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Article ; Online: Outbreak of anthrax in livestock with human occupational exposures - Minnesota, 2023.

Schenk, Kelly Elizabeth / Cornille, K / Cater, J / Vieira, A R / Holzbauer, S / Bye, M / Scheftel, J

2024 , Page(s) 1–4

Abstract: In July 2023, the Minnesota Department of Health (MDH) was notified of possible occupational exposures to anthrax during an outbreak in animals. In consultation with the Centers for Disease Control and Prevention, MDH epidemiologists created a ... ...

Abstract	In July 2023, the Minnesota Department of Health (MDH) was notified of possible occupational exposures to anthrax during an outbreak in animals. In consultation with the Centers for Disease Control and Prevention, MDH epidemiologists created a questionnaire that assessed exposure risks and helped determine individual illness monitoring and antibiotic post-exposure prophylaxis needs. This investigation and the resources developed for it could be useful in future scenarios where there are occupational exposures to naturally occurring anthrax.
Language	English
Publishing date	2024-01-23
Publishing country	England
Document type	Journal Article
ZDB-ID	1289325-0
ISSN	1545-0813 ; 1059-924X
ISSN (online)	1545-0813
ISSN	1059-924X
DOI	10.1080/1059924X.2024.2306835
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Article: Pharmacokinetics of Buprenorphine Buccal Film and Orally-administered Oxycodone in a Respiratory Study: An Analysis of Secondary Outcomes from a Randomized Controlled Trial.

Webster, Lynn R / Cater, Jacqueline / Smith, Thomas

Pain and therapy

2022 Volume 11, Issue 3, Page(s) 817–825

Abstract: Objective: To evaluate pharmacokinetic (PK) parameters and oxygen saturation as markers of abuse potential after administration of buprenorphine buccal film (BBF) and immediate-release (IR) oxycodone.: Methods: This was a secondary analysis of data ... ...

Abstract	Objective: To evaluate pharmacokinetic (PK) parameters and oxygen saturation as markers of abuse potential after administration of buprenorphine buccal film (BBF) and immediate-release (IR) oxycodone. Methods: This was a secondary analysis of data from a phase I randomized controlled trial. A total of 19 healthy subjects who self-identified as recreational opioid users were enrolled, with 15 completing the study. Subjects were administered 300, 600, and 900 µg BBF; 30 and 60 mg orally-administered oxycodone; and placebo. For PK analysis, blood samples were collected before dosing and at 0.5, 1, 2, 3, 4, and 6 h postdose. Respiratory drive/ventilatory response to hypercapnia and oxygen saturation were evaluated before dosing and up to 8 h after administration of test drugs. Results: Median time to maximum concentration (T Conclusion: These results indicate that BBF may have a decreased risk of abuse and respiratory depression compared with the full µ-opioid receptor agonist oxycodone. Trial registration: ClinicalTrials.gov identifier, NCT03996694.
Language	English
Publishing date	2022-05-07
Publishing country	New Zealand
Document type	Journal Article
ZDB-ID	2701614-6
ISSN	2193-651X ; 2193-8237
ISSN (online)	2193-651X
ISSN	2193-8237
DOI	10.1007/s40122-022-00380-2
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Article: Effects of buprenorphine buccal film and oral oxycodone on pupil diameter in a respiratory study.

Webster, Lynn / Cater, Jacqueline / Smith, Thomas

Journal of opioid management

2022 Volume 18, Issue 2, Page(s) 181–190

Abstract: Objective: Evaluate the pupillary-constricting effects following administration of buprenorphine buccal film (BBF) and immediate-release (IR) oxycodone.: Design: A double-blind, double-dummy, six-treatment, six-period, placebo-controlled, randomized ... ...

Abstract	Objective: Evaluate the pupillary-constricting effects following administration of buprenorphine buccal film (BBF) and immediate-release (IR) oxycodone. Design: A double-blind, double-dummy, six-treatment, six-period, placebo-controlled, randomized crossover study. Setting: Single-center, phase 1 exploratory pharmacodynamics. Participants: Healthy individuals who self-identify as recreational opioid users, confirmed via a naloxone challenge test on day 1. Interventions: Placebo: BBF 300, 600, and 900 mcg and IR oxycodone 30 and 60 mg. Main outcome measure: Minute ventilation (measured by the ventilatory response to hypercapnia) and pupil diameter (determined via standard pupillometry) were assessed predose and at 0.5, 1, 1.5, 2, 2.5, 3, and 4 hours post-dose. Results: Change from baseline in minute ventilation was moderately correlated with change from baseline in pupil diameter during treatment with BBF (Pearson's r = 0.38-0.40; p ≤ 0.0011) or oxycodone (Pearson's r = 0.34-0.37; p ≤ 0.005). The initial onset of significant (p < 0.05) pupil constriction relative to placebo occurred at 2, 1.5, and 1 hour after dosing with BBF 300, 600, and 900 mcg, respectively, and at 0.5 hours after dosing with oxycodone 30 or 60 mg. Conclusions: Although BBF and IR oxycodone achieved similar levels of pupil constriction, there was a delayed miosis seen with BBF relative to that found with oxycodone.
MeSH term(s)	Analgesics, Opioid/adverse effects ; Buprenorphine/adverse effects ; Cross-Over Studies ; Humans ; Oxycodone/adverse effects ; Pupil
Chemical Substances	Analgesics, Opioid ; Buprenorphine (40D3SCR4GZ) ; Oxycodone (CD35PMG570)
Language	English
Publishing date	2022-04-25
Publishing country	United States
Document type	Journal Article ; Randomized Controlled Trial
ZDB-ID	2397614-7
ISSN	1551-7489
ISSN	1551-7489
DOI	10.5055/jom.2022.0708
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Article ; Online: Quality of life in breast cancer survivors: An assessment of international breast cancer dragon boat racers.

Koehler, L / Rosenberg, S / Cater, J / Mikolajczyk, K / Moran, A / Metz, C / Monson, S

Lymphology

2021 Volume 53, Issue 4, Page(s) 195–203

Abstract: Resistance exercise is deemed safe for women recovering from conventional breast cancer therapies but few clinicians are aware that dragon boat racing, as a form of resistive exercise, is available to the breast cancer community. The objectives of this ... ...

Abstract	Resistance exercise is deemed safe for women recovering from conventional breast cancer therapies but few clinicians are aware that dragon boat racing, as a form of resistive exercise, is available to the breast cancer community. The objectives of this study were to 1) increase clinician awareness of dragon boat racing (DBR) in breast cancer survivors as a community-based physical activity, and 2) evaluate quality of life (QOL) in breast cancer survivors with or without lymphedema who participate in DBR. This prospective, observational study surveyed 1,069 international breast cancer dragon boat racers from eight countries to compare function, activity, and participation in women with and without selfreported lymphedema using the Lymph-ICF questionnaire. Seventy-one percent of women (n=758) completed the questionnaires. Results revealed significantly higher Lymph-ICF scores in the lymphedema participants, signifying reduced QOL, when compared to the nonlymphedema participants (p<0.05), except for "go on vacation" for which no statistical difference was reported (p=0.20). International breast cancer survivors with lymphedema participating in DBR at an international competition had reduced function, limited activity, and restricted participation compared to participants without lymphedema. Clinicians should consider utilizing DBR as a community-based activity to support exercise and physical activity after a breast cancer diagnosis.
MeSH term(s)	Breast Neoplasms/therapy ; Cancer Survivors ; Female ; Humans ; Lymphedema/etiology ; Prospective Studies ; Quality of Life
Language	English
Publishing date	2021-03-15
Publishing country	United States
Document type	Journal Article ; Observational Study ; Research Support, N.I.H., Extramural
ZDB-ID	80181-1
ISSN	2522-7963 ; 0024-7766
ISSN (online)	2522-7963
ISSN	0024-7766
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Article: Large Eddy Simulation of wind turbine fatigue loading and yaw dynamics induced by wake turbulence

Chanprasert, W. / Sharma, R.N. / Cater, J.E. / Norris, S.E.

Renewable energy. 2022 Mar. 16,

2022

Abstract: A coupled Large Eddy Simulation (LES) and aeroelastic code was used to evaluate control responses and fatigue loading of a four-inline wind turbine array. Neutral and unstably stratified atmospheric boundary layers with hub-height wind speeds of 7 and 15  ...

Abstract	A coupled Large Eddy Simulation (LES) and aeroelastic code was used to evaluate control responses and fatigue loading of a four-inline wind turbine array. Neutral and unstably stratified atmospheric boundary layers with hub-height wind speeds of 7 and 15 m/s were used for wind farm inflows. These cases operate in different control regions. It was found that for both incoming wind speeds, atmospheric stability has no significant impact on the fatigue loads of the front-row wind turbines. However, stability affected wake characteristics which caused differences in control response and fatigue experienced by downstream turbines. The most distinctive difference was observed at a downstream turbine in the above-rated condition where the shaft torsional load in neutral stability condition was up to 50% higher than the unstable case. A baseline active yaw controller was implemented in the below-rated condition, which caused higher fatigue on turbines in the wake compared to the fixed yaw turbine case, without any power output gain.
Keywords	turbulent flow ; wind farms ; wind turbines
Language	English
Dates of publication	2022-0316
Publishing place	Elsevier Ltd
Document type	Article
Note	Pre-press version
ZDB-ID	2001449-1
ISSN	1879-0682 ; 0960-1481
ISSN (online)	1879-0682
ISSN	0960-1481
DOI	10.1016/j.renene.2022.03.097
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: A dataset of action potentials recorded from the L5 dorsal rootlet of rat using a multiple electrode array.

Metcalfe, Benjamin / Hunter, Alan / Graham-Harper-Cater, Jonathan / Taylor, John

Data in brief

2020 Volume 33, Page(s) 106561

Abstract: This article describes a dataset of action potentials collected from a neural recording experiment conducted on an adult female Sprague Dawley rat. A teased fascicle from the ... ...

Abstract	This article describes a dataset of action potentials collected from a neural recording experiment conducted on an adult female Sprague Dawley rat. A teased fascicle from the 5
Language	English
Publishing date	2020-11-21
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	2786545-9
ISSN	2352-3409 ; 2352-3409
ISSN (online)	2352-3409
ISSN	2352-3409
DOI	10.1016/j.dib.2020.106561
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Article ; Online: A Phase I Placebo-Controlled Trial Comparing the Effects of Buprenorphine Buccal Film and Oral Oxycodone Hydrochloride Administration on Respiratory Drive.

Webster, Lynn R / Hansen, Erik / Cater, Jacqueline / Smith, Thomas

Advances in therapy

2020 Volume 37, Issue 11, Page(s) 4685–4696

Abstract: Introduction: Buprenorphine is a partial μ-opioid receptor agonist that, unlike full μ-opioid receptor agonists, has been shown to have a ceiling effect on respiratory depression. Buprenorphine buccal film (BBF) is approved by the US Food and Drug ... ...

Abstract	Introduction: Buprenorphine is a partial μ-opioid receptor agonist that, unlike full μ-opioid receptor agonists, has been shown to have a ceiling effect on respiratory depression. Buprenorphine buccal film (BBF) is approved by the US Food and Drug Administration for use in patients with chronic pain severe enough to require daily, around-the-clock, long-term opioid treatment and for whom alternative treatment options are inadequate. This study was conducted to compare the effects of BBF and immediate-release oral oxycodone hydrochloride administration on respiratory drive, as measured by the ventilatory response to hypercapnia (VRH) after drug administration. Methods: Subjects (N = 19) were men and women, ages 27-41 years, self-identifying as recreational opioid users who were not physically dependent on opioids as determined via a Naloxone Challenge Test. Respiratory drive was evaluated by measuring VRH through the assessment of the maximum decrease in minute ventilation (E Results: The least squares mean differences in minute volume E Conclusions: BBF did not significantly reduce respiratory drive at any dose compared with placebo, including at the maximum available prescription dose of 900 μg. Administration of oxycodone resulted in a significant dose-dependent decrease in respiratory drive. These data suggest that BBF may be a safer treatment option than full μ-opioid receptor agonists for patients with chronic pain. Trial registration: ClinicalTrials.gov identifier, NCT03996694.
MeSH term(s)	Administration, Oral ; Adult ; Analgesics, Opioid/therapeutic use ; Buprenorphine ; Double-Blind Method ; Female ; Humans ; Male ; Naloxone ; Oxycodone
Chemical Substances	Analgesics, Opioid ; Naloxone (36B82AMQ7N) ; Buprenorphine (40D3SCR4GZ) ; Oxycodone (CD35PMG570)
Language	English
Publishing date	2020-09-25
Publishing country	United States
Document type	Journal Article ; Randomized Controlled Trial ; Research Support, Non-U.S. Gov't
ZDB-ID	632651-1
ISSN	1865-8652 ; 0741-238X
ISSN (online)	1865-8652
ISSN	0741-238X
DOI	10.1007/s12325-020-01481-0
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Article ; Online: Modelling uptake and transport of therapeutic agents through the lymphatic system.

Jayathungage Don, T D / Suresh, V / Cater, J E / Clarke, R J

Computer methods in biomechanics and biomedical engineering

2021 Volume 25, Issue 8, Page(s) 861–874

Abstract: The ability of the lymphatic network to absorb large molecules and bypass the first-pass liver metabolism makes it appealing as a delivery system for therapeutic substances. In most cases, the drug is injected into the subcutaneous tissue and must ... ...

Abstract	The ability of the lymphatic network to absorb large molecules and bypass the first-pass liver metabolism makes it appealing as a delivery system for therapeutic substances. In most cases, the drug is injected into the subcutaneous tissue and must negotiate the tissue space, before being drained via the lymphatics. Tracking the transport of drug molecules through this route is challenging, and computational models of lymphatic drainage can play an important role in assessing the efficacy of a proposed delivery strategy. The three-dimensional computational model we present here of the peripheral lymphatic network and surrounding interstitium is informed by anatomical data, and quantifies the degree to which uptake and transit times are affected by drug particle size, physiological flow rates, and specifics of drug injection.
MeSH term(s)	Biological Transport ; Lymphatic System/metabolism ; Lymphatic Vessels
Language	English
Publishing date	2021-10-01
Publishing country	England
Document type	Journal Article
ZDB-ID	2071764-7
ISSN	1476-8259 ; 1025-5842
ISSN (online)	1476-8259
ISSN	1025-5842
DOI	10.1080/10255842.2021.1984434
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Book ; Online: Satellite-to-Ground Discrete Modulated Continuous Variable Quantum Key Distribution

Sayat, Mikhael / Shajilal, Biveen / Kish, Sebastian P. / Assad, Syed M. / Lam, Ping Koy / Rattenbury, Nicholas / Cater, John

The M-PSK and M-QAM Protocols in Low Earth Orbit

2022

Abstract: The Gaussian modulated continuous variable quantum key distribution (GM-CVQKD) protocol is known to maximise the mutual information between two parties during QKD. However, the reconciliation efficiency significantly decreases in low signal-to-noise ... ...

Abstract	The Gaussian modulated continuous variable quantum key distribution (GM-CVQKD) protocol is known to maximise the mutual information between two parties during QKD. However, the reconciliation efficiency significantly decreases in low signal-to-noise ratio (SNR) regimes. In contrast, the more resilient discrete modulated CVQKD (DM-CVQKD) protocol has better reconciliation efficiencies in low SNR regimes. In this paper, we study the Phase Shift Keying (M-PSK) and Quadrature Amplitude Modulation (M-QAM) DM-CVQKD protocols along with the GM-CVQKD protocol over a satellite-to-ground link in the low SNR regime. We use a satellite-to-ground link model which takes into account geometric, scintillation, and scattering losses from the link distance, atmospheric turbulence, and atmospheric aerosols, respectively. In addition, recent multidimensional (MD) and multilevel coding and multistage decoding (MLC-MSD) reconciliation method models in combination with multiedge-type low-density parity-check (MET-LDPC) code models have been used to determine the reconciliation efficiency. The results show that the 4-PSK and 8-PSK protocols outperform GM-CVQKD in both the asymptotic and finite size limit of collective attacks by producing positive key rates at larger link distances and lower elevation angles when the SNR is low. In addition, the M-QAM protocol produces larger positive secret key rates compared to M-PSK in the asymptotic limit. Comment: Submitted to IEEE Transactions on Communications. 12 pages, 11 figures
Keywords	Quantum Physics ; Physics - Space Physics
Subject code	621
Publishing date	2022-11-30
Publishing country	us
Document type	Book ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Book ; Online: Availability, outage, and capacity of spatially correlated, Australasian free-space optical networks

Birch, Marcus / Beattie, James R. / Bennet, Francis / Rattenbury, Nicholas / Copeland, Michael / Travouillon, Tony / Ferguson, Kate / Cater, John / Sayat, Mikhael

2022

Abstract: Network capacity and reliability for free space optical communication (FSOC) is strongly driven by ground station availability, dominated by local cloud cover causing an outage, and how availability relations between stations produce network diversity. ... ...

Abstract	Network capacity and reliability for free space optical communication (FSOC) is strongly driven by ground station availability, dominated by local cloud cover causing an outage, and how availability relations between stations produce network diversity. We combine remote sensing data and novel methods to provide a generalised framework for assessing and optimising optical ground station networks. This work is guided by an example network of eight Australian and New Zealand optical communication ground stations which would span approximately $60^\circ$ in longitude and $20^\circ$ in latitude. Utilising time-dependent cloud cover data from five satellites, we present a detailed analysis determining the availability and diversity of the network, finding the Australasian region is well-suited for an optical network with a 69% average site availability and low spatial cloud cover correlations. Employing methods from computational neuroscience, we provide a Monte Carlo method for sampling the joint probability distribution of site availabilities for an arbitrarily sized and point-wise correlated network of ground stations. Furthermore, we develop a general heuristic for site selection under availability and correlation optimisations, and combine this with orbital propagation simulations to compare the data capacity between optimised networks and the example network. We show that the example network may be capable of providing tens of terabits per day to a LEO satellite, and up to 99.97% reliability to GEO satellites. We therefore use the Australasian region to demonstrate novel, generalised tools for assessing and optimising FSOC ground station networks, and additionally, the suitability of the region for hosting such a network. Comment: Accepted in Journal of Optical Communications and Networking. 16 pages, 16 figures
Keywords	Electrical Engineering and Systems Science - Signal Processing
Subject code	003
Publishing date	2022-11-16
Publishing country	us
Document type	Book ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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