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Article ; Online: Colonic histoplasmosis.

Sangiorgi, Flavio / Torelli, Riccardo / Castri, Federica / Siciliano, Valentina / Cauda, Roberto / Fantoni, Massimo / Sanguinetti, Maurizio / Taccari, Francesco

Journal of travel medicine

2023 Volume 30, Issue 6

MeSH term(s)	Humans ; Histoplasmosis
Language	English
Publishing date	2023-01-13
Publishing country	England
Document type	Case Reports ; Journal Article
ZDB-ID	1212504-0
ISSN	1708-8305 ; 1195-1982
ISSN (online)	1708-8305
ISSN	1195-1982
DOI	10.1093/jtm/taad007
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Article: Malakoplakia of the appendix in a young healthy adult: a case report and literature review.

Pastena, Dario / Giambusso, Mauro / Castri, Federica / Potenza, Angelo Eugenio / Caprino, Paola / Sacchetti, Franco / Sofo, Luigi

Journal of surgical case reports

2022 Volume 2022, Issue 8, Page(s) rjac357

Abstract: Malakoplakia is a rare entity on inflammatory base that mostly occurs in immunocompromised individuals which is thought to be secondary to a bactericidal defect in macrophages. The genitourinary tract is typically affected. The appendix is a very rare ... ...

Abstract	Malakoplakia is a rare entity on inflammatory base that mostly occurs in immunocompromised individuals which is thought to be secondary to a bactericidal defect in macrophages. The genitourinary tract is typically affected. The appendix is a very rare localization. We report a case of malakoplakia in the appendix of a young healthy patient with a recent history of abdominal pain associated with diarrhea and nausea. The colonscopy and CT scan showed an extramucosal bumping mass pressing on the cecum and covered by normal mucosa. The patient underwent to laparoscopic appendectomy. The histology showed a malakoplakia of the appendix. Gastrointestinal localization of malakoplakia is often associated with preexisting diseases, which are probably responsible for an immune disorder underlying the etiopathogenesis of the disease. However, in our case, the patient had no comorbidities. Probably, a clinically unknown immune predisposition plays an important role. Further studies are needed to clarify this nexus.
Language	English
Publishing date	2022-08-04
Publishing country	England
Document type	Case Reports
ZDB-ID	2580919-2
ISSN	2042-8812
ISSN	2042-8812
DOI	10.1093/jscr/rjac357
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Article ; Online: Crystal-induced colitis.

Spasiano, Andrea / Castri, Federica / Giustiniani, Maria Cristina / Riccioni, Maria Elena / Naticchia, Alessandro / Grandaliano, Giuseppe / Panocchia, Nicola

Kidney international

2022 Volume 102, Issue 1, Page(s) 212

MeSH term(s)	Colitis/chemically induced ; Humans
Language	English
Publishing date	2022-06-23
Publishing country	United States
Document type	Case Reports
ZDB-ID	120573-0
ISSN	1523-1755 ; 0085-2538
ISSN (online)	1523-1755
ISSN	0085-2538
DOI	10.1016/j.kint.2022.02.002
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Zs.A 797: Show issues

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Article ; Online: Post-operative interventional radiotherapy (brachytherapy) in advanced ocular surface and eyelid tumors as an alternative to surgical retreatment.

Cuffaro, Giovanni / Fionda, Bruno / Piccinni, Fabrizio / Pagliara, Monica Maria / Sammarco, Maria Grazia / Blasi, Maria Antonietta / Molinario, Clelia / Castri, Federica / Tagliaferri, Luca / Massi, Daniela / Savino, Gustavo

European journal of ophthalmology

2023 , Page(s) 11206721231215105

Abstract: Purpose: The main purpose of treatment of advanced ocular surface and periocular malignant tumors is to eradicate the tumor while trying to preserve visual function and aesthetics. Our purpose is to describe the outcome of a retrospective case series of ...

Abstract	Purpose: The main purpose of treatment of advanced ocular surface and periocular malignant tumors is to eradicate the tumor while trying to preserve visual function and aesthetics. Our purpose is to describe the outcome of a retrospective case series of 10 patients with advanced ocular surface and periocular tumors treated surgically in first instance and then with postoperative interventional radiotherapy (IRT/Brachiterapy). Materials and methods: We describe the clinicopathological features, treatments and outcome, in a retrospective case series of 10 patients with advanced tumors involving ocular surface (staging ≥ T2) and eyelids (staging ≥ T3), with involvement of periocular and/or orbit tissues. Patients were first surgically treated, most of them with incomplete excision, and then underwent a post-operative interventional radiotherapy (IRT/Brachytherapy) as an alternative to more invasive and disfiguring surgical retreatment. Tumor location, risk factors, staging, histological features, and follow-up timing were analyzed. Results: Three patients had advanced eyelid basal cell carcinomas, 2 patients were diagnosed with eyelid and conjunctival squamous cell carcinomas, 3 as sebaceous carcinomas, and 2 as primary conjunctival melanomas. The mean follow-up time from IRT to last clinical follow-up was 58.6 weeks, range 28.4-168 (median 43.65, IQR 28.9-72.9). Two patients - one with ocular surface SCC, the other with conjunctival melanoma - had a local recurrence 23.4 and 40,9 weeks after IRT, respectively. An overview of the current knowledge on adjuvant or post-operative IRT is also provided. Conclusions: IRT can be considered an effective therapeutic option to avoid more invasive surgical retreatment in advanced tumors involving eyelids and ocular surface.
Language	English
Publishing date	2023-12-17
Publishing country	United States
Document type	Journal Article
ZDB-ID	1089461-5
ISSN	1724-6016 ; 1120-6721
ISSN (online)	1724-6016
ISSN	1120-6721
DOI	10.1177/11206721231215105
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Zs.A 3342: Show issues

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Article ; Online: Base-Excision Repair Mutational Signature in Two Sebaceous Carcinomas of the Eyelid.

Sangiorgi, Eugenio / Giannuzzi, Federico / Molinario, Clelia / Rapari, Giulia / Riccio, Melania / Cuffaro, Giovanni / Castri, Federica / Benvenuto, Roberta / Genuardi, Maurizio / Massi, Daniela / Savino, Gustavo

Genes

2023 Volume 14, Issue 11

Abstract: Personalized medicine aims to develop tailored treatments for individual patients based on specific mutations present in the affected organ. This approach has proven paramount in cancer treatment, as each tumor carries distinct driver mutations that ... ...

Abstract	Personalized medicine aims to develop tailored treatments for individual patients based on specific mutations present in the affected organ. This approach has proven paramount in cancer treatment, as each tumor carries distinct driver mutations that respond to targeted drugs and, in some cases, may confer resistance to other therapies. Particularly for rare conditions, personalized medicine has the potential to revolutionize treatment strategies. Rare cancers often lack extensive datasets of molecular and pathological information, large-scale trials for novel therapies, and established treatment guidelines. Consequently, surgery is frequently the only viable option for many rare tumors, when feasible, as traditional multimodal approaches employed for more common cancers often play a limited role. Sebaceous carcinoma of the eyelid is an exceptionally rare cancer affecting the eye's adnexal tissues, most frequently reported in Asia, but whose prevalence is significantly increasing even in Europe and the US. The sole established curative treatment is surgical excision, which can lead to significant disfigurement. In cases of metastatic sebaceous carcinoma, validated drug options are currently lacking. In this project, we set out to characterize the mutational landscape of two sebaceous carcinomas of the eyelid following surgical excision. Utilizing available bioinformatics tools, we demonstrated our ability to identify common features promptly and accurately in both tumors. These features included a Base-Excision Repair mutational signature, a notably high tumor mutational burden, and key driver mutations in somatic tissues. These findings had not been previously reported in similar studies. This report underscores how, in the case of rare tumors, it is possible to comprehensively characterize the mutational landscape of each individual case, potentially opening doors to targeted therapeutic options.
MeSH term(s)	Humans ; Sebaceous Gland Neoplasms/genetics ; Sebaceous Gland Neoplasms/pathology ; Sebaceous Gland Neoplasms/surgery ; Adenocarcinoma, Sebaceous/genetics ; Adenocarcinoma, Sebaceous/pathology ; Adenocarcinoma, Sebaceous/surgery ; Eyelids/pathology ; Carcinoma, Basal Cell ; Skin Neoplasms ; DNA Repair
Language	English
Publishing date	2023-11-08
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2527218-4
ISSN	2073-4425 ; 2073-4425
ISSN (online)	2073-4425
ISSN	2073-4425
DOI	10.3390/genes14112055
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Article: The Role of Plasma Cells as a Marker of Chronic Endometritis: A Systematic Review and Meta-Analysis.

Santoro, Angela / Travaglino, Antonio / Inzani, Frediano / Angelico, Giuseppe / Raffone, Antonio / Maruotti, Giuseppe Maria / Straccia, Patrizia / Arciuolo, Damiano / Castri, Federica / D'Alessandris, Nicoletta / Scaglione, Giulia / Valente, Michele / Cianfrini, Federica / Masciullo, Valeria / Zannoni, Gian Franco

Biomedicines

2023 Volume 11, Issue 6

Abstract: Chronic endometritis (CE) is the persistent inflammation of the endometrial lining associated with infertility and various forms of reproductive failures. The diagnosis of CE is based on the histological evidence of stromal plasma cells; however, ... ...

Abstract	Chronic endometritis (CE) is the persistent inflammation of the endometrial lining associated with infertility and various forms of reproductive failures. The diagnosis of CE is based on the histological evidence of stromal plasma cells; however, standardized methods to assess plasma cells are still lacking. In the present paper, we aimed to determine the most appropriate plasma cell threshold to diagnose CE based on pregnancy outcomes. Three electronic databases were searched from their inception to February 2022 for all studies comparing pregnancy outcomes between patients with CE and patients without CE. The relative risk (RR) of pregnancy, miscarriage, and/or live birth rates were calculated and pooled based on the plasma cell threshold adopted. A
Language	English
Publishing date	2023-06-15
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2720867-9
ISSN	2227-9059
ISSN	2227-9059
DOI	10.3390/biomedicines11061714
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Article ; Online: Cutaneous diphtheria most likely due to exposure in a detention camp in Libya.

Taccari, Francesco / Frondizi, Federico / Salvati, Federica / Giovannenze, Francesca / Del Giacomo, Paola / Damiano, Fernando / Spanu, Teresa / Graffeo, Rosalia / Menchinelli, Giulia / Mariotti, Melinda / Sanguinetti, Maurizio / Castri, Federica / Neumayr, Andreas / Brunetti, Enrico / Errico, Giulia / Murri, Rita / Cauda, Roberto / Scoppettuolo, Giancarlo

Journal of travel medicine

2023 Volume 30, Issue 5

MeSH term(s)	Humans ; Diphtheria ; Libya ; Corynebacterium diphtheriae ; Diphtheria Toxin
Chemical Substances	Diphtheria Toxin
Language	English
Publishing date	2023-05-24
Publishing country	England
Document type	Journal Article
ZDB-ID	1212504-0
ISSN	1708-8305 ; 1195-1982
ISSN (online)	1708-8305
ISSN	1195-1982
DOI	10.1093/jtm/taad073
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Zs.A 4120: Show issues

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Article ; Online: Gastroblastoma in old age.

Castri, Federica / Ravegnini, Gloria / Lodoli, Claudio / Fiorentino, Vincenzo / Abatini, Carlo / Giustiniani, Maria C / Angelini, Sabrina / Ricci, Riccardo

Histopathology

2019 Volume 75, Issue 5, Page(s) 778–782

MeSH term(s)	Aged ; Humans ; Male ; Neoplasms, Complex and Mixed/pathology ; Stomach Neoplasms/pathology
Language	English
Publishing date	2019-10-03
Publishing country	England
Document type	Case Reports ; Letter ; Research Support, Non-U.S. Gov't
ZDB-ID	131914-0
ISSN	1365-2559 ; 0309-0167
ISSN (online)	1365-2559
ISSN	0309-0167
DOI	10.1111/his.13951
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Zs.A 1328: Show issues

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Article ; Online: Telocytes are the physiological counterpart of inflammatory fibroid polyps and PDGFRA-mutant GISTs.

Ricci, Riccardo / Giustiniani, Maria Cristina / Gessi, Marco / Lanza, Paola / Castri, Federica / Biondi, Alberto / Persiani, Roberto / Vecchio, Fabio M / Risio, Mauro

Journal of cellular and molecular medicine

2018 Volume 22, Issue 10, Page(s) 4856–4862

Abstract: PDGFRA mutations in the gastrointestinal (GI) tract can cause GI stromal tumour (GIST) and inflammatory fibroid polyp (IFP). Hitherto no cell type has been identified as a physiological counterpart of the latter, while interstitial Cajal cells (ICC) are ... ...

Abstract	PDGFRA mutations in the gastrointestinal (GI) tract can cause GI stromal tumour (GIST) and inflammatory fibroid polyp (IFP). Hitherto no cell type has been identified as a physiological counterpart of the latter, while interstitial Cajal cells (ICC) are considered the precursor of the former. However, ICC hyperplasia (ICCH), which strongly supports the ICC role in GIST pathogenesis, has been identified in germline KIT-mutant settings but not in PDGFRA-mutant ones, challenging the precursor role of ICC for PDGFRA-driven GISTs. Telocytes are a recently described interstitial cell type, CD34+/PDGFRA+. Formerly considered fibroblasts, they are found in many organs, including the GI tract where they are thought to be involved in neurotransmission. Alongside IFPs and gastric GISTs, GI wall "fibrosis" has been reported in germline PDGFRA-mutants. Taking the opportunity offered by its presence in a germline PDGFRA-mutant individual, we demonstrate that this lesion is sustained by hyperplastic telocytes, constituting the PDGFRA-mutant counterpart of germline KIT mutation-associated ICCH. Moreover, our findings support a pathogenetic relationship between telocyte hyperplasia and both IFPs and PDGFRA-mutant GISTs. We propose the term "telocytoma" for defining IFP, as it conveys both the pathogenetic (neoplastic) and histotypic ("telocytary") essence of this tumour, unlike IFP, which rather evokes an inflammatory-hyperplastic lesion.
MeSH term(s)	Antigens, CD34/genetics ; Gastrointestinal Stromal Tumors/genetics ; Gastrointestinal Stromal Tumors/pathology ; Gastrointestinal Tract/metabolism ; Gastrointestinal Tract/pathology ; Germ-Line Mutation/genetics ; Humans ; Hyperplasia/genetics ; Hyperplasia/pathology ; Inflammation/genetics ; Inflammation/pathology ; Interstitial Cells of Cajal/metabolism ; Interstitial Cells of Cajal/pathology ; Leiomyoma/genetics ; Leiomyoma/pathology ; Proto-Oncogene Proteins c-kit/genetics ; Receptor, Platelet-Derived Growth Factor alpha/genetics ; Synaptic Transmission/genetics ; Telocytes/pathology
Chemical Substances	Antigens, CD34 ; KIT protein, human (EC 2.7.10.1) ; Proto-Oncogene Proteins c-kit (EC 2.7.10.1) ; Receptor, Platelet-Derived Growth Factor alpha (EC 2.7.10.1)
Language	English
Publishing date	2018-08-17
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2074559-X
ISSN	1582-4934 ; 1582-4934 ; 1582-1838
ISSN (online)	1582-4934
ISSN	1582-4934 ; 1582-1838
DOI	10.1111/jcmm.13748
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Zs.A 5752: Show issues

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Article ; Online: Characterization of mucosal cytokine profile in ulcerative colitis patients under conventional and anti-TNF-a treatment.

Lopetuso, Loris Riccardo / Corbi, Maddalena / Scaldaferri, Franco / Petito, Valentina / Graziani, Cristina / Castri, Federica / Neri, Matteo / Gasbarrini, Antonio / Sgambato, Alessandro / Papa, Alfredo

European journal of gastroenterology & hepatology

2020 Volume 32, Issue 12, Page(s) 1527–1532

Abstract: Objectives: Cytokines play a pivotal role in inflammatory bowel disease (IBD). We investigated the expression of inflammatory and regulatory cytokines in inflamed and uninflamed mucosal samples of ulcerative colitis patients.: Methods: Twenty-five ... ...

Abstract	Objectives: Cytokines play a pivotal role in inflammatory bowel disease (IBD). We investigated the expression of inflammatory and regulatory cytokines in inflamed and uninflamed mucosal samples of ulcerative colitis patients. Methods: Twenty-five ulcerative colitis patients were enrolled. Bioptic samples from inflamed and not inflamed intestinal areas were obtained. Multiplex analysis for inflammatory and regulatory cytokines was performed. Serum C-reactive protein (CRP) was assessed. Endoscopic Mayo score and histological simplified Geboes score were calculated. Results: Interleukin (IL)-1Ra, IL-6, IL-8, IL-17, induced Protein (IP)-10, monocyte chemoattractant protein (MCP)-1, macrophage inflammatory protein (MIP)-1a, MIP-1b resulted increased in ulcerative colitis inflamed vs ulcerative colitis not inflamed areas. No differences were registered between conventional and anti-tumor necrosis factor-a regimens. No difference with CRP levels was found. IL-7 resulted reduced in patients with endoscopic Mayo score ≥2. All the not inflamed samples had a Geboes score <2A, while all the inflamed specimens had a Geboes score ≥2B. IL-1Ra resulted increased in the group with a Geboes score ≥4. Conclusions: Inflamed and adjacent not inflamed mucosal areas in ulcerative colitis patients share detailed inflammatory molecular pathways, but can be differentiated endoscopically and histologically on the basis of specific cytokines levels. This underlines the complexity of the mucosal cytokine network in ulcerative colitis and highlights the major limitations of a single proinflammatory target therapeutic strategy in IBD.
MeSH term(s)	Colitis, Ulcerative/diagnosis ; Colitis, Ulcerative/drug therapy ; Cytokines ; Humans ; Inflammatory Bowel Diseases ; Intestinal Mucosa ; Tumor Necrosis Factor Inhibitors
Chemical Substances	Cytokines ; Tumor Necrosis Factor Inhibitors
Language	English
Publishing date	2020-10-21
Publishing country	England
Document type	Journal Article
ZDB-ID	1034239-4
ISSN	1473-5687 ; 0954-691X
ISSN (online)	1473-5687
ISSN	0954-691X
DOI	10.1097/MEG.0000000000001933
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