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  1. Article: Building a predictive model for assessing the risk of

    Bernad-Roche, María / Marín-Alcalá, Clara María / Cebollada-Solanas, Alberto / de Blas, Ignacio / Mainar-Jaime, Raúl Carlos

    Frontiers in microbiology

    2023  Volume 14, Page(s) 1232490

    Abstract: Salmonellosis continues to be a major cause of foodborne outbreaks worldwide, and pigs are one of the main sources of human infection. ...

    Abstract Salmonellosis continues to be a major cause of foodborne outbreaks worldwide, and pigs are one of the main sources of human infection.
    Language English
    Publishing date 2023-08-23
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2587354-4
    ISSN 1664-302X
    ISSN 1664-302X
    DOI 10.3389/fmicb.2023.1232490
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Placental Infection Associated with SARS-CoV-2 Wildtype Variant and Variants of Concern.

    Medel-Martinez, Ana / Paules, Cristina / Peran, María / Calvo, Pilar / Ruiz-Martinez, Sara / Ormazabal Cundin, María / Cebollada-Solanas, Alberto / Strunk, Mark / Schoorlemmer, Jon / Oros, Daniel / Fabre, Marta

    Viruses

    2023  Volume 15, Issue 9

    Abstract: The original SARS-CoV-2 lineages have been replaced by successive variants of concern (VOCs) over time. The aim of this study was to perform an assessment of the placental infection by SARS-CoV-2 according to the predominant variant at the moment of ... ...

    Abstract The original SARS-CoV-2 lineages have been replaced by successive variants of concern (VOCs) over time. The aim of this study was to perform an assessment of the placental infection by SARS-CoV-2 according to the predominant variant at the moment of COVID-19 diagnosis. This was a prospective study of SARS-CoV-2-positive pregnant women between March 2020 and March 2022. The population was divided into pregnancies affected by COVID-19 disease during 2020 (Pre-VOC group) and pregnancies affected after December 2020 by SARS-CoV-2 variants of concern (VOC group). The presence of virus was assessed by RT-PCR, and the viral variant was determined by whole genome sequencing. A total of 104 placentas were examined, among which 54 cases belonged to the Pre-VOC group and 50 cases belonged to the VOC group. Sixteen positive placental RT-PCR tests for SARS-CoV-2 were reported. The NGS analysis confirmed the SARS-CoV-2 lineage in placenta tissue. All samples corresponded to the Pre-VOC group, whereas no placental presence of SARS-CoV-2 was detected in the VOC group (16, 29.6% vs. 0, 0.0%
    Language English
    Publishing date 2023-09-13
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2516098-9
    ISSN 1999-4915 ; 1999-4915
    ISSN (online) 1999-4915
    ISSN 1999-4915
    DOI 10.3390/v15091918
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Correction to: Upregulation of selected HERVW loci in multiple sclerosis.

    Macías-Redondo, Sofía / Strunk, Mark / Cebollada-Solanas, Alberto / Ara, José-Ramón / Martín, Jesús / Schoorlemmer, Jon

    Mobile DNA

    2021  Volume 12, Issue 1, Page(s) 19

    Language English
    Publishing date 2021-08-11
    Publishing country England
    Document type Published Erratum
    ZDB-ID 2536054-1
    ISSN 1759-8753
    ISSN 1759-8753
    DOI 10.1186/s13100-021-00247-x
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: Salmonella

    Bernad-Roche, María / Casanova-Higes, Alejandro / Marín-Alcalá, Clara M / Cebollada-Solanas, Alberto / Mainar-Jaime, Raúl C

    Pathogens (Basel, Switzerland)

    2021  Volume 10, Issue 2

    Abstract: Few studies have focused on ... ...

    Abstract Few studies have focused on assessing
    Language English
    Publishing date 2021-01-25
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2695572-6
    ISSN 2076-0817
    ISSN 2076-0817
    DOI 10.3390/pathogens10020123
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: Upregulation of selected HERVW loci in multiple sclerosis.

    Macías-Redondo, Sofía / Strunk, Mark / Cebollada-Solanas, Alberto / Ara, José-Ramón / Martín, Jesús / Schoorlemmer, Jon

    Mobile DNA

    2021  Volume 12, Issue 1, Page(s) 18

    Language English
    Publishing date 2021-06-29
    Publishing country England
    Document type Journal Article
    ZDB-ID 2536054-1
    ISSN 1759-8753
    ISSN 1759-8753
    DOI 10.1186/s13100-021-00243-1
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Weaned piglets: another factor to be considered for the control of Salmonella infection in breeding pig farms.

    Casanova-Higes, Alejandro / Marín-Alcalá, Clara Mª / Andrés-Barranco, Sara / Cebollada-Solanas, Alberto / Alvarez, Julio / Mainar-Jaime, Raúl C

    Veterinary research

    2019  Volume 50, Issue 1, Page(s) 45

    Abstract: Field studies on Salmonella infection in suckling piglets are scarce due to the intrinsic difficulties of collecting proper samples (i.e. tonsils or mesenteric lymph nodes), and most of them rely on the analysis of rectal swabs that limit their accuracy. ...

    Abstract Field studies on Salmonella infection in suckling piglets are scarce due to the intrinsic difficulties of collecting proper samples (i.e. tonsils or mesenteric lymph nodes), and most of them rely on the analysis of rectal swabs that limit their accuracy. We used 495 slaughtered 4-weeks-old male piglets intended for human consumption from 5 Salmonella-seropositive breeding farms to collect gastrointestinal packages and perform a thorough detection of Salmonella on mesenteric lymph nodes and intestinal content. The overall prevalence of both infection and shedding was high (≈ 36%) indicating that piglets played an active role in Salmonella maintenance in the farms. Major serotypes found in piglets included 4,[5],12:i: (35.4%), Rissen (17.1%), Derby (10.9%) and Bovismorbificans (10.3%). In most of the infected animals (72.8%) the same serotype was found in mesenteric lymph nodes and feces. Significant higher ELISA OD% values were found in meat juice samples from non-infected piglets compared to infected ones (median OD% of 12.0 and 17.3, respectively; P = 0.002) suggesting some protective effect of sow's colostrum. Salmonella was also isolated from feces from weaned sows contemporary of the slaughtered piglets, and 89% of the serotypes identified in sows were also detected in piglets. Pulsed field gel electrophoresis analyses showed that 75% of the piglet isolates that were compared to those of sows were related to them, suggesting the circulation of Salmonella strains between sows and piglets. It appears that improving piglet colostrum intake along with the reduction of the shedding in sows may favor the control of Salmonella infection in breeding farms.
    MeSH term(s) Animals ; Bacterial Shedding ; Intestines/microbiology ; Lymph Nodes/microbiology ; Male ; Prevalence ; Salmonella/physiology ; Salmonella Infections, Animal/epidemiology ; Salmonella Infections, Animal/prevention & control ; Salmonella Infections, Animal/transmission ; Seroepidemiologic Studies ; Spain/epidemiology ; Sus scrofa ; Swine ; Swine Diseases/epidemiology ; Swine Diseases/prevention & control ; Swine Diseases/transmission ; Weaning
    Language English
    Publishing date 2019-06-18
    Publishing country England
    Document type Journal Article
    ZDB-ID 1146298-x
    ISSN 1297-9716 ; 0928-4249
    ISSN (online) 1297-9716
    ISSN 0928-4249
    DOI 10.1186/s13567-019-0666-7
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.B 1313: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  7. Article ; Online: Identification of FasL as a crucial host factor driving COVID-19 pathology and lethality.

    Albert, Marie-Christine / Uranga-Murillo, Iratxe / Arias, Maykel / De Miguel, Diego / Peña, Natacha / Montinaro, Antonella / Varanda, Ana Beatriz / Theobald, Sebastian J / Areso, Itziar / Saggau, Julia / Koch, Manuel / Liccardi, Gianmaria / Peltzer, Nieves / Rybniker, Jan / Hurtado-Guerrero, Ramón / Merino, Pedro / Monzón, Marta / Badiola, Juan J / Reindl-Schwaighofer, Roman /
    Sanz-Pamplona, Rebeca / Cebollada-Solanas, Alberto / Megyesfalvi, Zsolt / Dome, Balazs / Secrier, Maria / Hartmann, Boris / Bergmann, Michael / Pardo, Julián / Walczak, Henning

    Cell death and differentiation

    2024  

    Abstract: The dysregulated immune response and inflammation resulting in severe COVID-19 are still incompletely understood. Having recently determined that aberrant death-ligand-induced cell death can cause lethal inflammation, we hypothesized that this process ... ...

    Abstract The dysregulated immune response and inflammation resulting in severe COVID-19 are still incompletely understood. Having recently determined that aberrant death-ligand-induced cell death can cause lethal inflammation, we hypothesized that this process might also cause or contribute to inflammatory disease and lung failure following SARS-CoV-2 infection. To test this hypothesis, we developed a novel mouse-adapted SARS-CoV-2 model (MA20) that recapitulates key pathological features of COVID-19. Concomitantly with occurrence of cell death and inflammation, FasL expression was significantly increased on inflammatory monocytic macrophages and NK cells in the lungs of MA20-infected mice. Importantly, therapeutic FasL inhibition markedly increased survival of both, young and old MA20-infected mice coincident with substantially reduced cell death and inflammation in their lungs. Intriguingly, FasL was also increased in the bronchoalveolar lavage fluid of critically-ill COVID-19 patients. Together, these results identify FasL as a crucial host factor driving the immuno-pathology that underlies COVID-19 severity and lethality, and imply that patients with severe COVID-19 may significantly benefit from therapeutic inhibition of FasL.
    Language English
    Publishing date 2024-03-21
    Publishing country England
    Document type Journal Article
    ZDB-ID 1225672-9
    ISSN 1476-5403 ; 1350-9047
    ISSN (online) 1476-5403
    ISSN 1350-9047
    DOI 10.1038/s41418-024-01278-6
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4230: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)
    Zs.MG 80: Show issues

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  8. Article: Weaned piglets: another factor to be considered for the control of Salmonella infection in breeding pig farms

    Casanova-Higes, Alejandro / Marín-Alcalá, Clara Ma / Andrés-Barranco, Sara / Cebollada-Solanas, Alberto / Alvarez, Julio / Mainar-Jaime, Raúl C

    Veterinary research. 2019 Dec., v. 50, no. 1

    2019  

    Abstract: Field studies on Salmonella infection in suckling piglets are scarce due to the intrinsic difficulties of collecting proper samples (i.e. tonsils or mesenteric lymph nodes), and most of them rely on the analysis of rectal swabs that limit their accuracy. ...

    Abstract Field studies on Salmonella infection in suckling piglets are scarce due to the intrinsic difficulties of collecting proper samples (i.e. tonsils or mesenteric lymph nodes), and most of them rely on the analysis of rectal swabs that limit their accuracy. We used 495 slaughtered 4-weeks-old male piglets intended for human consumption from 5 Salmonella-seropositive breeding farms to collect gastrointestinal packages and perform a thorough detection of Salmonella on mesenteric lymph nodes and intestinal content. The overall prevalence of both infection and shedding was high (≈ 36%) indicating that piglets played an active role in Salmonella maintenance in the farms. Major serotypes found in piglets included 4,[5],12:i: (35.4%), Rissen (17.1%), Derby (10.9%) and Bovismorbificans (10.3%). In most of the infected animals (72.8%) the same serotype was found in mesenteric lymph nodes and feces. Significant higher ELISA OD% values were found in meat juice samples from non-infected piglets compared to infected ones (median OD% of 12.0 and 17.3, respectively; P = 0.002) suggesting some protective effect of sow’s colostrum. Salmonella was also isolated from feces from weaned sows contemporary of the slaughtered piglets, and 89% of the serotypes identified in sows were also detected in piglets. Pulsed field gel electrophoresis analyses showed that 75% of the piglet isolates that were compared to those of sows were related to them, suggesting the circulation of Salmonella strains between sows and piglets. It appears that improving piglet colostrum intake along with the reduction of the shedding in sows may favor the control of Salmonella infection in breeding farms.
    Keywords Salmonella ; breeding ; colostrum ; enzyme-linked immunosorbent assay ; farms ; feces ; humans ; intestines ; livestock and meat industry ; lymph nodes ; males ; meat juices ; piglets ; protective effect ; pulsed-field gel electrophoresis ; salmonellosis ; serotypes ; sows ; suckling ; tonsils ; veterinary medicine
    Language English
    Dates of publication 2019-12
    Size p. 45.
    Publishing place BioMed Central
    Document type Article
    ZDB-ID 1146298-x
    ISSN 1297-9716 ; 0928-4249
    ISSN (online) 1297-9716
    ISSN 0928-4249
    DOI 10.1186/s13567-019-0666-7
    Database NAL-Catalogue (AGRICOLA)

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    In stock of ZB MED Bonn / Germany

    Z 2609: Show issues

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