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  1. Article ; Online: Exceptional case of aortic atresia associated with atypical double aortic arch.

    Krokovay, Anna / Cavigelli-Brunner, Anna / Kretschmar, Oliver / Cesnjevar, Robert

    Interdisciplinary cardiovascular and thoracic surgery

    2023  Volume 36, Issue 4

    Abstract: We present the unique case of atretic aortic valve associated with hypoplastic ascending aorta and double aortic arch of unusual configuration supplying retrograde blood flow to the coronary arteries. ...

    Abstract We present the unique case of atretic aortic valve associated with hypoplastic ascending aorta and double aortic arch of unusual configuration supplying retrograde blood flow to the coronary arteries.
    Language English
    Publishing date 2023-03-21
    Publishing country England
    Document type Journal Article
    ISSN 2753-670X
    ISSN (online) 2753-670X
    DOI 10.1093/icvts/ivad047
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Antiarrhythmic Medication in Neonates and Infants with Supraventricular Tachycardia.

    Bruder, Diana / Weber, Roland / Gass, Matthias / Balmer, Christian / Cavigelli-Brunner, Anna

    Pediatric cardiology

    2022  Volume 43, Issue 6, Page(s) 1311–1318

    Abstract: Supraventricular tachycardia (SVT) is the most common arrhythmia in neonates and infants, and pharmacological therapy is recommended to prevent recurrent episodes. This retrospective study aims to describe and analyze the practice patterns, effectiveness, ...

    Abstract Supraventricular tachycardia (SVT) is the most common arrhythmia in neonates and infants, and pharmacological therapy is recommended to prevent recurrent episodes. This retrospective study aims to describe and analyze the practice patterns, effectiveness, and outcome of drug therapy for SVT in patients within the first year of life. Among the 67 patients analyzed, 48 presented with atrioventricular re-entrant tachycardia, 18 with focal atrial, and one with atrioventricular nodal re-entrant. Fetal tachycardia was reported in 27%. Antiarrhythmic treatment consisted of beta-receptor blocking agents in 42 patients, propafenone in 20, amiodarone in 20, and digoxin in 5. Arrhythmia control was achieved with single drug therapy in 70% of the patients, 21% needed dual therapy, and 6% triple. Propafenone was discontinued in 7 infants due to widening of the QRS complex. After 12 months (6-60), 75% of surviving patients were tachycardia-free and discontinued prophylactic treatment. Patients with fetal tachycardia had a significantly higher risk of persistent tachycardia (p: 0.007). Prophylactic antiarrhythmic medication for SVT in infancy is safe and well tolerated. Arrhythmia control is often achieved with single medication, and after cessation, most patients are free of arrhythmias. Infants with SVT and a history of fetal tachycardia are more prone to suffer from persistent SVT and relapses after cessation of prophylactic antiarrhythmic medication than infants with the first episode of SVT after birth.
    MeSH term(s) Adrenergic beta-Antagonists/therapeutic use ; Anti-Arrhythmia Agents/adverse effects ; Digoxin/therapeutic use ; Humans ; Infant ; Infant, Newborn ; Propafenone/therapeutic use ; Retrospective Studies ; Tachycardia, Supraventricular/drug therapy
    Chemical Substances Adrenergic beta-Antagonists ; Anti-Arrhythmia Agents ; Propafenone (68IQX3T69U) ; Digoxin (73K4184T59)
    Language English
    Publishing date 2022-03-08
    Publishing country United States
    Document type Journal Article
    ZDB-ID 800857-7
    ISSN 1432-1971 ; 0172-0643
    ISSN (online) 1432-1971
    ISSN 0172-0643
    DOI 10.1007/s00246-022-02853-9
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Prognostic value of troponin in infants with hypoplastic left heart syndrome between Stage I and II of palliation.

    Christmann, Martin / Valsangiacomo Büchel, Emanuela R / Dave, Hitendu / Klauwer, Dietrich / Cavigelli-Brunner, Anna

    Annals of pediatric cardiology

    2018  Volume 11, Issue 1, Page(s) 56–59

    Abstract: Background: The period between stage I and II procedure for treatment of hypoplastic left heart syndrome (HLHS) bears high mortality and morbidity.: Methods: We sought to analyze the prognostic value of Troponin T/I (Trop), a well-recognized marker ... ...

    Abstract Background: The period between stage I and II procedure for treatment of hypoplastic left heart syndrome (HLHS) bears high mortality and morbidity.
    Methods: We sought to analyze the prognostic value of Troponin T/I (Trop), a well-recognized marker for myocardial damage and heart failure, for predicting outcome in a retrospective analysis of 70 infants with HLHS at our institution between March 2001 and October 2014.
    Results: Stage I procedure consisted of Norwood I operation in 35 (50%) and Hybrid-approach in 22 (31%) patients. Palliative care was chosen for 13 (19%) patients. Trop values were collected from clinical charts and were analyzed in relation to the overall outcome. Trop was significantly higher after Norwood I operation in comparison to Hybrid-approach (median 7.1 μg/l (0.7-20.9), vs 1.2 μg/l (0.3-17.9),
    Conclusions: Patients with HLHS have significantly higher Trop levels after Norwood procedure than after Hybrid-approach. Maximal Trop values were related to mortality, but did not correlate with the need for reinterventions.
    Language English
    Publishing date 2018-01-31
    Publishing country India
    Document type Journal Article
    ZDB-ID 2430956-4
    ISSN 0974-5149 ; 0974-2069
    ISSN (online) 0974-5149
    ISSN 0974-2069
    DOI 10.4103/apc.APC_113_17
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Multimodality imaging in rare congenital heart disease: unilaterally absent proximal pulmonary artery in a newborn.

    Cavigelli-Brunner, Anna / Quandt, Daniel / Marcora, Simona / Valsangiacomo Büchel, Emanuela Regina

    European heart journal

    2017  Volume 39, Issue 12, Page(s) 1039–1040

    MeSH term(s) Diagnosis, Differential ; Echocardiography/methods ; Heart Defects, Congenital/diagnosis ; Humans ; Infant, Newborn ; Magnetic Resonance Angiography/methods ; Male ; Multimodal Imaging ; Pulmonary Artery/abnormalities ; Pulmonary Artery/diagnostic imaging ; Reproducibility of Results
    Language English
    Publishing date 2017-12-22
    Publishing country England
    Document type Journal Article
    ZDB-ID 603098-1
    ISSN 1522-9645 ; 0195-668X
    ISSN (online) 1522-9645
    ISSN 0195-668X
    DOI 10.1093/eurheartj/ehx712
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Biventricular intracorporeal ventricular assist device in a 10-year-old child.

    Schweiger, Martin / Krüger, Barnard / Cavigelli-Brunner, Anna / Dave, Hitendu / Schmiady, Martin / Hübler, Michael

    The International journal of artificial organs

    2016  Volume 39, Issue 1, Page(s) 48–50

    Abstract: Purpose: The pediatric population has benefited greatly by the evolution of ventricular assist devices (VADs) leading to miniaturization. Device design like the HeartWare® VAD allows for implantation in smaller patients or even as an implantable ... ...

    Abstract Purpose: The pediatric population has benefited greatly by the evolution of ventricular assist devices (VADs) leading to miniaturization. Device design like the HeartWare® VAD allows for implantation in smaller patients or even as an implantable biventricular assist device.
    Case report: A ten-year-old female patient (body surface area: 1.02 m2, 27 kg) waiting for 7 months for heart transplantation was admitted to the intensive care unit due to terminal heart failure. Transthoracal echocardiography revealed heart failure with an estimated ejection fraction of 15%, dilated left ventricle, moderate tricuspid and mitral regurgitation. Despite maximal medical therapy (including milrinone and 1 course of Levosimendan intravenous), her condition further worsened and mechanical circulatory support was indicated.After implantation of a HeartWare HVAD® device as an LVAD, a second pump was implanted as a right VAD (RVAD). The sewing ring of the HVAD was attached to the lateral wall of the right atrium. The device was implanted so that the axis of the inflow cannula was pointing towards the tricuspid valve. The outflow graft was anastomosed to the pulmonary artery truncus; the outflow graft diameter was not narrowed. Anticoagulation with IV heparin was started 8 hours postoperatively with a target antifactor Xa level of 0.3 to 0.6 IU/ml. The patient was extubated after 26 hours and fully mobilized. BVAD settings were: 2,300 revolutions per minute, calculated flow: 3.2 liters per minute and 2.7 W for the left side and 2,080 revolutions per minute, calculated flow: 3.3 L per minute and 2.1 W for the right side.
    MeSH term(s) Child ; Female ; Heart Failure/surgery ; Heart Transplantation ; Heart-Assist Devices ; Humans
    Language English
    Publishing date 2016-01
    Publishing country Italy
    Document type Case Reports ; Journal Article
    ZDB-ID 80456-3
    ISSN 1724-6040 ; 0391-3988
    ISSN (online) 1724-6040
    ISSN 0391-3988
    DOI 10.5301/ijao.5000463
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: Hypoplastisches Linksherzsyndrom. Pathophysiologie, Symptome und therapeutische Optionen

    Cavigelli-Brunner, Anna / Balmer, Christian

    Pädiatrie

    2011  Volume 16, Issue 3, Page(s) 39

    Language German
    Document type Article
    ZDB-ID 1364646-1
    ISSN 1424-8468 ; 0004-2897
    Database Current Contents Medicine

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  7. Article: Extracorporeal membrane oxygenation support in pediatrics.

    Erdil, Tugba / Lemme, Frithjof / Konetzka, Alexander / Cavigelli-Brunner, Anna / Niesse, Oliver / Dave, Hitendu / Hasenclever, Peter / Hübler, Michael / Schweiger, Martin

    Annals of cardiothoracic surgery

    2018  Volume 8, Issue 1, Page(s) 109–115

    Abstract: Extracorporeal membrane oxygenation (ECMO) is a general term that describes the short- or long-term support of the heart and/or lungs in neonates, children and adults. Due to favorable results and a steady decline in absolute contraindications, its use ... ...

    Abstract Extracorporeal membrane oxygenation (ECMO) is a general term that describes the short- or long-term support of the heart and/or lungs in neonates, children and adults. Due to favorable results and a steady decline in absolute contraindications, its use is increasing worldwide. Indications in children differ from those in adults. The ECMO circuit as well as cannulation strategies also are individualized, considering their implications in children. The aim of this article is to review the clinical indications, different circuits, and cannulation strategies for ECMO. We also present our institutional experience with 92 pediatric ECMO patients (34 neonates, 58 pediatric) with the majority (80%) of veno-arterial placements between 2014 until 2018. We further to also highlight ECMO use in the setting of cardiac arrest [extracorporeal cardiopulmonary resuscitation (CPR) or eCPR].
    Language English
    Publishing date 2018-10-22
    Publishing country China
    Document type Editorial
    ZDB-ID 2713627-9
    ISSN 2304-1021 ; 2225-319X
    ISSN (online) 2304-1021
    ISSN 2225-319X
    DOI 10.21037/acs.2018.09.08
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article: Prevention of Low Cardiac Output Syndrome After Pediatric Cardiac Surgery: A Double-Blind Randomized Clinical Pilot Study Comparing Dobutamine and Milrinone.

    Cavigelli-Brunner, Anna / Hug, Maja I / Dave, Hitendu / Baenziger, Oskar / Buerki, Christoph / Bettex, Dominique / Cannizzaro, Vincenzo / Balmer, Christian

    Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies

    2018  Volume 19, Issue 7, Page(s) 619–625

    Abstract: Objectives: Dobutamine and milrinone are commonly used after open-heart surgery to prevent or treat low cardiac output syndrome. We sought to compare efficacy and safety of these drugs in pediatric patients.: Design: Prospective, single-center, ... ...

    Abstract Objectives: Dobutamine and milrinone are commonly used after open-heart surgery to prevent or treat low cardiac output syndrome. We sought to compare efficacy and safety of these drugs in pediatric patients.
    Design: Prospective, single-center, double-blinded, randomized clinical pilot study.
    Setting: Tertiary-care university children's hospital postoperative pediatric cardiac ICU.
    Patients: After written consent, 50 consecutive patients (age, 0.2-14.2 yr; median, 1.2 yr) undergoing open-heart surgery for congenital malformations were included.
    Interventions: After cardiopulmonary bypass, a continuous infusion of either dobutamine or milrinone was administered for the first 36 postoperative hours. Maximum dose: dobutamine 6 µg/kg/min, milrinone 0.75 µg/kg/min.
    Measurements and main results: There were no significant differences in demographic data, complexity of surgery, and intraoperative characteristics between the two study groups (dobutamine vs milrinone). Efficacy was defined as need for additional vasoactive support, which did not differ between groups (dobutamine 61% vs milrinone 67%; p = 0.71). Sodium nitroprusside was used more often in the dobutamine group (42% vs 13%; p = 0.019). Systolic blood pressure showed a trend toward higher values in the dobutamine group, whereas both drugs increased heart rate early postoperatively. Echocardiography demonstrated a consistently good cardiac function in both groups. Central venous oxygen saturation, serum lactate levels, urine output, time to chest tube removal, length of mechanical ventilation, ICU, and hospital stay were similar in both groups. Both drugs were well tolerated, no serious adverse events occurred.
    Conclusions: Dobutamine and milrinone are safe, well tolerated, and equally effective in prevention of low cardiac output syndrome after pediatric cardiac surgery. The hemodynamic response of the two drugs is comparable. In uncomplicated cases, a trend toward the more cost-saving dobutamine might be anticipated; however, milrinone demonstrated a trend toward higher efficacy in afterload reduction.
    MeSH term(s) Adolescent ; Cardiac Output, Low/prevention & control ; Cardiopulmonary Bypass/adverse effects ; Cardiotonic Agents/administration & dosage ; Child ; Child, Preschool ; Dobutamine/administration & dosage ; Double-Blind Method ; Female ; Heart Defects, Congenital/surgery ; Humans ; Infant ; Intensive Care Units, Pediatric ; Male ; Milrinone/administration & dosage ; Pilot Projects ; Postoperative Period ; Prospective Studies
    Chemical Substances Cardiotonic Agents ; Dobutamine (3S12J47372) ; Milrinone (JU9YAX04C7)
    Language English
    Publishing date 2018-03-14
    Publishing country United States
    Document type Journal Article ; Randomized Controlled Trial ; Research Support, Non-U.S. Gov't
    ZDB-ID 2052349-X
    ISSN 1947-3893 ; 1529-7535
    ISSN (online) 1947-3893
    ISSN 1529-7535
    DOI 10.1097/PCC.0000000000001533
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Prenatal Diagnosis of Single Ventricle Physiology Impacts on Cardiac Morbidity and Mortality.

    Weber, Roland W / Stiasny, Brian / Ruecker, Beate / Fasnacht, Margrit / Cavigelli-Brunner, Anna / Valsangiacomo Buechel, Emanuela R

    Pediatric cardiology

    2018  Volume 40, Issue 1, Page(s) 61–70

    Abstract: We sought to evaluate the impact of prenatal diagnosis on morbidity and mortality in single ventricle (SV) lesions. All consecutive patients with pre- or postnatally diagnosed SV physiology admitted to our centre between January 2001 and June 2013 were ... ...

    Abstract We sought to evaluate the impact of prenatal diagnosis on morbidity and mortality in single ventricle (SV) lesions. All consecutive patients with pre- or postnatally diagnosed SV physiology admitted to our centre between January 2001 and June 2013 were reviewed. Primary endpoints included survival until 30 days after bidirectional cavopulmonary connection (BCPC) without transplant or BCPC takedown. Prenatal diagnosis was performed in 160 of 259 cases (62%). After excluding all cases with termination of pregnancy, intrauterine demise or treated with comfort care, a total of 180 neonates were admitted to our centre for treatment, including 87 with a prenatal and 93 with a postnatal diagnosis. Both groups showed similar distribution regarding diagnosis, dominant ventricle and risk factors such as restrictive foramen or some form of atrial isomerism. A larger proportion of postnatally diagnosed children presented at admission with elevated lactate > 10 mmol/l (p = 0.02), a higher dose of prostaglandin (p = 0.0013) and need for mechanical ventilation (p < 0.0001). Critical lesions such as hypoplastic left heart syndrome were an important determinant for morbidity and mortality. Thirty-days survival after BCPC was better in patients with prenatal diagnosis (p = 0.025). Prenatal diagnosis is associated with higher survival in neonates with SV physiology.
    MeSH term(s) Case-Control Studies ; Child ; Echocardiography ; Female ; Heart Ventricles/diagnostic imaging ; Heart Ventricles/physiopathology ; Humans ; Hypoplastic Left Heart Syndrome/diagnosis ; Hypoplastic Left Heart Syndrome/mortality ; Infant, Newborn ; Male ; Outcome Assessment (Health Care) ; Palliative Care/methods ; Pregnancy ; Prenatal Diagnosis ; Retrospective Studies ; Risk Factors
    Language English
    Publishing date 2018-08-18
    Publishing country United States
    Document type Journal Article
    ZDB-ID 800857-7
    ISSN 1432-1971 ; 0172-0643
    ISSN (online) 1432-1971
    ISSN 0172-0643
    DOI 10.1007/s00246-018-1961-1
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Does superior caval vein pressure impact head growth in Fontan circulation?

    Trachsel, Tina / Balmer, Christian / Wåhlander, Håkan / Weber, Roland / Dave, Hitendu / Poretti, Andrea / Kretschmar, Oliver / Cavigelli-Brunner, Anna

    Cardiology in the young

    2016  Volume 26, Issue 7, Page(s) 1327–1332

    Abstract: Background: Patients with bidirectional cavopulmonary anastomosis have unphysiologically high superior caval vein pressure as it equals pulmonary artery pressure. Elevated superior caval vein pressure may cause communicating hydrocephalus and ... ...

    Abstract Background: Patients with bidirectional cavopulmonary anastomosis have unphysiologically high superior caval vein pressure as it equals pulmonary artery pressure. Elevated superior caval vein pressure may cause communicating hydrocephalus and macrocephaly. This study analysed whether there exists an association between head circumference and superior caval vein pressure in patients with single ventricle physiology.
    Methods: We carried out a retrospective analysis of infants undergoing Fontan completion at our institution from 2007 to 2013. Superior caval vein pressures were measured during routine catheterisation before bidirectional cavopulmonary anastomosis and Fontan completion as well as head circumference, adjusted to longitudinal age-dependent percentiles.
    Results: We included 74 infants in our study. Median ages at bidirectional cavopulmonary anastomosis and Fontan were 4.8 (1.6-12) and 27.9 (7-40.6) months, respectively. Head circumference showed significant growth from bidirectional cavopulmonary anastomosis until Fontan completion (7th (0-100th) versus 20th (0-100th) percentile). There was no correlation between superior caval vein pressure and head circumference before Fontan (R2=0.001). Children with lower differences in superior caval vein pressures between pre-bidirectional cavopulmonary anastomosis and pre-Fontan catheterisations showed increased growth of head circumference (R2=0.19).
    Conclusions: Patients with moderately elevated superior caval vein pressure associated with single ventricle physiology did not have a tendency to develop macrocephaly. There is no correlation between superior caval vein pressure before Fontan and head circumference, but between bidirectional cavopulmonary anastomosis and Fontan head circumference increases significantly. This may be explained by catch-up growth of head circumference in patients with more favourable haemodynamics and concomitant venous pressures in the lower range. Further studies with focus on high superior caval vein pressures are needed to exclude or prove a correlation.
    MeSH term(s) Child, Preschool ; Female ; Fontan Procedure/methods ; Head/growth & development ; Heart Bypass, Right/methods ; Heart Defects, Congenital/surgery ; Heart Ventricles/surgery ; Hemodynamics ; Humans ; Infant ; Linear Models ; Male ; Pulmonary Artery/surgery ; Retrospective Studies ; Vena Cava, Superior/physiopathology
    Language English
    Publishing date 2016-10
    Publishing country England
    Document type Journal Article
    ZDB-ID 1078466-4
    ISSN 1467-1107 ; 1047-9511
    ISSN (online) 1467-1107
    ISSN 1047-9511
    DOI 10.1017/S1047951115002528
    Database MEDical Literature Analysis and Retrieval System OnLINE

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