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  1. Article ; Online: Outcomes of Airway Stents in the Palliative Care of Patients With Cancer.

    Catarata, Maria Joana Pereira / Saleiro, Sandra / Araújo, Vânia Sá

    The American journal of hospice & palliative care

    2020  Volume 38, Issue 1, Page(s) 19–24

    Abstract: Introduction: A significant proportion of patients with advanced primary or metastatic intrathoracic malignancy will eventually develop central airway obstruction. The morbidity associated with malignant airway obstruction (MAO) is considerable and the ... ...

    Abstract Introduction: A significant proportion of patients with advanced primary or metastatic intrathoracic malignancy will eventually develop central airway obstruction. The morbidity associated with malignant airway obstruction (MAO) is considerable and the management is difficult. Our aim was to evaluate the outcomes of tracheobronchial stenting in patients with MAO and its role in palliative care.
    Material and methods: This retrospective study involved a consecutive case series of patients with advanced cancer with MAO who underwent tracheobronchial stenting between August 2014 and August 2019. The European Cooperative Oncology Group (ECOG) scale was used to evaluate patient functional status before and after tracheobronchial stenting. Univariate survival analysis included Kaplan-Meier curves with Log-Rank test, while Cox regression was used as a multivariate analysis.
    Results: We included 28 patients with median age of 55.0 years (interquartile range = 49.3-66.5) and 89.3% male. The most frequent primary tumour was the esophagus followed by lungs. The majority of the patients (75%) expressed immediate symptom relief after stenting and there was a significant improvement in the mean ECOG performance status (PS;
    Conclusion: Airway stent is a safe and effective procedure that offers rapid palliation of symptoms with no major complications. Therefore, stent placement should be considered as part of the treatment of patients with terminal cancer.
    MeSH term(s) Female ; Humans ; Male ; Middle Aged ; Neoplasms/complications ; Palliative Care ; Retrospective Studies ; Stents ; Tracheal Stenosis/therapy ; Treatment Outcome
    Language English
    Publishing date 2020-05-26
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1074344-3
    ISSN 1938-2715 ; 1049-9091
    ISSN (online) 1938-2715
    ISSN 1049-9091
    DOI 10.1177/1049909120926466
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.B 3090: Show issues Location:
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    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  2. Article: ERS International Congress 2022: highlights from the Thoracic Oncology Assembly.

    Catarata, Maria Joana / Van Geffen, Wouter H / Banka, Radhika / Ferraz, Beatriz / Sidhu, Calvin / Carew, Alan / Viola, Lucia / Gijtenbeek, Rolof / Hardavella, Georgia

    ERJ open research

    2023  Volume 9, Issue 4

    Abstract: Thoracic malignancies are associated with a substantial public health burden. Lung cancer is the leading cause of cancer-related mortality worldwide, with significant impact on patients' quality of life. Following 2 years of virtual European Respiratory ... ...

    Abstract Thoracic malignancies are associated with a substantial public health burden. Lung cancer is the leading cause of cancer-related mortality worldwide, with significant impact on patients' quality of life. Following 2 years of virtual European Respiratory Society (ERS) Congresses due to the COVID-19 pandemic, the 2022 hybrid ERS Congress in Barcelona, Spain allowed peers from all over the world to meet again and present their work. Thoracic oncology experts presented best practices and latest developments in lung cancer screening, lung cancer diagnosis and management. Early lung cancer diagnosis, subsequent pros and cons of aggressive management, identification and management of systemic treatments' side-effects, and the application of artificial intelligence and biomarkers across all aspects of the thoracic oncology pathway were among the areas that triggered specific interest and will be summarised here.
    Language English
    Publishing date 2023-08-14
    Publishing country England
    Document type Journal Article
    ZDB-ID 2827830-6
    ISSN 2312-0541
    ISSN 2312-0541
    DOI 10.1183/23120541.00579-2022
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: ERS International Congress 2023: highlights from the Thoracic Oncology Assembly.

    Catarata, Maria Joana / Creamer, Andrew W / Dias, Margarida / Toland, Sile / Chaabouni, Malek / Verbeke, Koen / Vieira Naia, Joana / Hassan, Maged / Naidu, Sindhu Bhaarrati / Lynch, Geraldine A / Blyth, Kevin G / Rahman, Najib M / Hardavella, Georgia

    ERJ open research

    2024  Volume 10, Issue 1

    Abstract: Lung cancer is the leading cause of cancer mortality in the world. It greatly affects the patients' quality of life, and is thus a challenge for the daily practice in respiratory medicine. Advances in the genetic knowledge of thoracic tumours' mutational ...

    Abstract Lung cancer is the leading cause of cancer mortality in the world. It greatly affects the patients' quality of life, and is thus a challenge for the daily practice in respiratory medicine. Advances in the genetic knowledge of thoracic tumours' mutational landscape, and the development of targeted therapies and immune checkpoint inhibitors, have led to a paradigm shift in the treatment of lung cancer and pleural mesothelioma. During the 2023 European Respiratory Society Congress in Milan, Italy, experts from all over the world presented their high-quality research and reviewed best clinical practices. Lung cancer screening, management of early stages of lung cancer, application of artificial intelligence and biomarkers were discussed and they will be summarised here.
    Language English
    Publishing date 2024-02-26
    Publishing country England
    Document type Journal Article
    ZDB-ID 2827830-6
    ISSN 2312-0541
    ISSN 2312-0541
    DOI 10.1183/23120541.00860-2023
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: Renin-Angiotensin System in Lung Tumor and Microenvironment Interactions.

    Catarata, Maria Joana / Ribeiro, Ricardo / Oliveira, Maria José / Robalo Cordeiro, Carlos / Medeiros, Rui

    Cancers

    2020  Volume 12, Issue 6

    Abstract: The mechanistic involvement of the renin-angiotensin system (RAS) reaches beyond cardiovascular physiopathology. Recent knowledge pinpoints a pleiotropic role for this system, particularly in the lung, and mainly through locally regulated alternative ... ...

    Abstract The mechanistic involvement of the renin-angiotensin system (RAS) reaches beyond cardiovascular physiopathology. Recent knowledge pinpoints a pleiotropic role for this system, particularly in the lung, and mainly through locally regulated alternative molecules and secondary pathways. Angiotensin peptides play a role in cell proliferation, immunoinflammatory response, hypoxia and angiogenesis, which are critical biological processes in lung cancer. This manuscript reviews the literature supporting a role for the renin-angiotensin system in the lung tumor microenvironment and discusses whether blockade of this pathway in clinical settings may serve as an adjuvant therapy in lung cancer.
    Keywords covid19
    Language English
    Publishing date 2020-06-03
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2527080-1
    ISSN 2072-6694
    ISSN 2072-6694
    DOI 10.3390/cancers12061457
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Pharmacogenetics of advanced lung cancer: Predictive value of functional genetic polymorphism AGXT Pro11Leu in clinical outcome?

    Catarata, Maria Joana / Lourenço, Margarida / Martins, Maria Fátima / Frade, João / Pêgo, Alice / Cordeiro, Carlos Robalo / Medeiros, Rui / Ribeiro, Ricardo

    Pulmonology

    2021  

    Abstract: Introduction: AGXT gene codes for the enzyme alanine glyoxylate aminotransferase, which is involved in hepatic peroxisomal metabolism of platinum-based chemotherapeutic agents. The association of genetic variant AGXT rs34116584 on the clinical outcome ... ...

    Abstract Introduction: AGXT gene codes for the enzyme alanine glyoxylate aminotransferase, which is involved in hepatic peroxisomal metabolism of platinum-based chemotherapeutic agents. The association of genetic variant AGXT rs34116584 on the clinical outcome and response to chemotherapy of patients with non-small cell lung cancer (NSCLC) remains to be established. Our aim was to evaluate the association of functional AGXT gene polymorphism in NSCLC progression, considering as primary and secondary endpoint, progression free survival (PFS) and overall survival (OS), respectively.
    Methods: Genotyping of theAGXT rs34116584 genetic polymorphism was performed by mass spectrometry on 168 DNA samples from patients with NSCLC (stages IIIA-IVB). Univariate survival analysis included the study of Kaplan-Meier curves with the Log-Rank test, while Cox regression was used as a multivariate analysis.
    Results: Multivariate analysis showed shorter PFS for T carriers [HR=2.0, 95% CI, 1.4-3.0, p<0.0001] and shorter OS [HR=1.8, 95% CI, 1.1-3.0, p=0.017] globally, as well as in a subgroup of patients (n=144) treated with first line platinum-based chemotherapy [HR=2.0, 95% CI, 1.3-3.1, p=0.001] and [HR=1.8, 95% CI, 1.1-3.1, p=0.026], respectively.
    Conclusion: This polymorphism seems to have an impact on NSCLC progression, opening new perspectives for its inclusion as a pharmacogenetic predictor of response to platinum-based chemotherapy.
    Language English
    Publishing date 2021-01-03
    Publishing country Spain
    Document type Journal Article
    ZDB-ID 3009651-0
    ISSN 2531-0437 ; 2531-0429
    ISSN (online) 2531-0437
    ISSN 2531-0429
    DOI 10.1016/j.pulmoe.2020.11.007
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: Germline Genetic Variants of the Renin-Angiotensin System, Hypoxia and Angiogenesis in Non-Small Cell Lung Cancer Progression: Discovery and Validation Studies.

    Catarata, Maria Joana / Medeiros, Rui / Oliveira, Maria José / Pêgo, Alice / Frade, João Gonçalo / Martins, Maria Fátima / Robalo Cordeiro, Carlos / Herth, Felix J F / Thomas, Michael / Kriegsmann, Mark / Meister, Michael / Schneider, Marc A / Muley, Thomas / Ribeiro, Ricardo

    Cancers

    2020  Volume 12, Issue 12

    Abstract: Introduction: The renin-angiotensin system (RAS) is involved in cell proliferation, immunoinflammatory response, hypoxia and angiogenesis, which are critical biological processes in lung cancer. Our aim was to study the association of putatively ... ...

    Abstract Introduction: The renin-angiotensin system (RAS) is involved in cell proliferation, immunoinflammatory response, hypoxia and angiogenesis, which are critical biological processes in lung cancer. Our aim was to study the association of putatively functional genetic polymorphisms in genes coding for proteins involved in RAS, hypoxia and angiogenesis with non-small cell lung cancer (NSCLC) prognosis.
    Methods: Genotyping of 52 germline variants from genes of the RAS and hypoxic/angiogenic factors/receptors was performed using MassARRAY iPLEX Gold in a retrospective cohort (
    Results: Multivariate analysis on the discovery set revealed that
    Conclusion: This study provides evidence that
    Language English
    Publishing date 2020-12-18
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2527080-1
    ISSN 2072-6694
    ISSN 2072-6694
    DOI 10.3390/cancers12123834
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Patient-physician discordance in assessment of adherence to inhaled controller medication: a cross-sectional analysis of two cohorts.

    Jácome, Cristina / Pereira, Ana Margarida / Almeida, Rute / Ferreira-Magalhaes, Manuel / Couto, Mariana / Araujo, Luís / Pereira, Mariana / Correia, Magna Alves / Loureiro, Cláudia Chaves / Catarata, Maria Joana / Maia Santos, Lília / Pereira, João / Ramos, Bárbara / Lopes, Cristina / Mendes, Ana / Cidrais Rodrigues, José Carlos / Oliveira, Georgeta / Aguiar, Ana Paula / Afonso, Ivete /
    Carvalho, Joana / Arrobas, Ana / Coutinho Costa, José / Dias, Joana / Todo Bom, Ana / Azevedo, João / Ribeiro, Carmelita / Alves, Marta / Leiria Pinto, Paula / Neuparth, Nuno / Palhinha, Ana / Gaspar Marques, João / Pinto, Nicole / Martins, Pedro / Todo Bom, Filipa / Alvarenga Santos, Maria / Gomes Costa, Alberto / Silva Neto, Armandina / Santalha, Marta / Lozoya, Carlos / Santos, Natacha / Silva, Diana / Vasconcelos, Maria João / Taborda-Barata, Luís / Carvalhal, Célia / Teixeira, Maria Fernanda / Alves, Rodrigo Rodrigues / Moreira, Ana Sofia / Sofia Pinto, Cláudia / Morais Silva, Pedro / Alves, Carlos / Câmara, Raquel / Coelho, Didina / Bordalo, Diana / Fernandes, Ricardo M / Ferreira, Rosário / Menezes, Fernando / Gomes, Ricardo / Calix, Maria José / Marques, Ana / Cardoso, João / Emiliano, Madalena / Gerardo, Rita / Nunes, Carlos / Câmara, Rita / Ferreira, José Alberto / Carvalho, Aurora / Freitas, Paulo / Correia, Ricardo / Fonseca, Joao A

    BMJ open

    2019  Volume 9, Issue 11, Page(s) e031732

    Abstract: Objective: We aimed to compare patient's and physician's ratings of inhaled medication adherence and to identify predictors of patient-physician discordance.: Design: Baseline data from two prospective multicentre observational studies.: Setting: ... ...

    Abstract Objective: We aimed to compare patient's and physician's ratings of inhaled medication adherence and to identify predictors of patient-physician discordance.
    Design: Baseline data from two prospective multicentre observational studies.
    Setting: 29 allergy, pulmonology and paediatric secondary care outpatient clinics in Portugal.
    Participants: 395 patients (≥13 years old) with persistent asthma.
    Measures: Data on demographics, patient-physician relationship, upper airway control, asthma control, asthma treatment, forced expiratory volume in one second (FEV
    Results: High inhaler adherence was reported both by patients (median (percentile 25 to percentile 75) 85 (65-95) mm; 53% VAS>80) and by physicians (84 (68-95) mm; 53% VAS>80). Correlation between patient and physician VAS scores was moderate (r
    Conclusion: Although both patients and physicians report high inhaler adherence, discordance occurred in half of cases. Implementation of objective adherence measures and effective communication are needed to improve patient-physician agreement.
    MeSH term(s) Administration, Inhalation ; Adolescent ; Adult ; Asthma/drug therapy ; Cohort Studies ; Cross-Sectional Studies ; Female ; Humans ; Male ; Medication Adherence/statistics & numerical data ; Middle Aged ; Physician-Patient Relations ; Prospective Studies ; Young Adult
    Language English
    Publishing date 2019-11-07
    Publishing country England
    Document type Comparative Study ; Journal Article ; Multicenter Study ; Observational Study ; Research Support, Non-U.S. Gov't
    ZDB-ID 2599832-8
    ISSN 2044-6055 ; 2044-6055
    ISSN (online) 2044-6055
    ISSN 2044-6055
    DOI 10.1136/bmjopen-2019-031732
    Database MEDical Literature Analysis and Retrieval System OnLINE

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