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  1. Article ; Online: A Relationship between the Structures and Neurotoxic Effects of Aβ Oligomers Stabilized by Different Metal Ions.

    Chia, Sean / Cataldi, Rodrigo Lessa / Ruggeri, Francesco Simone / Limbocker, Ryan / Condado-Morales, Itzel / Pisani, Katarina / Possenti, Andrea / Linse, Sara / Knowles, Tuomas P J / Habchi, Johnny / Mannini, Benedetta / Vendruscolo, Michele

    ACS chemical neuroscience

    2024  Volume 15, Issue 6, Page(s) 1125–1134

    Abstract: Oligomeric assemblies of the amyloid β peptide (Aβ) have been investigated for over two decades as possible neurotoxic agents in Alzheimer's disease. However, due to their heterogeneous and transient nature, it is not yet fully established which of the ... ...

    Abstract Oligomeric assemblies of the amyloid β peptide (Aβ) have been investigated for over two decades as possible neurotoxic agents in Alzheimer's disease. However, due to their heterogeneous and transient nature, it is not yet fully established which of the structural features of these oligomers may generate cellular damage. Here, we study distinct oligomer species formed by Aβ40 (the 40-residue form of Aβ) in the presence of four different metal ions (Al
    MeSH term(s) Humans ; Amyloid beta-Peptides/chemistry ; Alzheimer Disease ; Metals ; Ions ; Peptide Fragments/chemistry
    Chemical Substances Amyloid beta-Peptides ; Metals ; Ions ; Peptide Fragments
    Language English
    Publishing date 2024-02-28
    Publishing country United States
    Document type Journal Article
    ISSN 1948-7193
    ISSN (online) 1948-7193
    DOI 10.1021/acschemneuro.3c00718
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Hematological change parameters in patients with pressure ulcer at long-term care hospital.

    Neiva, Giselle Protta / Carnevalli, Julia Romualdo / Cataldi, Rodrigo Lessa / Furtado, Denise Mendes / Fabri, Rodrigo Luiz / Silva, Pâmela Souza

    Einstein (Sao Paulo, Brazil)

    2014  Volume 12, Issue 3, Page(s) 304–309

    Abstract: Objective: To assess factors associated with the development of pressure ulcers, and to compare the effectiveness of pharmacological treatments.: Methods: The factors associated with the development of pressure ulcers were compared in lesion-carrying ...

    Abstract Objective: To assess factors associated with the development of pressure ulcers, and to compare the effectiveness of pharmacological treatments.
    Methods: The factors associated with the development of pressure ulcers were compared in lesion-carrying patients (n=14) and non-carriers (n=16). Lesion-carrying patients were treated with 1% silver sulfadiazine or 0.6IU/g collagenase and were observed for 8 weeks. The data collected was analyzed with p<0.05 being statistically relevant.
    Results: The prevalence of pressure ulcers was about 6%. The comparison of carrier and non-carrier groups of pressure ulcers revealed no statistically significant difference in its occurrence with respect to age, sex, skin color, mobility, or the use of diapers. However, levels of hemoglobin, hematocrit, and red blood cells were found to be statistically different between groups, being lower in lesion-carrying patients. There was no significant difference found in lesion area between patients treated with collagenase or silver sulfadiazine, although both groups showed an overall reduction in lesion area through the treatment course.
    Conclusion: Hematologic parameters showed a statistically significant difference between the two groups. Regarding the treatment of ulcers, there was no difference in the area of the lesion found between the groups treated with collagenase and silver sulfadiazine.
    MeSH term(s) Aged ; Aged, 80 and over ; Anti-Infective Agents, Local/therapeutic use ; Collagenases/therapeutic use ; Erythrocyte Count ; Female ; Hematocrit ; Hemoglobins/analysis ; Humans ; Length of Stay ; Long-Term Care ; Male ; Middle Aged ; Pressure Ulcer/blood ; Pressure Ulcer/drug therapy ; Pressure Ulcer/etiology ; Pressure Ulcer/pathology ; Risk Factors ; Silver Sulfadiazine/therapeutic use ; Statistics, Nonparametric ; Time Factors ; Treatment Outcome ; Wound Healing/drug effects
    Chemical Substances Anti-Infective Agents, Local ; Hemoglobins ; Collagenases (EC 3.4.24.-) ; Silver Sulfadiazine (W46JY43EJR)
    Language Portuguese
    Publishing date 2014-10-08
    Publishing country Brazil
    Document type Comparative Study ; Journal Article
    ZDB-ID 2418293-X
    ISSN 2317-6385 ; 1679-4508
    ISSN (online) 2317-6385
    ISSN 1679-4508
    DOI 10.1590/s1679-45082014ao3034
    Database MEDical Literature Analysis and Retrieval System OnLINE

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