative stress and inflammation related genes. Similarly, a significant increase in hydrogen peroxide production was observed after co-exposure. After single and four exposures, co-exposure revealed a greater number of differentially expressed genes (2251 and 4072, respectively). Of these genes, 1188 (single exposure) and 2061 (four exposures) were uniquely differentially expressed, with 35 mitochondrial ETC mRNA transcripts significantly impacted after four exposures. Both O Conclusions: CB and O
MeSH term(s)	Air Pollutants/toxicity ; Animals ; Inhalation Exposure/adverse effects ; Lung ; Mice ; Mice, Inbred C57BL ; Mitochondria ; Ozone/toxicity ; Soot/toxicity ; Transcriptome
Chemical Substances	Air Pollutants ; Soot ; Ozone (66H7ZZK23N)
Language	English
Publishing date	2021-12-15
Publishing country	England
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	2170936-1
ISSN	1743-8977 ; 1743-8977
ISSN (online)	1743-8977
ISSN	1743-8977
DOI	10.1186/s12989-021-00437-8
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Article ; Online: Beyond apoptosis of JNK1 in liver cancer.

Chen, Fei / Castranova, Vince

Cell cycle (Georgetown, Tex.)

2009 Volume 8, Issue 8, Page(s) 1145–1147

Abstract: Hepatocellular carcinoma (HCC) is the fourth most common neoplasm and the third leading cause of cancer-related death worldwide. Tremendous effort has been made during the past several years in understanding the molecular mechanisms governing the ... ...

Abstract	Hepatocellular carcinoma (HCC) is the fourth most common neoplasm and the third leading cause of cancer-related death worldwide. Tremendous effort has been made during the past several years in understanding the molecular mechanisms governing the pathogenesis and progression of HCC. Recent studies indicated that c-Jun N-terminal kinase 1 (JNK1), but not JNK2, played pivotal role in the expression of the key signature genes and the prognostic outcomes of HCC. Accordingly, we believe that targeting JNK1 is not only mechanistically sound but also clinically feasible for the treatment of HCC.
MeSH term(s)	Animals ; Apoptosis ; Carcinoma, Hepatocellular/enzymology ; Carcinoma, Hepatocellular/genetics ; Carcinoma, Hepatocellular/pathology ; Enzyme Activation ; Humans ; Liver Neoplasms/enzymology ; Liver Neoplasms/genetics ; Liver Neoplasms/pathology ; Mice ; Mitogen-Activated Protein Kinase 8/metabolism ; Mitogen-Activated Protein Kinase 9/metabolism
Chemical Substances	Mitogen-Activated Protein Kinase 9 (EC 2.7.1.24) ; Mitogen-Activated Protein Kinase 8 (EC 2.7.11.24)
Language	English
Publishing date	2009-04-16
Publishing country	United States
Document type	Journal Article ; Research Support, U.S. Gov't, P.H.S.
ZDB-ID	2146183-1
ISSN	1551-4005 ; 1538-4101 ; 1554-8627
ISSN (online)	1551-4005
ISSN	1538-4101 ; 1554-8627
DOI	10.4161/cc.8.8.8200
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Article ; Online: Microprocessor of microRNAs

Chen Fei / Castranova Vince / Beezhold Kevin J

Molecular Cancer, Vol 9, Iss 1, p

regulation and potential for therapeutic intervention

2010 Volume 134

Abstract: Abstract MicroRNAs (miRNAs) are a class of small, noncoding RNAs critically involved in a wide spectrum of normal and pathological processes of cells or tissues by fine-tuning the signals important for stem cell development, cell differentiation, cell ... ...

Abstract	Abstract MicroRNAs (miRNAs) are a class of small, noncoding RNAs critically involved in a wide spectrum of normal and pathological processes of cells or tissues by fine-tuning the signals important for stem cell development, cell differentiation, cell cycle regulation, apoptosis, and transformation. Considerable progress has been made in the past few years in understanding the transcription, biogenesis and functional regulation of miRNAs. Numerous studies have implicated altered expression of miRNAs in human cancers, suggesting that aberrant expression of miRNAs is one of the hallmarks for carcinogenesis. In this review, we briefly discuss most recent discoveries on the regulation of miRNAs at the level of microprocessor-mediated biogenesis of miRNAs.
Keywords	Neoplasms. Tumors. Oncology. Including cancer and carcinogens ; RC254-282 ; Internal medicine ; RC31-1245 ; Medicine ; R ; DOAJ:Oncology ; DOAJ:Medicine (General) ; DOAJ:Health Sciences
Subject code	500
Language	English
Publishing date	2010-06-01T00:00:00Z
Publisher	BioMed Central
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Nuclear factor-kappaB, an unappreciated tumor suppressor.

Chen, Fei / Castranova, Vince

Cancer research

2007 Volume 67, Issue 23, Page(s) 11093–11098

Abstract: The notion that nuclear factor-kappaB (NF-kappaB) is a tumor-promoting transcription factor has become a widely accepted dogma in biology. However, recent findings suggest an inhibitory role for NF-kappaB in carcinogenesis and tumorigenesis. Although the ...

Abstract	The notion that nuclear factor-kappaB (NF-kappaB) is a tumor-promoting transcription factor has become a widely accepted dogma in biology. However, recent findings suggest an inhibitory role for NF-kappaB in carcinogenesis and tumorigenesis. Although the tumor suppressor-like effect of NF-kappaB remains to be rigorously established by further studies using cellular and animal models, these latest findings warrant caution with respect to blockage of NF-kappaB activation as a broad strategy in treating cancers.
MeSH term(s)	Genes, Tumor Suppressor/physiology ; Humans ; NF-kappa B/antagonists & inhibitors ; NF-kappa B/physiology ; Neoplasms/drug therapy
Chemical Substances	NF-kappa B
Language	English
Publishing date	2007-12-01
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Intramural ; Review
ZDB-ID	1432-1
ISSN	1538-7445 ; 0008-5472
ISSN (online)	1538-7445
ISSN	0008-5472
DOI	10.1158/0008-5472.CAN-07-1576
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Article ; Online: Mouse pulmonary dose- and time course-responses induced by exposure to nitrogen-doped multi-walled carbon nanotubes.

Porter, Dale W / Orandle, Marlene / Zheng, Peng / Wu, Nianqiang / Hamilton, Raymond F / Holian, Andrij / Chen, Bean T / Andrew, Michael / Wolfarth, Michael G / Battelli, Lori / Tsuruoka, Shuji / Terrones, Mauricio / Castranova, Vince

Inhalation toxicology

2020 Volume 32, Issue 1, Page(s) 24–38

Abstract: Objective: ...

Abstract	Objective:
MeSH term(s)	Animals ; Bronchoalveolar Lavage Fluid/chemistry ; Cytokines/analysis ; Dose-Response Relationship, Drug ; Humans ; Inflammasomes/immunology ; Inflammasomes/metabolism ; Inhalation Exposure/adverse effects ; Lung/drug effects ; Lung/immunology ; Lung/pathology ; Macrophages, Alveolar/drug effects ; Macrophages, Alveolar/immunology ; Macrophages, Alveolar/pathology ; Male ; Mice, Inbred C57BL ; Nanotubes, Carbon/chemistry ; Nanotubes, Carbon/toxicity ; Nitrogen/chemistry ; Nitrogen/toxicity ; Particle Size ; Pneumonia/chemically induced ; Pneumonia/immunology ; Pneumonia/pathology ; Surface Properties ; THP-1 Cells ; Time Factors
Chemical Substances	Cytokines ; Inflammasomes ; Nanotubes, Carbon ; Nitrogen (N762921K75)
Language	English
Publishing date	2020-02-07
Publishing country	England
Document type	Journal Article
ZDB-ID	1038809-6
ISSN	1091-7691 ; 0895-8378
ISSN (online)	1091-7691
ISSN	0895-8378
DOI	10.1080/08958378.2020.1723746
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Article ; Online: Microprocessor of microRNAs: regulation and potential for therapeutic intervention.

Beezhold, Kevin J / Castranova, Vince / Chen, Fei

Molecular cancer

2010 Volume 9, Page(s) 134

Abstract: MicroRNAs (miRNAs) are a class of small, noncoding RNAs critically involved in a wide spectrum of normal and pathological processes of cells or tissues by fine-tuning the signals important for stem cell development, cell differentiation, cell cycle ... ...

Abstract	MicroRNAs (miRNAs) are a class of small, noncoding RNAs critically involved in a wide spectrum of normal and pathological processes of cells or tissues by fine-tuning the signals important for stem cell development, cell differentiation, cell cycle regulation, apoptosis, and transformation. Considerable progress has been made in the past few years in understanding the transcription, biogenesis and functional regulation of miRNAs. Numerous studies have implicated altered expression of miRNAs in human cancers, suggesting that aberrant expression of miRNAs is one of the hallmarks for carcinogenesis. In this review, we briefly discuss most recent discoveries on the regulation of miRNAs at the level of microprocessor-mediated biogenesis of miRNAs.
MeSH term(s)	Animals ; Gene Expression Regulation ; Humans ; MicroRNAs/physiology ; Neoplasms/genetics
Chemical Substances	MicroRNAs
Language	English
Publishing date	2010-06-01
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Review
ISSN	1476-4598
ISSN (online)	1476-4598
DOI	10.1186/1476-4598-9-134
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Article: Single- and multi-wall carbon nanotubes versus asbestos: are the carbon nanotubes a new health risk to humans?

Pacurari, Maricica / Castranova, Vince / Vallyathan, Val

Journal of toxicology and environmental health. Part A

2010 Volume 73, Issue 5, Page(s) 378–395

Abstract: Carbon nanotubes (CNT), since their discovery, have become one of the most promising nanomaterials in many industrial and biomedical applications. Due to their unique physicochemical properties, interest is growing in the manufacture of CNT-based ... ...

Abstract	Carbon nanotubes (CNT), since their discovery, have become one of the most promising nanomaterials in many industrial and biomedical applications. Due to their unique physicochemical properties, interest is growing in the manufacture of CNT-based products and their subsequent marketing. Since their discovery, the prospect of possible undesirable human health effects has been a focus of many scientific studies. Although CNT possess unique physical properties that include (1) nanoscale diameter, (2) a wide length distribution ranging from tens of nanometers to several micrometers, and (3) high aspect ratio, the fibrous-like shape and durability suggest that their toxic properties may be analogous to those observed with other fibrous particles, such as asbestos. The present study provides a summary of published findings on CNT bioactivity, such as the potential of CNT, especially of multi-wall carbon nanotubes (MWCNT), to activate signaling pathways modulating transcription factor activity, induce apoptosis, induce DNA damage, and initiate biological responses. Assessment of risks to human health and adoption of appropriate exposure controls is critical for the safe and successful introduction of CNT -based products for future applications.
MeSH term(s)	Asbestos/chemistry ; Asbestos/toxicity ; Carcinogens/chemistry ; Carcinogens/toxicity ; Carcinoma, Bronchogenic/chemically induced ; DNA Damage ; Epithelium/metabolism ; Humans ; Mesothelioma/chemically induced ; Mitogen-Activated Protein Kinases/metabolism ; NF-kappa B/metabolism ; Nanotubes, Carbon/chemistry ; Nanotubes, Carbon/toxicity ; Particle Size ; Risk Assessment ; Signal Transduction/drug effects ; Transcription Factor AP-1/metabolism
Chemical Substances	Carcinogens ; NF-kappa B ; Nanotubes, Carbon ; Transcription Factor AP-1 ; Asbestos (1332-21-4) ; Mitogen-Activated Protein Kinases (EC 2.7.11.24)
Language	English
Publishing date	2010
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	1413345-3
ISSN	1528-7394 ; 0098-4108 ; 1087-2620
ISSN	1528-7394 ; 0098-4108 ; 1087-2620
DOI	10.1080/15287390903486527
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