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  1. Article ; Online: Valproate, risperidone, and paliperidone: A case of valproate-induced hyperammonemic encephalopathy.

    Wesselman, Kyle / Cavaliere, Vincent / Goyal, Rakesh / Anderson, Eric

    The mental health clinician

    2024  Volume 14, Issue 1, Page(s) 28–32

    Abstract: Hyperammonemia is a well-known adverse effect of valproate that can progress to a potentially fatal condition known as valproate-induced hyperammonemic encephalopathy (VHE). VHE is more common when valproate is used in combination therapy with other ... ...

    Abstract Hyperammonemia is a well-known adverse effect of valproate that can progress to a potentially fatal condition known as valproate-induced hyperammonemic encephalopathy (VHE). VHE is more common when valproate is used in combination therapy with other antiepileptic medications. A growing number of case reports have pointed to a possible interaction with the antipsychotic risperidone leading to an increased risk of VHE. We present a case of VHE in which a 20-year-old male patient with bipolar affective disorder developed VHE when on concomitant valproate, risperidone, and paliperidone palmitate. On the seventh day of treatment with oral risperidone, oral divalproex sodium was added. Intramuscular paliperidone palmitate was initiated on day 13, and oral risperidone was discontinued after the second loading dose on day 16. The following day, the patient displayed worsening psychomotor retardation, swaying gait, drowsiness, and vomiting. The patient was found to have hyperammonemia and transferred to the emergency department for treatment of suspected VHE.
    Language English
    Publishing date 2024-02-01
    Publishing country United States
    Document type Case Reports
    ISSN 2168-9709
    ISSN (online) 2168-9709
    DOI 10.9740/mhc.2024.02.028
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Effect of aminergic signaling on the humoral innate immunity response of

    Cattabriga, Giulia / Giordani, Giorgia / Gargiulo, Giuseppe / Cavaliere, Valeria

    Frontiers in physiology

    2023  Volume 14, Page(s) 1249205

    Abstract: Biogenic amines are crucial signaling molecules that modulate various physiological life functions both in vertebrates and invertebrates. In humans, these neurotransmitters influence the innate and adaptive immunity systems. In this work, we analyzed ... ...

    Abstract Biogenic amines are crucial signaling molecules that modulate various physiological life functions both in vertebrates and invertebrates. In humans, these neurotransmitters influence the innate and adaptive immunity systems. In this work, we analyzed whether the aminergic neurotransmission of dopamine, serotonin, and octopamine could have an impact on the humoral innate immune response of
    Language English
    Publishing date 2023-08-24
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2564217-0
    ISSN 1664-042X
    ISSN 1664-042X
    DOI 10.3389/fphys.2023.1249205
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Silencing of Euchromatic Transposable Elements as a Consequence of Nuclear Lamina Dysfunction.

    Cavaliere, Valeria / Lattanzi, Giovanna / Andrenacci, Davide

    Cells

    2020  Volume 9, Issue 3

    Abstract: Transposable elements (TEs) are mobile genomic sequences that are normally repressed to avoid proliferation and genome instability. Gene silencing mechanisms repress TEs by RNA degradation or heterochromatin formation. Heterochromatin maintenance is ... ...

    Abstract Transposable elements (TEs) are mobile genomic sequences that are normally repressed to avoid proliferation and genome instability. Gene silencing mechanisms repress TEs by RNA degradation or heterochromatin formation. Heterochromatin maintenance is therefore important to keep TEs silent. Loss of heterochromatic domains has been linked to lamin mutations, which have also been associated with derepression of TEs. In fact, lamins are structural components of the nuclear lamina (NL), which is considered a pivotal structure in the maintenance of heterochromatin domains at the nuclear periphery in a silent state. Here, we show that a lethal phenotype associated with
    MeSH term(s) Animals ; DNA Transposable Elements/genetics ; DNA Transposable Elements/physiology ; Drosophila ; Drosophila melanogaster/metabolism ; Genomic Instability/genetics ; Genomics/methods ; Heterochromatin/metabolism ; Lamins/genetics ; Lamins/metabolism ; Nuclear Lamina/metabolism ; Retroelements/physiology
    Chemical Substances DNA Transposable Elements ; Heterochromatin ; Lamins ; Retroelements
    Language English
    Publishing date 2020-03-05
    Publishing country Switzerland
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2661518-6
    ISSN 2073-4409 ; 2073-4409
    ISSN (online) 2073-4409
    ISSN 2073-4409
    DOI 10.3390/cells9030625
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Retrotransposons Down- and Up-Regulation in Aging Somatic Tissues.

    Giordani, Giorgia / Cavaliere, Valeria / Gargiulo, Giuseppe / Lattanzi, Giovanna / Andrenacci, Davide

    Cells

    2021  Volume 11, Issue 1

    Abstract: The transposon theory of aging hypothesizes the activation of transposable elements (TEs) in somatic tissues with age, leading to a shortening of the lifespan. It is thought that TE activation in aging produces an increase in DNA double-strand breaks, ... ...

    Abstract The transposon theory of aging hypothesizes the activation of transposable elements (TEs) in somatic tissues with age, leading to a shortening of the lifespan. It is thought that TE activation in aging produces an increase in DNA double-strand breaks, contributing to genome instability and promoting the activation of inflammatory responses. To investigate how TE regulation changes in somatic tissues during aging, we analyzed the expression of some TEs, as well as a source of small RNAs that specifically silence the analyzed TEs; the
    MeSH term(s) Aging/genetics ; Animals ; Down-Regulation/genetics ; Drosophila melanogaster/genetics ; Retroelements/genetics ; Up-Regulation/genetics
    Chemical Substances Retroelements
    Language English
    Publishing date 2021-12-28
    Publishing country Switzerland
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2661518-6
    ISSN 2073-4409 ; 2073-4409
    ISSN (online) 2073-4409
    ISSN 2073-4409
    DOI 10.3390/cells11010079
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: The role of transposable elements activity in aging and their possible involvement in laminopathic diseases.

    Andrenacci, Davide / Cavaliere, Valeria / Lattanzi, Giovanna

    Ageing research reviews

    2019  Volume 57, Page(s) 100995

    Abstract: Eukaryotic genomes contain a large number of transposable elements, part of which are still active and able to transpose in the host genome. Mobile element activation is repressed to avoid deleterious effects, such as gene mutations or chromosome ... ...

    Abstract Eukaryotic genomes contain a large number of transposable elements, part of which are still active and able to transpose in the host genome. Mobile element activation is repressed to avoid deleterious effects, such as gene mutations or chromosome rearrangements. Control of transposable elements includes a variety of mechanisms comprising silencing pathways, which are based on the production of small non-coding RNAs. Silencing can occur either through transposable element RNA degradation or through the targeting of DNA sequences by heterochromatin formation and consequent transcriptional inhibition. Since the important role of the heterochromatin silencing, the gradual loss of heterochromatin marks in constitutive heterochromatin regions during the aging process promotes derepression of transposable elements, which is considered a cause of the progressive increase in genomic instability and of the activation of inflammatory responses. This review provides an overview of the effects of heterochromatin loss on the activity of transposable elements during the aging process and the possible impact on genome function. In this context, we discuss the possible role of the nuclear lamina, a major player in heterochromatin dynamics, in the regulation of transposable element activity and potential implications in laminopathic diseases.
    MeSH term(s) Aging ; Animals ; DNA Damage ; DNA Transposable Elements ; Genomic Instability ; Heterochromatin ; Humans ; Inflammation ; Lamins
    Chemical Substances DNA Transposable Elements ; Heterochromatin ; Lamins
    Language English
    Publishing date 2019-11-28
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 2075672-0
    ISSN 1872-9649 ; 1568-1637
    ISSN (online) 1872-9649
    ISSN 1568-1637
    DOI 10.1016/j.arr.2019.100995
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5579: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  6. Article ; Online: Role of neuronal and non-neuronal acetylcholine signaling in Drosophila humoral immunity.

    Giordani, Giorgia / Cattabriga, Giulia / Becchimanzi, Andrea / Di Lelio, Ilaria / De Leva, Giovanna / Gigliotti, Silvia / Pennacchio, Francesco / Gargiulo, Giuseppe / Cavaliere, Valeria

    Insect biochemistry and molecular biology

    2022  Volume 153, Page(s) 103899

    Abstract: Acetylcholine (ACh) is one the major neurotransmitters in insects, whose role in mediating synaptic interactions between neurons in the central nervous system is well characterized. It also plays largely unexplored regulatory functions in non-neuronal ... ...

    Abstract Acetylcholine (ACh) is one the major neurotransmitters in insects, whose role in mediating synaptic interactions between neurons in the central nervous system is well characterized. It also plays largely unexplored regulatory functions in non-neuronal tissues. Here we demonstrate that ACh signaling is involved in the modulation of the innate immune response of Drosophila melanogaster. Knockdown of ACh synthesis or ACh vesicular transport in neurons reduced the activation of drosomycin (drs), a gene encoding an antimicrobial peptide, in adult flies infected with a Gram-positive bacterium. drs transcription was similarly affected in Drosophila α7 nicotinic acetylcholine receptor, nAChRalpha7 (Dα7) mutants, as well as in flies expressing in the nervous system a dominant negative form (Dα7
    MeSH term(s) Animals ; Acetylcholine ; Drosophila/metabolism ; Drosophila melanogaster/metabolism ; Immunity, Humoral ; Neurons/metabolism ; Receptors, Nicotinic/genetics
    Chemical Substances Acetylcholine (N9YNS0M02X) ; Receptors, Nicotinic
    Language English
    Publishing date 2022-12-31
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1483248-3
    ISSN 1879-0240 ; 0965-1748
    ISSN (online) 1879-0240
    ISSN 0965-1748
    DOI 10.1016/j.ibmb.2022.103899
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article: Vps28 Is Involved in the Intracellular Trafficking of Awd, the

    Mezzofanti, Elisa / Ignesti, Marilena / Hsu, Tien / Gargiulo, Giuseppe / Cavaliere, Valeria

    Frontiers in physiology

    2019  Volume 10, Page(s) 983

    Abstract: ... ...

    Abstract The
    Language English
    Publishing date 2019-08-02
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2564217-0
    ISSN 1664-042X
    ISSN 1664-042X
    DOI 10.3389/fphys.2019.00983
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  8. Article: Comparative Expression Profiling of Wild Type

    Ignesti, Marilena / Andrenacci, Davide / Fischer, Bettina / Cavaliere, Valeria / Gargiulo, Giuseppe

    Frontiers in physiology

    2019  Volume 10, Page(s) 619

    Language English
    Publishing date 2019-05-21
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2564217-0
    ISSN 1664-042X
    ISSN 1664-042X
    DOI 10.3389/fphys.2019.00619
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article: Knowledge sharing in manufacturing firms

    Cavaliere, Vincenzo / Lombardi, Sara

    Il ruolo dell'azienda nell'economia : esiste un modello aziendale orientato alla crescita? , p. 323-335

    interaction terms shaping employees' orientation in exchanging information

    2015  , Page(s) 323–335

    Author's details Vincenzo Cavaliere e Sara Lombardi
    Language English
    Size graph. Darst.
    Publisher Il mulino
    Publishing place Bologna
    Document type Article
    ISBN 978-88-15-25462-7 ; 88-15-25462-5
    Database ECONomics Information System

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  10. Article: Exploring different cultural configurations

    Cavaliere, Vincenzo / Lombardi, Sara

    Journal of knowledge management Vol. 19, No. 2 , p. 141-163

    how do they affect subsidiaries' knowledge sharing behaviors?

    2015  Volume 19, Issue 2, Page(s) 141–163

    Author's details Vincenzo Cavaliere and Sara Lombardi
    Keywords Top management support ; Knowledge sharing ; Organizational culture ; Subsidiaries ; Multinational companies
    Language English
    Size graph. Darst.
    Publisher Emerald Group Publ. Ltd
    Publishing place Bingley
    Document type Article
    ZDB-ID 1495109-5 ; 2009195-3
    ISSN 1367-3270
    ISSN 1367-3270
    Database ECONomics Information System

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