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  1. Article ; Online: Multicomponent vaccines to fight SARS-CoV-2 variants of concern.

    Cassone, Antonio / Cauda, Roberto

    Vaccine

    2021  Volume 39, Issue 48, Page(s) 6969–6971

    MeSH term(s) Antibodies, Neutralizing ; COVID-19 ; Humans ; SARS-CoV-2 ; Vaccines
    Chemical Substances Antibodies, Neutralizing ; Vaccines
    Language English
    Publishing date 2021-11-01
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 605674-x
    ISSN 1873-2518 ; 0264-410X
    ISSN (online) 1873-2518
    ISSN 0264-410X
    DOI 10.1016/j.vaccine.2021.10.069
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    Zs.A 1930: Show issues Location:
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  2. Article ; Online: The Glycan Ectodomain of SARS-CoV-2 Spike Protein Modulates Cytokine Production and Expression of CD206 Mannose Receptor in PBMC Cultures of Pre-COVID-19 Healthy Subjects.

    Barbati, Cristiana / Bromuro, Carla / Vendetti, Silvia / Torosantucci, Antonella / Cauda, Roberto / Cassone, Antonio / Palma, Carla

    Viruses

    2024  Volume 16, Issue 4

    Abstract: The ability of recombinant, SARS-CoV-2 Spike (S) protein to modulate the production of two COVID-19 relevant, pro-inflammatory cytokines (IL-6 and IFN-γ) in PBMC cultures of healthy, pre-COVID-19 subjects was investigated. We observed that cytokine ... ...

    Abstract The ability of recombinant, SARS-CoV-2 Spike (S) protein to modulate the production of two COVID-19 relevant, pro-inflammatory cytokines (IL-6 and IFN-γ) in PBMC cultures of healthy, pre-COVID-19 subjects was investigated. We observed that cytokine production was largely and diversely modulated by the S protein depending on antigen or mitogen stimulation, as well as on the protein source, insect (S-in) or human (S-hu) cells. While both proteins co-stimulated cytokine production by polyclonally CD3-activated T cells, PBMC activation by the mitogenic lectin Concanavalin A (Con A) was up-modulated by S-hu protein and down-modulated by S-in protein. These modulatory effects were likely mediated by the S glycans, as demonstrated by direct Con A-S binding experiments and use of yeast mannan as Con A binder. While being ineffective in modulating memory antigenic T cell responses, the S proteins and mannan were able to induce IL-6 production in unstimulated PBMC cultures and upregulate the expression of the mannose receptor (CD206), a marker of anti-inflammatory M2 macrophage. Our data point to a relevant role of N-glycans, particularly N-mannosidic chains, decorating the S protein in the immunomodulatory effects here reported. These novel biological activities of the S glycan ectodomain may add to the comprehension of COVID-19 pathology and immunity to SARS-CoV-2.
    MeSH term(s) Humans ; Spike Glycoprotein, Coronavirus/metabolism ; Spike Glycoprotein, Coronavirus/immunology ; Spike Glycoprotein, Coronavirus/genetics ; Lectins, C-Type/metabolism ; Receptors, Cell Surface/metabolism ; Mannose Receptor ; Leukocytes, Mononuclear/metabolism ; Leukocytes, Mononuclear/immunology ; COVID-19/immunology ; COVID-19/virology ; COVID-19/metabolism ; SARS-CoV-2/immunology ; SARS-CoV-2/metabolism ; Mannose-Binding Lectins/metabolism ; Interleukin-6/metabolism ; Cytokines/metabolism ; Interferon-gamma/metabolism ; Cells, Cultured ; Polysaccharides/metabolism ; Healthy Volunteers ; T-Lymphocytes/immunology ; T-Lymphocytes/metabolism ; Lymphocyte Activation ; Concanavalin A/metabolism
    Chemical Substances Spike Glycoprotein, Coronavirus ; Lectins, C-Type ; Receptors, Cell Surface ; Mannose Receptor ; spike protein, SARS-CoV-2 ; Mannose-Binding Lectins ; Interleukin-6 ; Cytokines ; Interferon-gamma (82115-62-6) ; Polysaccharides ; Concanavalin A (11028-71-0)
    Language English
    Publishing date 2024-03-24
    Publishing country Switzerland
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2516098-9
    ISSN 1999-4915 ; 1999-4915
    ISSN (online) 1999-4915
    ISSN 1999-4915
    DOI 10.3390/v16040497
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  3. Article ; Online: Gene Xpert MTB/RIF assay confirms its value in the first multicentre, randomised, controlled trial conducted in primary-care settings in Africa.

    Cauda, Roberto

    Pathogens and global health

    2014  Volume 108, Issue 3, Page(s) 127

    MeSH term(s) Female ; Humans ; Male ; Point-of-Care Systems/standards ; Tuberculosis, Pulmonary/diagnosis
    Language English
    Publishing date 2014-04-28
    Publishing country England
    Document type Journal Article ; Comment
    ZDB-ID 2625162-0
    ISSN 2047-7732 ; 2047-7724
    ISSN (online) 2047-7732
    ISSN 2047-7724
    DOI 10.1179/2047772414Z.000000000200
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  4. Article ; Online: A call to research: the relationship between SARS-2-CoV, ACE 2 and antihypertensives.

    Cassone, Antonio / Gucciardo, Donatella / Cauda, Roberto

    Pathogens and global health

    2020  Volume 114, Issue 4, Page(s) 165–167

    MeSH term(s) Angiotensin-Converting Enzyme 2 ; Angiotensin-Converting Enzyme Inhibitors/pharmacology ; Animals ; Antihypertensive Agents/pharmacology ; Blood Pressure/drug effects ; COVID-19 ; Coronavirus Infections/drug therapy ; Coronavirus Infections/genetics ; Coronavirus Infections/metabolism ; Coronavirus Infections/virology ; Humans ; Lung/drug effects ; Lung/metabolism ; Lung/virology ; Mice ; Pandemics ; Peptidyl-Dipeptidase A/genetics ; Peptidyl-Dipeptidase A/metabolism ; Pneumonia, Viral/drug therapy ; Pneumonia, Viral/genetics ; Pneumonia, Viral/metabolism ; Pneumonia, Viral/virology ; Protein Binding/drug effects ; SARS Virus/drug effects ; SARS Virus/genetics ; SARS Virus/metabolism ; SARS Virus/physiology ; Spike Glycoprotein, Coronavirus/genetics ; Spike Glycoprotein, Coronavirus/metabolism
    Chemical Substances Angiotensin-Converting Enzyme Inhibitors ; Antihypertensive Agents ; Spike Glycoprotein, Coronavirus ; spike protein, SARS-CoV-2 ; Peptidyl-Dipeptidase A (EC 3.4.15.1) ; ACE2 protein, human (EC 3.4.17.23) ; Ace2 protein, mouse (EC 3.4.17.23) ; Angiotensin-Converting Enzyme 2 (EC 3.4.17.23)
    Keywords covid19
    Language English
    Publishing date 2020-05-25
    Publishing country England
    Document type Journal Article
    ZDB-ID 2625162-0
    ISSN 2047-7732 ; 2047-7724
    ISSN (online) 2047-7732
    ISSN 2047-7724
    DOI 10.1080/20477724.2020.1765650
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  5. Article ; Online: Knowing more about chloroquine/hydroxycloroquine in COVID-19 patients.

    Cassone, Antonio / Iacoviello, Licia / Cauda, Roberto

    Future microbiology

    2020  Volume 15, Page(s) 1523–1526

    MeSH term(s) Anti-Inflammatory Agents/therapeutic use ; Antiviral Agents/therapeutic use ; Chloroquine/therapeutic use ; Humans ; Hydroxychloroquine/therapeutic use ; Immunomodulation ; Randomized Controlled Trials as Topic ; COVID-19 Drug Treatment
    Chemical Substances Anti-Inflammatory Agents ; Antiviral Agents ; Hydroxychloroquine (4QWG6N8QKH) ; Chloroquine (886U3H6UFF)
    Language English
    Publishing date 2020-11-18
    Publishing country England
    Document type Editorial
    ZDB-ID 2254620-0
    ISSN 1746-0921 ; 1746-0913
    ISSN (online) 1746-0921
    ISSN 1746-0913
    DOI 10.2217/fmb-2020-0247
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  6. Article ; Online: The SARS-CoV-2 Mu variant should not be left aside: It warrants attention for its immuno-escaping ability.

    Pascarella, Stefano / Bianchi, Martina / Giovanetti, Marta / Narzi, Daniele / Cauda, Roberto / Cassone, Antonio / Ciccozzi, Massimo

    Journal of medical virology

    2022  Volume 94, Issue 6, Page(s) 2479–2486

    Abstract: The COVID-19 pandemic continues to have a threatening impact on a global scale, largely due to the emergence of newly SARS-CoV-2 variants. The Mu (PANGO lineage B.1.621), was first identified in Colombia in January 2021 and was classified as a variant of ...

    Abstract The COVID-19 pandemic continues to have a threatening impact on a global scale, largely due to the emergence of newly SARS-CoV-2 variants. The Mu (PANGO lineage B.1.621), was first identified in Colombia in January 2021 and was classified as a variant of interest (VOI) in August 2021, due to a constellation of mutations that likely-mediate an unexpectedly enhanced immune resistance to inactivated vaccine-elicited antibodies. Despite recent studies suggesting that the Mu variant appears to have less infectivity than the Delta variant, here we examined the structural effect of the Mu spike protein mutations and predicted the potential impact on infectivity of the Mu variant compared with the Delta and Delta plus spike protein.
    MeSH term(s) Attention ; COVID-19 ; COVID-19 Vaccines ; Humans ; Mutation ; Pandemics ; SARS-CoV-2/genetics ; Spike Glycoprotein, Coronavirus
    Chemical Substances COVID-19 Vaccines ; Spike Glycoprotein, Coronavirus ; spike protein, SARS-CoV-2
    Language English
    Publishing date 2022-02-28
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 752392-0
    ISSN 1096-9071 ; 0146-6615
    ISSN (online) 1096-9071
    ISSN 0146-6615
    DOI 10.1002/jmv.27663
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    Zs.A 1320: Show issues Location:
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  7. Article ; Online: The value of electrostatic potentials of the spike receptor binding and N-terminal domains in addressing transmissibility and infectivity of SARS-CoV-2 variants of concern.

    Pascarella, Stefano / Ciccozzi, Massimo / Bianchi, Martina / Benvenuto, Domenico / Cauda, Roberto / Cassone, Antonio

    The Journal of infection

    2022  Volume 84, Issue 5, Page(s) e62–e63

    MeSH term(s) COVID-19 ; Humans ; Mutation ; Protein Binding ; SARS-CoV-2/genetics ; Spike Glycoprotein, Coronavirus/genetics ; Spike Glycoprotein, Coronavirus/metabolism ; Static Electricity
    Chemical Substances Spike Glycoprotein, Coronavirus ; spike protein, SARS-CoV-2
    Language English
    Publishing date 2022-02-23
    Publishing country England
    Document type Letter
    ZDB-ID 424417-5
    ISSN 1532-2742 ; 0163-4453
    ISSN (online) 1532-2742
    ISSN 0163-4453
    DOI 10.1016/j.jinf.2022.02.023
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  8. Article ; Online: Peculiar Variations of the Electrostatic Potential of Spike Protein N-terminal Domain Associated with the Emergence of Successive SARS-CoV-2 Omicron Lineages.

    Pascarella, Stefano / Ciccozzi, Massimo / Benvenuto, Domenico / Borsetti, Alessandra / Cauda, Roberto / Cassone, Antonio

    The Journal of infection

    2022  Volume 86, Issue 1, Page(s) 66–117

    MeSH term(s) Humans ; COVID-19 ; SARS-CoV-2 ; Spike Glycoprotein, Coronavirus/genetics ; Static Electricity ; Mutation
    Chemical Substances spike protein, SARS-CoV-2 ; Spike Glycoprotein, Coronavirus
    Language English
    Publishing date 2022-07-29
    Publishing country England
    Document type Letter
    ZDB-ID 424417-5
    ISSN 1532-2742 ; 0163-4453
    ISSN (online) 1532-2742
    ISSN 0163-4453
    DOI 10.1016/j.jinf.2022.07.018
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  9. Article ; Online: Identification of two anti-

    Bromuro, Carla / Posteraro, Brunella / Murri, Rita / Fantoni, Massimo / Tumbarello, Mario / Sanguinetti, Maurizio / Dattilo, Rosanna / Cauda, Roberto / Cassone, Antonio / Torosantucci, Antonella

    mBio

    2023  Volume 15, Issue 1, Page(s) e0276923

    Abstract: Importance: Candidemia (bloodstream invasion ... ...

    Abstract Importance: Candidemia (bloodstream invasion by
    MeSH term(s) Humans ; Candida ; Candidemia/diagnosis ; Candidemia/drug therapy ; Prospective Studies ; Candidiasis, Invasive/drug therapy ; Antigens, Fungal ; Antibodies/therapeutic use ; Antifungal Agents/therapeutic use
    Chemical Substances Antigens, Fungal ; Antibodies ; Antifungal Agents
    Language English
    Publishing date 2023-12-13
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2557172-2
    ISSN 2150-7511 ; 2161-2129
    ISSN (online) 2150-7511
    ISSN 2161-2129
    DOI 10.1128/mbio.02769-23
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  10. Article ; Online: Colonic histoplasmosis.

    Sangiorgi, Flavio / Torelli, Riccardo / Castri, Federica / Siciliano, Valentina / Cauda, Roberto / Fantoni, Massimo / Sanguinetti, Maurizio / Taccari, Francesco

    Journal of travel medicine

    2023  Volume 30, Issue 6

    MeSH term(s) Humans ; Histoplasmosis
    Language English
    Publishing date 2023-01-13
    Publishing country England
    Document type Case Reports ; Journal Article
    ZDB-ID 1212504-0
    ISSN 1708-8305 ; 1195-1982
    ISSN (online) 1708-8305
    ISSN 1195-1982
    DOI 10.1093/jtm/taad007
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