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  1. Article ; Online: Chronic Exposure to a PFAS Mixture Resembling AFFF-Impacted Surface Water Decreases Body Size in Northern Leopard Frogs (

    Hoskins, Tyler D / Flynn, R Wesley / Coogan, Grace S M / Catlin, Ann C / de Perre, Chloe / Modiri Gharehveran, Mahsa / Choi, Youn Jeong / Lee, Linda S / Hoverman, Jason T / Sepúlveda, Maria S

    Environmental science & technology

    2023  Volume 57, Issue 40, Page(s) 14797–14806

    Abstract: Per- and polyfluoroalkyl substances (PFAS) occur in the environment as mixtures, yet mixture toxicity remains poorly understood. Aqueous film-forming foams (AFFFs) are a common source of PFAS. Our objective was to examine chronic effects of a complex ... ...

    Abstract Per- and polyfluoroalkyl substances (PFAS) occur in the environment as mixtures, yet mixture toxicity remains poorly understood. Aqueous film-forming foams (AFFFs) are a common source of PFAS. Our objective was to examine chronic effects of a complex PFAS mixture on amphibian growth and development. We tested toxicity of a five-chemical PFAS mixture summing to 10 μg/L and that accounts for >90% of the PFAS in AFFF-affected surface waters: perfluorooctane sulfonate (PFOS, 40%), perfluorohexane sulfonic acid (PFHxS, 30%), perflurooctanoic acid (PFOA, 12.5%), perfluorohexanoic acid (PFHxA, 12.5%), and perfluoropentanoic acid (PFPeA, 5%). We also included treatments to determine whether PFOS drove mixture toxicity and whether PFOS and mixture components act additively. We exposed Northern leopard frog (
    MeSH term(s) Animals ; Water ; Rana pipiens ; Water Pollutants, Chemical/toxicity ; Water Pollutants, Chemical/analysis ; Alkanesulfonic Acids/toxicity ; Fluorocarbons/toxicity ; Fluorocarbons/analysis ; Larva ; Body Size
    Chemical Substances Water (059QF0KO0R) ; Water Pollutants, Chemical ; Alkanesulfonic Acids ; Fluorocarbons
    Language English
    Publishing date 2023-08-23
    Publishing country United States
    Document type Journal Article ; Research Support, U.S. Gov't, Non-P.H.S.
    ISSN 1520-5851
    ISSN (online) 1520-5851
    DOI 10.1021/acs.est.3c01118
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Clinic-Based Pediatric Disclosure Intervention Trial Improves Pediatric HIV Status Disclosure in Ghana.

    Paintsil, Elijah / Kyriakides, Tassos C / Antwi, Sampson / Renner, Lorna / Nichols, Justin S / Amissah, Kofi / Kusah, Jonas T / Alhassan, Amina / Ofori, Irene P / Catlin, Ann C / Gan, Geliang / Lartey, Margaret / Reynolds, Nancy R

    Journal of acquired immune deficiency syndromes (1999)

    2020  Volume 84, Issue 1, Page(s) 122–131

    Abstract: Background: Disclosing HIV status to HIV-positive children is a major challenge facing families and health care providers. Despite recommendations for disclosure, rates remain low. We tested whether a pediatric HIV disclosure intervention delivered as ... ...

    Abstract Background: Disclosing HIV status to HIV-positive children is a major challenge facing families and health care providers. Despite recommendations for disclosure, rates remain low. We tested whether a pediatric HIV disclosure intervention delivered as an integral component of routine HIV health care in Ghana would improve disclosure to children.
    Methods: Dyads of HIV-infected children aged 7-18 years and their caregivers were enrolled from 2 HIV clinics in Accra and Kumasi, Ghana. The sites were randomly assigned to one of the 2 intervention arms to avoid treatment contamination between intervention and control participants. Trained interventionist used theory-guided therapeutic communication and personalized interaction to promote disclosure. Disclosure outcomes were measured at 12-week intervals. All analyses were completed using a modified intention-to-treat approach.
    Results: We enrolled 446 child-caregiver dyads (N = 240 intervention group; N = 206 control group); 52% of the children were boys, mean age 9.78 (±2.27) years. For disclosure at 1 year, a better overall treatment effect was observed (P < 0.001). Children in the treatment group had greater disclosure at each time point (P < 0.001) and a higher proportion of them had been disclosed to by 1 year (51.4% vs. 16.2%; P < 0.001; un-adjusted hazard ratio = 3.98: 95% confidence interval: 2.63 to 6.03) and 3 years (71.3% vs. 34.0%; unadjusted hazard ratio = 4.21: 95% confidence interval: 3.09 to 5.72). In the multivariate Cox model, factors associated with disclosure were treatment group (P < 0.001), children <11 years of age (P < 0.001), HIV-infected caregivers (P = 0.015), and caregiver's with greater education (P = 0.022).
    Conclusions: This practical clinic-based disclosure intervention shows excellent promise as a means of improving HIV pediatric disclosure outcomes.
    MeSH term(s) Adolescent ; Ambulatory Care Facilities/organization & administration ; Caregivers ; Child ; Female ; Ghana ; HIV Infections/nursing ; HIV Infections/psychology ; Humans ; Inservice Training/organization & administration ; Male ; Pediatrics ; Self Disclosure ; Stereotyping
    Language English
    Publishing date 2020-03-20
    Publishing country United States
    Document type Journal Article ; Multicenter Study ; Randomized Controlled Trial ; Research Support, N.I.H., Extramural
    ZDB-ID 645053-2
    ISSN 1944-7884 ; 1077-9450 ; 0897-5965 ; 0894-9255 ; 1525-4135
    ISSN (online) 1944-7884 ; 1077-9450
    ISSN 0897-5965 ; 0894-9255 ; 1525-4135
    DOI 10.1097/QAI.0000000000002316
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2442: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  3. Article ; Online: Prevalence and correlates of depression among caregivers of children living with HIV in Ghana: findings from the Sankofa pediatric disclosure study.

    Ofori-Atta, Angela / Reynolds, Nancy R / Antwi, Sampson / Renner, Lorna / Nichols, Justin S / Lartey, Margaret / Amissah, Kofi / Tettey, Jonas Kusah / Alhassan, Amina / Ofori, Irene Pokuaa / Catlin, Ann C / Gan, Geliang / Kyriakides, Tassos C / Paintsil, Elijah

    AIDS care

    2018  Volume 31, Issue 3, Page(s) 283–292

    Abstract: Prior studies show an association between caregiver depression and child health outcomes. There has been little examination of depression among caregivers of HIV-infected children in sub-Saharan countries where pediatric HIV is concentrated. Using ... ...

    Abstract Prior studies show an association between caregiver depression and child health outcomes. There has been little examination of depression among caregivers of HIV-infected children in sub-Saharan countries where pediatric HIV is concentrated. Using baseline data collected in the pediatric HIV disclosure intervention trial, Sankofa, we examined the prevalence and factors associated with depression among caregivers (N = 446) of children infected with HIV in Ghana. Data were analyzed with descriptive and regression analyses. The mean age of the caregivers was 42.2 ± 10.4 years. Eighty percent of the caregivers were female and 59% were HIV-infected. Twenty-eight percent (n = 126) of the caregivers were found to have mild to severe depression. In the adjusted model, factors significantly associated with caregiver depression included: HIV-positive caregiver status (P = 0.04), low income (P = 0.02), lower social support, (P = 0.01), lower HIV knowledge, (P = 0.01), worse HIV illness perceptions (P≤0.001), and greater perceived HIV stigma (P≤0.001). Although we found a high prevalence of depression among our study participants, several of the risks factors identified are modifiable and amenable to interventions that are locally available and affordable.
    MeSH term(s) Adult ; Caregivers/psychology ; Caregivers/statistics & numerical data ; Child ; Depression/epidemiology ; Female ; Ghana/epidemiology ; HIV Infections/nursing ; HIV Infections/psychology ; Health Knowledge, Attitudes, Practice ; Humans ; Male ; Middle Aged ; Poverty ; Prevalence ; Risk Factors ; Social Stigma ; Social Support
    Language English
    Publishing date 2018-10-25
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 1012651-x
    ISSN 1360-0451 ; 0954-0121
    ISSN (online) 1360-0451
    ISSN 0954-0121
    DOI 10.1080/09540121.2018.1537463
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2799: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  4. Article ; Online: High prevalence of non-adherence to antiretroviral therapy among undisclosed HIV-infected children in Ghana.

    Nichols, Justin S / Kyriakides, Tassos C / Antwi, Sampson / Renner, Lorna / Lartey, Margaret / Seaneke, Obedia A / Obeng, Raphael / Catlin, Ann C / Gan, Geliang / Reynolds, Nancy R / Paintsil, Elijah

    AIDS care

    2018  Volume 31, Issue 1, Page(s) 25–34

    Abstract: Adherence to antiretroviral therapy (ART) remains one of the greatest obstacles in pediatric HIV care. We sought to determine the prevalence of adherence to ART among undisclosed HIV-infected children and adolescents in Ghana. We analyzed baseline data ... ...

    Abstract Adherence to antiretroviral therapy (ART) remains one of the greatest obstacles in pediatric HIV care. We sought to determine the prevalence of adherence to ART among undisclosed HIV-infected children and adolescents in Ghana. We analyzed baseline data from HIV-infected children and adolescents aged 7-18 years old enrolled in the SANKOFA Pediatric HIV disclosure intervention study in Ghana. Antiretroviral medication adherence was measured using caregiver 3-day recall; child 3-day recall; and pharmacy records for antiretroviral time-to-refill. Four hundred and twenty child-caregiver dyads were enrolled from January 2013 to June 2016. The median adherence (interquartile range), as measured by time-to-refill, was 93.2% (68.0%-100.0%). However, only 47.5% of children had ≥95% adherence ("good adherence") using time-to-refill data. Children of caregivers who had received secondary or higher level of education versus no school (aOR, 2.90, 95% Confidence Interval, CI 1.29-6.56), p = 0.010) or elementary education only (aOR, 2.20, CI, 1.24-3.88, p = 0.007) were more likely to have "good adherence" (≥95%). In this cohort of children unaware of their HIV positive status, median ART adherence rate was sub-optimal (by World Health Organization definition) while 38% had poor adherence (<85%).
    MeSH term(s) Adolescent ; Adult ; Anti-Retroviral Agents/therapeutic use ; Caregivers/psychology ; Child ; Cohort Studies ; Disclosure ; Educational Status ; Female ; Ghana/epidemiology ; HIV Infections/drug therapy ; HIV Infections/ethnology ; HIV Infections/psychology ; Humans ; Male ; Medication Adherence/ethnology ; Medication Adherence/statistics & numerical data ; Middle Aged ; Pediatrics ; Pharmacies ; Prevalence ; World Health Organization
    Chemical Substances Anti-Retroviral Agents
    Language English
    Publishing date 2018-09-20
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 1012651-x
    ISSN 1360-0451 ; 0954-0121
    ISSN (online) 1360-0451
    ISSN 0954-0121
    DOI 10.1080/09540121.2018.1524113
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 2799: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

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