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  1. Article: Rare Diaphragmatic Hernias in Adults-Experience of a Tertiary Center in Esophageal Surgery and Narrative Review of the Literature.

    Predescu, Dragos / Achim, Florin / Socea, Bogdan / Ceaușu, Mihail Constantin / Constantin, Adrian

    Diagnostics (Basel, Switzerland)

    2023  Volume 14, Issue 1

    Abstract: A rare entity of non-hiatal type transdiaphragmatic hernias, which must be clearly differentiated from paraoesophageal hernias, are the phrenic defects that bear the generic name of congenital hernias-Bochdalek hernia and Larey-Morgagni hernia, ... ...

    Abstract A rare entity of non-hiatal type transdiaphragmatic hernias, which must be clearly differentiated from paraoesophageal hernias, are the phrenic defects that bear the generic name of congenital hernias-Bochdalek hernia and Larey-Morgagni hernia, respectively. The etiological substrate is relatively simple: the presence of preformed anatomical openings, which either do or do not enable transit from the thoracic region to the abdominal region or, most often, vice versa, from the abdomen to the thorax, of various visceral elements (spleen, liver, stomach, colon, pancreas, etc.). Apart from the congenital origin, a somewhat rarer group is described, representing about 1-7% of the total: an acquired variant of the traumatic type, frequently through a contusive type mechanism, which produces diaphragmatic strains/ruptures. Apparently, the symptomatology is heterogeneous, being dependent on the location of the hernia, the dimensions of the defect, which abdominal viscera is involved through the hernial opening, its degree of migration, and whether there are volvulation/ischemia/obstruction phenomena. Often, its clinical appearance is modest, mainly incidental discoveries, the majority being digestive manifestations. Severe digestive complications such as strangulation, volvus, and perforation are rare and are accompanied by severe shock, suddenly appearing after several non-specific digestive prodromes. Diagnosis combines imaging evaluations (plain radiology, contrast, CT) with endoscopic ones. Surgical treatment is recommended regardless of the side on which the diaphragmatic defect is located or the secondary symptoms due to potential complications. The approach options are thoracic, abdominal or combined thoracoabdominal approach, and classic or minimally invasive. Most often, selection of the type of approach should be made taking into account two elements: the size of the defect, assessed by CT, and the presence of major complications. Any hiatal defect that is larger than 5 cm
    Language English
    Publishing date 2023-12-29
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2662336-5
    ISSN 2075-4418
    ISSN 2075-4418
    DOI 10.3390/diagnostics14010085
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: The Polyvalent Role of CD30 for Cancer Diagnosis and Treatment.

    Dumitru, Adrian Vasile / Țăpoi, Dana Antonia / Halcu, Georgian / Munteanu, Octavian / Dumitrascu, David-Ioan / Ceaușu, Mihail Constantin / Gheorghișan-Gălățeanu, Ancuța-Augustina

    Cells

    2023  Volume 12, Issue 13

    Abstract: CD30, also known as TNFRSF8 (tumor necrosis factor receptor superfamily member 8), is a protein receptor that is heavily glycosylated inside the Golgi apparatus, as well as a tumor marker that is found on the surface of specific cells in the body, ... ...

    Abstract CD30, also known as TNFRSF8 (tumor necrosis factor receptor superfamily member 8), is a protein receptor that is heavily glycosylated inside the Golgi apparatus, as well as a tumor marker that is found on the surface of specific cells in the body, including certain immune cells and cancer ones. This review aims to shed light on the critical importance of CD30, from its emergence in the cell to its position in diagnosing various diseases, including Hodgkin lymphoma, where it is expressed on Hodgkin and Reed-Sternberg cells, as well as embryonal carcinoma, anaplastic large cell lymphoma (ALCL), and cutaneous T-cell lymphoma (CTCL). In addition to its role in positive diagnosis, targeting CD30 has been a promising approach treating CD30-positive lymphomas, and there is ongoing research into the potential use of CD30-targeted therapies for autoimmune disorders. We aim to elaborate on CD30's roles as a tumor marker, supporting thus the hypothesis that this receptor might be the aim of cytostatic treatment.
    MeSH term(s) Humans ; Hodgkin Disease/metabolism ; Lymphoma/metabolism ; Lymphoma, Large-Cell, Anaplastic/diagnosis ; Lymphoma, Large-Cell, Anaplastic/drug therapy ; Reed-Sternberg Cells/metabolism ; Reed-Sternberg Cells/pathology ; Ki-1 Antigen/metabolism ; Biomarkers, Tumor/metabolism
    Chemical Substances Ki-1 Antigen ; Biomarkers, Tumor
    Language English
    Publishing date 2023-07-05
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2661518-6
    ISSN 2073-4409 ; 2073-4409
    ISSN (online) 2073-4409
    ISSN 2073-4409
    DOI 10.3390/cells12131783
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Tensioned space after pneumonectomy for cancer with mediastinal shift and cardiac tamponade-causes and treatment (Review).

    Motas, Natalia / Manolache, Veronica / Rus, Ovidiu / Davidescu, Mihnea / Cioalca-Iliescu, Madalina Cristiana / Socea, Bogdan / Ceausu, Mihail Constantin / Trifanescu, Oana Gabriela

    Experimental and therapeutic medicine

    2022  Volume 24, Issue 3, Page(s) 548

    Abstract: Regarding the pleural space after pneumonectomy for malignancy, a vast number of studies have assessed early drop in the fluid level, suggesting a broncho-pleural fistula, but only a small number of studies reported on the abnormal increase in the fluid ... ...

    Abstract Regarding the pleural space after pneumonectomy for malignancy, a vast number of studies have assessed early drop in the fluid level, suggesting a broncho-pleural fistula, but only a small number of studies reported on the abnormal increase in the fluid level-a potentially lethal complication. In the present study, the available databases worldwide were screened and 19 cases were retrieved, including 14 chylothorax and 3 hydrothorax cases, 1 pneumothorax and 1 haemothorax case. Tension chylothorax is caused by mediastinal lymph node dissection as an assumed risk in radical cancer surgery. For tensioned haemothorax, the cause has not been elucidated, although lymphatic stasis associated with deep venous thrombosis was suspected. Tensioned pneumothorax was caused by chest wall damage after extrapleural pneumonectomy combined with low aspiration pressure on the chest drain. No cause was determined for none of the tensioned hydrothorax-all 3 cases had the scenario of pericardial resection in addition to pneumonectomy in common. Tensioned space after pneumonectomy for cancer manifests as cardiac tamponade. Initial management is emergent decompression of the heart and mediastinum. Final management depends on the fluid type (chyle, transudate, air, blood) and the medical context of each case. Of the 19 cases, 12 required a major surgical procedure as the definitive management.
    Language English
    Publishing date 2022-07-01
    Publishing country Greece
    Document type Journal Article ; Review
    ZDB-ID 2683844-8
    ISSN 1792-1015 ; 1792-0981
    ISSN (online) 1792-1015
    ISSN 1792-0981
    DOI 10.3892/etm.2022.11485
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Histopathological findings in the advanced natural evolution of the SARS-CoV-2 infection.

    Cîrstea, Andreea Elena / Buzulică, Radu Lucian / Pirici, Daniel / Ceauşu, Mihail Constantin / Iman, Radu Vasile / Gheorghe, Ovidiu Mircea / Neamţu, Simona Daniela / Stanca, Liliana / Ene, Răzvan / Kumar-Singh, Samir / Mogoantă, Laurenţiu

    Romanian journal of morphology and embryology = Revue roumaine de morphologie et embryologie

    2020  Volume 61, Issue 1, Page(s) 209–218

    Abstract: We are reporting a case of natural evolution and pathological data from a young person that was diagnosed with coronavirus disease 2019 (COVID-19). All data has been collected from the autopsy of a 30-year-old female, which was performed by the ... ...

    Abstract We are reporting a case of natural evolution and pathological data from a young person that was diagnosed with coronavirus disease 2019 (COVID-19). All data has been collected from the autopsy of a 30-year-old female, which was performed by the Department of Forensic Medicine from Emergency County Hospital, Drobeta Turnu Severin, Mehedinţi County, Romania. The infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) was confirmed by reverse transcription polymerase chain reaction (RT-PCR) on the lung tissue which was obtained during autopsy. This case provides the opportunity to study the natural evolution of COVID-19 pneumonia in a young person with clinical signs of pneumonia but without associated comorbidities. The patient had not received any treatment. The histopathological examination of the lung revealed a process of productive proliferation, proteinaceous and fibrin-macrophagic interalveolar spaces exudate, and lesions consistent with vasculitis. In the heart, we identified a cardiac thrombus. These changes are likely to suggest an advanced natural evolution of SARS-CoV-2 virus infection.
    MeSH term(s) Adult ; Autopsy ; Betacoronavirus ; COVID-19 ; COVID-19 Testing ; Clinical Laboratory Techniques ; Coronavirus Infections/diagnosis ; Coronavirus Infections/physiopathology ; Coronavirus Infections/virology ; Female ; Humans ; Kidney/pathology ; Liver/pathology ; Lung/pathology ; Lung/virology ; Myocardium/pathology ; Pancreas/pathology ; Pandemics ; Pneumonia, Viral/physiopathology ; Pneumonia, Viral/virology ; Reverse Transcriptase Polymerase Chain Reaction ; Romania ; SARS-CoV-2 ; Thrombosis/pathology ; Thrombosis/virology
    Keywords covid19
    Language English
    Publishing date 2020-10-19
    Publishing country Romania
    Document type Case Reports ; Journal Article
    ZDB-ID 1062519-7
    ISSN 2066-8279 ; 1220-0522 ; 0035-4007
    ISSN (online) 2066-8279
    ISSN 1220-0522 ; 0035-4007
    DOI 10.47162/RJME.61.1.23
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: Histopathological findings in the advanced natural evolution of the SARS-CoV-2 infection

    Cîrstea, Andreea Elena / Buzulica, Radu Lucian / Pirici, Daniel / Ceausu, Mihail Constantin / Iman, Radu Vasile / Gheorghe, Ovidiu Mircea / Neamtu, Simona Daniela / Stanca, Liliana / Ene, Razvan / Kumar-Singh, Samir / Mogoanta, Laurentiu

    Rom J Morphol Embryol

    Abstract: We are reporting a case of natural evolution and pathological data from a young person that was diagnosed with coronavirus disease 2019 (COVID-19). All data has been collected from the autopsy of a 30-year-old female, which was performed by the ... ...

    Abstract We are reporting a case of natural evolution and pathological data from a young person that was diagnosed with coronavirus disease 2019 (COVID-19). All data has been collected from the autopsy of a 30-year-old female, which was performed by the Department of Forensic Medicine from Emergency County Hospital, Drobeta Turnu Severin, Mehedinti County, Romania. The infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) was confirmed by reverse transcription polymerase chain reaction (RT-PCR) on the lung tissue which was obtained during autopsy. This case provides the opportunity to study the natural evolution of COVID-19 pneumonia in a young person with clinical signs of pneumonia but without associated comorbidities. The patient had not received any treatment. The histopathological examination of the lung revealed a process of productive proliferation, proteinaceous and fibrin-macrophagic interalveolar spaces exudate, and lesions consistent with vasculitis. In the heart, we identified a cardiac thrombus. These changes are likely to suggest an advanced natural evolution of SARS-CoV-2 virus infection.
    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #693877
    Database COVID19

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  6. Article: A histopathological and immunohistochemical approach of surgical emergencies of GIST. An interdisciplinary study.

    Constantin, Vlad Denis / Socea, Bogdan / Popa, Florian / Carâp, Alexandru Constantin / Popescu, Gheorghe / Vlădescu, Teodora / Ceauşu, Zenaida / Berteşteanu, Şerban Vifor Gabriel / Ceauşu, Mihail Constantin

    Romanian journal of morphology and embryology = Revue roumaine de morphologie et embryologie

    2014  Volume 55, Issue 2 Suppl, Page(s) 619–627

    Abstract: The tailored approach to gastrointestinal stromal tumors (GISTs) has led to better prognosis for these types of tumors. Also, finding out GIST's pathology has led to a better understanding of oncogenesis and cancer therapy in general. The rapid expansion ...

    Abstract The tailored approach to gastrointestinal stromal tumors (GISTs) has led to better prognosis for these types of tumors. Also, finding out GIST's pathology has led to a better understanding of oncogenesis and cancer therapy in general. The rapid expansion of molecular and pathological knowledge of GISTs has given this disease a promising future. We analyze 30 cases of GISTs operated on in our clinic with confirmed diagnosis by immunohistochemistry. Most of the cases were acute cases that required urgent surgical therapy. An extended analysis of these cases is performed in order to underline their special features. We recorded 17 GISTs of the stomach, 12 GISTs of the small bowel and one esophageal GIST. Of the 30 cases, 15 cases required urgent surgery presenting with GI bleeding or shock following intraperitoneal rupture and bleeding or intestinal obstruction. Of the 15 cases that required urgent surgery 12 cases presented with serosal involvement. Twenty-four cases presented spindle cell histology, four cases were epithelioid and two cases presented mixed cellularity. Although acute presentation of GISTs is not the rule, 15 of 30 of our cases required immediate surgery and a high proportion of them (12/15) presented with serosal involvement. Serosal involvement may warrant the need for a macroscopic classification of GISTs and correlation to therapy. While overall mortality was not high in our series, morbidity is affected by acute presentation, though not specifically pertaining to the diagnosis of GIST. Acute presentations were more frequent, in our series, for small bowel GISTs, compared to gastric GISTs. Serosal involvement was more frequent in the group with acute presentation compared with non-acute GISTs and was present at the most cases of small bowel GISTs with acute onset. The Ki-67 index showed no difference between acute and non-acute onset of GISTs.
    MeSH term(s) Adult ; Aged ; Emergency Service, Hospital ; Female ; Follow-Up Studies ; Gastrointestinal Stromal Tumors/pathology ; Gastrointestinal Stromal Tumors/surgery ; Humans ; Immunohistochemistry ; Interdisciplinary Studies ; Male ; Middle Aged
    Language English
    Publishing date 2014
    Publishing country Romania
    Document type Journal Article
    ZDB-ID 1062519-7
    ISSN 2066-8279 ; 1220-0522 ; 0035-4007
    ISSN (online) 2066-8279
    ISSN 1220-0522 ; 0035-4007
    Database MEDical Literature Analysis and Retrieval System OnLINE

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