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Article ; Online: Effectiveness of gastrostomy for improving nutritional status and quality of life in patients with epidermolysis bullosa: a systematic review.

Zidorio, A P C / Dutra, E S / Castro, L C G / Carvalho, K M B

2018 Volume 179, Issue 1, Page(s) 42–49

Abstract: Individuals with epidermolysis bullosa (EB) may present with a broad spectrum of growth impairment and multiorgan disorders, with compromised nutritional status and quality of life. The provision of nutrients through a gastrostomy tube may minimize EB- ... ...

Abstract	Individuals with epidermolysis bullosa (EB) may present with a broad spectrum of growth impairment and multiorgan disorders, with compromised nutritional status and quality of life. The provision of nutrients through a gastrostomy tube may minimize EB-related malnourishment but may also result in skin injuries and infections. In this systematic review we consider the current evidence about the effectiveness of gastrostomy in restoring nutritional status and improving quality of life in patients with EB. Seven studies (n = 146) met selection criteria and patients ranged in age from 6 weeks to 33 years of age. Although it is not a risk-free procedure, the placement of a gastrostomy tube is a feasible and safe alternative to provide nutritional support and to improve the quality of life of patients.
MeSH term(s)	Adolescent ; Adult ; Child ; Child, Preschool ; Enteral Nutrition/methods ; Epidemiologic Methods ; Epidermolysis Bullosa Dystrophica/psychology ; Epidermolysis Bullosa Dystrophica/surgery ; Female ; Gastrostomy ; Humans ; Infant ; Male ; Malnutrition/prevention & control ; Malnutrition/psychology ; Nutritional Status ; Quality of Life ; Young Adult
Language	English
Publishing date	2018-04-17
Publishing country	England
Document type	Journal Article ; Meta-Analysis ; Systematic Review
ZDB-ID	80076-4
ISSN	1365-2133 ; 0007-0963
ISSN (online)	1365-2133
ISSN	0007-0963
DOI	10.1111/bjd.16139
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Article ; Online: Unequal Impact of

Journal of dental research

2023 Volume 102, Issue 6, Page(s) 616–625

Abstract: Dentinogenesis imperfecta (DI) is the main orodental manifestation of osteogenesis imperfecta (OI) caused ... ...

Abstract	Dentinogenesis imperfecta (DI) is the main orodental manifestation of osteogenesis imperfecta (OI) caused by
MeSH term(s)	Humans ; Collagen Type I/genetics ; Collagen Type I, alpha 1 Chain ; Dentinogenesis Imperfecta/genetics ; Genetic Association Studies ; Mutation ; Osteogenesis Imperfecta/diagnostic imaging ; Osteogenesis Imperfecta/genetics
Chemical Substances	COL1A2 protein, human ; Collagen Type I ; Collagen Type I, alpha 1 Chain ; Collagen Type I, alpha2 Subunit ; COL1A1 protein, human
Language	English
Publishing date	2023-03-23
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	80207-4
ISSN	1544-0591 ; 0022-0345
ISSN (online)	1544-0591
ISSN	0022-0345
DOI	10.1177/00220345231154569
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Article ; Online: Pamidronate affects the mandibular cortex of children with osteogenesis imperfecta.

Apolinário, A C / Figueiredo, P T / Guimarães, A T / Acevedo, A C / Castro, L C / Paula, A P / Paula, L M / Melo, N S / Leite, A F

Journal of dental research

2015 Volume 94, Issue 3 Suppl, Page(s) 95S–102S

Abstract: We hypothesized that mandibular cortical width (MCW) is smaller in children with osteogenesis imperfecta (OI) than in healthy children and that pamidronate can improve the cortical mandibular thickness. The aim of this study was to assess changes in the ... ...

Abstract	We hypothesized that mandibular cortical width (MCW) is smaller in children with osteogenesis imperfecta (OI) than in healthy children and that pamidronate can improve the cortical mandibular thickness. The aim of this study was to assess changes in the MCW on dental panoramic radiographs (DPRs) of children with normal bone mineral density (BMD) and with OI. We also compared the MCW of children with different types of OI regarding the number of pamidronate cycles and age at the beginning of treatment. MCW measurements were retrospectively obtained from 197 DPRs of 66 children with OI types I, III, and IV who were in treatment with a comparable dosage of cyclical intravenous pamidronate between 2007 and 2013. The control group had 92 DPRs from normal BMD children. Factorial analysis of variance was used to compare MCW measurements among different age groups and between sexes and also to compare MCW measurements of children with different types of OI among different pamidronate cycles and age at the beginning of treatment. No significant differences in results were found between male and female subjects in both OI and healthy children, so they were evaluated altogether (P > 0.05). There was an increase of MCW values related to aging in all normal BMD and OI children but on a smaller scale in children with OI types I and III. Children with OI presented lower mean MCW values than did children with normal BMD at the beginning of treatment (P < 0.05). A linear model estimated the number of pamidronate cycles necessary to achieve mean MCW values equivalent to those of healthy children. The thinning of the mandibular cortex depended on the number of pamidronate cycles, the type of OI, and the age at the beginning of treatment. DPRs could thus provide a way to identify cyclic pamidronate treatment outcomes in patients with OI.
MeSH term(s)	Absorptiometry, Photon/methods ; Administration, Intravenous ; Adolescent ; Age Factors ; Bone Density/drug effects ; Bone Density Conservation Agents/administration & dosage ; Bone Density Conservation Agents/therapeutic use ; Case-Control Studies ; Cephalometry/methods ; Child ; Child, Preschool ; Diphosphonates/administration & dosage ; Diphosphonates/therapeutic use ; Female ; Humans ; Image Processing, Computer-Assisted/methods ; Male ; Mandible/drug effects ; Osteogenesis Imperfecta/drug therapy ; Radiography, Panoramic/methods ; Retrospective Studies ; Young Adult
Chemical Substances	Bone Density Conservation Agents ; Diphosphonates ; pamidronate (OYY3447OMC)
Language	English
Publishing date	2015-03
Publishing country	United States
Document type	Comparative Study ; Journal Article
ZDB-ID	80207-4
ISSN	1544-0591 ; 0022-0345
ISSN (online)	1544-0591
ISSN	0022-0345
DOI	10.1177/0022034514567334
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Article: Effect of hemodialysis on uterine and umbilical artery Doppler flow velocity waveforms.

Krakow, D / Castro, L C / Schwieger, J

American journal of obstetrics and gynecology

1994 Volume 170, Issue 5 Pt 1, Page(s) 1386–1388

Abstract: A case of a pregnant woman with membranous glomerulonephropathy requiring hemodialysis is described. During hemodialysis the patient underwent Doppler flow studies of the uterine and umbilical arteries. In spite of avoidance of hypotension and major ... ...

Abstract	A case of a pregnant woman with membranous glomerulonephropathy requiring hemodialysis is described. During hemodialysis the patient underwent Doppler flow studies of the uterine and umbilical arteries. In spite of avoidance of hypotension and major fluid shifts, hemodialysis was accompanied by a significant increase in the systolic/diastolic ratio of the proximal uterine artery. There was no significant change in the umbilical artery systolic/diastolic ratio.
MeSH term(s)	Adult ; Blood Flow Velocity ; Female ; Fetal Growth Retardation/etiology ; Humans ; Kidney Failure, Chronic/complications ; Kidney Failure, Chronic/physiopathology ; Kidney Failure, Chronic/therapy ; Obstetric Labor, Premature/etiology ; Pre-Eclampsia/etiology ; Pregnancy ; Pregnancy Complications/physiopathology ; Pregnancy Complications/therapy ; Regional Blood Flow ; Renal Dialysis ; Ultrasonography ; Umbilical Arteries/diagnostic imaging ; Umbilical Arteries/physiology ; Uterus/blood supply
Language	English
Publishing date	1994-05
Publishing country	United States
Document type	Case Reports ; Journal Article
ZDB-ID	80016-8
ISSN	1097-6868 ; 0002-9378
ISSN (online)	1097-6868
ISSN	0002-9378
DOI	10.1016/s0002-9378(94)70166-0
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Article: Plasma levels of atrial natriuretic peptide in normal and hypertensive pregnancies: a meta-analysis.

Castro, L C / Hobel, C J / Gornbein, J

American journal of obstetrics and gynecology

1994 Volume 171, Issue 6, Page(s) 1642–1651

Abstract: Objective: Our goals were (1) to use meta-analysis to determine whether pregnancy and the puerperium are accompanied by alterations in plasma atrial natriuretic peptide levels when compared with the nonpregnant state and (2) to evaluate the additional ... ...

Abstract	Objective: Our goals were (1) to use meta-analysis to determine whether pregnancy and the puerperium are accompanied by alterations in plasma atrial natriuretic peptide levels when compared with the nonpregnant state and (2) to evaluate the additional effects of hypertensive disease during pregnancy on plasma atrial natriuretic peptide levels. Study design: Articles measuring atrial natriuretic peptide levels during pregnancy were reviewed. Data from articles meeting inclusion criteria were abstracted, and a meta-analysis was performed with the use of the maximum likelihood methods of Jennrich and Schluchter (Biometrics 1986;42:805-20). Results: The mean atrial natriuretic peptide level in nonpregnant control subjects was 28.7 pg/ml (95% confidence interval 22.5 to 36.7). The mean plasma atrial natriuretic peptide level rose 41% to 40.5 pg/ml (95% confidence interval 31.7 to 51.8) in the third trimester (p < 0.0001). It was 71.1 pg/ml (95% confidence interval 51.2 to 98.7) or 148% greater than the mean nonpregnant level during the first week post partum (p < 0.0001). Compared with levels in pregnant control subjects, plasma atrial natriuretic peptide levels increased 52% to 52.1 pg/ml (95% confidence interval 32.9 to 82.5) in women with gestational hypertension (p < 0.005) and 130% to 78.8 pg/ml (95% confidence interval 52.3 to 118.8) in women with preeclampsia (p < 0.0001). Chronic hypertension did not significantly alter atrial natriuretic peptide levels. Conclusions: The 41% increase in atrial natriuretic peptide levels in the third trimester suggests that atrial stretch receptors sense the expanded blood volume as normal to moderately increased. The rise in atrial natriuretic peptide during the first week post partum is consistent with known hemodynamic changes and suggests that atrial natriuretic peptide may be involved in the postpartum diuresis. The marked increase in plasma atrial natriuretic peptide levels observed in preeclampsia is not likely to result from elevated arterial pressures alone but may reflect underlying factors unique to this disease process.
MeSH term(s)	Atrial Natriuretic Factor/blood ; Female ; Humans ; Hypertension/blood ; Pre-Eclampsia/blood ; Pregnancy/blood ; Pregnancy Complications, Cardiovascular/blood ; Reference Values
Chemical Substances	Atrial Natriuretic Factor (85637-73-6)
Language	English
Publishing date	1994-12
Publishing country	United States
Document type	Journal Article ; Meta-Analysis ; Research Support, Non-U.S. Gov't
ZDB-ID	80016-8
ISSN	1097-6868 ; 0002-9378
ISSN (online)	1097-6868
ISSN	0002-9378
DOI	10.1016/0002-9378(94)90416-2
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Article: Sequential use of Prepidil and extra-amniotic saline infusion for the induction of labor in nulliparous women with very low Bishop scores.

Chammas, M F / Nguyen, T M / Vasavada, R A / Nuwayhid, B S / Castro, L C

The Journal of maternal-fetal medicine

2001 Volume 10, Issue 3, Page(s) 193–196

Abstract: Objective: To evaluate the efficacy of sequential use of Prepidil (prostaglandin E2 gel) and extra-amniotic saline infusion for the induction of labor in nulliparous women with very low Bishop scores.: Study design: Nulliparous women with singleton ... ...

Abstract	Objective: To evaluate the efficacy of sequential use of Prepidil (prostaglandin E2 gel) and extra-amniotic saline infusion for the induction of labor in nulliparous women with very low Bishop scores. Study design: Nulliparous women with singleton gestations, intact membranes and a cervical Bishop score of < or = 2 who received Prepidil gel and extra-amniotic saline infusion sequentially for the induction of labor between July 1996 and July 1998 were studied. Results: Thirty-one women met the inclusion criteria. Indications for induction included post-dates (six of 31), pre-eclampsia (ten of 31), diabetes (three of 31), oligohydramnios (three of 31), intrauterine growth restriction (two of 31) and non-reactive non-stress test (NST) (seven of 31). The average time from onset of induction to delivery was 38.1 +/- 13.5 h. Vaginal delivery was achieved in 80.6%. Women requiring > 2 doses of Prepidil had a higher risk of delivering abdominally (OR = 3.5). Three of seven (42.9%) women with labor induced for non-reactive NST but only three of 24 (12.5%) with labor induced for other indications had a Cesarean section delivery (p < 0.001). Conclusions: Nulliparous women with very unfavorable cervices can be counselled that they have an 80% chance of vaginal delivery using sequential Prepidil and extra-amniotic saline infusion as an induction method, with 90% delivering within the first 48 h.
MeSH term(s)	Administration, Intravaginal ; Adolescent ; Adult ; Amnion/drug effects ; Apgar Score ; Cervical Ripening/drug effects ; Cesarean Section ; Dinoprostone/administration & dosage ; Dinoprostone/therapeutic use ; Female ; Gestational Age ; Humans ; Infant, Newborn ; Infusions, Parenteral ; Labor Onset/drug effects ; Labor, Induced ; Oxytocics/administration & dosage ; Oxytocics/therapeutic use ; Parity ; Pregnancy ; Pregnancy Outcome ; Sodium Chloride/administration & dosage ; Sodium Chloride/therapeutic use ; Time Factors
Chemical Substances	Oxytocics ; Sodium Chloride (451W47IQ8X) ; Dinoprostone (K7Q1JQR04M)
Language	English
Publishing date	2001-02-28
Publishing country	United States
Document type	Clinical Trial ; Journal Article
ZDB-ID	1131764-4
ISSN	1057-0802
ISSN	1057-0802
DOI	10.1080/714904325
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Article: Long-term nitric oxide blockade in the pregnant rat: effects on blood pressure and plasma levels of endothelin-1.

Edwards, D L / Arora, C P / Bui, D T / Castro, L C

American journal of obstetrics and gynecology

1996 Volume 175, Issue 2, Page(s) 484–488

Abstract: Objective: Abnormalities in the production of nitric oxide and endothelin-1 have been implicated in the development of preeclampsia. We postulated that long-term nitric oxide synthase inhibition with L-nitro-arginine methyl ester would induce sustained ... ...

Abstract	Objective: Abnormalities in the production of nitric oxide and endothelin-1 have been implicated in the development of preeclampsia. We postulated that long-term nitric oxide synthase inhibition with L-nitro-arginine methyl ester would induce sustained hypertension, a rise in plasma levels of endothelin-1, and fetal growth restriction. Study design: Conscious virgin and pregnant Sprague-Dawley rats received infusions of vehicle or L-nitro-arginine methyl ester (2.5 mg/kg/hr) for 11 days. Mean arterial pressure was assessed serially. On day 21 of gestation (or equivalent in virgin rats) plasma was collected for endothelin-1 levels; pup weight and litter size were determined. Data were analyzed with analysis of variance and regression techniques. Results: Mean arterial pressure was constant in virgin control rats (n = 7) but declined in pregnant control rats (n = 11) as gestation advanced. Nitric oxide synthase inhibition in virgin (n = 10) and pregnant (n = 11) rats caused sustained elevations in mean arterial pressure (165 +/- 7 vs 100 +/- 3 mm Hg, L-nitro-arginine methyl ester vs control virgin rats, p < 0.0001; 149 +/- 5 vs 91 +/- 2 mm Hg, L-nitro-arginine methyl ester vs control pregnant rats, p < 0.0001). L-nitro-arginine methyl ester induced a rise in plasma endothelin-1 levels in virgin (4.4 +/- 0.1 vs 3.5 +/- 0.1 pg/ml, L-nitro-arginine methyl ester vs control, p < 0.0001) and pregnant rats (3.0 +/- 0.1 vs 2.6 +/- 0.1 pg/ml, L-nitro-arginine methyl ester vs control, p < 0.0001). Pregnant rats had lower endothelin-1 levels than did virgin rats (p < 0.0001). Mean arterial pressure and endothelin-1 were significantly correlated in pregnant rats. L-nitro-arginine methyl ester decreased pup weight (2.4 +/- 0.4 vs 3.7 +/- 0.2 gm/pup/litter, L-nitro-arginine methyl ester vs control, p < 0.01) and litter size (6.6 +/- 1.3 vs 10.2 +/- 0.9 pups/litter, L-nitro-arginine methyl ester vs control, p < 0.05). Conclusions: Long-term nitric oxide synthase blockade causes sustained hypertension, elevated levels of endothelin-1, and fetal growth restriction. Although the endocrine and pressor effects are not unique to pregnancy, this model clearly induces some of the changes seen in preeclampsia and may be useful for studying specific interventions.
MeSH term(s)	Animals ; Blood Pressure/drug effects ; Body Weight/drug effects ; Embryonic and Fetal Development/drug effects ; Endothelin-1/blood ; Female ; Hypertension/chemically induced ; Litter Size/drug effects ; NG-Nitroarginine Methyl Ester/pharmacology ; Nitric Oxide/antagonists & inhibitors ; Nitric Oxide Synthase/antagonists & inhibitors ; Pregnancy ; Pregnancy Complications, Cardiovascular/chemically induced ; Pregnancy, Animal/blood ; Pregnancy, Animal/physiology ; Rats ; Rats, Sprague-Dawley ; Time Factors
Chemical Substances	Endothelin-1 ; Nitric Oxide (31C4KY9ESH) ; Nitric Oxide Synthase (EC 1.14.13.39) ; NG-Nitroarginine Methyl Ester (V55S2QJN2X)
Language	English
Publishing date	1996-08
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	80016-8
ISSN	1097-6868 ; 0002-9378
ISSN (online)	1097-6868
ISSN	0002-9378
DOI	10.1016/s0002-9378(96)70166-7
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Article: Expectant management of severe preterm preeclampsia: is intrauterine growth restriction an indication for immediate delivery?

Chammas, M F / Nguyen, T M / Li, M A / Nuwayhid, B S / Castro, L C

American journal of obstetrics and gynecology

2000 Volume 183, Issue 4, Page(s) 853–858

Abstract: Objective: Expectant management of severe preterm preeclampsia is gaining widespread acceptance in clinical practice. The objective of our study was 2-fold-to determine the frequency of fetal deterioration with expectant management of severe preterm ... ...

Abstract	Objective: Expectant management of severe preterm preeclampsia is gaining widespread acceptance in clinical practice. The objective of our study was 2-fold-to determine the frequency of fetal deterioration with expectant management of severe preterm preeclampsia and to evaluate whether the presence of intrauterine growth restriction on admission is associated with a shorter admission-to-delivery interval or more deliveries resulting from nonreassuring fetal status in comparison with pregnancies with preeclampsia but without intrauterine growth restriction. Study design: This was an observational study of women with singleton pregnancies at <34 completed weeks' gestation who were admitted to the hospital with the diagnosis of severe preeclampsia and managed expectantly. Fetal status on admission, admission-to-delivery interval, indication for delivery, and neonatal outcome were examined. Results: Forty-seven women were studied during a 3-year period (1996-1999). Gestational age at admission was 29.8 +/- 2.6 weeks. The mean admission-to-delivery interval for the entire group was 6.0 +/- 5.1 days; in 42.5% delivery was for fetal indications. In comparison with the absence of intrauterine growth restriction, the presence of intrauterine growth restriction at admission resulted in a significantly shorter admission-to-delivery interval (3.1 +/- 2.1 vs 6.6 +/- 6.1 days; P <.05). Most fetuses with intrauterine growth restriction (85.7%) were delivered before 1 week. Although 57% of fetuses with intrauterine growth restriction were delivered for fetal indications, versus 39% of fetuses without intrauterine growth restriction, these rates were not found to be significantly different. Neonatal outcomes, as reflected by Apgar scores, number of admissions to and duration of stay in the neonatal intensive care unit, and neonatal mortality rates, were similar. Conclusion: Pregnancies complicated by severe preterm preeclampsia and the presence of intrauterine growth restriction at admission may not benefit from expectant management beyond the 48 hours needed for betamethasone to act. Furthermore, all patients may benefit from close fetal monitoring before delivery because of the high rate of intervention for deteriorating fetal status.
MeSH term(s)	Adolescent ; Adult ; Delivery, Obstetric ; Female ; Fetal Growth Retardation/complications ; Fetal Weight ; Gestational Age ; Heart Rate, Fetal ; Humans ; Oligohydramnios/complications ; Pre-Eclampsia/complications ; Pre-Eclampsia/therapy ; Pregnancy ; Time Factors
Language	English
Publishing date	2000-10
Publishing country	United States
Document type	Case Reports ; Journal Article
ZDB-ID	80016-8
ISSN	1097-6868 ; 0002-9378
ISSN (online)	1097-6868
ISSN	0002-9378
DOI	10.1067/mob.2000.109049
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Article: Gangliosides on intestinal microcirculation and animal survival during reperfusion.

Montero, E F S / von Kossel, K / Castro, L C / Manna, M C B / Lauz, S H / Fagundes, D J

Transplantation proceedings

2004 Volume 36, Issue 4, Page(s) 857–859

Abstract: This study investigated the effect of gangliosides (Gang) on small bowel microcirculation and animal survival after normothermic intestinal ischemia-reperfusion injury. Five adult male EPM-1 Wistar rats in each of three groups received FK506 (0.2 mg/kg), ...

Abstract	This study investigated the effect of gangliosides (Gang) on small bowel microcirculation and animal survival after normothermic intestinal ischemia-reperfusion injury. Five adult male EPM-1 Wistar rats in each of three groups received FK506 (0.2 mg/kg), Gang (3 mg/kg), or vehicle (at same volume) either 24 or 12 hours prior to the experiment. The animals were anesthetized intramuscularly with ketamine (60 mg/kg) and xylazine (10 mg/kg) and hydrated with 80 mL/kg of prewarmed saline solution delivered subcutaneously before the ischemic insult and 40 mL/kg at 1 hour after reperfusion. Under anesthesia, they underwent a laparotomy with clamping of the superior mesenteric artery (SMA) at its origin for 75 minutes. Microcirculation was evaluated with a laser Doppler flowmeter, 5 minutes before ischemia (baseline) and reperfusion (ischemia), and 20, 40, and 60 minutes after reperfusion. Animal survival was observed up to 24 hours. Small bowel flow measured before ischemia was considered to be the baseline level (100%). After SMA occlusion a significant reduction in microcirculatory tissue perfusion to about 8% was observed in all groups. At 20, 40, and 60 minutes of reperfusion treatment with Gang (77%, 81%, and 100%) or FK506 (70%, 85%, and 98%) promoted better recovery of the intestinal microcirculation when compared to the control group (45%, 72%, and 75%). Concerning animal survival there was no difference between groups (just one animal from each group, Gang and FK506, survived up to 24 hours). Based on our data we conclude that Gang and FK506 improve intestinal microcirculation in ischemia-reperfusion injury but do not change animal survival after severe ischemia.
MeSH term(s)	Animals ; Flow Cytometry ; Gangliosides/pharmacology ; Immunosuppressive Agents/pharmacology ; Intestines/blood supply ; Intestines/drug effects ; Intestines/pathology ; Male ; Microcirculation/drug effects ; Rats ; Rats, Wistar ; Reperfusion Injury/prevention & control ; Tacrolimus/pharmacology
Chemical Substances	Gangliosides ; Immunosuppressive Agents ; Tacrolimus (WM0HAQ4WNM)
Language	English
Publishing date	2004-05
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	82046-5
ISSN	1873-2623 ; 0041-1345
ISSN (online)	1873-2623
ISSN	0041-1345
DOI	10.1016/j.transproceed.2004.03.107
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Article: Atrial natriuretic peptide metabolism during pregnancy in the rat.

Castro, L C / Arora, C P / Krakow, D E / Allen, R

American journal of obstetrics and gynecology

1994 Volume 170, Issue 4, Page(s) 1184–1188

Abstract: Objective: Our purpose was to determine whether plasma clearance rates and production rates of atrial natriuretic peptide 99-126 are altered during pregnancy in the rat.: Study design: Twelve virgin and 12 late-pregnant chronically instrumented, ... ...

Abstract	Objective: Our purpose was to determine whether plasma clearance rates and production rates of atrial natriuretic peptide 99-126 are altered during pregnancy in the rat. Study design: Twelve virgin and 12 late-pregnant chronically instrumented, conscious, unrestrained Sprague-Dawley rats were studied. Mean arterial pressure, heart rate, and plasma atrial natriuretic peptide levels were measured before and during a 40-minute continuous infusion of atrial natriuretic peptide (10 ng/kg/min). Results: Control mean arterial pressure was 106 +/- 5 mm Hg in virgin rats versus 97 +/- 4 mm Hg in pregnant rats. Atrial natriuretic peptide infusion did not significantly affect mean arterial pressure in either group of animals but decreased heart rate in virgin rats. Basal plasma atrial natriuretic peptide levels were significantly higher in virgin than in pregnant rats (107 +/- 10 vs 78 +/- 7 pg/ml, respectively, p < 0.05). Atrial natriuretic peptide infusion significantly increased plasma levels in both groups to similar (183 +/- 19 and 154 +/- 14 pg/ml, virgin vs pregnant rats). Calculated plasma clearance rates were similar in virgin and pregnant rats (166 +/- 27 vs 155 +/- 17 ml/kg/min). Estimated production rates of atrial natriuretic peptide were higher in virgin then in pregnant rats (15.1 +/- 1.4 vs 11.4 +/- 1.1 ng/kg/min, p < 0.05). Conclusions: Plasma atrial natriuretic peptide levels are lower in chronically instrumented near-term pregnant rats compared with levels in virgin rats. This is not related to differences in plasma atrial natriuretic peptide clearance rates but rather to a decrease in production rates in late pregnancy.
MeSH term(s)	Animals ; Atrial Natriuretic Factor/metabolism ; Female ; Metabolic Clearance Rate ; Pregnancy ; Pregnancy, Animal/metabolism ; Rats ; Rats, Sprague-Dawley
Chemical Substances	Atrial Natriuretic Factor (85637-73-6)
Language	English
Publishing date	1994-04
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	80016-8
ISSN	1097-6868 ; 0002-9378
ISSN (online)	1097-6868
ISSN	0002-9378
DOI	10.1016/s0002-9378(94)70119-9
Database	MEDical Literature Analysis and Retrieval System OnLINE

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