Article ; Online: SARS-CoV-2 spike mRNA vaccine sequences circulate in blood up to 28 days after COVID-19 vaccination.
APMIS : acta pathologica, microbiologica, et immunologica Scandinavica
2023 Volume 131, Issue 3, Page(s) 128–132
Abstract: In Denmark, vaccination against Severe Acute Respiratory Syndrome Corona Virus 2 (SARS-CoV-2) has been with the Pfizer-BioNTech (BTN162b2) or the Moderna (mRNA-1273) mRNA vaccines. Patients with chronic hepatitis C virus (HCV) infection followed in our ... ...
Abstract | In Denmark, vaccination against Severe Acute Respiratory Syndrome Corona Virus 2 (SARS-CoV-2) has been with the Pfizer-BioNTech (BTN162b2) or the Moderna (mRNA-1273) mRNA vaccines. Patients with chronic hepatitis C virus (HCV) infection followed in our clinic received mRNA vaccinations according to the Danish roll-out vaccination plan. To monitor HCV infection, RNA was extracted from patient plasma and RNA sequencing was performed on the Illumina platform. In 10 of 108 HCV patient samples, full-length or traces of SARS-CoV-2 spike mRNA vaccine sequences were found in blood up to 28 days after COVID-19 vaccination. Detection of mRNA vaccine sequences in blood after vaccination adds important knowledge regarding this technology and should lead to further research into the design of lipid-nanoparticles and the half-life of these and mRNA vaccines in humans. |
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MeSH term(s) | Humans ; COVID-19 Vaccines ; SARS-CoV-2/genetics ; Hepatitis C, Chronic ; COVID-19/prevention & control ; Vaccination ; Hepacivirus ; Hepatitis C ; Antibodies, Viral |
Chemical Substances | COVID-19 Vaccines ; Antibodies, Viral |
Language | English |
Publishing date | 2023-01-29 |
Publishing country | Denmark |
Document type | Journal Article |
ZDB-ID | 93340-5 |
ISSN | 1600-0463 ; 0903-4641 |
ISSN (online) | 1600-0463 |
ISSN | 0903-4641 |
DOI | 10.1111/apm.13294 |
Database | MEDical Literature Analysis and Retrieval System OnLINE |
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