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  1. Article: Progression of a Rare Disease, Takayasu Arteritis, With Hematologic and Gastrointestinal Manifestations: A Four-Year Follow-Up Study.

    Sacoto, Daniel Hernan / Turbay-Caballero, Valentina / Reyes-Castro, Tiago / Quintanilla, Bryan S / Lolo, Delatre

    Cureus

    2023  Volume 15, Issue 9, Page(s) e45950

    Abstract: Takayasu arteritis (TA) is a heterogeneous disease whose presentation and progression have not yet been well described. An elderly female was diagnosed with TA after presenting with bilateral arm claudication, elevated ESR, and bilateral subclavian ... ...

    Abstract Takayasu arteritis (TA) is a heterogeneous disease whose presentation and progression have not yet been well described. An elderly female was diagnosed with TA after presenting with bilateral arm claudication, elevated ESR, and bilateral subclavian arterial stenosis. In the first two years after diagnosis, she was diagnosed with monoclonal gammopathy of undetermined significance and alpha thalassemia minor. For the next two years, she presented with a non-ST elevation myocardial infarction, three oozing Dieulafoy lesions, and eosinophilic esophagitis. As we observed, TA can have an unusual and unpredictable progression. Therefore, a multidisciplinary approach and clinical surveillance are paramount.
    Language English
    Publishing date 2023-09-25
    Publishing country United States
    Document type Case Reports
    ZDB-ID 2747273-5
    ISSN 2168-8184
    ISSN 2168-8184
    DOI 10.7759/cureus.45950
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: The effect of parenting behaviours on adolescents' rumination: a systematic review of longitudinal studies.

    Castro, Tiago / Pinto, Tiago Miguel / Morais, Ana / Costa, Raquel / Jongenelen, Inês / Lamela, Diogo

    European child & adolescent psychiatry

    2023  

    Abstract: Rumination is an emotional regulation mechanism strongly associated with the development and maintenance of internalising psychopathology in adolescence and adulthood. Parenting behaviours (PBs) play a pivotal role in the development of rumination in ... ...

    Abstract Rumination is an emotional regulation mechanism strongly associated with the development and maintenance of internalising psychopathology in adolescence and adulthood. Parenting behaviours (PBs) play a pivotal role in the development of rumination in children and adolescents. Nonetheless, the specific PBs that can either protect against or increase the risk of rumination development remain poorly understood. This systematic review aimed to explore the (1) temporal associations between PBs and adolescents' rumination and (2) potential moderators influencing these associations. We conducted a comprehensive search across Web of Science, Scopus, PubMed, Academic Search Complete and Eric databases, adhering to PRISMA reporting guidelines. Out of 1,868 abstracts screened, 182 articles underwent full-text examination, with nine meeting the inclusion criteria for the systematic review. Overall, the studies indicated that PBs characterised by criticism, rejection and control were positively associated with the development of rumination in adolescents, whilst PBs marked by authoritative practises exhibited a negative association with rumination. Gender, temperament, environmental sensitivity and pubertal timing emerged as significant moderators in the effects of PBs on rumination. However, conclusions were limited due to the studies' methodological heterogeneity. Future studies on PBs and rumination should address various dimensions of PBs and different moderators to identify factors that can modify the development of rumination across adolescence. Findings may inform family-based prevention programmes to promote emotion regulation in adolescents as a protective factor against internalising psychopathology across adulthood.
    Language English
    Publishing date 2023-10-09
    Publishing country Germany
    Document type Journal Article ; Review
    ZDB-ID 1118299-4
    ISSN 1435-165X ; 1018-8827 ; 1433-5719
    ISSN (online) 1435-165X
    ISSN 1018-8827 ; 1433-5719
    DOI 10.1007/s00787-023-02309-2
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Dietary protein shapes the profile and repertoire of intestinal CD4+ T cells.

    Lockhart, Ainsley / Reed, Aubrey / Rezende de Castro, Tiago / Herman, Calvin / Campos Canesso, Maria Cecilia / Mucida, Daniel

    The Journal of experimental medicine

    2023  Volume 220, Issue 8

    Abstract: The intestinal immune system must tolerate food antigens to avoid allergy, a process requiring CD4+ T cells. Combining antigenically defined diets with gnotobiotic models, we show that food and microbiota distinctly influence the profile and T cell ... ...

    Abstract The intestinal immune system must tolerate food antigens to avoid allergy, a process requiring CD4+ T cells. Combining antigenically defined diets with gnotobiotic models, we show that food and microbiota distinctly influence the profile and T cell receptor repertoire of intestinal CD4+ T cells. Independent of the microbiota, dietary proteins contributed to accumulation and clonal selection of antigen-experienced CD4+ T cells at the intestinal epithelium, imprinting a tissue-specialized transcriptional program including cytotoxic genes on both conventional and regulatory CD4+ T cells (Tregs). This steady state CD4+ T cell response to food was disrupted by inflammatory challenge, and protection against food allergy in this context was associated with Treg clonal expansion and decreased proinflammatory gene expression. Finally, we identified both steady-state epithelium-adapted CD4+ T cells and tolerance-induced Tregs that recognize dietary antigens, suggesting that both cell types may be critical for preventing inappropriate immune responses to food.
    MeSH term(s) CD4-Positive T-Lymphocytes ; Intestines ; T-Lymphocytes, Regulatory ; Immune Tolerance ; Antigens/metabolism ; Dietary Proteins/metabolism
    Chemical Substances Antigens ; Dietary Proteins
    Language English
    Publishing date 2023-05-16
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 218343-2
    ISSN 1540-9538 ; 0022-1007
    ISSN (online) 1540-9538
    ISSN 0022-1007
    DOI 10.1084/jem.20221816
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: Dietary protein shapes the profile and repertoire of intestinal CD4

    Lockhart, Ainsley / Reed, Aubrey / de Castro, Tiago Rezende / Herman, Calvin / Canesso, Maria Cecilia Campos / Mucida, Daniel

    bioRxiv : the preprint server for biology

    2023  

    Abstract: The intestinal immune system must tolerate food antigens to avoid allergy, a process requiring ... ...

    Abstract The intestinal immune system must tolerate food antigens to avoid allergy, a process requiring CD4
    Language English
    Publishing date 2023-04-13
    Publishing country United States
    Document type Preprint
    DOI 10.1101/2023.04.11.536475
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Stepwise chromatin and transcriptional acquisition of an intraepithelial lymphocyte program.

    London, Mariya / Bilate, Angelina M / Castro, Tiago B R / Sujino, Tomohisa / Mucida, Daniel

    Nature immunology

    2021  Volume 22, Issue 4, Page(s) 449–459

    Abstract: Mesenteric lymph node (mLN) T cells undergo tissue adaptation upon migrating to intestinal lamina propria and epithelium, ensuring appropriate balance between tolerance and resistance. By combining mouse genetics with single-cell and chromatin analyses, ... ...

    Abstract Mesenteric lymph node (mLN) T cells undergo tissue adaptation upon migrating to intestinal lamina propria and epithelium, ensuring appropriate balance between tolerance and resistance. By combining mouse genetics with single-cell and chromatin analyses, we uncovered the molecular imprinting of gut epithelium on T cells. Transcriptionally, conventional and regulatory (T
    MeSH term(s) Animals ; Cell Differentiation ; Cell Lineage ; Cells, Cultured ; Chromatin Assembly and Disassembly ; Gene Expression Profiling ; Gene Expression Regulation, Developmental ; Genomic Imprinting ; Intestinal Mucosa/immunology ; Intestinal Mucosa/metabolism ; Intraepithelial Lymphocytes/immunology ; Intraepithelial Lymphocytes/metabolism ; Lymph Nodes/immunology ; Lymph Nodes/metabolism ; Mice, Knockout ; Phenotype ; RNA-Seq ; Single-Cell Analysis ; T-Lymphocytes, Regulatory/immunology ; T-Lymphocytes, Regulatory/metabolism ; Transcription Factors/genetics ; Transcription Factors/metabolism ; Transcription, Genetic ; Transcriptome ; Mice
    Chemical Substances Th-POK protein, mouse ; Transcription Factors
    Language English
    Publishing date 2021-03-08
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 2016987-5
    ISSN 1529-2916 ; 1529-2908
    ISSN (online) 1529-2916
    ISSN 1529-2908
    DOI 10.1038/s41590-021-00883-8
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Newly recruited intraepithelial Ly6A

    Parsa, Roham / London, Mariya / Rezende de Castro, Tiago Bruno / Reis, Bernardo / Buissant des Amorie, Julian / Smith, Jason G / Mucida, Daniel

    Immunity

    2022  Volume 55, Issue 7, Page(s) 1234–1249.e6

    Abstract: The intestinal epithelium comprises the body's largest surface exposed to viruses. Additionally, the gut epithelium hosts a large population of intraepithelial T lymphocytes, or IELs, although their role in resistance against viral infections remains ... ...

    Abstract The intestinal epithelium comprises the body's largest surface exposed to viruses. Additionally, the gut epithelium hosts a large population of intraepithelial T lymphocytes, or IELs, although their role in resistance against viral infections remains elusive. By fate-mapping T cells recruited to the murine intestine, we observed an accumulation of newly recruited CD4
    MeSH term(s) Animals ; Antigens, Ly ; CD4-Positive T-Lymphocytes ; Intestinal Mucosa ; Intestine, Small ; Membrane Proteins ; Mice ; Receptors, Chemokine ; Virus Diseases
    Chemical Substances Antigens, Ly ; Ly6a protein, mouse ; Membrane Proteins ; Receptors, Chemokine
    Language English
    Publishing date 2022-05-25
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 1217235-2
    ISSN 1097-4180 ; 1074-7613
    ISSN (online) 1097-4180
    ISSN 1074-7613
    DOI 10.1016/j.immuni.2022.05.001
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Outcomes With Peripheral Venoarterial Extracorporeal Membrane Oxygenation for Suspected Acute Myocarditis: 10-Year Experience From the Extracorporeal Life Support Organization Registry.

    Nunez, Jose I / Grandin, E Wilson / Reyes-Castro, Tiago / Sabe, Marwa / Quintero, Pablo / Motiwala, Shweta / Fleming, Lisa M / Sriwattanakomen, Roy / Ho, Jennifer E / Kennedy, Kevin / Tonna, Joseph E / Garan, A Reshad

    Circulation. Heart failure

    2023  Volume 16, Issue 7, Page(s) e010152

    Abstract: Background: Acute myocarditis can result in severe hemodynamic compromise requiring venoarterial extracorporeal membrane oxygenation (VA-ECMO). Outcomes and factors associated with mortality among myocarditis patients are not well described in the ... ...

    Abstract Background: Acute myocarditis can result in severe hemodynamic compromise requiring venoarterial extracorporeal membrane oxygenation (VA-ECMO). Outcomes and factors associated with mortality among myocarditis patients are not well described in the modern ECMO era.
    Methods: We queried the Extracorporeal Life Support Organization registry from 2011 to 2020 for adults with suspected acute myocarditis undergoing peripheral VA-ECMO support. The primary outcome was in-hospital mortality and was compared to all-comers receiving VA-ECMO in the registry over the same period. Secondary outcomes were rates of bridging to advanced therapies and ECMO complications. We used multivariable logistic regression to examine factors associated with in-hospital mortality.
    Results: Among 850 patients with suspected acute myocarditis receiving peripheral VA-ECMO, the mean age was 41 years, 52% were men, 39% Asian race, and 14.8% underwent extracorporeal cardiopulmonary resuscitation. During the study period, in-hospital mortality steadily declined and was 58.3% for all all-comers receiving VA-ECMO compared with 34.9% for patients with myocarditis (
    Conclusions: Compared with all-comers supported with VA-ECMO, in-hospital mortality for patients with acute myocarditis is significantly lower, with nearly two-thirds of patients surviving to discharge. Major modifiable risk factors for mortality were ongoing cardiopulmonary resuscitation requiring ECMO and markers of illness severity prior to ECMO.
    MeSH term(s) Male ; Adult ; Humans ; Female ; Extracorporeal Membrane Oxygenation/adverse effects ; Myocarditis/therapy ; Myocarditis/complications ; Heart Failure/therapy ; Risk Factors ; Registries ; Retrospective Studies ; Shock, Cardiogenic/etiology
    Language English
    Publishing date 2023-06-22
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 2429459-7
    ISSN 1941-3297 ; 1941-3289
    ISSN (online) 1941-3297
    ISSN 1941-3289
    DOI 10.1161/CIRCHEARTFAILURE.122.010152
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Insulinautoimmunsyndrom : Eine seltene, aber wichtige Differentialdiagnose der Hypoglykämie.

    de Castro, Tiago / Beier, Christoph / Terkamp, Christoph / Oehler, Lucia / Schmidt, Bernhard M W / Heck, Johannes / Stichtenoth, Dirk / Wedemeyer, Heiner / Leitolf, Holger

    Der Internist

    2021  Volume 63, Issue 2, Page(s) 217–220

    Abstract: A 69-year-old female patient was referred to the Medical University of Hanover for further diagnostic evaluation of recurrent severe hypoglycemia. The patient had previously been started on clopidogrel after arterial stenting for peripheral arterial ... ...

    Title translation Insulin autoimmune syndrome : A rare, but important differential diagnosis of hypoglycemia.
    Abstract A 69-year-old female patient was referred to the Medical University of Hanover for further diagnostic evaluation of recurrent severe hypoglycemia. The patient had previously been started on clopidogrel after arterial stenting for peripheral arterial obstructive disease (PAOD). The presence of an insulinoma and paraneoplastic syndrome was excluded. Increased serum insulin and insulin autoantibodies levels were confirmed, despite normal to low blood sugar levels. An insulin autoimmune syndrome was diagnosed, most likely induced by the prior intake of clopidogrel. Treatment with immunoadsorption was initiated, achieving a significant reduction in hypoglycemic events and a lasting response to treatment over 3 months.
    MeSH term(s) Aged ; Autoimmune Diseases/diagnosis ; Autoimmune Diseases/drug therapy ; Diagnosis, Differential ; Female ; Humans ; Hypoglycemia/chemically induced ; Hypoglycemia/diagnosis ; Insulin ; Insulinoma ; Pancreatic Neoplasms/diagnosis
    Chemical Substances Insulin
    Language German
    Publishing date 2021-10-26
    Publishing country Germany
    Document type Case Reports ; Journal Article
    ZDB-ID 2913-0
    ISSN 1432-1289 ; 0020-9554
    ISSN (online) 1432-1289
    ISSN 0020-9554
    DOI 10.1007/s00108-021-01180-0
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article: Vulnerability of Cerrado threatened mammals: an integrative landscape and climate modeling approach

    De Marco, Paulo, Jr / Villén, Sara / Mendes, Poliana / Nóbrega, Caroline / Cortes, Lara / Castro, Tiago / Souza, Rodrigo

    Biodiversity and conservation. 2020 Apr., v. 29, no. 5

    2020  

    Abstract: Species vulnerability is defined based on their exposition, sensitivity and adaptive capacity to a given impact. Considering limitations to estimate the sensitivity component, we developed a framework integrating the knowledge on ecological niche models ... ...

    Abstract Species vulnerability is defined based on their exposition, sensitivity and adaptive capacity to a given impact. Considering limitations to estimate the sensitivity component, we developed a framework integrating the knowledge on ecological niche models and extinction thresholds, generating species sensitivity scenarios at the landscape scale. Our aim was to assess species and landscape vulnerability for threatened mammal species from the Brazilian Cerrado by considering seven types of human-impacts and climatic suitability. We assumed that climatic-suitable landscapes with less than 50% of remaining natural vegetation are not suitable for species, while in landscapes with 50–60% of remaining natural vegetation, populations are highly vulnerable. We found a spatial match between climatic-suitable areas and highly-impacted landscape (< 50% of remaining vegetation), specifically in southern Cerrado. We attribute this result to two main reasons: (1) similar characteristics affecting both suitability for species and human activities; and (2) highly impacted landscapes are likely to shelter threatened species. Vulnerable cells, with 50–60% of remaining vegetation, were distributed throughout Cerrado, meaning that there is no spatial bias within their distribution. Range-restricted species exhibited higher variability in vulnerability compared to widely-distributed species, what could be explained by human occupation being spatially clumped. Agriculture is the major impact affecting highly-impacted landscapes (< 50% of remaining vegetation), transport infra-structure has higher impact on vulnerable landscapes. We believe that our approach can be easily applied for assessing species and landscape vulnerability in many ecological domains by adapting extinction thresholds according to the focus taxon.
    Keywords biodiversity ; cerrado ; climate ; extinction ; humans ; landscapes ; niches ; occupations ; threatened species
    Language English
    Dates of publication 2020-04
    Size p. 1637-1658.
    Publishing place Springer Netherlands
    Document type Article
    Note NAL-AP-2-clean
    ZDB-ID 2000787-5
    ISSN 1572-9710 ; 0960-3115
    ISSN (online) 1572-9710
    ISSN 0960-3115
    DOI 10.1007/s10531-018-1615-x
    Database NAL-Catalogue (AGRICOLA)

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  10. Book ; Online: Satellite galaxy abundance dependency on cosmology in Magneticum simulations

    Ragagnin, Antonio / Fumagalli, Alessandra / Castro, Tiago / Dolag, Klaus / Saro, Alexandro / Costanzi, Matteo / Bocquet, Sebastian

    2021  

    Abstract: Context: Modelling satellite galaxy abundance $N_s$ in Galaxy Clusters (GCs) is a key element in modelling the Halo Occupation Distribution (HOD), which itself is a powerful tool to connect observational studies with numerical simulations. Aims: To study ...

    Abstract Context: Modelling satellite galaxy abundance $N_s$ in Galaxy Clusters (GCs) is a key element in modelling the Halo Occupation Distribution (HOD), which itself is a powerful tool to connect observational studies with numerical simulations. Aims: To study the impact of cosmological parameters on satellite abundance both in cosmological simulations and in mock observations. Methods: We build an emulator (HODEmu, \url{https://github.com/aragagnin/HODEmu/}) of satellite abundance based on cosmological parameters $\Omega_m, \Omega_b, \sigma_8, h_0$ and redshift $z.$ We train our emulator using \magneticum hydrodynamic simulations that span 15 different cosmologies, each over $4$ redshift slices between $0<z<0.5,$ and for each setup we fit normalisation $A$, log-slope $\beta$ and Gaussian fractional-scatter $\sigma$ of the $N_s-M$ relation. The emulator is based on multi-variate output Gaussian Process Regression (GPR). Results: We find that $A$ and $\beta$ depend on cosmological parameters, even if weakly, especially on $\Omega_m,$ $\Omega_b.$ This dependency can explain some discrepancies found in literature between satellite HOD of different cosmological simulations (Magneticum, Illustris, BAHAMAS). We also show that satellite abundance cosmology dependency differs between full-physics (FP) simulations, dark-matter only (DMO), and non-radiative simulations. Conclusions: This work provides a preliminary calibration of the cosmological dependency of the satellite abundance of high mass halos, and we showed that modelling HOD with cosmological parameters is necessary to interpret satellite abundance, and we showed the importance of using FP simulations in modelling this dependency.<br />
    Comment: 15 pages, 13 figues, submitted to A&A
    Keywords Astrophysics - Cosmology and Nongalactic Astrophysics ; Astrophysics - Astrophysics of Galaxies ; Computer Science - Machine Learning
    Subject code 520
    Publishing date 2021-10-11
    Publishing country us
    Document type Book ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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