LIVIVO - Search results -

Search results

Result 1 - 10 of total 100

Search options

Article: Circulating salivary and serum miRNA-182, 320a, 375 and 503 expression levels in type 2 diabetes.

Monfared, Yousef Khazaei / Honardoost, Maryam / Cea, Michele / Gholami, Soheyla / Mirzaei-Dizgah, Iraj / Hashemipour, Sima / Sarookhani, Mohamad Reza / Farzam, Seyed Amir

Journal of diabetes and metabolic disorders

2022 Volume 21, Issue 2, Page(s) 1469–1478

Abstract: Aim: Early-stage diagnosis of diabetes through non-invasive and diagnostic biofluid-like saliva has become a very popular approach to facilitate future preventive interventions and improve patient care. Meanwhile, the alteration of small non-coding RNA ... ...

Abstract	Aim: Early-stage diagnosis of diabetes through non-invasive and diagnostic biofluid-like saliva has become a very popular approach to facilitate future preventive interventions and improve patient care. Meanwhile, the alteration of small non-coding RNA in human fluids has been suggested as a probable precedent for the early stages of diabetes. Methods: In the present study, we checked the expression of miR-320a, 182-5p, 503, and 375 by using quantitative PCR in both stimulated and unstimulated saliva and blood samples of 40 adult patients with type-2 diabetes compared to 40 healthy individuals. In addition, we have sought to understand the possibility that miRNAs could provide new information about the status of type 2 diabetes in salivary samples beyond what can now be identified from blood samples and link their expression to the presence of clinically relevant risk factors. For this purpose, we have used a set of multivariate models. Results: The results showed that three miRNAs were more highly expressed in patients with type 2 diabetes, while miR-320-a was down-regulated in those patients compared to healthy subjects. Furthermore, the data showed that miR-320a was the most reliable predictor for distinguishing diabetic patients from healthy subjects, with AUCs of 0.997, 0.97, and 0.99 (97.4% sensitivity and 100% specificity, Conclusions: Interestingly, the results of this study indicated that the amount of four miRNAs expressed in stimulated saliva was the same as in serum samples, which could conclude that specific miR-320a and 503 in stimulated saliva may introduce credible, non-invasive, and diagnostic biomarkers that can be used to monitor diabetic patients' status, while there is a need to design more research studies to confirm these findings.
Language	English
Publishing date	2022-07-28
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2680289-2
ISSN	2251-6581
ISSN	2251-6581
DOI	10.1007/s40200-022-01082-4
Database	MEDical Literature Analysis and Retrieval System OnLINE

Full text online

Accessible to users with ZB MED library card

Order via subito

This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

Details ▾
- Full text online
- Order with fees

Article ; Online: Sirtuin 6 Regulates the Activation of the ATP/Purinergic Axis in Endothelial Cells.

Astigiano, Cecilia / Piacente, Francesco / Laugieri, Maria Elena / Benzi, Andrea / Di Buduo, Christian A / Miguel, Carolina P / Soncini, Debora / Cea, Michele / Antonelli, Antonella / Magnani, Mauro / Balduini, Alessandra / De Flora, Antonio / Bruzzone, Santina

International journal of molecular sciences

2023 Volume 24, Issue 7

Abstract: Sirtuin 6 (SIRT6) is a member of the mammalian ... ...

Abstract	Sirtuin 6 (SIRT6) is a member of the mammalian NAD
MeSH term(s)	Humans ; Adenosine Triphosphate ; Human Umbilical Vein Endothelial Cells/metabolism ; NAD ; Sirtuins/metabolism ; Tumor Necrosis Factor-alpha/pharmacology
Chemical Substances	Adenosine Triphosphate (8L70Q75FXE) ; NAD (0U46U6E8UK) ; SIRT6 protein, human (EC 3.5.1.-) ; Sirtuins (EC 3.5.1.-) ; Tumor Necrosis Factor-alpha
Language	English
Publishing date	2023-04-04
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2019364-6
ISSN	1422-0067 ; 1422-0067 ; 1661-6596
ISSN (online)	1422-0067
ISSN	1422-0067 ; 1661-6596
DOI	10.3390/ijms24076759
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article: Daratumumab in the treatment of C3 glomerulopathy with monoclonal gammopathy: a case report and literature review.

Esposito, Pasquale / Picciotto, Daniela / Costigliolo, Francesca / Russo, Elisa / Macciò, Lucia / Cenacchi, Giovanna / Cagnetta, Antonia / Cea, Michele / Lemoli, Roberto M / Viazzi, Francesca

Frontiers in medicine

2023 Volume 10, Page(s) 1266172

Abstract: Although rare, C3 glomerulopathy (C3G) is increasingly recognized thanks to the currently available diagnostic skills. C3G is not a single disease but a group of disorders with distinct pathogenesis and progression. Thus, an essential step for its ... ...

Abstract	Although rare, C3 glomerulopathy (C3G) is increasingly recognized thanks to the currently available diagnostic skills. C3G is not a single disease but a group of disorders with distinct pathogenesis and progression. Thus, an essential step for its management remains an in-depth characterization of the specific form and the identification of underlying conditions, which may also impact treatment choices as well. Among these entities, an emerging condition is the association of C3G with monoclonal gammopathy, which confers poor outcomes. Overall, diagnosis of C3G remains challenging, and determining the appropriate treatment remains unclear. Conventional immunosuppressive therapy has proven ineffective in such cases, while clone-directed therapies have shown promising results in small interventional studies and case series. Here, we report a case of a patient affected by C3G with monoclonal gammopathy of renal significance who experienced rapid deterioration of kidney function requiring replacement therapy. After the failure of first-line treatment, a switch to the anti-CD38 therapy with daratumumab resulted in the progressive improvement of the patient's kidney function, leading to the discontinuation of hemodialysis after approximately 10 months. Serial renal biopsies were also performed to study the disease's evolution in response to the treatment. Based on the description of this single case, we have comprehensively reviewed available studies on daratumumab use in patients with C3G associated with monoclonal gammopathy to provide insights for the design of prospective studies which aim to enhance the management of such poor prognosis disease.
Language	English
Publishing date	2023-09-01
Publishing country	Switzerland
Document type	Case Reports
ZDB-ID	2775999-4
ISSN	2296-858X
ISSN	2296-858X
DOI	10.3389/fmed.2023.1266172
Database	MEDical Literature Analysis and Retrieval System OnLINE

Full text online

Accessible to users with ZB MED library card

Order via subito

Details ▾
- Full text online
- Order with fees

Article: Harnessing Immune Response in Acute Myeloid Leukemia.

Riva, Carola / Vernarecci, Chiara / Minetto, Paola / Goda, Rayan / Greppi, Marco / Pesce, Silvia / Chies, Maria / Zecchetti, Giada / Ferro, Beatrice / Maio, Elena / Cea, Michele / Lemoli, Roberto Massimo / Marcenaro, Emanuela / Guolo, Fabio

Journal of clinical medicine

2023 Volume 12, Issue 18

Abstract: Despite the results achieved with the evolution of conventional chemotherapy and the inclusion of targeted therapies in the treatment of acute myeloid leukemia (AML), survival is still not satisfying, in particular in the setting of relapsed/refractory ( ... ...

Abstract	Despite the results achieved with the evolution of conventional chemotherapy and the inclusion of targeted therapies in the treatment of acute myeloid leukemia (AML), survival is still not satisfying, in particular in the setting of relapsed/refractory (R/R) disease or elderly/unfit patients. Among the most innovative therapeutic options, cellular therapy has shown great results in different hematological malignancies such as acute lymphoblastic leukemia and lymphomas, with several products already approved for clinical use. However, despite the great interest in also expanding the application of these new treatments to R/R AML, no product has been approved yet for clinical application. Furthermore, cellular therapy could indeed represent a powerful tool and an appealing alternative to allogeneic hematopoietic stem cell transplantation for ineligible patients. In this review, we aim to provide an overview of the most recent clinical research exploring the effectiveness of cellular therapy in AML, moving from consolidated approaches such as post- transplant donor's lymphocytes infusion, to modern adoptive immunotherapies such as alloreactive NK cell infusions, engineered T and NK cells (CAR-T, CAR-NK) and novel platforms of T and NK cells engaging (i.e., BiTEs, DARTs and ANKET
Language	English
Publishing date	2023-09-07
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2662592-1
ISSN	2077-0383
ISSN	2077-0383
DOI	10.3390/jcm12185824
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article ; Online: Targeting the deacetylase SIRT6 unveils spliceosome deregulation as exploitable vulnerability for aggressive myeloma.

Gelli, Elisa / Soncini, Debora / Becherini, Pamela / Martinuzzi, Claudia / Todoerti, Katia / Cagnetta, Antonia / Aquino, Sara / Guolo, Fabio / Miglino, Maurizio / Bruzzone, Santina / Nencioni, Alessio / Neri, Antonino / Lemoli, Roberto M / Cea, Michele

Blood advances

2023 Volume 7, Issue 14, Page(s) 3472–3478

MeSH term(s)	Humans ; Spliceosomes/genetics ; Multiple Myeloma/genetics ; Sirtuins
Chemical Substances	Sirtuins (EC 3.5.1.-) ; SIRT6 protein, human (EC 3.5.1.-)
Language	English
Publishing date	2023-03-09
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2915908-8
ISSN	2473-9537 ; 2473-9529
ISSN (online)	2473-9537
ISSN	2473-9529
DOI	10.1182/bloodadvances.2022009035
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 7153: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Nutrients in the Prevention of Alzheimer's Disease.

Cremonini, Anna Laura / Caffa, Irene / Cea, Michele / Nencioni, Alessio / Odetti, Patrizio / Monacelli, Fiammetta

Oxidative medicine and cellular longevity

2019 Volume 2019, Page(s) 9874159

Abstract: Alzheimer's disease (AD) is a disease caused by the complex interaction of multiple mechanisms, some of which are still not fully understood. To date, pharmacological treatments and supplementation of individual nutrients have been poorly effective in ... ...

Abstract	Alzheimer's disease (AD) is a disease caused by the complex interaction of multiple mechanisms, some of which are still not fully understood. To date, pharmacological treatments and supplementation of individual nutrients have been poorly effective in terms of the prevention and treatment of AD, while alternative strategies based on multimodal approaches (diet, exercise, and cognitive training) seem to be more promising. In this context, the focus on dietary patterns rather than on single food components could be more useful in preventing or counteracting the pathological processes typical of AD, thanks to the potential synergistic effects of various nutrients (neuronutrients). The aim of this narrative review is to summarize the currently existing preclinical and clinical evidence regarding the Mediterranean diet (MeDi), the Dietary Approaches to Stop Hypertension (DASH) diet, and the Mediterranean-DASH Intervention for Neurodegenerative Delay (MIND) diet, which are three dietary patterns with well-known anti-inflammatory and antioxidant properties. Recently, they have been related to brain protection and AD prevention, perhaps thanks to their high content of neuroprotective bioactive compounds. Similarly, intermittent fasting (IF) or calorie restriction (CR) is emerging as interesting approaches that seem to promote hippocampal neurogenesis, activate adaptive stress response systems, and enhance neuronal plasticity, thus leading to motor and cognitive improvements in animal models of AD and hopefully also in human beings.
MeSH term(s)	Alzheimer Disease/prevention & control ; Diet, Mediterranean ; Humans ; Nutrients/pharmacology ; Nutrients/therapeutic use
Language	English
Publishing date	2019-09-04
Publishing country	United States
Document type	Journal Article ; Review
ISSN	1942-0994
ISSN (online)	1942-0994
DOI	10.1155/2019/9874159
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Article ; Online: Author Correction: Cyclic fasting bolsters cholesterol biosynthesis inhibitors' anticancer activity.

Khalifa, Amr / Guijarro, Ana / Ravera, Silvia / Bertola, Nadia / Adorni, Maria Pia / Papotti, Bianca / Raffaghello, Lizzia / Benelli, Roberto / Becherini, Pamela / Namatalla, Asmaa / Verzola, Daniela / Reverberi, Daniele / Monacelli, Fiammetta / Cea, Michele / Pisciotta, Livia / Bernini, Franco / Caffa, Irene / Nencioni, Alessio

Nature communications

2023 Volume 14, Issue 1, Page(s) 7614

Language	English
Publishing date	2023-11-22
Publishing country	England
Document type	Published Erratum
ZDB-ID	2553671-0
ISSN	2041-1723 ; 2041-1723
ISSN (online)	2041-1723
ISSN	2041-1723
DOI	10.1038/s41467-023-43184-4
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article ; Online: Cyclic fasting bolsters cholesterol biosynthesis inhibitors' anticancer activity.

Nature communications

2023 Volume 14, Issue 1, Page(s) 6951

Abstract: Identifying oncological applications for drugs that are already approved for other medical indications is considered a possible solution for the increasing costs of cancer treatment. Under the hypothesis that nutritional stress through fasting might ... ...

Abstract	Identifying oncological applications for drugs that are already approved for other medical indications is considered a possible solution for the increasing costs of cancer treatment. Under the hypothesis that nutritional stress through fasting might enhance the antitumour properties of at least some non-oncological agents, by screening drug libraries, we find that cholesterol biosynthesis inhibitors (CBIs), including simvastatin, have increased activity against cancers of different histology under fasting conditions. We show fasting's ability to increase CBIs' antitumour effects to depend on the reduction in circulating insulin, insulin-like growth factor-1 and leptin, which blunts the expression of enzymes from the cholesterol biosynthesis pathway and enhances cholesterol efflux from cancer cells. Ultimately, low cholesterol levels through combined fasting and CBIs reduce AKT and STAT3 activity, oxidative phosphorylation and energy stores in the tumour. Our results support further studies of CBIs in combination with fasting-based dietary regimens in cancer treatment and highlight the value of fasting for drug repurposing in oncology.
MeSH term(s)	Simvastatin/pharmacology ; Simvastatin/therapeutic use ; Fasting ; Diet ; Insulin ; Cholesterol
Chemical Substances	Simvastatin (AGG2FN16EV) ; Insulin ; Cholesterol (97C5T2UQ7J)
Language	English
Publishing date	2023-10-31
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2553671-0
ISSN	2041-1723 ; 2041-1723
ISSN (online)	2041-1723
ISSN	2041-1723
DOI	10.1038/s41467-023-42652-1
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article ; Online: Anticancer Activities of Novel Nicotinamide Phosphoribosyltransferase Inhibitors in Hematological Malignancies.

Biniecka, Paulina / Matsumoto, Saki / Belotti, Axel / Joussot, Jessie / Bai, Jian Fei / Majjigapu, Somi Reddy / Thoueille, Paul / Spaggiari, Dany / Desfontaine, Vincent / Piacente, Francesco / Bruzzone, Santina / Cea, Michele / Decosterd, Laurent A / Vogel, Pierre / Nencioni, Alessio / Duchosal, Michel A / Nahimana, Aimable

Molecules (Basel, Switzerland)

2023 Volume 28, Issue 4

Abstract: Targeting cancer cells that are highly dependent on the nicotinamide adenine dinucleotide (NAD+) metabolite is a promising therapeutic strategy. Nicotinamide phosphoribosyltransferase (NAMPT) is the rate-limiting enzyme catalyzing ... ...

Abstract	Targeting cancer cells that are highly dependent on the nicotinamide adenine dinucleotide (NAD+) metabolite is a promising therapeutic strategy. Nicotinamide phosphoribosyltransferase (NAMPT) is the rate-limiting enzyme catalyzing NAD
MeSH term(s)	Animals ; Humans ; Mice ; Cell Line, Tumor ; Cytokines/metabolism ; Enzyme Inhibitors/pharmacology ; Hematologic Neoplasms/drug therapy ; NAD/metabolism ; Nicotinamide Phosphoribosyltransferase/antagonists & inhibitors ; Reactive Oxygen Species
Chemical Substances	Cytokines ; Enzyme Inhibitors ; NAD (0U46U6E8UK) ; Nicotinamide Phosphoribosyltransferase (EC 2.4.2.12) ; Reactive Oxygen Species
Language	English
Publishing date	2023-02-16
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	1413402-0
ISSN	1420-3049 ; 1431-5165 ; 1420-3049
ISSN (online)	1420-3049
ISSN	1431-5165 ; 1420-3049
DOI	10.3390/molecules28041897
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.MO 81: Show issues

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Do Cancer Drugs Counteract Neurodegeneration? Repurposing for Alzheimer's Disease.

Monacelli, Fiammetta / Cea, Michele / Borghi, Roberta / Odetti, Patrizio / Nencioni, Alessio

Journal of Alzheimer's disease : JAD

2017 Volume 55, Issue 4, Page(s) 1295–1306

Abstract: In spite of in depth investigations in the field of the amyloid cascade hypothesis, so far, no disease modifying therapy has been developed for Alzheimer's disease (AD). The pathophysiology provides some evidence of the inverse correlation between cancer ...

Abstract	In spite of in depth investigations in the field of the amyloid cascade hypothesis, so far, no disease modifying therapy has been developed for Alzheimer's disease (AD). The pathophysiology provides some evidence of the inverse correlation between cancer and AD. Both AD and cancer are characterized by abnormal cellular behaviors; trigger factors along with a meta synchronously action is expected to drive cancer or neurodegeneration, supporting, respectively, progressive neuronal loss or uncontrolled cell proliferation in cancer cells. So far, cancer and AD are seemingly two opposite ends of the same biological spectrum. Basic science increasingly indicates shared molecular mechanisms between cancer and AD and gives weight to key relevant biological theories; according to them, the inverse tuning of clustered gene expression, the sharing of mutual independent pathway or the deregulated unfolded proteins system (UPR) may count for this inverse association. Additionally, the common biological background gave credibility to the recent discovery of a repurposing role for cancer drugs in AD. It refers to the development of new uses for existing pharmaceuticals having the same role as the original mechanism or to the discovery of a new drug action with disease modifying effects. The present review summarizes the most important biological theories that link neurodegeneration and cancer and provides an up-to-date revision of the repurposing cancer agents for AD. The review also addresses the gap of knowledge, since drug cancer repositioning holds an important promise but further investigations are warranted to ascertain the clinical relevance of such attractive clinical candidate compounds for AD.
Language	English
Publishing date	2017
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	1440127-7
ISSN	1875-8908 ; 1387-2877
ISSN (online)	1875-8908
ISSN	1387-2877
DOI	10.3233/JAD-160840
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 6084: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

To top

Full text online

More links

Kategorien

Order via subito

More links

Kategorien

Order via subito

Full text online

More links

Kategorien

Order via subito

More links

Kategorien

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

Order via subito

Inter-library loan at ZB MED

More links

Kategorien

Order via subito

More links

Kategorien

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito