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  1. Article ; Online: Assessment of the hypoglycemic effect of Bixin in alloxan-induced diabetic rats:

    Keita, Hady / Dos Santos, Cleydson Breno Rodrigues / Ramos, Matheus Mercês / Padilha, Elias Carvalho / Serafim, Rodolfo Bortolozo / Castro, Andres Navarrete / Amado, Jesus Rafael Rodriguez / da Silva, Gabriel Monteiro / Ferreira, Irlon Maciel / Giuliatti, Silvana / Carvalho, José Carlos Tavares

    Journal of biomolecular structure & dynamics

    2020  Volume 39, Issue 3, Page(s) 1017–1028

    Abstract: The objectives of this study were to extract and purify Bixin from the seeds ... ...

    Abstract The objectives of this study were to extract and purify Bixin from the seeds of
    MeSH term(s) Alloxan ; Animals ; Carotenoids ; Diabetes Mellitus, Experimental/drug therapy ; Hypoglycemic Agents/pharmacology ; Molecular Docking Simulation ; PPAR gamma ; Rats ; Thiazolidinediones
    Chemical Substances Hypoglycemic Agents ; PPAR gamma ; Thiazolidinediones ; Carotenoids (36-88-4) ; Alloxan (6SW5YHA5NG) ; bixin (9L7T4VB66G)
    Language English
    Publishing date 2020-02-13
    Publishing country England
    Document type Journal Article
    ZDB-ID 49157-3
    ISSN 1538-0254 ; 0739-1102
    ISSN (online) 1538-0254
    ISSN 0739-1102
    DOI 10.1080/07391102.2020.1724567
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2093: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  2. Article ; Online: Action of the hydroethanolic extract of the flowers of Acmella oleracea (L.) R.K. Jansen on the reproductive performance of Wistar females rats: A popular female aphrodisiac from the Amazon.

    da Rocha, Clarice Flexa / de Medeiros Souza Lima, Yuri / Carvalho, Helison Oliveira / Pinto, Rodrigo Costa / Ferreira, Irlon Maciel / Castro, Andres Navarrete / Lima, Clarissa Silva / Carvalho, José Carlos Tavares

    Journal of ethnopharmacology

    2018  Volume 214, Page(s) 301–308

    Abstract: Ethnopharmacological relevance: The species Acmella oleracea (L.) R.K. Jansen (Asteraceae), popularly known as jambú, is marketed in fairs as a female aphrodisiac and has several pharmacological activities already confirmed, among them the sexual ... ...

    Abstract Ethnopharmacological relevance: The species Acmella oleracea (L.) R.K. Jansen (Asteraceae), popularly known as jambú, is marketed in fairs as a female aphrodisiac and has several pharmacological activities already confirmed, among them the sexual stimulant action. The objective of this study was to evaluate the effects of the oral administration of the hydroethanolic extract of A. oleracea flowers (EHAo) on wistar rats during the pre-mating, mating, and pre-implantation period.
    Material and methods: During the treatment period, measurements of feed intake, water intake, weight, estrous cycle, behavior, reproductive parameters, biochemical parameters, hematological parameters, and histopathology of ovaries were performed daily.
    Results: In the gas chromatography analysis - mass spectrometry characterization, the compound (2E, 6Z, 8E) -N-isobutyldeca-2,6,8-trienamide (spilanthol) was detected as the majority compound at the 84% concentration. In the conditions of this study, EHAo did not cause maternal toxicity. However, in the estrous cycle, the frequency of the Proestrous (P) and Estrous (E) phase was significantly increased with the doses of 88.91 and 444.57mg/kg of the EHAo in relation to the control. On the other hand, the metaestrous (M) and diestrous (D) phases showed a significant reduction in their frequency in the groups treated with EHAo. Water intake increased significantly (p < 0.01), as well as the triglyceride levels, the total cholesterol and fractions (p < 0.05), and the percentage of neutrophils (p < 0.05).
    Conclusion: It is concluded, therefore, that the treatment with EHAo, which is one of the forms popularly used, is safe in the concentrations and time of treatment studied as it is able to influence the estrous cycle without altering folliculogenesis and fertility.
    MeSH term(s) Animals ; Aphrodisiacs/isolation & purification ; Aphrodisiacs/pharmacology ; Asteraceae/chemistry ; Cholesterol/blood ; Dose-Response Relationship, Drug ; Drinking/drug effects ; Estrous Cycle/drug effects ; Ethanol/chemistry ; Female ; Flowers/chemistry ; Neutrophils/drug effects ; Ovary/drug effects ; Ovary/physiology ; Phytotherapy ; Plant Extracts/isolation & purification ; Plant Extracts/pharmacology ; Plants, Medicinal ; Pregnancy ; Rats, Wistar ; Reproduction/drug effects ; Solvents/chemistry ; Time Factors ; Triglycerides/blood
    Chemical Substances Aphrodisiacs ; Plant Extracts ; Solvents ; Triglycerides ; Ethanol (3K9958V90M) ; Cholesterol (97C5T2UQ7J)
    Language English
    Publishing date 2018-03-25
    Publishing country Ireland
    Document type Journal Article
    ZDB-ID 134511-4
    ISSN 1872-7573 ; 0378-8741
    ISSN (online) 1872-7573
    ISSN 0378-8741
    DOI 10.1016/j.jep.2017.12.024
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 1494: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  3. Article ; Online: Anti-inflammatory and antialgic actions of a nanoemulsion of Rosmarinus officinalis L. essential oil and a molecular docking study of its major chemical constituents.

    Borges, Raphaelle Sousa / Lima, Emerson Silva / Keita, Hady / Ferreira, Irlon Maciel / Fernandes, Caio Pinho / Cruz, Rodrigo Alves Soares / Duarte, Jonatas Lobato / Velázquez-Moyado, Josué / Ortiz, Brenda Lorena Sánchez / Castro, Andrés Navarrete / Ferreira, Jaderson Vieira / da Silva Hage-Melim, Lorane Izabel / Carvalho, José Carlos Tavares

    Inflammopharmacology

    2018  Volume 26, Issue 1, Page(s) 183–195

    Abstract: We evaluate the anti-inflammatory and antialgic potency of a nanoemulsion (NEORO) containing the essential oil of Rosmarinus officinalis L. (EORO), which is composed primarily of limonene, camphor and 1,8-cineole. The EORO and NEORO were administered ... ...

    Abstract We evaluate the anti-inflammatory and antialgic potency of a nanoemulsion (NEORO) containing the essential oil of Rosmarinus officinalis L. (EORO), which is composed primarily of limonene, camphor and 1,8-cineole. The EORO and NEORO were administered orally 30 min prior to starting the experiments. In a test of rat paw oedema induced by carrageenan, NEORO was effective in doses of 498 µg/kg, and it inhibited 46% of the maximum peak of the oedema; in a dose of 300 mg/kg, EORO inhibited 50% of the maximum peak of the oedema. In an acetic acid-induced writhing test, NEORO yielded a dose-dependent effect, and a dose of 830 µg/kg inhibited 84% of the algesic process; a dose of 100 mg/kg of EORO inhibited 55%. In an assay for H
    MeSH term(s) Animals ; Anti-Inflammatory Agents/pharmacology ; Carrageenan/pharmacology ; Cyclohexenes/pharmacology ; Edema/chemically induced ; Edema/drug therapy ; Emulsions/pharmacology ; Inflammation/drug therapy ; Male ; Molecular Docking Simulation/methods ; Nanoparticles/administration & dosage ; Oils, Volatile/pharmacology ; Plant Extracts/pharmacology ; Rats ; Rats, Wistar ; Rosmarinus/chemistry ; Terpenes/pharmacology
    Chemical Substances Anti-Inflammatory Agents ; Cyclohexenes ; Emulsions ; Oils, Volatile ; Plant Extracts ; Terpenes ; Carrageenan (9000-07-1) ; limonene (9MC3I34447)
    Language English
    Publishing date 2018-02
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 1080058-x
    ISSN 1568-5608 ; 0925-4692
    ISSN (online) 1568-5608
    ISSN 0925-4692
    DOI 10.1007/s10787-017-0374-8
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 3274: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  4. Article ; Online: Anti-inflammatory activity of nanoemulsions of essential oil from Rosmarinus officinalis L.: in vitro and in zebrafish studies.

    Borges, Raphaelle Sousa / Keita, Hady / Ortiz, Brenda Lorena Sánchez / Dos Santos Sampaio, Tafnis Ingret / Ferreira, Irlon Maciel / Lima, Emerson Silva / de Jesus Amazonas da Silva, Márcia / Fernandes, Caio Pinho / de Faria Mota Oliveira, Anna Eliza Maciel / da Conceição, Edemilson Cardoso / Rodrigues, Alex Bruno Lobato / Filho, Arlindo César Matias Pereira / Castro, Andrés Navarrete / Carvalho, José Carlos Tavares

    Inflammopharmacology

    2018  Volume 26, Issue 4, Page(s) 1057–1080

    Abstract: The essential oil from Rosmarinus officinalis L. (OERO) has bioactive compounds with anti-inflammatory activity. The objective of this study was to evaluate the anti-inflammatory potency of nanoemulsions containing essential oil of Rosmarinus officinalis ...

    Abstract The essential oil from Rosmarinus officinalis L. (OERO) has bioactive compounds with anti-inflammatory activity. The objective of this study was to evaluate the anti-inflammatory potency of nanoemulsions containing essential oil of Rosmarinus officinalis L. (NOERO, NECHA, NECULT, and NECOM) in vitro and in vivo. This study was accomplished in a quantitative format through tests with diphenyl picrylhydrazyl (DPPH) and 2,2'-azino-bis(3-ethylbenzothiazoline-6-sulphonic acid) (ABTS), cellular antioxidant activity (CCA), determination of nitric oxide production, cellular viability and anti-inflammatory activity in zebrafish. OERO's were submitted to the analysis-coupled gas chromatography-mass spectrometry (GC-MS), which highlighted 1,8-cineol and camphor as major compounds. NOEROs were obtained by a low-energy method and presenting the medium size smaller than 200 nm. The efficiency of encapsulation by spectrometry and gas chromatographic analysis was 67.61 and 75.38%, respectively. In the CCA assay, all of the samples presented percentage values of inhibition similar to the quercetin pattern, indicating antioxidant activity. In the test for determination of NO·, all of the samples inhibited the production of NO· when compared to LPS, and NOEROS were more effective than OEROS to 5 µg/mL. In the cell viability assay, the cells remained viable after contact with the samples, demonstrating an absence of cytotoxicity. This study showed that all nanoemulsions (NECHA, NECULT, and NECOM) showed no toxicity to macrophages, besides demonstrating antioxidant activity and potentiation of the essential oil effect in the proliferation of viable fibroblasts. Nanoemulsions has also shown the ability to potentiate the anti-inflammatory action of essential oils by exerting immunomodulatory activity by inhibiting the production of the pro-inflammatory mediator nitric oxide. The results obtained with NECHA in zebrafish confirm the hypothesis that prominent terpenic compounds, alpha-pinene, 1,8-cineole, and camphor, became more available at the target sites, inhibiting the inflammatory process in this animal species.
    MeSH term(s) Animals ; Anti-Inflammatory Agents/administration & dosage ; Anti-Inflammatory Agents/isolation & purification ; Anti-Inflammatory Agents/pharmacology ; Antioxidants/administration & dosage ; Antioxidants/isolation & purification ; Antioxidants/pharmacology ; Cell Proliferation/drug effects ; Cell Survival/drug effects ; Disease Models, Animal ; Emulsions ; Fibroblasts/drug effects ; Fibroblasts/metabolism ; Gas Chromatography-Mass Spectrometry ; Inflammation/drug therapy ; Inflammation/pathology ; Male ; Mice ; Mice, Inbred BALB C ; Nanoparticles ; Nitric Oxide/metabolism ; Oils, Volatile/administration & dosage ; Oils, Volatile/isolation & purification ; Oils, Volatile/pharmacology ; Particle Size ; Rosmarinus/chemistry ; Zebrafish
    Chemical Substances Anti-Inflammatory Agents ; Antioxidants ; Emulsions ; Oils, Volatile ; Nitric Oxide (31C4KY9ESH)
    Language English
    Publishing date 2018-02-05
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 1080058-x
    ISSN 1568-5608 ; 0925-4692
    ISSN (online) 1568-5608
    ISSN 0925-4692
    DOI 10.1007/s10787-017-0438-9
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 3274: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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