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  1. Article ; Online: Long-Term Outcomes of Resynchronization-Defibrillation for Heart Failure.

    Pintea Bentea, Georgiana / Castro Rodriguez, Jose

    The New England journal of medicine

    2024  Volume 390, Issue 14, Page(s) 1344

    MeSH term(s) Humans ; Heart Failure/therapy ; Defibrillators, Implantable
    Language English
    Publishing date 2024-04-10
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 207154-x
    ISSN 1533-4406 ; 0028-4793
    ISSN (online) 1533-4406
    ISSN 0028-4793
    DOI 10.1056/NEJMc2402048
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Intravenous magnesium sulfate for asthma exacerbations in children: Systematic review with meta-analysis.

    Ambrożej, Dominika / Adamiec, Aleksander / Forno, Erick / Orzołek, Izabela / Feleszko, Wojciech / Castro-Rodriguez, Jose A

    Paediatric respiratory reviews

    2024  

    Abstract: Background: Asthma is the most prevalent chronic disease in children and constitutes a significant healthcare burden. First-line therapy for acute asthma exacerbations is well established. However, secondary treatments, including intravenous magnesium ... ...

    Abstract Background: Asthma is the most prevalent chronic disease in children and constitutes a significant healthcare burden. First-line therapy for acute asthma exacerbations is well established. However, secondary treatments, including intravenous magnesium sulfate (IV-MgSO4), remain variable due to scarcity of data on its efficacy and safety.
    Objective: To assess the effectiveness and safety of IV-MgSO4 as a second line of treatment in managing children with asthma exacerbations.
    Methods: We searched five databases from inception until April 2023 on randomized clinical trials of IV-MgSO4 in children with acute asthma exacerbations. The primary outcomes were hospitalization rate and length, and change in the severity score. Secondary outcomes included percentage increase in peak expiratory flow rate (PEFR), hospital re-admission rate, need and length for pediatric intensive care unit (PICU) treatment, and adverse effects. Meta-analysis was performed for three outcomes with estimated odds ratios (ORs) or mean differences (MDs) and 95% confidence intervals (CIs).
    Results: Eleven studies met the final criteria. In comparison to control, administration of IV-MgSO4 was associated with a reduced hospitalization risk (OR 0.15; 95%CI: 0.03, 0.73) in four studies, and improvement of lung function (MD 26.77% PEFR; 95%CI: 18.41, 54.79) in two studies. There were no significant differences in the length of stay between groups. Due to heterogeneity, a narrative synthesis of other outcomes was performed.
    Conclusion: The use of IV-MgSO4 demonstrated a reduction in the hospitalization rate and PEFR improvement in children with asthma exacerbations. Adverse effects were rare. Further well-designed studies are needed to better determine the efficacy and safety profile of IV-MgSO4.
    Language English
    Publishing date 2024-02-12
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2147664-0
    ISSN 1526-0550 ; 1526-0542
    ISSN (online) 1526-0550
    ISSN 1526-0542
    DOI 10.1016/j.prrv.2024.01.003
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Asthma Phenotypes in the Era of Personalized Medicine.

    Gonzalez-Uribe, Victor / Romero-Tapia, Sergio J / Castro-Rodriguez, Jose A

    Journal of clinical medicine

    2023  Volume 12, Issue 19

    Abstract: Asthma is a widespread disease affecting approximately 300-million people globally. This condition leads to significant morbidity, mortality, and economic strain worldwide. Recent clinical and laboratory research advancements have illuminated the ... ...

    Abstract Asthma is a widespread disease affecting approximately 300-million people globally. This condition leads to significant morbidity, mortality, and economic strain worldwide. Recent clinical and laboratory research advancements have illuminated the immunological factors contributing to asthma. As of now, asthma is understood to be a heterogeneous disease. Personalized medicine involves categorizing asthma by its endotypes, linking observable characteristics to specific immunological mechanisms. Identifying these endotypic mechanisms is paramount in accurately profiling patients and tailoring therapeutic approaches using innovative biological agents targeting distinct immune pathways. This article presents a synopsis of the key immunological mechanisms implicated in the pathogenesis and manifestation of the disease's phenotypic traits and individualized treatments for severe asthma subtypes.
    Language English
    Publishing date 2023-09-26
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2662592-1
    ISSN 2077-0383
    ISSN 2077-0383
    DOI 10.3390/jcm12196207
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  4. Article ; Online: Higher levels of insulin-like growth factor-1 in cord blood associate with risk of asthma at age 3.

    Castro-Rodriguez, Jose A / Padilla, Oslando / Casanello, Paola / Forno, Erick

    Pediatric pulmonology

    2023  Volume 59, Issue 2, Page(s) 482–487

    Abstract: Rationale: Experimental studies and epidemiological data in adults suggest that somatomedin-C (insulin-like growth factor-1, IGF-1) may play a role in asthma by modulating airway inflammation, bronchial hyperreactivity, and airway smooth muscle ... ...

    Abstract Rationale: Experimental studies and epidemiological data in adults suggest that somatomedin-C (insulin-like growth factor-1, IGF-1) may play a role in asthma by modulating airway inflammation, bronchial hyperreactivity, and airway smooth muscle hyperplasia. However, its role in children with asthma is not well understood.
    Methods: We established a birth cohort with 339 Chilean pregnant mothers enrolled at the time of delivery from December 2014 to January 2016. We obtained cord blood at birth and followed the offspring every 6 months until 30 months of age, recording data on atopy, wheezing, and other respiratory illnesses. We measured IGF-1 in cord blood and determined the Asthma Predictive Index (API) at 30 months. The cohort was divided according to the API.
    Results: Complete data were available for 307/339 (91%) dyads, including 44 preschoolers with API+ and 263 with API-. Demographic characteristics were similar between groups, but mothers of API+ children had a higher prevalence of obesity, previous use of oral contraceptives, and higher education than those of API- children. API+ children had higher birth weight and significantly higher IGF-1 in cord blood (37.4 ± 13.2 in API+ vs. 30.5 ± 13.0 ng/ml in API-, p = .01). In the multivariable analysis, IGF-1 in cord blood remained independently associated with a higher risk of asthma (adjusted OR for API+ per ng/ml higher IGF-1 = 1.03 [1.0-1.06], p = .015).
    Conclusions: Higher insulin-like growth factor-1 in cord blood is associated with asthma risk in the preschool years.
    MeSH term(s) Pregnancy ; Infant, Newborn ; Child ; Female ; Child, Preschool ; Adult ; Humans ; Insulin-Like Growth Factor I ; Insulin-Like Peptides ; Fetal Blood ; Birth Weight ; Asthma/epidemiology
    Chemical Substances Insulin-Like Growth Factor I (67763-96-6) ; Insulin-Like Peptides
    Language English
    Publishing date 2023-11-28
    Publishing country United States
    Document type Journal Article
    ZDB-ID 632784-9
    ISSN 1099-0496 ; 8755-6863
    ISSN (online) 1099-0496
    ISSN 8755-6863
    DOI 10.1002/ppul.26780
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  5. Article ; Online: Hypertension during pregnancy unveils a congenital triade.

    Anghel, Laura / Castro Rodriguez, Jose / Dessy, Hughe / Damry, Nash / Morissens, Marielle

    Acta cardiologica

    2023  Volume 78, Issue 10, Page(s) 1133–1135

    MeSH term(s) Pregnancy ; Female ; Humans ; Hypertension ; Aortic Coarctation
    Language English
    Publishing date 2023-07-20
    Publishing country England
    Document type Journal Article
    ZDB-ID 390197-x
    ISSN 1784-973X ; 0001-5385
    ISSN (online) 1784-973X
    ISSN 0001-5385
    DOI 10.1080/00015385.2023.2232689
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  6. Article ; Online: "The flying thymus sign".

    Nguyen, Damien / Nguyen, Thomas / Castro Rodriguez, José

    Internal and emergency medicine

    2021  Volume 16, Issue 6, Page(s) 1701–1702

    MeSH term(s) Adolescent ; Chest Pain/etiology ; Humans ; Male ; Mediastinal Emphysema/diagnosis ; Mediastinal Emphysema/diagnostic imaging ; Radiography/methods ; Thymus Gland/abnormalities ; Thymus Gland/diagnostic imaging
    Language English
    Publishing date 2021-01-16
    Publishing country Italy
    Document type Case Reports ; Journal Article
    ZDB-ID 2454173-4
    ISSN 1970-9366 ; 1828-0447
    ISSN (online) 1970-9366
    ISSN 1828-0447
    DOI 10.1007/s11739-020-02626-3
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  7. Article ; Online: Reactance inversion in moderate to severe persistent asthma: low birth weight, prematurity effect, and bronchodilator response.

    González Vera, Ramiro / Vidal Grell, Alberto / Castro-Rodríguez, José A / Palomino Montenegro, María A / Méndez Yarur, Alejandra

    The Journal of asthma : official journal of the Association for the Care of Asthma

    2024  , Page(s) 1–7

    Abstract: Introduction: Reactance inversion (RI) has been associated with impaired peripheral airway function in persistent asthma. However, there is little to no data about the difference between asthmatic children with and without RI. This study aimed to detect ...

    Abstract Introduction: Reactance inversion (RI) has been associated with impaired peripheral airway function in persistent asthma. However, there is little to no data about the difference between asthmatic children with and without RI. This study aimed to detect clinical and lung function differences in moderate-severe asthmatic children with and without RI.
    Methods: This study was conducted between 2021 and 2022 in asthmatic school-age children. Impulse oscillometry (IOS) and spirometry were performed according to ATS/ERS standards.
    Results: A total of 62 patients, with a mean age of 8.4 years, 54.8% were males and were divided into three groups: group 1 (32.3%) with no RI, group 2 (27.4%) with RI but disappearing after bronchodilator test and group 3 (40.3%) with persistent RI after bronchodilator test. Children in groups 2 and 3 had significantly lower birth weights than in group 1. Group 2 had lower gestational age compared to group 1. FEV
    Conclusion: RI is frequently found in children with moderate-severe persistent asthma, particularly in those with a history of prematurity or low birth weight. In some patients, RI disappears after the bronchodilator test; however, it, persists in those with the worst pulmonary function. RI could be a small airway dysfunction marker.
    Language English
    Publishing date 2024-03-07
    Publishing country England
    Document type Journal Article
    ZDB-ID 603816-5
    ISSN 1532-4303 ; 0277-0903
    ISSN (online) 1532-4303
    ISSN 0277-0903
    DOI 10.1080/02770903.2024.2324865
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  8. Article: Prevalence of Left Atrial Septal Pouch Among Patients with Embolic Stroke of Undetermined Source Or Stroke of Known Etiology: a Retrospective Study.

    Steyaert, Hugo / Castro Rodriguez, Jose / Gazagnes, Marie-Dominique / Morissens, Marielle

    Journal of translational internal medicine

    2022  Volume 10, Issue 1, Page(s) 48–55

    Abstract: Background and objectives: Cryptogenic strokes can be defined by the criteria established for an embolic stroke of undetermined source (ESUS). Some embolic events might be caused by a left atrial septal pouch (LASP), due to the potential of thrombus ... ...

    Abstract Background and objectives: Cryptogenic strokes can be defined by the criteria established for an embolic stroke of undetermined source (ESUS). Some embolic events might be caused by a left atrial septal pouch (LASP), due to the potential of thrombus formation. In this study we aimed to determine if LASP is a risk factor for ESUS when compared to a population of strokes of known origin, the LASP screening rate in our institution and if LASP dimensions influences the risk of ESUS.
    Methods: We retrospectively analyzed transesophageal echocardiograms (TEEs) in a large cohort of patients that had experienced ischemic strokes. Two authors performed blinded, independent searches for LASPs by reviewing 1152 TEEs from patients that had experienced a stroke or transient ischemic attack. We excluded 26 TEEs, due to incorrect imaging. Next, we reviewed patient medical files.
    Results: Among the 1126 included patients, 148 had an ESUS (ESUS+ group) and 978 had strokes of known origin (ESUS- group). A LASP was present in 176 patients, including 32 patients (21.6% of LASPs) in the ESUS+ group and 144 patients (14.7% of LASPs) in the ESUS- group. In multivariate analysis, LASP was independently associated with ESUS (
    Conclusion: This study demonstrated that LASPs were more prevalent in patients with ESUS than in patients with strokes of known origin. Our results gave rise to the question of whether anticoagulation would be appropriate for some patients with ESUS. New large-scale, prospective studies should be conducted to address this issue. Additionally, considering the low rate of LASP descriptions, we concluded that the awareness of operators should be raised to improve their success in identifying LASPs.
    Language English
    Publishing date 2022-04-09
    Publishing country Poland
    Document type Journal Article
    ZDB-ID 2861892-0
    ISSN 2224-4018 ; 2450-131X
    ISSN (online) 2224-4018
    ISSN 2450-131X
    DOI 10.2478/jtim-2022-0032
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  9. Article ; Online: High altitude pulmonary edema in children: A systematic review.

    Ucrós, Santiago / Aparicio, Camila / Castro-Rodriguez, Jose A / Ivy, Dunbar

    Pediatric pulmonology

    2022  Volume 58, Issue 4, Page(s) 1059–1067

    Abstract: Introduction: High altitude pulmonary edema (HAPE) is a form of acute noncardiogenic pulmonary edema caused by altitude-related hypoxia seen in children as well as in adults. In this systematic review we focus in HAPE occurring in children and ... ...

    Abstract Introduction: High altitude pulmonary edema (HAPE) is a form of acute noncardiogenic pulmonary edema caused by altitude-related hypoxia seen in children as well as in adults. In this systematic review we focus in HAPE occurring in children and adolescents.
    Methods: A systematic review was conducted including publications in children 0-18 years of age from three databases up to June 2022.
    Results: Thirty-five studies representing 210 cases were found. The mean age was 9.8 ± 3.6 years with a male/female ratio of 2.6. The peak age incidence was seen in children between 6 and 10 years old. Only two children (0.9%) were ≤2 years old. The mean altitude in 166 cases was 2861 masl. Only 17 cases (8.1%) occurred at altitudes below 2500 masl. Regarding the different HAPE subtypes there was a predominance of re-entry HAPE (R-HAPE) with 58%, followed by classic HAPE (C-HAPE) with 37.6%. The mean time between arrival and onset of symptoms was 16.5 h. The mortality rate was 1.4%. In 10/28 (36%) of C-HAPE cases there was a structural cardiac/pulmonary anomaly compared to 1/19 (5%) in R-HAPE (p < 0.01). HAPE recurrence was found in 46 cases (21.9%). The involvement in the chest X-rays was seen predominantly in the apices and in the right lung.
    Conclusions: R-HAPE was the most common HAPE subtype; HAPE peak age was found between 6 and 10 years of age; HAPE was more frequent in males and was rare in children under 2 years old; associated HAPE structural abnormalities were more common in C-HAPE than in R-HAPE.
    MeSH term(s) Adult ; Adolescent ; Child ; Humans ; Female ; Male ; Infant ; Child, Preschool ; Altitude ; Pulmonary Edema/epidemiology ; Pulmonary Edema/etiology ; Altitude Sickness/complications ; Altitude Sickness/epidemiology ; Altitude Sickness/diagnosis ; Hypertension, Pulmonary/etiology ; Hypertension, Pulmonary/complications ; Hypoxia/complications
    Language English
    Publishing date 2022-12-29
    Publishing country United States
    Document type Systematic Review ; Journal Article
    ZDB-ID 632784-9
    ISSN 1099-0496 ; 8755-6863
    ISSN (online) 1099-0496
    ISSN 8755-6863
    DOI 10.1002/ppul.26294
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  10. Article ; Online: A new childhood asthma phenotype: obese with early menarche.

    Castro-Rodriguez, Jose A

    Paediatric respiratory reviews

    2016  Volume 18, Page(s) 85–89

    Abstract: Three concomitant phenomena occur in the later years of childhood: increases in the incidence of asthma, obesity and early menarche. This article is an overview of the current epidemiologic, basic, genetic and epigenetic evidence about this relationship. ...

    Abstract Three concomitant phenomena occur in the later years of childhood: increases in the incidence of asthma, obesity and early menarche. This article is an overview of the current epidemiologic, basic, genetic and epigenetic evidence about this relationship. As a consequence we propose that obese girls who have an early menarche (≤ 11 years of age) constitute a new asthma phenotype in childhood. Future studies need to be carried out in order to find the best control and treatment of this new asthma phenotype.
    MeSH term(s) Age Factors ; Asthma/epidemiology ; Asthma/etiology ; Female ; Global Health ; Humans ; Incidence ; Menarche ; Obesity/complications ; Phenotype ; Risk Factors
    Language English
    Publishing date 2016-03
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2147664-0
    ISSN 1526-0550 ; 1526-0542
    ISSN (online) 1526-0550
    ISSN 1526-0542
    DOI 10.1016/j.prrv.2015.10.006
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