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  1. Article ; Online: Surgical Volume Is Important for Radical Prostatectomy, but Now We Need to Move Beyond Volume as a Proxy for Quality.

    Shah, Taimur T / Cathcart, Paul

    European urology

    2021  Volume 80, Issue 5, Page(s) 546–548

    MeSH term(s) Humans ; Male ; Prostate ; Prostatectomy ; Seminal Vesicles
    Language English
    Publishing date 2021-06-03
    Publishing country Switzerland
    Document type Editorial ; Comment
    ZDB-ID 193790-x
    ISSN 1873-7560 ; 1421-993X ; 0302-2838
    ISSN (online) 1873-7560 ; 1421-993X
    ISSN 0302-2838
    DOI 10.1016/j.eururo.2021.05.021
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    Zs.MO 294: Show issues

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  2. Article ; Online: Further evidence that surgery after focal therapy for prostate cancer is safe.

    Stonier, Thomas / Cathcart, Paul

    BJU international

    2020  Volume 125, Issue 4, Page(s) 481–482

    MeSH term(s) Humans ; Male ; Prostatectomy ; Prostatic Neoplasms/surgery ; Salvage Therapy
    Language English
    Publishing date 2020-05-18
    Publishing country England
    Document type Editorial ; Comment
    ZDB-ID 1462191-5
    ISSN 1464-410X ; 1464-4096 ; 1358-8672
    ISSN (online) 1464-410X
    ISSN 1464-4096 ; 1358-8672
    DOI 10.1111/bju.15050
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  3. Article ; Online: Virtual clinic triage of breast referrals during the COVID-19 pandemic: retrospective outcome analysis.

    Cathcart, Paul / Clayton, Gill / Smith, Simon / Dua, Sascha / Gandamihardja, Tasha

    The British journal of surgery

    2021  Volume 109, Issue 2, Page(s) e26–e28

    Language English
    Publishing date 2021-12-06
    Publishing country England
    Document type Journal Article
    ZDB-ID 2985-3
    ISSN 1365-2168 ; 0263-1202 ; 0007-1323 ; 1355-7688
    ISSN (online) 1365-2168
    ISSN 0263-1202 ; 0007-1323 ; 1355-7688
    DOI 10.1093/bjs/znab424
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  4. Article ; Online: A cross-section of UK prostate cancer diagnostics during the coronavirus disease 2019 (COVID-19) era - a shifting paradigm?

    Stroman, Luke / Cathcart, Paul / Lamb, Alastair / Challacombe, Ben / Popert, Rick

    BJU international

    2020  Volume 127, Issue 1, Page(s) 30–34

    MeSH term(s) COVID-19/epidemiology ; Comorbidity ; Humans ; Incidence ; Male ; Neoplasm Staging/methods ; Prostate/pathology ; Prostatic Neoplasms/diagnosis ; Prostatic Neoplasms/epidemiology ; SARS-CoV-2 ; United Kingdom/epidemiology
    Keywords covid19
    Language English
    Publishing date 2020-10-28
    Publishing country England
    Document type Letter ; Review
    ZDB-ID 1462191-5
    ISSN 1464-410X ; 1464-4096 ; 1358-8672
    ISSN (online) 1464-410X
    ISSN 1464-4096 ; 1358-8672
    DOI 10.1111/bju.15259
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  5. Article ; Online: Aloe vera, a natural cancer soother?

    Cathcart, Paul / Stebbing, Justin

    The Lancet. Oncology

    2016  Volume 17, Issue 4, Page(s) 421

    MeSH term(s) Aloe ; Humans ; Neoplasms/drug therapy ; Phytotherapy ; Plant Extracts/therapeutic use
    Chemical Substances Plant Extracts
    Language English
    Publishing date 2016-03-29
    Publishing country England
    Document type Journal Article
    ZDB-ID 2049730-1
    ISSN 1474-5488 ; 1470-2045
    ISSN (online) 1474-5488
    ISSN 1470-2045
    DOI 10.1016/S1470-2045(16)00161-3
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  6. Article: Stumped by rapid symptomatic prostatic regrowth: A case report on a STUMP tumour of the prostate resected with HoLEP.

    Al Tell, Tareq / Marconi, Lorenzo / Cathcart, Paul / Challacombe, Benjamin

    International journal of surgery case reports

    2019  Volume 62, Page(s) 24–26

    Abstract: Introduction: Stromal Tumour of Undetermined malignant potential (STUMP) is a rare category of the prostate benign tumours, which has a variable clinical presentation, behavior and different approaches to manage it.: Case presentation: A 57 year-old ... ...

    Abstract Introduction: Stromal Tumour of Undetermined malignant potential (STUMP) is a rare category of the prostate benign tumours, which has a variable clinical presentation, behavior and different approaches to manage it.
    Case presentation: A 57 year-old male presented with voiding symptoms of the urinary tract and an increased PSA (14.7 ng/ml). Ultrasound and multiparametric MRI showed an enlarged prostate of 41 ml. Transurethral resection of the prostate (TURP) was performed with 11 g benign tissue removed. The patient presented one year later with the same symptoms; further ultrasound and parametric MRI demonstrated huge recurrence in the transition zone with a new prostate size of 131 ml.
    Discussion: Despite no malignancy being identified in the initial TURP histology, the transition zone prostatic tumour behaved aggressively and recurred in just one year. For the first time in literature, the tumour recurred rapidly to three times the initial size and was removed using Holmium Laser enucleation of the prostate (HoLEP), after which no recurrence was seen in 11 months period.
    Conclusion: HoLEP can be used to successfully enucleate STUMP tumours but the clinical behavior of the STUMP in prostate is still not understood well because of its rareness.
    Language English
    Publishing date 2019-07-26
    Publishing country Netherlands
    Document type Journal Article
    ISSN 2210-2612
    ISSN 2210-2612
    DOI 10.1016/j.ijscr.2019.07.058
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  7. Article ; Online: Treatment-related toxicity using prostate bed versus prostate bed and pelvic lymph node radiation therapy following radical prostatectomy: A national population-based study.

    Sujenthiran, Arunan / Parry, Matthew G / Dodkins, Joanna / Nossiter, Julie / Morris, Melanie / Berry, Brendan / Nathan, Arjun / Cathcart, Paul / Clarke, Noel W / Payne, Heather / van der Meulen, Jan / Aggarwal, Ajay

    Clinical and translational radiation oncology

    2023  Volume 40, Page(s) 100622

    Abstract: Purpose There is debate about the effectiveness and toxicity of pelvic lymph node (PLN) irradiation in addition to prostate bed radiotherapy when used to treat disease recurrence following radical prostatectomy. We compared toxicity from radiation ... ...

    Abstract Purpose There is debate about the effectiveness and toxicity of pelvic lymph node (PLN) irradiation in addition to prostate bed radiotherapy when used to treat disease recurrence following radical prostatectomy. We compared toxicity from radiation therapy (RT) to the prostate bed and pelvic lymph nodes (PBPLN-RT) with prostatebed only radiation therapy (PBO-RT) following radical prostatectomy. Methods and Materials Patients with prostate cancer who underwent post-prostatectomy RT between 2010 and 2016 were identified by using the National Prostate Cancer Audit (NPCA) database. Follow-up data was available up to December 31, 2018. Validated outcome measures, based on a framework of procedural and diagnostic codes, were used to capture ≥Grade 2 gastrointestinal (GI) and genitourinary (GU) toxicity. An adjusted competing-risks regression analysis estimated subdistribution hazard ratios (sHR). A sHR > 1 indicated a higher incidence of toxicity with PBPLN-RT than with PBO-RT. Results 5-year cumulative incidences in the PBO-RT (n = 5,087) and PBPLNRT (n = 593) groups was 18.2% and 15.9% for GI toxicity, respectively. For GU toxicity it was 19.1% and 20.7%, respectively. There was no evidence of difference in GI or GU toxicity after adjustment between PBO-RT and PBPLN-RT (GI: adjusted sHR, 0.90, 95% CI, 0.67-1.19; P = 0.45); (GU: adjusted sHR, 1.19, 95% CI, 0.99-1.44; P = 0.09). Conclusions This national population-based study found that including PLNs in the radiation field following radical prostatectomy is not associated with a significant increase in rates of ≥Grade 2 GI or GU toxicity at 5 years.
    Language English
    Publishing date 2023-04-11
    Publishing country Ireland
    Document type Journal Article
    ISSN 2405-6308
    ISSN (online) 2405-6308
    DOI 10.1016/j.ctro.2023.100622
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  8. Article ; Online: Decision Regret in Patients with Localised Prostate Cancer: A Systematic Review and Meta-analysis.

    Fanshawe, Jack B / Wai-Shun Chan, Vinson / Asif, Aqua / Ng, Alexander / Van Hemelrijck, Mieke / Cathcart, Paul / Challacombe, Ben / Brown, Christian / Popert, Rick / Elhage, Oussama / Ahmed, Kamran / Brunckhorst, Oliver / Dasgupta, Prokar

    European urology oncology

    2023  Volume 6, Issue 5, Page(s) 456–466

    Abstract: Context: Treatment choice for localised prostate cancer remains a significant challenge for patients and clinicians, with uncertainty over decisions potentially leading to conflict and regret. There is a need to further understand the prevalence and ... ...

    Abstract Context: Treatment choice for localised prostate cancer remains a significant challenge for patients and clinicians, with uncertainty over decisions potentially leading to conflict and regret. There is a need to further understand the prevalence and prognostic factors of decision regret to improve patient quality of life.
    Objective: To generate the best estimates for the prevalence of significant decision regret localised prostate cancer patients, and to investigate prognostic patient, oncological, and treatment factors associated with regret.
    Evidence acquisition: We performed a systematic search of MEDLINE, Embase, and PsychINFO databases including studies evaluating the prevalence or patient, treatment, or oncological prognostic factors in localised prostate cancer patients. A pooled prevalence of significant regret was calculated with the formal prognostic factor evaluation conducted per factor identified.
    Evidence synthesis: Significant decision regret was present in a pooled 20% (95% confidence interval 16-23) of patients across 14 studies and 17883 patients. This was lower in active surveillance (13%), with little difference between those who underwent radiotherapy (19%) and those who underwent prostatectomy (18%). Evaluation of individual prognostic factors demonstrated higher regret in those with poorer post-treatment bowel, sexual, and urinary function; decreased involvement in the decision-making process; and Black ethnicity. However, evidence remains conflicting, with low or moderate certainty of findings.
    Conclusions: A significant proportion of men experience decision regret after a localised prostate cancer diagnosis. Monitoring those with increased functional symptoms and improving patient involvement in the decision-making process through education and decision aids may reduce regret.
    Patient summary: We looked at how common regret in treatment decisions is after treatment for early-stage prostate cancer and factors linked with this. We found that one in five regret their decision, with those who had experienced side effects or were less involved in the decision-making process more likely to have regret. By addressing these, clinicians could reduce regret and improve quality of life.
    Language English
    Publishing date 2023-03-03
    Publishing country Netherlands
    Document type Journal Article ; Review
    ISSN 2588-9311
    ISSN (online) 2588-9311
    DOI 10.1016/j.euo.2023.02.005
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  9. Article ; Online: Chilli-too hot to handle?

    Craddock, Charles / Cathcart, Paul / Stebbing, Justin

    The Lancet. Oncology

    2017  Volume 18, Issue 8, Page(s) 1005

    MeSH term(s) Antineoplastic Agents, Phytogenic/adverse effects ; Antineoplastic Agents, Phytogenic/isolation & purification ; Antineoplastic Agents, Phytogenic/therapeutic use ; Capsaicin/adverse effects ; Capsaicin/isolation & purification ; Capsaicin/therapeutic use ; Capsicum/adverse effects ; Capsicum/chemistry ; Evidence-Based Medicine ; Humans ; Neoplasms/drug therapy ; Neoplasms/epidemiology ; Neoplasms/pathology ; Phytotherapy ; Plants, Medicinal ; Risk Assessment
    Chemical Substances Antineoplastic Agents, Phytogenic ; Capsaicin (S07O44R1ZM)
    Language English
    Publishing date 2017-07-26
    Publishing country England
    Document type Journal Article
    ZDB-ID 2049730-1
    ISSN 1474-5488 ; 1470-2045
    ISSN (online) 1474-5488
    ISSN 1470-2045
    DOI 10.1016/S1470-2045(17)30522-3
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  10. Article ; Online: Fasting: starving cancer.

    Cathcart, Paul / Craddock, Charles / Stebbing, Justin

    The Lancet. Oncology

    2017  Volume 18, Issue 4, Page(s) 431

    MeSH term(s) Animals ; Caloric Restriction/adverse effects ; Cell Death ; Combined Modality Therapy ; Energy Metabolism ; Evidence-Based Medicine ; Fasting/adverse effects ; Humans ; Neoplasms/diagnosis ; Neoplasms/metabolism ; Neoplasms/therapy ; Quackery ; Treatment Outcome
    Language English
    Publishing date 2017-04-03
    Publishing country England
    Document type Journal Article
    ZDB-ID 2049730-1
    ISSN 1474-5488 ; 1470-2045
    ISSN (online) 1474-5488
    ISSN 1470-2045
    DOI 10.1016/S1470-2045(17)30196-1
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