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  1. Article: Effect of aminergic signaling on the humoral innate immunity response of

    Cattabriga, Giulia / Giordani, Giorgia / Gargiulo, Giuseppe / Cavaliere, Valeria

    Frontiers in physiology

    2023  Volume 14, Page(s) 1249205

    Abstract: Biogenic amines are crucial signaling molecules that modulate various physiological life functions both in vertebrates and invertebrates. In humans, these neurotransmitters influence the innate and adaptive immunity systems. In this work, we analyzed ... ...

    Abstract Biogenic amines are crucial signaling molecules that modulate various physiological life functions both in vertebrates and invertebrates. In humans, these neurotransmitters influence the innate and adaptive immunity systems. In this work, we analyzed whether the aminergic neurotransmission of dopamine, serotonin, and octopamine could have an impact on the humoral innate immune response of
    Language English
    Publishing date 2023-08-24
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2564217-0
    ISSN 1664-042X
    ISSN 1664-042X
    DOI 10.3389/fphys.2023.1249205
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Role of neuronal and non-neuronal acetylcholine signaling in Drosophila humoral immunity.

    Giordani, Giorgia / Cattabriga, Giulia / Becchimanzi, Andrea / Di Lelio, Ilaria / De Leva, Giovanna / Gigliotti, Silvia / Pennacchio, Francesco / Gargiulo, Giuseppe / Cavaliere, Valeria

    Insect biochemistry and molecular biology

    2022  Volume 153, Page(s) 103899

    Abstract: Acetylcholine (ACh) is one the major neurotransmitters in insects, whose role in mediating synaptic interactions between neurons in the central nervous system is well characterized. It also plays largely unexplored regulatory functions in non-neuronal ... ...

    Abstract Acetylcholine (ACh) is one the major neurotransmitters in insects, whose role in mediating synaptic interactions between neurons in the central nervous system is well characterized. It also plays largely unexplored regulatory functions in non-neuronal tissues. Here we demonstrate that ACh signaling is involved in the modulation of the innate immune response of Drosophila melanogaster. Knockdown of ACh synthesis or ACh vesicular transport in neurons reduced the activation of drosomycin (drs), a gene encoding an antimicrobial peptide, in adult flies infected with a Gram-positive bacterium. drs transcription was similarly affected in Drosophila α7 nicotinic acetylcholine receptor, nAChRalpha7 (Dα7) mutants, as well as in flies expressing in the nervous system a dominant negative form (Dα7
    MeSH term(s) Animals ; Acetylcholine ; Drosophila/metabolism ; Drosophila melanogaster/metabolism ; Immunity, Humoral ; Neurons/metabolism ; Receptors, Nicotinic/genetics
    Chemical Substances Acetylcholine (N9YNS0M02X) ; Receptors, Nicotinic
    Language English
    Publishing date 2022-12-31
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1483248-3
    ISSN 1879-0240 ; 0965-1748
    ISSN (online) 1879-0240
    ISSN 0965-1748
    DOI 10.1016/j.ibmb.2022.103899
    Database MEDical Literature Analysis and Retrieval System OnLINE

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