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  1. AU="Catherine Durdux"
  2. AU="Rachel Marie Towle"
  3. AU="Soriano-Ursúa, Marvin A"
  4. AU="Cagnin, A"
  5. AU="Ivens, Al C"
  6. AU="Juan Mucci"
  7. AU="Alejandro Hlavnika"
  8. AU="Makarenko V."

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  1. Artikel ; Online: Complete pathological response to olaparib and bevacizumab in advanced cervical cancer following chemoradiation in a BRCA1 mutation carrier

    Rosa Montero-Macias / Meriem Koual / Céline Crespel / Marie Aude Le Frére-Belda / Hélène Blons Hélène / Huyen-Thu Nguyen-Xuan / Simon Garinet / Géraldine Perkins / Vincent Balay / Catherine Durdux / Marie Florin / Hélène Péré / Anne-Sophie Bats

    Journal of Medical Case Reports, Vol 15, Iss 1, Pp 1-

    a case report

    2021  Band 5

    Abstract: Abstract Background Homologous recombination deficiency is a marker of response to poly(ADP-ribose) polymerase inhibitors in different cancer types including ovary, prostate, and pancreatic cancer. To date, no report about poly(ADP-ribose) polymerase ... ...

    Abstract Abstract Background Homologous recombination deficiency is a marker of response to poly(ADP-ribose) polymerase inhibitors in different cancer types including ovary, prostate, and pancreatic cancer. To date, no report about poly(ADP-ribose) polymerase inhibitors has been published on cervical cancer. Case presentation Here we present the case of a patient with cervical cancer treated in this setting. A 49-year-old woman diagnosed with International Federation of Obstetricians and Gynecologists stage 2018 IIIC2 locally advanced undifferentiated cervical cancer received first-line chemoradiotherapy followed by carboplatin, paclitaxel, and bevacizumab with partial response. Because of a family history of cancers, the patient was tested and found positive for a pathogenic BRCA1 germline and somatic mutation, which motivated bevacizumab plus olaparib maintenance treatment. A simple hysterectomy was performed after 2 years stable disease; pathological report showed complete pathological response, and 12 months follow-up showed no recurrence. Conclusion Poly(ADP-ribose) polymerase inhibitors could be an alternative maintenance treatment for patients with persistent advanced cervical cancer previously treated with platinum, especially when familial history of cancers is reported. Clinical trials using poly(ADP-ribose) polymerase inhibitors for advanced cervical cancer are warranted.
    Schlagwörter Advanced cervical cancer ; BRCA1 ; PARP inhibitor ; Olaparib ; Precision oncology ; Medicine ; R
    Sprache Englisch
    Erscheinungsdatum 2021-04-01T00:00:00Z
    Verlag BMC
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  2. Artikel ; Online: Nivolumab plus chemoradiotherapy in locally-advanced cervical cancer

    Manuel Rodrigues / Giulia Vanoni / Pierre Loap / Coraline Dubot / Eleonora Timperi / Mathieu Minsat / Louis Bazire / Catherine Durdux / Virginie Fourchotte / Enora Laas / Nicolas Pouget / Zahra Castel-Ajgal / Gregoire Marret / Laetitia Lesage / Didier Meseure / Anne Vincent-Salomon / Lolita Lecompte / Nicolas Servant / Sophie Vacher /
    Ivan Bieche / Caroline Malhaire / Virginie Huchet / Laurence Champion / Maud Kamal / Sebastian Amigorena / Olivier Lantz / Marion Chevrier / Emanuela Romano

    Nature Communications, Vol 14, Iss 1, Pp 1-

    the NICOL phase 1 trial

    2023  Band 15

    Abstract: Abstract Concurrent chemoradiotherapy (CRT) with blockade of the PD-1 pathway may enhance immune-mediated tumor control through increased phagocytosis, cell death, and antigen presentation. The NiCOL phase 1 trial (NCT03298893) is designed to determine ... ...

    Abstract Abstract Concurrent chemoradiotherapy (CRT) with blockade of the PD-1 pathway may enhance immune-mediated tumor control through increased phagocytosis, cell death, and antigen presentation. The NiCOL phase 1 trial (NCT03298893) is designed to determine the safety/tolerance profile and the recommended phase-II dose of nivolumab with and following concurrent CRT in 16 women with locally advanced cervical cancer. Secondary endpoints include objective response rate (ORR), progression free survival (PFS), disease free survival, and immune correlates of response. Three patients experience grade 3 dose-limiting toxicities. The pre-specified endpoints are met, and overall response rate is 93.8% [95%CI: 69.8–99.8%] with a 2-year PFS of 75% [95% CI: 56.5–99.5%]. Compared to patients with progressive disease (PD), progression-free (PF) subjects show a brisker stromal immune infiltrate, higher proximity of tumor-infiltrating CD3+ T cells to PD-L1+ tumor cells and of FOXP3+ T cells to proliferating CD11c+ myeloid cells. PF show higher baseline levels of PD-1 and ICOS-L on tumor-infiltrating EMRA CD4+ T cells and tumor-associated macrophages, respectively; PD instead, display enhanced PD-L1 expression on TAMs, higher peripheral frequencies of proliferating Tregs at baseline and higher PD-1 levels at week 6 post-treatment initiation on CD4 and CD8 T cell subsets. Concomitant nivolumab plus definitive CRT is safe and associated with encouraging PFS rates. Further validation in the subset of locally advanced cervical cancer displaying pre-existing, adaptive immune activation is warranted.
    Schlagwörter Science ; Q
    Thema/Rubrik (Code) 610
    Sprache Englisch
    Erscheinungsdatum 2023-06-01T00:00:00Z
    Verlag Nature Portfolio
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  3. Artikel ; Online: Radiomics and Machine Learning for Radiotherapy in Head and Neck Cancers

    Paul Giraud / Philippe Giraud / Anne Gasnier / Radouane El Ayachy / Sarah Kreps / Jean-Philippe Foy / Catherine Durdux / Florence Huguet / Anita Burgun / Jean-Emmanuel Bibault

    Frontiers in Oncology, Vol

    2019  Band 9

    Abstract: Introduction: An increasing number of parameters can be considered when making decisions in oncology. Tumor characteristics can also be extracted from imaging through the use of radiomics and add to this wealth of clinical data. Machine learning can ... ...

    Abstract Introduction: An increasing number of parameters can be considered when making decisions in oncology. Tumor characteristics can also be extracted from imaging through the use of radiomics and add to this wealth of clinical data. Machine learning can encompass these parameters and thus enhance clinical decision as well as radiotherapy workflow.Methods: We performed a description of machine learning applications at each step of treatment by radiotherapy in head and neck cancers. We then performed a systematic review on radiomics and machine learning outcome prediction models in head and neck cancers.Results: Machine Learning has several promising applications in treatment planning with automatic organ at risk delineation improvements and adaptative radiotherapy workflow automation. It may also provide new approaches for Normal Tissue Complication Probability models. Radiomics may provide additional data on tumors for improved machine learning powered predictive models, not only on survival, but also on risk of distant metastasis, in field recurrence, HPV status and extra nodal spread. However, most studies provide preliminary data requiring further validation.Conclusion: Promising perspectives arise from machine learning applications and radiomics based models, yet further data are necessary for their implementation in daily care.
    Schlagwörter radiomics ; machine learning in head and neck cancer ; predictive medicine ; radiation oncology ; treatment planning ; Neoplasms. Tumors. Oncology. Including cancer and carcinogens ; RC254-282
    Thema/Rubrik (Code) 006
    Sprache Englisch
    Erscheinungsdatum 2019-03-01T00:00:00Z
    Verlag Frontiers Media S.A.
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  4. Artikel ; Online: Acute radiation pneumonitis after conformational radiotherapy for nonsmall cell lung cancer

    Etienne Giroux Leprieur / Diego Fernandez / Gilles Chatellier / Sylvain Klotz / Philippe Giraud / Catherine Durdux

    Journal of Cancer Research and Therapeutics, Vol 9, Iss 3, Pp 447-

    Clinical, dosimetric, and associated-treatment risk factors

    2013  Band 451

    Abstract: Background: Conformational thoracic radiotherapy (CTR) is a key-treatment in locally advanced nonsmall cell lung cancer (LA-NSCLC). Acute radiation pneumonitis (ARP) is one of the major complications. Aims: To evaluate the predictors of ARP after CTR in ... ...

    Abstract Background: Conformational thoracic radiotherapy (CTR) is a key-treatment in locally advanced nonsmall cell lung cancer (LA-NSCLC). Acute radiation pneumonitis (ARP) is one of the major complications. Aims: To evaluate the predictors of ARP after CTR in the treatment of LA-NSCLC. Materials and methods: A total of 47 consecutive patients (pts) were treated with CTR for LA-NSCLC and retrospectively analyzed. The mean total dose of radiation therapy (RT) was 65 Gy, with respiratory gating (RG) in 19 cases. Induction and concomitant chemotherapy was performed in 33 pts (70%) and 41 pts (87%), respectively. Results: Eleven pts (23%) had an ARP resulting in death for one pt. In univariate analysis, age, sex, pretherapeutic value of forced expiratory volume (FEV), not-gated radiotherapy and type of concomitant chemotherapy did not appear as contributing factors in contrast to the administration of induction gemcitabine ( p = 0.03). The occurrence of ARP was significantly associated with nontumor lung volumes irradiated to 13 Gy (V13, p = 0.04), 20 Gy (V20, p = 0.02), and 25 Gy (V25, p = 0.006), the mean lung dose ( p = 0.008) and lung normal tissue complication probability (NTCP) ( p = 0.004). In multivariate logistic regression analysis, the occurrence of ARP was significantly associated with age >75 years (odds ratio (OR) = 16.72, confidence interval (CI) 95% 1.77-157.87) and administration of induction gemcitabine (OR = 18.08, CI 95% 1.09-300.08). Conclusion: ARP is a common acute complication, requiring close posttreatment follow-up, particularly for elderly patients. The use of gemcitabine before radiation should be avoided. The benefits and risks of CTR must be carefully analyzed, according to the dosimetric parameters.
    Schlagwörter Locally advanced stage ; nonsmall cell lung cancer ; pneumonitis ; radiotherapy ; Neoplasms. Tumors. Oncology. Including cancer and carcinogens ; RC254-282 ; Internal medicine ; RC31-1245 ; Medicine ; R
    Thema/Rubrik (Code) 610 ; 616
    Sprache Englisch
    Erscheinungsdatum 2013-01-01T00:00:00Z
    Verlag Medknow Publications
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  5. Artikel ; Online: Author Correction

    Jean-Emmanuel Bibault / Philippe Giraud / Martin Housset / Catherine Durdux / Julien Taieb / Anne Berger / Romain Coriat / Stanislas Chaussade / Bertrand Dousset / Bernard Nordlinger / Anita Burgun

    Scientific Reports, Vol 8, Iss 1, Pp 1-

    Deep Learning and Radiomics predict complete response after neo-adjuvant chemoradiation for locally advanced rectal cancer

    2018  Band 2

    Abstract: A correction to this article has been published and is linked from the HTML and PDF versions of this paper. The error has been fixed in the paper. ...

    Abstract A correction to this article has been published and is linked from the HTML and PDF versions of this paper. The error has been fixed in the paper.
    Schlagwörter Medicine ; R ; Science ; Q
    Sprache Englisch
    Erscheinungsdatum 2018-11-01T00:00:00Z
    Verlag Nature Publishing Group
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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