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  1. Article ; Online: Folliculitis decalvans and dystrophic epidermolysis bullosa: a significant association.

    Matard, Bruno / Bourrat, Emmanuelle / Cavalié, Marine / Chiaverini, Christine / Reygagne, Pascal

    The British journal of dermatology

    2022  Volume 187, Issue 6, Page(s) 1026–1028

    Abstract: This work reports 30 cases of folliculitis decalvans (FD) in patients with dystrophic epidermolysis bullosa (DEB) among a cohort of 125 DEB patients seen between 2010 and 2021 in 2 French expert centers for the management of inherited epidermolysis ... ...

    Abstract This work reports 30 cases of folliculitis decalvans (FD) in patients with dystrophic epidermolysis bullosa (DEB) among a cohort of 125 DEB patients seen between 2010 and 2021 in 2 French expert centers for the management of inherited epidermolysis bullosa. Such an association between two rare diseases cannot be fortuitous and implies a physiopathological link that we discuss in this paper. This association is a new significant fact to add to the reflexion on FD causes, suggesting that skin abnormality of DEB could act as a factor of a specific skin barrier alteration which could favor FD. Scarring alopecia with tufted folliculitis and pustules on inflamed skin at the vertex of a woman with dominant dystrophic epidermolysis bullosa.
    MeSH term(s) Female ; Humans ; Epidermolysis Bullosa Dystrophica/complications ; Epidermolysis Bullosa Dystrophica/pathology ; Alopecia/etiology ; Alopecia/pathology ; Skin/pathology ; Folliculitis/complications ; Epidermolysis Bullosa/pathology
    Language English
    Publishing date 2022-09-06
    Publishing country England
    Document type Letter
    ZDB-ID 80076-4
    ISSN 1365-2133 ; 0007-0963
    ISSN (online) 1365-2133
    ISSN 0007-0963
    DOI 10.1111/bjd.21796
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Treatment of keloids with laser-assisted topical steroid delivery: a retrospective study of 23 cases.

    Cavalié, Marine / Sillard, Laura / Montaudié, Henri / Bahadoran, Philippe / Lacour, Jean-Philippe / Passeron, Thierry

    Dermatologic therapy

    2015  Volume 28, Issue 2, Page(s) 74–78

    Abstract: Topical or intralesional corticosteroids are referred to as gold standard treatments for keloids. Recent studies showed that ablative fractional laser (AFL) treatment facilitates delivery of topical drug deeply into the skin by creating vertical channels. ...

    Abstract Topical or intralesional corticosteroids are referred to as gold standard treatments for keloids. Recent studies showed that ablative fractional laser (AFL) treatment facilitates delivery of topical drug deeply into the skin by creating vertical channels. The objective of the present study was to assess the ablative erbium laser in fractionated mode, combined with topical high potent corticosteroid cream for treating resistant keloid scars. We conducted a retrospective study in the laser center of the Department of Dermatology (University Hospital of Nice, France), from January 2010 to June 2012, on patients with keloids who were resistant to a first-line of treatment. A 2940-nm ablative fractional erbium laser was used. Topical betamethasone cream was applied twice a day under occlusion with transparent film dressings. A total of 23 patients with 70 keloids were treated from January 2010 to June 2012. The median percentage of improvement was 50% (range -43 to 84). The mean follow-up was 8 months (range 3-18), and a recurrence was observed for eight lesions (22%). Although this observation warrants a prospective comparative evaluation, it supports the interest of the laser-assisted delivery of steroids for treating keloids scars.
    MeSH term(s) Administration, Cutaneous ; Adolescent ; Adult ; Betamethasone/administration & dosage ; Child ; Drug Delivery Systems/instrumentation ; Female ; France ; Glucocorticoids/administration & dosage ; Hospitals, University ; Humans ; Keloid/diagnosis ; Keloid/drug therapy ; Lasers, Solid-State ; Male ; Middle Aged ; Recurrence ; Retrospective Studies ; Skin/drug effects ; Skin/pathology ; Time Factors ; Treatment Outcome ; Young Adult
    Chemical Substances Glucocorticoids ; Betamethasone (9842X06Q6M)
    Language English
    Publishing date 2015-03
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1354801-3
    ISSN 1529-8019 ; 1396-0296
    ISSN (online) 1529-8019
    ISSN 1396-0296
    DOI 10.1111/dth.12187
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  3. Article ; Online: Maintenance therapy of adult vitiligo with 0.1% tacrolimus ointment: a randomized, double blind, placebo-controlled study.

    Cavalié, Marine / Ezzedine, Khaled / Fontas, Eric / Montaudié, Henri / Castela, Emeline / Bahadoran, Philippe / Taïeb, Alain / Lacour, Jean-Philippe / Passeron, Thierry

    The Journal of investigative dermatology

    2015  Volume 135, Issue 4, Page(s) 970–974

    Abstract: The risk of relapse after successful repigmentation in vitiligo is estimated to 40% within the first year. It has been shown in atopic dermatitis that continuous low-level use of topical corticosteroids and calcineurin inhibitors in previously affected ... ...

    Abstract The risk of relapse after successful repigmentation in vitiligo is estimated to 40% within the first year. It has been shown in atopic dermatitis that continuous low-level use of topical corticosteroids and calcineurin inhibitors in previously affected skin can prevent new flares. We hypothesized that a twice-weekly application of 0.1% tacrolimus ointment might be effective for maintaining repigmentation in therapeutically repigmented lesions of vitiligo patients. After randomization, sixteen patients with 31 patches were assigned to the placebo group and 19 patients with 41 patches were assigned to the tacrolimus group. In the intention-to-treat analysis, 48.4% of lesions showed depigmentation in the placebo group, whereas 26.8% did in the tacrolimus group (P=0.059). The intention-to-treat results did not remain significant after adjustment for within-patient clustering, odds ratio (OR) 2.55; 95% confidence interval (CI; 0.65-9.97); P=0.1765. The per-protocol analysis (n=56) showed that 40% of lesions had some depigmentation in the placebo group, whereas only 9.7% did in the tacrolimus group (P=0.0075). The per-protocol results remained significant after adjustment for within-patient clustering: OR 6.22; 95% CI (1.48-26.12); P=0.0299. Our study shows that twice-weekly application of 0.1% tacrolimus ointment is effective in preventing the depigmentation of vitiligo patches that have been previously successfully repigmented.
    MeSH term(s) Administration, Topical ; Adult ; Calcineurin Inhibitors/therapeutic use ; Cluster Analysis ; Dermatologic Agents/therapeutic use ; Double-Blind Method ; Female ; Humans ; Immunosuppressive Agents/therapeutic use ; Male ; Middle Aged ; Odds Ratio ; Pigmentation ; Quality of Life ; Recurrence ; Skin/drug effects ; Tacrolimus/therapeutic use ; Treatment Outcome ; Vitiligo/drug therapy ; Vitiligo/psychology
    Chemical Substances Calcineurin Inhibitors ; Dermatologic Agents ; Immunosuppressive Agents ; Tacrolimus (WM0HAQ4WNM)
    Language English
    Publishing date 2015-04
    Publishing country United States
    Document type Journal Article ; Randomized Controlled Trial ; Research Support, Non-U.S. Gov't
    ZDB-ID 80136-7
    ISSN 1523-1747 ; 0022-202X
    ISSN (online) 1523-1747
    ISSN 0022-202X
    DOI 10.1038/jid.2014.527
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  4. Article ; Online: Reflectance confocal microscopy features of Degos disease.

    Cavalié, Marine / Tsilika, Katerina / Sillard, Laura / Cardot-Leccia, Nathalie / Passeron, Thierry / Lacour, Jean-Philippe / Bahadoran, Philippe

    JAMA dermatology

    2014  Volume 150, Issue 1, Page(s) 96–97

    MeSH term(s) Dermoscopy/methods ; Humans ; Male ; Malignant Atrophic Papulosis/diagnosis ; Malignant Atrophic Papulosis/pathology ; Microscopy, Confocal/methods ; Middle Aged ; Skin/pathology
    Language English
    Publishing date 2014-01
    Publishing country United States
    Document type Case Reports ; Journal Article
    ZDB-ID 2701761-8
    ISSN 2168-6084 ; 2168-6068
    ISSN (online) 2168-6084
    ISSN 2168-6068
    DOI 10.1001/jamadermatol.2013.4662
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  5. Article ; Online: An explosive reaction to a spider-bite.

    Martis, Nihal / Denis, Eric / Cavalie, Marine / Queyrel, Viviane / Risso, Karine / De Salvador, Francine / Roger, Pierre-Marie

    Presse medicale (Paris, France : 1983)

    2014  Volume 43, Issue 4 Pt 1, Page(s) 469–471

    MeSH term(s) Acute Kidney Injury/etiology ; Aged ; Hand Injuries/complications ; Humans ; Male ; Myalgia/etiology ; Myositis/etiology ; Parapsoriasis/etiology ; Polyarteritis Nodosa/etiology ; Spider Bites/complications
    Language English
    Publishing date 2014-04
    Publishing country France
    Document type Case Reports ; Letter
    ZDB-ID 120943-7
    ISSN 2213-0276 ; 0032-7867 ; 0755-4982 ; 0301-1518
    ISSN (online) 2213-0276
    ISSN 0032-7867 ; 0755-4982 ; 0301-1518
    DOI 10.1016/j.lpm.2013.07.028
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  6. Article ; Online: Transcriptional Analysis of Vitiligo Skin Reveals the Alteration of WNT Pathway: A Promising Target for Repigmenting Vitiligo Patients.

    Regazzetti, Claire / Joly, Florence / Marty, Carine / Rivier, Michel / Mehul, Bruno / Reiniche, Pascale / Mounier, Carine / Rival, Yves / Piwnica, David / Cavalié, Marine / Chignon-Sicard, Bérengère / Ballotti, Robert / Voegel, Johannes / Passeron, Thierry

    The Journal of investigative dermatology

    2015  Volume 135, Issue 12, Page(s) 3105–3114

    Abstract: Vitiligo affects 1% of the worldwide population. Halting disease progression and repigmenting the lesional skin represent the two faces of therapeutic challenge in vitiligo. We performed transcriptome analysis on lesional, perilesional, and non- ... ...

    Abstract Vitiligo affects 1% of the worldwide population. Halting disease progression and repigmenting the lesional skin represent the two faces of therapeutic challenge in vitiligo. We performed transcriptome analysis on lesional, perilesional, and non-depigmented skin from vitiligo patients and on matched skin from healthy subjects. We found a significant increase in CXCL10 in non-depigmented and perilesional vitiligo skin compared with levels in healthy control skin; however, neither CXCL10 nor other immune factors were deregulated in depigmented vitiligo skin. Interestingly, the WNT pathway, which is involved in melanocyte differentiation, was altered specifically in vitiligo skin. We demonstrated that oxidative stress decreases WNT expression/activation in keratinocytes and melanocytes. We developed an ex vivo skin model and confirmed the decrease activation of the WNT pathway in human skin subjected to oxidative stress. Finally, using pharmacological agents that activate the WNT pathway, we treated ex vivo depigmented skin from vitiligo patients and successfully induced differentiation of resident stem cells into pre-melanocytes. Our results shed light on the previously unrecognized role of decreased WNT activation in the prevention of melanocyte differentiation in depigmented vitiligo skin. Furthermore, these results support further clinical exploration of WNT agonists to repigment vitiligo lesions.
    MeSH term(s) Chemokine CXCL10/analysis ; Gene Expression Profiling ; Humans ; Lymphoid Enhancer-Binding Factor 1/physiology ; Oxidative Stress ; Skin/metabolism ; Skin Pigmentation ; Vitiligo/etiology ; Vitiligo/physiopathology ; Wnt Signaling Pathway
    Chemical Substances CXCL10 protein, human ; Chemokine CXCL10 ; LEF1 protein, human ; Lymphoid Enhancer-Binding Factor 1
    Language English
    Publishing date 2015-12
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 80136-7
    ISSN 1523-1747 ; 0022-202X
    ISSN (online) 1523-1747
    ISSN 0022-202X
    DOI 10.1038/jid.2015.335
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