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  1. Article ; Online: Atoh1

    Wu, Sih-Rong / Butts, Jessica C / Caudill, Matthew S / Revelli, Jean-Pierre / Dhindsa, Ryan S / Durham, Mark A / Zoghbi, Huda Y

    Science advances

    2023  Volume 9, Issue 26, Page(s) eadg1671

    Abstract: Pontine nuclei (PN) neurons mediate the communication between the cerebral cortex andthe cerebellum to refine skilled motor functions. Prior studies showed that PN neurons fall into two subtypes based on their anatomic location and region-specific ... ...

    Abstract Pontine nuclei (PN) neurons mediate the communication between the cerebral cortex andthe cerebellum to refine skilled motor functions. Prior studies showed that PN neurons fall into two subtypes based on their anatomic location and region-specific connectivity, but the extent of their heterogeneity and its molecular drivers remain unknown.
    MeSH term(s) Animals ; Mice ; Cell Differentiation ; Cerebellum ; Cell Cycle ; Cell Division ; Neurons ; Basic Helix-Loop-Helix Transcription Factors/genetics
    Chemical Substances Atoh1 protein, mouse ; Basic Helix-Loop-Helix Transcription Factors
    Language English
    Publishing date 2023-06-30
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2810933-8
    ISSN 2375-2548 ; 2375-2548
    ISSN (online) 2375-2548
    ISSN 2375-2548
    DOI 10.1126/sciadv.adg1671
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  2. Article ; Online: A weakened recurrent circuit in the hippocampus of Rett syndrome mice disrupts long-term memory representations.

    He, Lingjie / Caudill, Matthew S / Jing, Junzhan / Wang, Wei / Sun, Yaling / Tang, Jianrong / Jiang, Xiaolong / Zoghbi, Huda Y

    Neuron

    2022  Volume 110, Issue 10, Page(s) 1689–1699.e6

    Abstract: Successful recall of a contextual memory requires reactivating ensembles of hippocampal cells that were allocated during memory formation. Altering the ratio of excitation-to-inhibition (E/I) during memory retrieval can bias cell participation in an ... ...

    Abstract Successful recall of a contextual memory requires reactivating ensembles of hippocampal cells that were allocated during memory formation. Altering the ratio of excitation-to-inhibition (E/I) during memory retrieval can bias cell participation in an ensemble and hinder memory recall. In the case of Rett syndrome (RTT), a neurological disorder with severe learning and memory deficits, the E/I balance is altered, but the source of this imbalance is unknown. Using in vivo imaging during an associative memory task, we show that during long-term memory retrieval, RTT CA1 cells poorly distinguish mnemonic context and form larger ensembles than wild-type mouse cells. Simultaneous multiple whole-cell recordings revealed that mutant somatostatin expressing interneurons (SOM) are poorly recruited by CA1 pyramidal cells and are less active during long-term memory retrieval in vivo. Chemogenetic manipulation revealed that reduced SOM activity underlies poor long-term memory recall. Our findings reveal a disrupted recurrent CA1 circuit contributing to RTT memory impairment.
    MeSH term(s) Animals ; Hippocampus/physiology ; Interneurons/physiology ; Memory Disorders/genetics ; Memory, Long-Term ; Mice ; Pyramidal Cells/physiology ; Rett Syndrome/genetics
    Language English
    Publishing date 2022-03-14
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 808167-0
    ISSN 1097-4199 ; 0896-6273
    ISSN (online) 1097-4199
    ISSN 0896-6273
    DOI 10.1016/j.neuron.2022.02.014
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2496: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (2.OG)
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    Zs.MG 92: Show issues

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  3. Article ; Online: Antisense oligonucleotide therapy rescues disturbed brain rhythms and sleep in juvenile and adult mouse models of Angelman syndrome.

    Lee, Dongwon / Chen, Wu / Kaku, Heet Naresh / Zhuo, Xinming / Chao, Eugene S / Soriano, Armand / Kuncheria, Allen / Flores, Stephanie / Kim, Joo Hyun / Rivera, Armando / Rigo, Frank / Jafar-Nejad, Paymaan / Beaudet, Arthur L / Caudill, Matthew S / Xue, Mingshan

    eLife

    2023  Volume 12

    Abstract: ... ...

    Abstract UBE3A
    MeSH term(s) Mice ; Animals ; Angelman Syndrome ; Brain/metabolism ; Oligonucleotides, Antisense/metabolism ; Oligonucleotides, Antisense/therapeutic use ; Mice, Knockout ; Sleep ; Ubiquitin-Protein Ligases/metabolism ; Disease Models, Animal
    Chemical Substances Oligonucleotides, Antisense ; Ubiquitin-Protein Ligases (EC 2.3.2.27)
    Language English
    Publishing date 2023-01-03
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural
    ZDB-ID 2687154-3
    ISSN 2050-084X ; 2050-084X
    ISSN (online) 2050-084X
    ISSN 2050-084X
    DOI 10.7554/eLife.81892
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  4. Article ; Online: A Disinhibitory Circuit for Contextual Modulation in Primary Visual Cortex.

    Keller, Andreas J / Dipoppa, Mario / Roth, Morgane M / Caudill, Matthew S / Ingrosso, Alessandro / Miller, Kenneth D / Scanziani, Massimo

    Neuron

    2020  Volume 108, Issue 6, Page(s) 1181–1193.e8

    Abstract: Context guides perception by influencing stimulus saliency. Accordingly, in visual cortex, responses to a stimulus are modulated by context, the visual scene surrounding the stimulus. Responses are suppressed when stimulus and surround are similar but ... ...

    Abstract Context guides perception by influencing stimulus saliency. Accordingly, in visual cortex, responses to a stimulus are modulated by context, the visual scene surrounding the stimulus. Responses are suppressed when stimulus and surround are similar but not when they differ. The underlying mechanisms remain unclear. Here, we use optical recordings, manipulations, and computational modeling to show that disinhibitory circuits consisting of vasoactive intestinal peptide (VIP)-expressing and somatostatin (SOM)-expressing inhibitory neurons modulate responses in mouse visual cortex depending on similarity between stimulus and surround, primarily by modulating recurrent excitation. When stimulus and surround are similar, VIP neurons are inactive, and activity of SOM neurons leads to suppression of excitatory neurons. However, when stimulus and surround differ, VIP neurons are active, inhibiting SOM neurons, which leads to relief of excitatory neurons from suppression. We have identified a canonical cortical disinhibitory circuit that contributes to contextual modulation and may regulate perceptual saliency.
    MeSH term(s) Animals ; Calcium/metabolism ; Mice ; Models, Neurological ; Neural Inhibition/physiology ; Neurons/metabolism ; Photic Stimulation ; Somatostatin/metabolism ; Vasoactive Intestinal Peptide/metabolism ; Visual Cortex/metabolism ; Visual Cortex/physiology ; Visual Pathways/metabolism ; Visual Pathways/physiology ; Visual Perception/physiology
    Chemical Substances Vasoactive Intestinal Peptide (37221-79-7) ; Somatostatin (51110-01-1) ; Calcium (SY7Q814VUP)
    Language English
    Publishing date 2020-12-09
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S.
    ZDB-ID 808167-0
    ISSN 1097-4199 ; 0896-6273
    ISSN (online) 1097-4199
    ISSN 0896-6273
    DOI 10.1016/j.neuron.2020.11.013
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2496: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
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    Zs.MG 92: Show issues

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  5. Article ; Online: Electrophysiological properties of isthmic neurons in frogs revealed by in vitro and in vivo studies.

    Caudill, Matthew S / Eggebrecht, Adam T / Gruberg, Edward R / Wessel, Ralf

    Journal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiology

    2010  Volume 196, Issue 4, Page(s) 249–262

    Abstract: The frog nucleus isthmi (parabigeminal nucleus in mammals) is a visually responsive, cholinergic and anatomically well-defined group of neurons in the midbrain. It shares reciprocal topographic projections with the ipsilateral optic tectum (superior ... ...

    Abstract The frog nucleus isthmi (parabigeminal nucleus in mammals) is a visually responsive, cholinergic and anatomically well-defined group of neurons in the midbrain. It shares reciprocal topographic projections with the ipsilateral optic tectum (superior colliculus in mammals) and strongly influences visual processing. Anatomical and biochemical information indicates the existence of distinct neural populations within the frog nucleus isthmi, which raises the question: are there electrophysiological distinctions between neurons that are putatively classified by their anatomical and biochemical properties? To address this question, we measured frog nucleus isthmi neuron cellular properties in vitro and visual response properties in vivo. No evidence for distinct electrophysiological classes of neurons was found. We thus conclude that, despite the anatomical and biochemical differences, the cells of the frog nucleus isthmi respond homogeneously to both current injections and simple visual stimuli.
    MeSH term(s) Animals ; Electrophysiological Phenomena/physiology ; Patch-Clamp Techniques ; Photic Stimulation ; Rana pipiens/physiology ; Sensory Receptor Cells/physiology ; Synaptic Transmission/physiology ; Visual Pathways/physiology
    Language English
    Publishing date 2010-02-24
    Publishing country Germany
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 120907-3
    ISSN 1432-1351 ; 0302-9824 ; 0373-0859 ; 0340-7594
    ISSN (online) 1432-1351
    ISSN 0302-9824 ; 0373-0859 ; 0340-7594
    DOI 10.1007/s00359-010-0511-y
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    Uc I Zs.170: Show issues Location:
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  6. Article ; Online: Intricate phase diagram of a prevalent visual circuit reveals universal dynamics, phase transitions, and resonances.

    Caudill, Matthew S / Brandt, Sebastian F / Nussinov, Zohar / Wessel, Ralf

    Physical review. E, Statistical, nonlinear, and soft matter physics

    2009  Volume 80, Issue 5 Pt 1, Page(s) 51923

    Abstract: Neural feedback-triads consisting of two feedback loops with a nonreciprocal lateral connection from one loop to the other are ubiquitous in the brain. We show analytically that the dynamics of this network topology are determined by algebraic ... ...

    Abstract Neural feedback-triads consisting of two feedback loops with a nonreciprocal lateral connection from one loop to the other are ubiquitous in the brain. We show analytically that the dynamics of this network topology are determined by algebraic combinations of its five synaptic weights. Exploration of network activity over the parameter space demonstrates the importance of the nonreciprocal lateral connection and reveals intricate behavior involving continuous transitions between qualitatively different activity states. In addition, we show that the response to periodic inputs is narrowly tuned around a center frequency determined by the effective synaptic parameters.
    MeSH term(s) Animals ; Computer Simulation ; Humans ; Models, Neurological ; Nerve Net/physiology ; Synaptic Transmission/physiology ; Visual Cortex/physiology ; Visual Pathways/physiology ; Visual Perception/physiology
    Language English
    Publishing date 2009-11-25
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ISSN 1550-2376
    ISSN (online) 1550-2376
    DOI 10.1103/PhysRevE.80.051923
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  7. Article: Electrophysiological properties of isthmic neurons in frogs revealed by in vitro and in vivo studies

    Caudill, Matthew S / Eggebrecht, Adam T / Gruberg, Edward R / Wessel, Ralf

    Journal of comparative physiology. A, Sensory, neural, and behavioral physiology. 2010 Apr., v. 196, no. 4

    2010  

    Abstract: The frog nucleus isthmi (parabigeminal nucleus in mammals) is a visually responsive, cholinergic and anatomically well-defined group of neurons in the midbrain. It shares reciprocal topographic projections with the ipsilateral optic tectum (superior ... ...

    Abstract The frog nucleus isthmi (parabigeminal nucleus in mammals) is a visually responsive, cholinergic and anatomically well-defined group of neurons in the midbrain. It shares reciprocal topographic projections with the ipsilateral optic tectum (superior colliculus in mammals) and strongly influences visual processing. Anatomical and biochemical information indicates the existence of distinct neural populations within the frog nucleus isthmi, which raises the question: are there electrophysiological distinctions between neurons that are putatively classified by their anatomical and biochemical properties? To address this question, we measured frog nucleus isthmi neuron cellular properties in vitro and visual response properties in vivo. No evidence for distinct electrophysiological classes of neurons was found. We thus conclude that, despite the anatomical and biochemical differences, the cells of the frog nucleus isthmi respond homogeneously to both current injections and simple visual stimuli.
    Language English
    Dates of publication 2010-04
    Size p. 249-262.
    Publisher Springer-Verlag
    Publishing place Berlin/Heidelberg
    Document type Article
    ZDB-ID 231244-x
    ISSN 1432-1351 ; 0340-7594
    ISSN (online) 1432-1351
    ISSN 0340-7594
    DOI 10.1007/s00359-010-0511-y
    Database NAL-Catalogue (AGRICOLA)

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    In stock of ZB MED Bonn / Germany

    Z 46/353: Show issues

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