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Article ; Online: Inflammation in Development and Aging: Insights from the Zebrafish Model.

Mastrogiovanni, Marta / Martínez-Navarro, Francisco Juan / Bowman, Teresa V / Cayuela, María L

International journal of molecular sciences

2024 Volume 25, Issue 4

Abstract: Zebrafish are an emergent animal model to study human diseases due to their significant genetic similarity to humans, swift development, and genetic manipulability. Their utility extends to the exploration of the involvement of inflammation in host ... ...

Abstract	Zebrafish are an emergent animal model to study human diseases due to their significant genetic similarity to humans, swift development, and genetic manipulability. Their utility extends to the exploration of the involvement of inflammation in host defense, immune responses, and tissue regeneration. Additionally, the zebrafish model system facilitates prompt screening of chemical compounds that affect inflammation. This study explored the diverse roles of inflammatory pathways in zebrafish development and aging. Serving as a crucial model, zebrafish provides insights into the intricate interplay of inflammation in both developmental and aging contexts. The evidence presented suggests that the same inflammatory signaling pathways often play instructive or beneficial roles during embryogenesis and are associated with malignancies in adults.
MeSH term(s)	Animals ; Humans ; Zebrafish/genetics ; Models, Animal ; Inflammation ; Aging/genetics ; Signal Transduction
Language	English
Publishing date	2024-02-10
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2019364-6
ISSN	1422-0067 ; 1422-0067 ; 1661-6596
ISSN (online)	1422-0067
ISSN	1422-0067 ; 1661-6596
DOI	10.3390/ijms25042145
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Paracetamol degradation pathways in soil after biochar addition.

Chacón, Francisco J / Cayuela, Maria L / Sánchez-Monedero, Miguel A

Environmental pollution (Barking, Essex : 1987)

2022 Volume 307, Page(s) 119546

Abstract: Little is known about the effect of biochar on the degradation of paracetamol in soil, considering the ubiquity of this pollutant in the environment. Given the importance of the electrochemical properties of biochar for contaminant remediation, we ... ...

Abstract	Little is known about the effect of biochar on the degradation of paracetamol in soil, considering the ubiquity of this pollutant in the environment. Given the importance of the electrochemical properties of biochar for contaminant remediation, we investigated the influence of raw and designer redox-active biochars on paracetamol degradation in soil. Metabolite quantification indicated that a minimum of 53% of the spiked paracetamol was transformed in biochar-amended soil, resulting in the accumulation of different degradation products. The identification of these products allowed us to chart paracetamol degradation pathways in soil with and without biochar amendment. Some of the major degradation routes were observed to proceed via catechol and phenol, despite being previously described as having only a minor role in paracetamol metabolism. Additionally, a new transformation route from paracetamol to NAPQI was discovered in anaerobic soil originating from direct redox reactions on the surface of the designer biochars. These results may contribute to change our understanding of the environmental fate of paracetamol in soil and the role of biochar in its biodegradation.
MeSH term(s)	Acetaminophen ; Charcoal/chemistry ; Environmental Restoration and Remediation ; Soil/chemistry ; Soil Pollutants/analysis
Chemical Substances	Soil ; Soil Pollutants ; biochar ; Charcoal (16291-96-6) ; Acetaminophen (362O9ITL9D)
Language	English
Publishing date	2022-05-26
Publishing country	England
Document type	Journal Article
ZDB-ID	280652-6
ISSN	1873-6424 ; 0013-9327 ; 0269-7491
ISSN (online)	1873-6424
ISSN	0013-9327 ; 0269-7491
DOI	10.1016/j.envpol.2022.119546
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Article ; Online: Nitrogen availability in biochar-based fertilizers depending on activation treatment and nitrogen source.

Castejón-Del Pino, Raúl / Cayuela, María L / Sánchez-García, María / Sánchez-Monedero, Miguel A

Waste management (New York, N.Y.)

2023 Volume 158, Page(s) 76–83

Abstract: Different activation and N-doping treatments were used to produce biochar-based fertilizers (BBFs) with increased N concentration and slow N release. Pristine biochars were produced by pyrolysis of olive tree pruning feedstock at low and high ... ...

Abstract	Different activation and N-doping treatments were used to produce biochar-based fertilizers (BBFs) with increased N concentration and slow N release. Pristine biochars were produced by pyrolysis of olive tree pruning feedstock at low and high temperatures (400 and 800 °C). These biochars were activated either by ultrasonication, or oxidation with hydrogen peroxide (H
MeSH term(s)	Fertilizers/analysis ; Nitrogen ; Hydrogen Peroxide ; Charcoal ; Soil ; Urea ; Water
Chemical Substances	biochar ; Fertilizers ; Nitrogen (N762921K75) ; Hydrogen Peroxide (BBX060AN9V) ; Charcoal (16291-96-6) ; Soil ; Urea (8W8T17847W) ; Water (059QF0KO0R)
Language	English
Publishing date	2023-01-13
Publishing country	United States
Document type	Journal Article
ZDB-ID	2001471-5
ISSN	1879-2456 ; 0956-053X
ISSN (online)	1879-2456
ISSN	0956-053X
DOI	10.1016/j.wasman.2023.01.007
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Article ; Online: The Spike protein of SARS-CoV-2 signals via Tlr2 in zebrafish

Tyrkalska, Sylwia D. / Martínez-López, Alicia / Pedoto, Annamaria / Candel, Sergio / Cayuela, María L. / Mulero, Victoriano

Developmental and Comparative Immunology. 2023 Mar., v. 140 p.104626-

2023

Abstract: One of the most studied defense mechanisms against invading pathogens, including viruses, are Toll-like receptors (TLRs). Among them, TLR3, TLR7, TLR8 and TLR9 detect different forms of viral nucleic acids in endosomal compartments, whereas TLR2 and TLR4 ...

Abstract	One of the most studied defense mechanisms against invading pathogens, including viruses, are Toll-like receptors (TLRs). Among them, TLR3, TLR7, TLR8 and TLR9 detect different forms of viral nucleic acids in endosomal compartments, whereas TLR2 and TLR4 recognize viral structural and nonstructural proteins outside the cell. Although many different TLRs have been shown to be involved in SARS-CoV-2 infection and detection of different structural proteins, most studies have been performed in vitro and the results obtained are rather contradictory. In this study, we report using the unique advantages of the zebrafish model for in vivo imaging and gene editing that the S1 domain of the Spike protein from the Wuhan strain (S1WT) induced hyperinflammation in zebrafish larvae via a Tlr2/Myd88 signaling pathway and independently of interleukin-1β production. In addition, S1WT also triggered emergency myelopoiesis, but in this case through a Tlr2/Myd88-independent signaling pathway. These results shed light on the mechanisms involved in the fish host responses to viral proteins.
Keywords	Danio rerio ; Severe acute respiratory syndrome coronavirus 2 ; fish ; genes ; immunology ; models ; Spike protein ; Inflammation ; Hematopoiesis ; TLRs ; Interleukin-1 ; Zebrafish
Language	English
Dates of publication	2023-03
Publishing place	Elsevier Ltd
Document type	Article ; Online
Note	Use and reproduction
ZDB-ID	752411-0
ISSN	1879-0089 ; 0145-305X
ISSN (online)	1879-0089
ISSN	0145-305X
DOI	10.1016/j.dci.2022.104626
Database	NAL-Catalogue (AGRICOLA)

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Zs.A 1327: Show issues

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Article ; Online: Nitrogen availability in biochar-based fertilizers depending on activation treatment and nitrogen source

Castejón-del Pino, Raúl / Cayuela, María L. / Sánchez-García, María / Sánchez-Monedero, Miguel A.

Waste Management. 2023 Mar., v. 158 p.76-83

2023

Abstract	Different activation and N-doping treatments were used to produce biochar-based fertilizers (BBFs) with increased N concentration and slow N release. Pristine biochars were produced by pyrolysis of olive tree pruning feedstock at low and high temperatures (400 and 800 °C). These biochars were activated either by ultrasonication, or oxidation with hydrogen peroxide (H₂O₂) or nitric acid (HNO₃) to increase their N retention potential. Subsequently biochars were enriched with N with either urea or ammonium sulfate. The activation of low-temperature biochars with HNO₃ was the most effective treatment leading to new surface carboxylic groups that facilitated the later enrichment with N. When treated with urea, BBFs reached 7.0 N%, whereas the H₂O₂ activation only allowed an increase up to 2.0 N%. The use of urea as the external N source was the most efficient for incorporating N. Urea treated biochars had a water-soluble fraction that represented up to 14.5 % of the total N. The hydrolyzable N fraction, composed by amides and simple N heterocycles originated by the N-doping treatments, and nitro groups generated from HNO₃ activation, represented up to 60 % of the total N. This study relates the N chemical forms in the new BBFs to potential N availability in soil. The presence of water-soluble, hydrolyzable and non-hydrolyzable N implied that these BBFs may supply N that would be progressively available for plants, acting as slow-release fertilizers.
Keywords	Olea europaea ; ammonium sulfate ; biochar ; feedstocks ; heterocyclic compounds ; hydrogen peroxide ; nitric acid ; nitrogen ; oxidation ; pyrolysis ; soil ; total nitrogen ; ultrasonic treatment ; urea ; waste management ; water solubility ; Agricultural waste ; Olive tree pruning ; N-doped biochar ; Available N ; Nitrogen use efficiency ; Oxidizing treatment
Language	English
Dates of publication	2023-03
Size	p. 76-83.
Publishing place	Elsevier Ltd
Document type	Article ; Online
Note	Use and reproduction
ZDB-ID	2001471-5
ISSN	1879-2456 ; 0956-053X
ISSN (online)	1879-2456
ISSN	0956-053X
DOI	10.1016/j.wasman.2023.01.007
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Article: Overcoming biochar limitations to remediate pentachlorophenol in soil by modifying its electrochemical properties

Chacón, Francisco J. / Cayuela, Maria L. / Cederlund, Harald / Sánchez-Monedero, Miguel A.

Journal of hazardous materials. 2022 Mar. 15, v. 426

2022

Abstract: In this study, we produced modified biochars with enhanced electrochemical properties to increase PCP remediation in soil. Although all biochars enhanced PCP remediation in aerobic conditions, only a few did in anaerobic soil. The most successful ... ...

Abstract	In this study, we produced modified biochars with enhanced electrochemical properties to increase PCP remediation in soil. Although all biochars enhanced PCP remediation in aerobic conditions, only a few did in anaerobic soil. The most successful modifications were (i) the preloading of biomass with 10% w/w FeCl₃, to obtain a biochar rich in redox-active metals (B-Fe); (ii) the oxidation of a conductive biochar pyrolyzed at 1000 ºC with 0.025 M KMnO₄, to produce a biochar with both moderate conductivity and redox capacity (B-1000-KMnO₄); and (iii) KMnO₄ oxidation of an amorphous biochar pyrolyzed at 400 ºC to obtain a biochar with very high redox capacity (B-KMnO₄). B-Fe reduced extractable PCP to almost zero after 50 days in both incubations, but showed slow kinetics of remediation in aerobic soil. B-1000-KMnO₄ had the highest rate of remediation under aerobic conditions, but no significant effect under anaerobic conditions. B-KMnO₄, however, presented high rates of remediation and high removal of extractable PCP under both conditions, which made it the recommended modification strategy for increased PCP remediation. We found that the degree of remediation primarily depends on the redox capacity, while the rate of remediation was determined by both the conductivity and redox capacity of biochar.
Keywords	biochar ; biomass ; electrochemistry ; oxidation ; pentachlorophenol ; remediation ; soil
Language	English
Dates of publication	2022-0315
Publishing place	Elsevier B.V.
Document type	Article
ZDB-ID	1491302-1
ISSN	1873-3336 ; 0304-3894
ISSN (online)	1873-3336
ISSN	0304-3894
DOI	10.1016/j.jhazmat.2021.127805
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Article: Paracetamol degradation pathways in soil after biochar addition

Chacón, Francisco J. / Cayuela, Maria L. / Sánchez-Monedero, Miguel A.

Environmental pollution. 2022 Aug. 15, v. 307

2022

Abstract	Little is known about the effect of biochar on the degradation of paracetamol in soil, considering the ubiquity of this pollutant in the environment. Given the importance of the electrochemical properties of biochar for contaminant remediation, we investigated the influence of raw and designer redox-active biochars on paracetamol degradation in soil. Metabolite quantification indicated that a minimum of 53% of the spiked paracetamol was transformed in biochar-amended soil, resulting in the accumulation of different degradation products. The identification of these products allowed us to chart paracetamol degradation pathways in soil with and without biochar amendment. Some of the major degradation routes were observed to proceed via catechol and phenol, despite being previously described as having only a minor role in paracetamol metabolism. Additionally, a new transformation route from paracetamol to NAPQI was discovered in anaerobic soil originating from direct redox reactions on the surface of the designer biochars. These results may contribute to change our understanding of the environmental fate of paracetamol in soil and the role of biochar in its biodegradation.
Keywords	acetaminophen ; biochar ; biodegradation ; catechol ; electrochemistry ; environmental fate ; metabolism ; metabolites ; phenol ; pollutants ; pollution ; remediation ; soil
Language	English
Dates of publication	2022-0815
Publishing place	Elsevier Ltd
Document type	Article
ZDB-ID	280652-6
ISSN	1873-6424 ; 0013-9327 ; 0269-7491
ISSN (online)	1873-6424
ISSN	0013-9327 ; 0269-7491
DOI	10.1016/j.envpol.2022.119546
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: The Spike protein of SARS-CoV-2 signals via Tlr2 in zebrafish.

Tyrkalska, Sylwia D / Martínez-López, Alicia / Pedoto, Annamaria / Candel, Sergio / Cayuela, María L / Mulero, Victoriano

Developmental and comparative immunology

2022 Volume 140, Page(s) 104626

Abstract	One of the most studied defense mechanisms against invading pathogens, including viruses, are Toll-like receptors (TLRs). Among them, TLR3, TLR7, TLR8 and TLR9 detect different forms of viral nucleic acids in endosomal compartments, whereas TLR2 and TLR4 recognize viral structural and nonstructural proteins outside the cell. Although many different TLRs have been shown to be involved in SARS-CoV-2 infection and detection of different structural proteins, most studies have been performed in vitro and the results obtained are rather contradictory. In this study, we report using the unique advantages of the zebrafish model for in vivo imaging and gene editing that the S1 domain of the Spike protein from the Wuhan strain (S1WT) induced hyperinflammation in zebrafish larvae via a Tlr2/Myd88 signaling pathway and independently of interleukin-1β production. In addition, S1WT also triggered emergency myelopoiesis, but in this case through a Tlr2/Myd88-independent signaling pathway. These results shed light on the mechanisms involved in the fish host responses to viral proteins.
MeSH term(s)	Animals ; COVID-19/immunology ; Myeloid Differentiation Factor 88/genetics ; SARS-CoV-2 ; Spike Glycoprotein, Coronavirus ; Toll-Like Receptor 2/genetics ; Zebrafish/genetics
Chemical Substances	Myeloid Differentiation Factor 88 ; Spike Glycoprotein, Coronavirus ; spike protein, SARS-CoV-2 ; Toll-Like Receptor 2
Language	English
Publishing date	2022-12-30
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	752411-0
ISSN	1879-0089 ; 0145-305X
ISSN (online)	1879-0089
ISSN	0145-305X
DOI	10.1016/j.dci.2022.104626
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Article ; Online: Analysis of 16S rRNA Gene Sequence of Nasopharyngeal Exudate Reveals Changes in Key Microbial Communities Associated with Aging.

Candel, Sergio / Tyrkalska, Sylwia D / Pérez-Sanz, Fernando / Moreno-Docón, Antonio / Esteban, Ángel / Cayuela, María L / Mulero, Victoriano

International journal of molecular sciences

2023 Volume 24, Issue 4

Abstract: Functional or compositional perturbations of the microbiome can occur at different sites, of the body and this dysbiosis has been linked to various diseases. Changes in the nasopharyngeal microbiome are associated to patient's susceptibility to multiple ... ...

Abstract	Functional or compositional perturbations of the microbiome can occur at different sites, of the body and this dysbiosis has been linked to various diseases. Changes in the nasopharyngeal microbiome are associated to patient's susceptibility to multiple viral infections, supporting the idea that the nasopharynx may be playing an important role in health and disease. Most studies on the nasopharyngeal microbiome have focused on a specific period in the lifespan, such as infancy or the old age, or have other limitations such as low sample size. Therefore, detailed studies analyzing the age- and sex-associated changes in the nasopharyngeal microbiome of healthy people across their whole life are essential to understand the relevance of the nasopharynx in the pathogenesis of multiple diseases, particularly viral infections. One hundred twenty nasopharyngeal samples from healthy subjects of all ages and both sexes were analyzed by 16S rRNA sequencing. Nasopharyngeal bacterial alpha diversity did not vary in any case between age or sex groups. Proteobacteria, Firmicutes, Actinobacteria, and Bacteroidetes were the predominant phyla in all the age groups, with several sex-associated.
MeSH term(s)	Male ; Female ; Humans ; RNA, Ribosomal, 16S/genetics ; Genes, rRNA ; Nasopharynx/microbiology ; Microbiota/genetics ; Bacteria/genetics ; Aging ; Virus Diseases/genetics
Chemical Substances	RNA, Ribosomal, 16S
Language	English
Publishing date	2023-02-18
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2019364-6
ISSN	1422-0067 ; 1422-0067 ; 1661-6596
ISSN (online)	1422-0067
ISSN	1422-0067 ; 1661-6596
DOI	10.3390/ijms24044127
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Article ; Online: Overcoming biochar limitations to remediate pentachlorophenol in soil by modifying its electrochemical properties.

Chacón, Francisco J / Cayuela, Maria L / Cederlund, Harald / Sánchez-Monedero, Miguel A

Journal of hazardous materials

2021 Volume 426, Page(s) 127805

Abstract	In this study, we produced modified biochars with enhanced electrochemical properties to increase PCP remediation in soil. Although all biochars enhanced PCP remediation in aerobic conditions, only a few did in anaerobic soil. The most successful modifications were (i) the preloading of biomass with 10% w/w FeCl
MeSH term(s)	Charcoal ; Environmental Restoration and Remediation ; Pentachlorophenol ; Soil ; Soil Pollutants/analysis
Chemical Substances	Soil ; Soil Pollutants ; biochar ; Charcoal (16291-96-6) ; Pentachlorophenol (D9BSU0SE4T)
Language	English
Publishing date	2021-11-16
Publishing country	Netherlands
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1491302-1
ISSN	1873-3336 ; 0304-3894
ISSN (online)	1873-3336
ISSN	0304-3894
DOI	10.1016/j.jhazmat.2021.127805
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